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Total number of found documents : 42
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1.

Type of document : Magazine article
Edition cipher :
Author(s) : Chumak A. V., Fedosova N. I., Shcherbina V. M., Cheremshenko N. L., Karaman O. M., Chekhun V. F.
Title : Influence of bacterial lectin on key regulatory links of functional activity of macrophages in mice with Ehrlich carcinoma
Place of publication : Experimental Oncology. - К., 2021. - Том 43, N 3. - С. 197-203 (Cipher ЕУ12/2021/43/3)
MeSH-main: КАРЦИНОМА, ЭРЛИХА ОПУХОЛЬ -- CARCINOMA, EHRLICH TUMOR
ИММУНОТЕРАПИЯ -- IMMUNOTHERAPY
МАКРОФАГИ -- MACROPHAGES
ЭУКАРИОТЫ -- EUKARYOTA
Annotation: Recent studies have shown the potential of using different approaches for immunotherapy in cancer treatment. Macrophages (Mph) are one of the promising targets for immunotherapy. Aim: To investigate changes in the functional activity of Mph in mice with Ehrlich carcinoma by nitric oxide (NO)/arginase (Arg), IRF4/IRF5 and STAT1/STAT6 ratios caused by administration of lectin from B. subtilis IMV-7724. Materials and Methods: From the 2nd day after Ehrlich carcinoma inoculation into female Balb/c mice, lectin from B. subtilis IMV B-7724 (0.02 mg/mouse) was administered for 10 days. The peritoneal Mph were isolated on days 14, 21, and 28 after tumor transplantation and their functional state (NO production, Arg activity and cytotoxic activity) was examined. The levels of mRNA expression of transcription factors STAT-1, STAT-6, IRF5, IRF4 were evaluated. Results: In lectin-treated animals with Ehrlich carcinoma, the functional state of Mph (NO/Arg ratio, index of cytotoxic activity) was maintained at the level of intact mice exceeding the values in untreated animals with Ehrlich carcinoma at late terms of tumor growth (21, 28 days). Analysis of mRNA expression levels of transcription factors in these animals showed a significant increase (p 0.05) in the ratio of STAT1/STAT6 on the day 21 and IRF5/IRF4 on day 28 of tumor growth compared to that in untreated mice. Conclusions: Administration of lectin from B. subtilis IMV B-7724 to mice with Ehrlich carcinoma led to the prevalence of Mph exhibiting the functional properties of M1 type at late-term tumor growth. The transcription factors of the STAT and IRF signaling pathways are involved in the process of Mph polarization induced by lectin from B. subtilis IMV B-7724
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2.

Title of magazine :Экспериментальная онкология -2021year т.43,N 3
Interesting articles :
To the thirties anniversary of the independence of Ukraine priorities in cancer research: retrospective and prospective aspects (стр.194-196)
Chumak A. V. Influence of bacterial lectin on key regulatory links of functional activity of macrophages in mice with Ehrlich carcinoma/ A. V. Chumak [et al.] (стр.197-203)
Kovalevska L. M. Expression pattern of MRPS 18 family genes in gliomas/ L. M. Kovalevska [et al.] (стр.204-208)
Roomi M. W. A nutrient mixture reduced tumor growth of SK-UT-1 human leiomyosarcoma cells IN VIVO and IN VITRO by inhibiting MMPS and inducing apoptosis/ M. W. Roomi [et al.] (стр.209-216)
Khranovska N. Magnetically sensitive nanocomplex enhances antitumor efficacy of dendritic cell-based immunotherapy/ N. Khranovska [et al.] (стр.217-223)
Abramenko I. Association of lipoprotein lipase expression with TP53 gene polymorphisms in chronic lymphocytic leukemia cells/ I. Abramenko [et al.] (стр.224-228)
Zotova O. V. 11q23/MLL rearrangements in adult acute leukemia/ O. V. Zotova [et al.] (стр.229-233)
Horacek J. M. Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival/ J. M. Horacek [et al.] (стр.234-236)
Konovalenko V. F. Experimental substantiation of the use of hydroxyapatite - tricalcium phosphate bioceramics for replacing bone defects after tumor removal/ V. F. Konovalenko [et al.] (стр.237-241)
Ivankova V. S. Effects of brachytherapy on cytogenetic parameters and oxidative status in peripheral blood lymphocytes of gynecologic cancer patients/ V. S. Ivankova [et al.] (стр.242-246)
Rawoot S. Neutrophil to lymphocyte ratio as a prognostic marker for non-metastatic renal cell carcinoma - does it add to what we already know?/ S. Rawoot [et al.] (стр.247-251)
Vlachou M. S. Plasma ctDNA ras status selects patients for anti-EGER treatment rechallenge in metastatic colorectal cancer: a meta-analysis/ M. S. Vlachou [et al.] (стр.252-256)
Kukushkina M. Safety profile and clinical outcome of adjuvant radiation therapy and intermediate-dose interferon in comparison with intermediate dose interferon alone in patients with melanoma metastases in regional lymph nodes and unfavorable prognostic factors/ M. Kukushkina [et al.] (стр.252-260)
Burlaka A. P. Redox dependent features of tumors, adipose tissue. neutrophiles and platelets in patients with metastatic colorectal cancer/ A. P. Burlaka [et al.] (стр.261-265)
Kornatska A. G. ESR1 gene variants affect FSHR-depended risk of fibrocystic mastopapthy in infertile women/ A. G. Kornatska [et al.] (стр.266-269)
Solyanik G. I. Oxamate, an inhibitor of lactate dehydrogenase, can stimulate M2 polarization of peritoneal macrophages in mice with Lewis lung carcinoma/ G. I. Solyanik [et al.] (стр.270-276)
Chekhun V. F. Can SARS-CJV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical background)/ V. F. Chekhun, E. A. Domina (стр.277-280)
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3.

Type of document : Magazine article
Edition cipher :
Author(s) : Chekhun V. F., Domina E. A.
Title : Can SARS-CJV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical backlground)
Place of publication : Experimental Oncology. - К., 2021. - Том 43, N 3. - С. 277-280 (Cipher ЕУ12/2021/43/3)
MeSH-main: КОРОНАВИРУСНЫЕ ИНФЕКЦИИ -- CORONAVIRUS INFECTIONS
РАДИОТОЛЕРАНТНОСТЬ -- RADIATION TOLERANCE
Annotation: R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Science of Ukraine has been studying the mechanisms and specificities of individual radiation sensitivity (IRS) formation in professionals who work in the field of ionizing radiation, cancer patients and representatives of other population groups. Our data based on the use of G2-test in in vitro irradiated blood lymphocytes in late G2-period of cell cycle indicated an increased carcinogenic risk in professionals with high IRS. We suggest that the COVID-19 pandemic could make significant adjustments in the formation of IRS in professionals who have survived the disease and continue to work with ionizing radiation (IR). Increased systemic inflammatory activity, which persists for a long time in COVID-19 patients, in combination with low-dose range irradiation (professionals who continue to work with IR) and with local irradiation in the high-dose range (radiation therapy for cancer patients) may affect IRS. Repeated determination of IRS in professionals who have had COVID-19 infection, using chromosomal G2-radiation sensitivity assay will answer the question: can SARS-CoV-2 coronavirus affect the IRS? The proposed hypothesis of the radiosensitivity evolution needs further experimental validation using a set of radiobiological indices to clarify the mechanism of IRS formation following COVID-19 infection. The detected changes (increase) of human IRS after COVID-19 must be taken into account for personalized planning of radiotherapy of COVID-19 cancer patients
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4.

Type of document : Magazine article
Edition cipher :
Author(s) : Chumak A. V., Fedosova N.I., Cheremshenko N. L., Symchych T. V., Voyeykova I. M., Chekhun V. F.
Title : Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis
Parallel titles :Зміни поляризації макрофагів у динаміці росту метастазуючої карциноми Льюїс
Place of publication : Экспериментальная онкология. - 2021. - Т. 43, № 1. - С. 15-20 (Cipher ЕУ12/2021/43/1)
Notes : Bibliogr. at the end of the art.
MeSH-main: КАРЦИНОМА ЛЬЮИС ЛЕГКОГО -- CARCINOMA, LEWIS LUNG
НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS
МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL
Annotation: To assess the functional state of macrophages based on various manifestations of their activity at the different stages of metastatic tumor growth in C57Bl mice. Materials and Methods: On days 7, 14, 21 and 28 after Lewis lung carcinoma transplantation to C57Bl mice, macrophages from various anatomic sites were isolated and tested on their cytotoxicity, metabolic activity, NO production and arginase activity. Results: In the populations of peritoneal and splenic macrophages, on days 7 and 21 of tumor growth antitumor (M1) cells prevailed while on days 14 and 28 tumor-promoting (M2) macrophages predominated. In the population of lung macrophages, cells with M1 phenotype were in the majority in the early stages of tumor growth. On days 21 and 28, M1 cells were gradually substituted by cells exhibiting M2 phenotype. This shift correlated with metastasis to lungs. Conclusion: Lewis lung carcinoma growth is accompanied by the gradual change in macrophage polarization from antitumor (M1) towards tumor-promoting (M2) type. These changes were more evident in population of lung macrophages and correlated with the parameters of metastasisОцінити стан макрофагів мишей лінії С57Вl за різними проявами їх функціональної активності на різних стадіях росту метастазуючої пухлини. Матеріали та методи: У дослідженні використовували мишей лінії C57Bl з епідермоїдною метастазуючою карциномою легені Льюїс. На 7-, 14-, 21- та 28-й день після перещеплення пухлини макрофаги з різних ніш були виділені та піддані функціональному аналізу. Результати: Макрофаги, отримані з різних біологічних ніш у інтактних тварин, за дослідженими показниками функціональної активності мали фенотип М1. У популяціях макрофагів, отриманих з селезінки та перитонеальної порожнини мишей лінії С57Вl на 7-і 21-шу доби росту карциноми легені Льюїс переважали клітини з протипухлинними властивостями (М1), на 14- та 28-му добу — клітини з пропухлинними властивостями (М2). У популяції легеневих макрофагів на ранніх стадіях пухлинного процесу переважали клітини з фенотипом М1, до 28-ї доби спостерігали поступову їх поляризацію до фенотипу М2. Такі зміни корелювали з показниками метастазування в легені в ці терміни. Висновок: Aналіз показників функціо­нальної активності макрофагів свідчить про їх поступову поляризацію від клітин з проти- (М1) до клітин з пропухлинними (М2) властивостями в динаміці росту карциноми легені Льюїс. Виявлені зміни були найбільш вираженими в популяції легеневих макрофагів та мали кореляційний зв’язок з показниками метастазування
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5.

Title of magazine :Экспериментальная онкология -2021year т.43,N 1
Interesting articles :
Cavalli M. A non-coding cancer mutation disrupting an HNF4α binding motif affects an enhancer regulating genes associated to the progression of liver cancer/ M. Cavalli [та ін.] (стр.2-7)
Yakovlev P. G. Changes in expression of TLR-4, TGF-β, INF-γ, TNF-α in cultured T24/83 cells of invasive bladder cancer treated with cisplatin and/or polyphenolic adjuvant melanin/ P. G. Yakovlev [та ін.] (стр.7-14)
Chumak A. V. Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis/ A. V. Chumak [та ін.] (стр.15-20)
Yushko L. A. Comparative study of biochemical and morphological parameters in rats with Walker 256 and Walker 256/DOX carcinosarcoma/ L. A. Yushko [та ін.] (стр.21-25)
Prokhorova I. V. ROS production by circulating phagocytes and Guerin carcinoma resistance to cisplatin/ I. V. Prokhorova [та ін.] (стр.26-30)
Elemam O. Emergency oncology admissions during COVID-19 pandemic: a major institution experience from Saudi Arabia/ O. Elemam [та ін.] (стр.31-35)
Kravets O. V. Significance of expression of tumor-associated microRNA-21 and -375 for predicting the course of cancer of oral cavity/ O. V. Kravets [та ін.] (стр.36-40)
Boyko O. Erythropoietin as an independent prognostic factor in myelodysplastic syndromes/ O. Boyko [та ін.] (стр.41-45)
Samoylenko O. A. Ornithine decarboxylase activity in prostate cancer/ О. А. Samoylenko [та ін.] (стр.46-51)
Gervas P. New germline mutations in BRCA1, ATM, MUTYH, and RAD51D genes in Tuvans early-onset breast cancer patients/ P. Gervas [та ін.] (стр.52-55)
Lobanova O. E. Prevalence of BRCA1 and BRCA2 genes promoter hypermethylation in breast cancer tissue/ O. E. Lobanova [та ін.] (стр.56-60)
Hergebue K. Therapeutic results and prognostic factors of stage III NSCLC: a population-based study in Tunisia/ K. Hergebue [та ін.] (стр.61-66)
Tsip N. P. Experience with the use of HIPEC in advanced serous ovarian cancer after complete and optimal cytoreduction/ N. P. Tsip [та ін.] (стр.67-72)
Gurianov D. S. Nuclear localization of BCR and cortactin indicates their potential role in regulation of actin branching in nucleus/ D. S. Gurianov, S. V. Antonenko, G. D. Telegeev (стр.73-76)
Yanish Yu. V. Application of gold and silver nanoparticles for selective assay of spermine in mixture with spermidine/ Yu. V. Yanish [та ін.] (стр.77-81)
Drogovoz S. M. Experience and prospects for the use of off-label drugs in oncology/ S. M. Drogovoz [та ін.] (стр.82-86)
Gluzman D. F. Immunodeficiency-associated lymphoproliferative disorders and lymphoid neoplasms in post-COVID-19 pandemic era/ D. F. Gluzman [та ін.] (стр.87-91)
Moreno M. An uncommon case of vulvar cancer metastatic to breast/ M. Moreno [та ін.] (стр.92-95)
Ada Leonidivna Vorontsova (1934–2020) (стр.96)
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6.

Type of document : Magazine article
Edition cipher :
Author(s) : Todor I. N., Lukianova N. Yu., Primin M. А., Nedayvoda I. V., Chekhun V. F.
Title : Biomagnetism of tumor in rats with Guerin’s carcinoma after injection of ferromagnetic nanocomposite (Ferroplat): contactless measurement
Place of publication : Экспериментальная онкология. - 2020. - Т. 42, № 3. - С. 204-207 (Cipher ЕУ12/2020/42/3)
Notes : Бібліогр.: в кінці ст.
MeSH-main: НОВООБРАЗОВАНИЯ ЭКСПЕРИМЕНТАЛЬНЫЕ -- NEOPLASMS, EXPERIMENTAL
ДИАГНОСТИКА -- DIAGNOSIS
МАГНИТНЫЕ ПОЛЯ -- MAGNETIC FIELDS
МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL
НАНОКОМПОЗИТЫ -- NANOCOMPOSITES
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Key words (''Своб.индексиров.''): карциноми герена
Annotation: In order to develop fundamentally new technologies for non-invasive and safer diagnosis of cancer, we aimed to detect non-contact magnetic signals from a malignant tumor in animals treated or not-treated with the ferromagnetic nanocomposite Ferroplat. Materials and Methods: Guerin’s carcinoma was used as a model of tumor growth. The biomagnetism of the tumor was evaluated in the dynamics of its growth. Ten days after tumor transplantation, Ferroplat was administered intravenously to half of the animals with the tumor and to half of the control animals. The magnitude of the magnetic signals was determined 1 h and every two days after administration of the nanocomposite using a Superconducting Quantum Interference Device magnetometer of the original design. Results: We have found that the magnetic signals coming from the tumor are significantly higher compared to control tumor-free animals. Intravenous administration of a ferromagnetic nanocomposite (Ferroplat: Fe3O4 + cisplatinum) led to a significant increase of the magnetic signal, especially in the tumor tissue, and inhibition of Guerin’s carcinoma growth. Ferromagnetic nanoparticles (32.7 nm) are retained in malignant cells for a longer time than in normal ones. Conclusion: Tumor cells accumulate iron nanoparticles more intensively than normal ones. Nanocomposite Ferroplat can be used for a targeted delivery of cisplatin to malignant cells
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7.

Type of document : Magazine article
Edition cipher :
Author(s) : Zadvornyi T. V., Lukianova N. Yu., Borikun T. V., Vitruk Yu. V., Stakhovsky E. O., Chekhun V. F.
Title : Nanog as prognostic factor of prostate cancer course
Place of publication : Experimental Oncology. - К., 2020. - Том 42, N 2. - С. 94-100 (Cipher ЕУ12/2020/42/2)
MeSH-main: ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS
Annotation: The variability of the clinical course of prostate cancer (PC) indicates the need to find factors that could predict the aggressive potential of neoplasms accounting the biological characteristics of tumor cells. In this context, the role of NANOG, a transcription factor involved in maintaining pluripotency and one of the markers of cancer stem cells (CSCs), is being actively studied today. Aim: To investigate the level of NANOG mRNA in tumor tissue of patients with PC and to analyze the possibility of its use as a marker of the disease course. Materials and Methods: The study involved 85 patients with PC of stages II–IV. Morphological and immunohistochemical studies were performed on serial paraffin sections of resected PC using monoclonal antibodies to Ki-67 and androgen receptor. NANOG and miR-214 mRNA expression in tumor cells was analyzed by real-time reverse transcription polymerase chain reaction. The identification of CSCs was performed by double-labeled immunohistochemical method using primary antibodies to CD24 and CD44. Results: We have revealed notable variability of NANOG mRNA levels in tumor tissue of patients with PC (mean 4.18 ± 0.65 a.u. with individual deviations from 0.11 ± 0.03 a.u. to 15.24 ± 0.36 a.u.). According to NANOG mRNA levels, two groups of the PC patients were delineated: group 1 and group 2, with the average NANOG mRNA levels of 2.12 ± 0.16 a.u., and 8.68 ± 1.24 a.u., respectively. The NANOG mRNA levels in tumor tissue of PC patients of groups 1 and 2 correlated with preoperative serum prostate-specific antigen level (r = 0.58; p 0.05 and r
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8.

Type of document : Magazine article
Edition cipher :
Author(s) : Symchych T. V., Fedosova N. I., Chumak A. V., Cheremshenko N. L., Karaman O. M., Burlaka A. P., Voyeykova I. M., Chekhun V. F.
Title : Functions of tumor-associated macrophages and macrophages residing in remote anatomical niches in Ehrlich carcinoma bearing mice
Place of publication : Экспериментальная онкология. - 2020. - Т. 42, № 3. - С. 197-203 (Cipher ЕУ12/2020/42/3)
Notes : Бібліогр.: в кінці ст.
MeSH-main: БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
КАРЦИНОМА, ЭРЛИХА ОПУХОЛЬ -- CARCINOMA, EHRLICH TUMOR
МАКРОФАГИ -- MACROPHAGES
МИКРОСКОПИЯ ПОЛЯРИЗАЦИОННАЯ -- MICROSCOPY, POLARIZATION
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: The impact of growing tumor on polarization and functions of tumor-associated macrophages is well known while its influence on residential macrophages occupying different anatomical niches reminds to be elucidated. Aim: To study changes in polarization and functions of macrophages isolated from discrete anatomical niches in tumor-bearing mice at different stages of tumor growth. Materials and Methods: Ehrlich carcinoma was transplanted intramuscularly to Balb/c male mice. On days 7, 14, 21 and 28 after tumor transplantation, macrophages from tumor tissue, peritoneal cavity and spleen were isolated and analyzed. Nitric oxide production was measured by standard Griess reaction, arginase activity was determined by the measurement of urea, reactive oxygen species production was checked using NBT dye reduction assay and electron paramagnetic resonance spectroscopy, cytotoxic activity was estimated in MTT-assay. Results: Independently of their localization in different anatomic niches, macrophages in mice with transplanted Ehrlich carcinoma gradually lose their tumoricidal activities while arginase activity is upregulated. This indicates the shift of polarization from M1-like towards M2-like phenotype. Conclusion: Our findings demonstrated that growing tumor could be able to subvert functioning of macrophages at the systemic level
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9.

Title of magazine :Экспериментальная онкология -2020year т.42,N 3
Interesting articles :
Chekhun V. F. Association of circulating miR-21, -205, and -182 with response of luminal breast cancers to neoadjuvant FAC and AC treatment/ V. F. Chekhun [та ін.] (стр.162-166)
Kirkilevsky S. I. Prognostic significance of microRNA-200b and ERCC1 expression in tumor cells of patients with esophageal cancer/ S. I. Kirkilevsky [та ін.] (стр.167-171)
Abramenko I. V. Analysis of immunoglobulin heavy variable chain rearrangement in chronic lymphocytic leukemia patients among Chornobyl clean-up workers/ I. V. Abramenko [та ін.] (стр.172-177)
Ghosh S. K. Antiproliferative and apoptotic effect of ethanolic extract of Calocybe indica on PANC-1 and MIAPaCa2 cell lines of pancreatic cancer/ S. K. Ghosh, T. Sanyal (стр.178-182)
Sanaei M. Effect of valproic acid and zebularine on SOCS-1 and SOCS-3 gene expression in colon carcinoma SW48 cell line/ M. Sanaei, F. Kavoosi, H. Behjoo (стр.183-187)
Mehri S. Osteopontin siRNA does not confer resistance to toxic effects of parthenolide in Jurkat cells/ S. Mehri [та ін.] (стр.188-191)
Pyaskovskaya O. N. Tumor microenvironment changes tumor cell sensitivity to action of energy metabolism modifiers/ O. N. Pyaskovskaya [та ін.] (стр.192-196)
Symchych T. V. Functions of tumor-associated macrophages and macrophages residing in remote anatomical niches in Ehrlich carcinoma bearing mice/ T. V. Symchych [та ін.] (стр.197-203)
Todor I. N. Biomagnetism of tumor in rats with Guerin’s carcinoma after injection of ferromagnetic nanocomposite (Ferroplat): contactless measurement/ I. N. Todor [та ін.] (стр.204-207)
Çavuş B. Assessment of prognostic and diagnostic value of some biomarkers in hepatocellular carcinoma/ B. Çavuş [та ін.] (стр.208-214)
Babkina T. M. Detection of breast cancer presenting as a mass in women with dense breasts — digital breast tomosynthesis versus full-field digital mammography/ T. M. Babkina [та ін.] (стр.215-219)
Dumanskiy Y. V. Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas/ Y. V. Dumanskiy [та ін.] (стр.220-223)
Stakhovskyi O. E. Quality of life in patients after radical cystectomy with modified ureterocutaneostomy and Bricker urinary diversion/ O. E. Stakhovskyi [та ін.] (стр.224-227)
Kravets O. V. Comparative analysis of the efficacy of definitive chemoradiation therapy and surgery followed by adjuvant radiation therapy in advanced-stage oral tongue cancer/ O. V. Kravets [та ін.] (стр.228-232)
Baranovska V. V. Histological differential diagnostics of renal oncocytoma/ V. V. Baranovska, A. M. Romanenko, L. M. Zakhartseva (стр.233-237)
Trociukas I. Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma/ I. Trociukas [та ін.] (стр.238-241)
Golovko A. Thyroid metastasis of vaginal leiomyosarcoma: a case report and review of the literature/ A. Golovko [та ін.] (стр.242-244)
Filenko B. M. Clinicomorphological observation of refractory hepatoblastoma: a case report/ B. M. Filenko [та ін.] (стр.245-247)
Zinovkin D. A. Water clear cell adenoma of parathyroid gland: a rare lesion/ D. A. Zinovkin, M. Yu. Zhandarov, M. Z .I. Pranjol (стр.248)
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10.

Type of document : Magazine article
Edition cipher :
Author(s) : Chekhun V. F., Borikun T. V., Bazas V. M., Andriiv A. V., Klyusov O. М., Yalovenko T. М., Lukianova N. Yu.
Title : Association of circulating miR-21, -205, and -182 with response of luminal breast cancers to neoadjuvant FAC and AC treatment
Place of publication : Экспериментальная онкология. - 2020. - Т. 42, № 3. - С. 162-166 (Cipher ЕУ12/2020/42/3)
Notes : Бібліогр.: в кінці ст.
MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
ЛЕКАРСТВЕННАЯ ТЕРАПИЯ КОМБИНИРОВАННАЯ -- DRUG THERAPY, COMBINATION
ЭКСПРЕССИРУЕМОЙ ПОСЛЕДОВАТЕЛЬНОСТИ МАРКЕРЫ -- EXPRESSED SEQUENCE TAGS
РНК НОВООБРАЗОВАНИЙ -- RNA, NEOPLASM
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To identify the association of serum miRNAs with neoadjuvant polychemotherapy response in patients with breast cancer of luminal A and B subtypes. Materials and Methods: We analyzed the expression levels of circulating miR-21, -155, -182, -373, -199a, -205, -375 in serum of 182 breast cancer patients using real-time polymerase chain reaction. Each case was characterized by TMN criteria using morphological and immunohistochemical analyses. Results: Serum levels of miR-205 and -375 are associated with the response of luminal A tumors and miR-205 and -21 with the response of luminal B tumors to neoadjuvant polychemotherapy in fluorouracil + doxorubicin + cyclophosphamide and doxorubicin + cyclophosphamide regimens. In addition, we found correlation of miR-155, -182, -199a, -375 with 3-year relapse-free survival of patients. Based on the obtained data, we developed innovative prognostic and predictive panels to assess the drug sensitivity of tumors and lower the risk of breast cancer recurrence, which would significantly improve the treatment outcomes and the quality of life of patients. Conclusions: Serum levels of miR-155, -182, -199a, -205, -375 can be used as predictive and prognostic panel for monitoring BC course in Ukrainian population
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11.

Type of document : Magazine article
Edition cipher :
Author(s) : Shvets Yu. V., Lukianova N. Yu., Chekhun V. F.
Title : Human microbiota and effectiveness of cancer chemotherapy
Place of publication : Experimental Oncology. - К., 2020. - Том 42, N 2. - С. 82-93 (Cipher ЕУ12/2020/42/2)
MeSH-main: НОВООБРАЗОВАНИЯ -- NEOPLASMS
Annotation: This review presents up-to-date information on the effects of microbiota on the individual chemotherapy sensitivity in cancer treatment. Recent studies have shown that a fine balance between the intestinal microbiota and the immune system is crucial for maintaining an efficacy of cancer chemotherapy. A number of antitumor drugs have complex mechanisms of action involving not only direct effects but also the activity of the intestinal microbiota and the immune system. A unique combination of these factors contributes to the individual chemotherapy sensitivity
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12.

Type of document : Magazine article
Edition cipher :
Author(s) : Naleskina L. A., Kunska L. M., Chekhun V. F.
Title : Modern views on the role of main components of stroma and tumor microinvironment in invasion, migration and metastasis
Place of publication : Экспериментальная онкология. - 2020. - Т. 42, № 4. - С. 252-262 (Cipher ЕУ12/2020/42/4)
Notes : Бібліогр.: в кінці ст.
MeSH-main: ОБЗОР -- REVIEW
НОВООБРАЗОВАНИЙ МИКРООКРУЖЕНИЕ -- TUMOR MICROENVIRONMENT
ФИБРОБЛАСТОВ ФАКТОРЫ РОСТА -- FIBROBLAST GROWTH FACTORS
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL
Annotation: The review presents modern ideas about tumor microenvironment, which most researchers recognize as the main “player” in tumor cell invasion, cell migration and metastasis. The current data on the main components of the stroma and the microenvironment, which play the role of the driving force in tumor progression, are analyzed. In particular, the review highlights the issues of origin, biological traits, phenotypic plasticity, functional heterogeneity of activated fibroblasts — myofibroblasts and tumor-associated fibroblasts, which in recent years have received much attention. Such components of the extracellular matrix proteome as collagen and matrix metalloproteinases are discussed in detail. They are mostly produced by activated fibroblasts and, on the one hand, initiate the development of desmoplasia due to type I collagen and, on the other hand, promote degradation of extracellular matrix proteins due to metalloproteinases, which generally leads to tissue remodeling that promotes tumor progression. Possibilities of using the most important indicators of extracellular matrix remodeling as potential markers and targets of clinical strategy are discussed
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13.

Title of magazine :Экспериментальная онкология -2020year т.42,N 4
Interesting articles :
Commitment to ideals of science. To the 90th birthday anniversary of academician Vadym Pinchuk (стр.250-251)
Naleskina L. A. Modern views on the role of main components of stroma and tumor microinvironment in invasion, migration and metastasis/ L. A. Naleskina, L. M. Kunska, V. F. Chekhun (стр.252-262)
Gaptulbarova K. A. NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer/ K. A. Gaptulbarova [та ін.] (стр.263-269)
Tykhomyrov A. A. Plasminogen/plasmin affects expression of glycolysis regulator TIGAR and induces autophagy in lung adenocarcinoma A549 cells/ A. A. Tykhomyrov [та ін.] (стр.270-276)
Kumar A. Microarray based gene expression profiling of advanced gall bladder cancer/ A. Kumar [та ін.] (стр.277-284)
Auziņa D. Dickkopf-related protein 1 expression in bone marrow of multiple myeloma patients: correlation with bone disease and plasma cell malignancy type/ D. Auziņa [та ін.] (стр.285-288)
Buchynska L. G. Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium/ L. G. Buchynska [та ін.] (стр.289-294)
Kovalevska L. Expression pattern of MRPS18 family genes in malignantly transformed b-cells/ L. Kovalevska, E. Kashuba (стр.295-299)
Buchynska L. G. Molecular phenotype of high-grade endometrioid carcinoma of the endometrium/ L. G. Buchynska [та ін.] (стр.300-305)
Shamrai D. Granulosa and theca cell tumor in rat’s ovary after modified Biskind operation/ D. Shamrai, E. Koshik, N. Melnyk (стр.306-309)
Bolgova L. S. Histogenesis of central lung cancer: cytological investigation/ L. S. Bolgova [та ін.] (стр.310-313)
Shcherbynina M. Histological criteria for “intraepithelial squamous cell carcinoma” of the esophagus: continued dialogue between Ukrainian and Japanese pathologists/ M. Shcherbynina, M. Itabashi, N. Soloviova (стр.314-317)
Yevstakhevych Yu. L. Autoimmune cytopenia in chronic lymphocytic leukemia: diagnosis and treatment/ Yu. L. Yevstakhevych [та ін.] (стр.318-323)
Korovin S. Burden of malignant melanoma in Ukraine in 2002–2013: incidence, mortality and survival/ S. Korovin [та ін.] (стр.324-329)
Burlaka A. P. Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer/ A. P. Burlaka [та ін.] (стр.330-332)
Kitsera N. Woman with Turner syndrome and her child with acute leukemia (a case report)/ N. Kitsera, O. Dorosh, H. Makukh (стр.333-336)
Buchatskyi L. P. Hypoxia induces melanotic pseudotumors in the larvae of mosquitoes of Culicidae family/ L. P. Buchatskyi (стр.337)
Mykola Oleksandrovych Druzhyna (1940–2020) (стр.338)
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14.

Title of magazine :Экспериментальная онкология -2020year т.42,N 2
Interesting articles :
Shvets Yu. V. Human microbiota and effectiveness of cancer chemotherapy/ Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun (стр.82-93)
Zadvornyi T. V. Nanog as prognostic factor of prostate cancer course/ T. V. Zadvornyi [et al.] (стр.94-100)
Lamdan H. Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin/ H. Lamdan [et al.] (стр.101-108)
Antonenko S. V. Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells/ S. V. Antonenko, G. D. Telegeev (стр.109-114)
Onyshchenko K. V. Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma/ K. V. Onyshchenko [et al.] (стр.115-119)
Stegantseva M. V. Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model/ M. V. Stegantseva [et al.] (стр.120-125)
Andreieva S. V. Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias/ S. V. Andreieva [et al.] (стр.126-129)
Bialik P. HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer/ P. Bialik [et al.] (стр.130-134)
Pankaj D. Clinicopathological correlation of the expression of excision repair cross complementation group 1 (ERCC1) in oral cavity squamous cell carcinomas: an immunohistochemical study/ D. Pankaj, V. Guddattu, M. C. Solomon (стр.135-139)
Lyalkin S. A. Prognostic role of androgen receptor expression in patients with metastatic triple negative breast cancer/ S. A. Lyalkin [et al.] (стр.140-143)
Perekhrestenko T. Expression of Ki-67 and CD34 on blood and bone marrow cells of CML patients with different response to imatinib and nilotinib therapy/ T. Perekhrestenko [et al.] (стр.144-147)
Glavatskyi O. Ya. Temozolomide in glioblastoma treatment: 15-year clinical experience and analysis of its efficacy/ O. Ya. Glavatskyi [et al.] (стр.148-156)
Kliusov O. M. Specialized care provided to patients with rectal cancer in Kyiv city/ O. M. Kliusov (стр.157-160)
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15.

Type of document : Magazine article
Edition cipher :
Author(s) : Lukianova N. Yu., Borikun T.V., Chekhun V. F.
Title : Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 242-247 (Cipher ЕУ12/2019/41/3)
Notes : Bibliogr. at the end of the art.
MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY
МИКРО-РНК -- MICRORNAS
ГЕННАЯ ЭКСПРЕССИЯ -- GENE EXPRESSION
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) were analyzed in tissue of BC using immunohistochemical method. Relative expression levels of the miR-155, -320a, and -205 were examined in tissue and sera from BC patients using quantitative reverse transcription polymerase chain reaction. Results: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. Nevertheless, we established the relation of circulating and tissue miR-155, -320a, and -205 to lymph node metastases and basal breast cancer subtype. Conclusions: Changes of miR-155, -320a, and -205 expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC
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16.

Type of document : Magazine article
Edition cipher :
Author(s) : Chekhun V. F.
Title : MicroRNAs are a key factor in the globalization of tumor-host relationships
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 188-194 (Cipher ЕУ12/2019/41/3)
Notes : Bibliogr. at the end of the art.
MeSH-main: ОБЗОР -- REVIEW
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
ЭПИГЕНЕЗ ГЕНЕТИЧЕСКИЙ -- EPIGENESIS, GENETIC
МИКРО-РНК -- MICRORNAS
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL
ДИАГНОСТИКА ДИФФЕРЕНЦИАЛЬНАЯ -- DIAGNOSIS, DIFFERENTIAL
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: A new round of molecular oncology development in the post-genomic era significantly changes the conventional understanding of the nature and origin of the malignant process. Increasingly, fundamental phenomena are emerging that change the “canonical” views of the dominant role of gene mutations that contribute to the uncontrolled proliferation and emergence of heterogeneous malignant cells. Recent numerous studies have shown that significant variability in the initiation, proliferation and control of the apoptotic program of tumor cells is due to numerous epigenetic processes, including the level of expression of microRNAs (miRNAs). This paper reviews the literature data and presents the results of own research in which miRNAs have been found to form a molecular phenotype for malignancy. Their role as a “conductor” of the functioning of a genetic-epigenetic orchestra that coordinates various aspects of malignancy has been suggested. MiRNAs have been shown to be an active participant in balancing mechanisms in the development of controversial processes in breast cancer cell lines of varying degrees of malignancy. The analysis of the literature data and the own studies of the expression profile of only a few miRNAs suggests that scientists and clinicians have received a new marker and a target that simultaneously plays the role of an active insider in both the oncogene-oncosuppressor relationship and in the globalization of this process at the tumor-host level. Further investigation of the “alarm” marker in this network will allow to reconsider the molecular genetic classification of neoplastic disease, which will provide the development of a new strategy for cancer therapy
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17.

Title of magazine :Экспериментальная онкология -2019year т.41,N 1
Interesting articles :
Solyanik G. I. Quinazoline compounds for antitumor treatment/ G. I. Solyanik (стр.3-6)
Mahmoudian J. Expression profiling of plac1 in murine cancer cell lines/ J. Mahmoudian [та ін.] (стр.7-13)
Kolesnik D. L. Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma/ D. L. Kolesnik [та ін.] (стр.14-19)
Lozovska Yu. V. The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma/ Yu. V. Lozovska [та ін.] (стр.20-25)
Burlaka A. A. DNA oxidation in patients with metastastic colorectal cancer: clinical significance of 8-hydroxy-deoxyguanosine as an independent prognostic factor/ A. A. Burlaka [та ін.] (стр.26-31)
Stakheyeva M. Integral characteristic of the immune system state predicts breast cancer outcome/ M. Stakheyeva [та ін.] (стр.32-38)
Bilous N. Analysis of LPL gene expression in patients with chronic lymphocytic leukemia/ N. Bilous [та ін.] (стр.39-45)
Alghamdi S. Evaluation of dose calculation algorithms using different density materials for in-field and out-of-field conditions/ S. Alghamdi, A. Tajaldeen (стр.46-52)
Poluben L. Copy number alterations and copy-neutral loss of heterozygosity in Ukrainian patients with primary myelofibrosis/ L. Poluben [та ін.] (стр.53-56)
Bakai O. A. Radiation research to determine local tumor invasion in patients with cervical cancer/ O. A. Bakai [та ін.] (стр.57-60)
Zabolotnyi D. I. Aggregated proteins in malignant and benign neoplasms/ D. I. Zabolotnyi [та ін.] (стр.61-68)
Shirin V. Assessment of trace elements in serum of acute lymphoblastic and myeloid leukemia patients/ V. Shirin [та ін.] (стр.69-71)
Tkachenko R. Parathyroid carcinoma: a case report/ R. Tkachenko [та ін.] (стр.72-75)
Semko S. A case of synchronous bilateral calyx urothelial carcinoma: combined treatment approach/ S. Semko [та ін.] (стр.76-79)
De Giorgi V. Cutaneous leiomyosarcoma: a clinical, dermoscopic, pathologic case study/ Giorgi V. De [та ін.] (стр.80-81)
Langabeer S. E. Suboptimal molecular response to tyrosine kinase inhibition associated with acquisition of a T240A ABL1 kinase domain mutation in a patient with chronic myeloid leukemia/ S. E. Langabeer [та ін.] (стр.82-83)
Brieieva O. Scientific and Practical Conference of Young Scientists “Fundamental Medicine: Integrated Approaches to Cancer Therapy”/ O. Brieieva (стр.84-86)
Tumor and Host: Novel Aspects of Old Problem (стр.87)
Ludmyla Zakharivna Polishchuk (1937–2019) (стр.88)
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18.

Type of document : Magazine article
Edition cipher :
Author(s) : Lozovska Yu. V., Andrusishina I. M., Lukianova N. Yu., Burlaka A. P., Naleskina L. A., Todor I. N., Chekhun V. F.
Title : The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 20-25 (Cipher ЕУ12/2019/41/1)
Notes : Bibliogr. at the end of the art.
MeSH-main: КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER
ЛАКТОФЕРРИН -- LACTOFERRIN
ЦЕРУЛОПЛАЗМИН -- CERULOPLASMIN
ПЕРОКСИДАЗА -- PEROXIDASE
ТРАНСФЕРРИН -- TRANSFERRIN
ФЕРМЕНТОВ АКТИВАТОРЫ -- ENZYME ACTIVATORS
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To investigate the content of essential elements (EE): copper, zinc, magnesium, iron and calcium and the evaluation of the activity of metal-containing enzymes — ceruloplasmin (CP), myeloperoxidase (MPO) and the content of transferrin (TF) in blood plasma (BP) and tumor tissue (TT) of animals with Walker-256 carcinosarcoma treated with lactoferrin (LF). Materials and Methods: The study of the EE content and the activity of the abovementioned enzymes was carried out on rats with Walker-256 carcinosarcoma treated with LF at the doses of 1 and 10 mg/kg of body weight. The quantitative content of EE in BP and TT of animals was determined using the inductively coupled plasma atomic emission spectroscopy (ICP-AES). Determination of CP activity, content of TF and hemochromes was performed using the method of electron paramagnetic resonance (EPR), and MPO — by unified biochemical method. Results: The introduction of LF at the doses of 1 and 10 mg/kg resulted in a decrease in the ratio of Cu/Zn in BP and even more expressed decrease of Ca/Mg ratio in TT. Administration of LF, especially at a dose of 10 mg/kg, affected the increase in CP and MPO activity in BP. It has been shown that administration of LF at a dose of 10 mg/kg led to an increase in oxidative products of destruction of the hemoglobin-hemochrom system in the TT, against the background of lowering the TF content. Conclusions: The administration of LF, especially at a dose of 10 mg/kg, led to metabolic alterations associated with inhibition of the tumor process. The detected modulating effect of LF on the content of the EE and the activity of the CP and MPO may be a basis for correction of the elemental balance in carcinogenesis
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19.

Title of magazine :Экспериментальная онкология -2019year т.41,N 3
Interesting articles :
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine: 25 years with the OECI (стр.187)
Chekhun V. F. MicroRNAs are a key factor in the globalization of tumor-host relationships/ V. F. Chekhun (стр.188-194)
Shlyakhovenko V. O. The dual role of ribonucleases in tumor-host relationship/ V. O. Shlyakhovenko, O. A. Samoylenko (стр.195-199)
Shuba Ya. M. Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies?/ Ya. M. Shuba (стр.200-206)
Ivanivska T. S. Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia/ T. S. Ivanivska [та ін.] (стр.207-209)
Holotiuk V. V. Role of nitric oxide in pathogenesis of tumor growth and its possible application in cancer treatment/ V. V. Holotiuk [та ін.] (стр.210-215)
Oshyvalova O. Modern view on epidermal dysplasia carcinogenesis/ O. Oshyvalova, Z. Rossokha (стр.216-223)
Bazalytska S. V. Моlecular mechanisms of initiation of carcinogenesis in the testis/ S. V. Bazalytska, Y. Persidsky, A. M. Romanenko (стр.224-234)
Bogdanova T. Histopathological characteristics and post-operative follow-up of patients with potentially radiogenic papillary thyroid carcinoma depending on oncocytic changes availability in the tumor cells/ T. Bogdanova [та ін.] (стр.235-241)
Lukianova N. Yu. Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer/ N. Yu. Lukianova, T. V. Borikun, V. F. Chekhun (стр.242-247)
Patysheva M. Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes/ M. Patysheva [та ін.] (стр.248-253)
Sakhno L. A. Adsorptive therapy as a modificator for tumor-host interaction/ L. A. Sakhno [та ін.] (стр.254-257)
Materials of the II International Conference “Tumor and Host: Novel Aspects of Old Problem” (November 21–22, 2019, Kyiv, Ukraine) (стр.258-280)
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20.

Type of document : Magazine article
Edition cipher :
Author(s) : Karaman O. M., Ivanchenko A. V., Chekhun V. F.
Title : Macrophages - a perspective target for antineoplastic immunotherapy
Place of publication : Experimental Oncology. - К., 2019. - Том 41, N 4. - С. 282-290 (Cipher ЕУ12/2019/41/4)
MeSH-main: ОБЗОР -- REVIEW
МАКРОФАГА-1 АНТИГЕН -- MACROPHAGE-1 ANTIGEN
ГЕНЕТИЧЕСКИЕ МАРКЕРЫ -- GENETIC MARKERS
НОВООБРАЗОВАНИЙ КОЛИЧЕСТВЕННЫЕ ХАРАКТЕРИСТИКИ -- TUMOR BURDEN
АРГИНАЗА -- ARGINASE
Key words (''Своб.индексиров.''): макрофаги м2
Annotation: The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity
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