Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

Home page

Simplified mode

Video-instruction

Description

Data bases

Periodicals- results of search

Type of search

Periodicals

Search field

in the found

the format of presenting the found documents:
full	informational	short

Sort out the found documents by:
to the author	by title	Year of publication	document type

Search inquiry: (<.>A=Chekhun, V. F.$<.>)

Total number of found documents : 36
Shown documents from 1 till 20

1-20 21-36

Type of document : Magazine article
Edition cipher :
Author(s) : Chumak A. V., Fedosova N. I., Shcherbina V. M., Cheremshenko N. L., Karaman O. M., Chekhun V. F.
Title : Influence of bacterial lectin on key regulatory links of functional activity of macrophages in mice with Ehrlich carcinoma
Place of publication : Experimental Oncology. - К., 2021. - Том 43, N 3. - С. 197-203 (Cipher ЕУ12/2021/43/3)
MeSH-main: КАРЦИНОМА, ЭРЛИХА ОПУХОЛЬ -- CARCINOMA, EHRLICH TUMOR
ИММУНОТЕРАПИЯ -- IMMUNOTHERAPY
МАКРОФАГИ -- MACROPHAGES
ЭУКАРИОТЫ -- EUKARYOTA
Annotation: Recent studies have shown the potential of using different approaches for immunotherapy in cancer treatment. Macrophages (Mph) are one of the promising targets for immunotherapy. Aim: To investigate changes in the functional activity of Mph in mice with Ehrlich carcinoma by nitric oxide (NO)/arginase (Arg), IRF4/IRF5 and STAT1/STAT6 ratios caused by administration of lectin from B. subtilis IMV-7724. Materials and Methods: From the 2nd day after Ehrlich carcinoma inoculation into female Balb/c mice, lectin from B. subtilis IMV B-7724 (0.02 mg/mouse) was administered for 10 days. The peritoneal Mph were isolated on days 14, 21, and 28 after tumor transplantation and their functional state (NO production, Arg activity and cytotoxic activity) was examined. The levels of mRNA expression of transcription factors STAT-1, STAT-6, IRF5, IRF4 were evaluated. Results: In lectin-treated animals with Ehrlich carcinoma, the functional state of Mph (NO/Arg ratio, index of cytotoxic activity) was maintained at the level of intact mice exceeding the values in untreated animals with Ehrlich carcinoma at late terms of tumor growth (21, 28 days). Analysis of mRNA expression levels of transcription factors in these animals showed a significant increase (p 0.05) in the ratio of STAT1/STAT6 on the day 21 and IRF5/IRF4 on day 28 of tumor growth compared to that in untreated mice. Conclusions: Administration of lectin from B. subtilis IMV B-7724 to mice with Ehrlich carcinoma led to the prevalence of Mph exhibiting the functional properties of M1 type at late-term tumor growth. The transcription factors of the STAT and IRF signaling pathways are involved in the process of Mph polarization induced by lectin from B. subtilis IMV B-7724
Find similar

Title of magazine :Экспериментальная онкология -2021year т.43,N 3
Interesting articles :
To the thirties anniversary of the independence of Ukraine priorities in cancer research: retrospective and prospective aspects (стр.194-196)
Chumak A. V. Influence of bacterial lectin on key regulatory links of functional activity of macrophages in mice with Ehrlich carcinoma/ A. V. Chumak [et al.] (стр.197-203)
Kovalevska L. M. Expression pattern of MRPS 18 family genes in gliomas/ L. M. Kovalevska [et al.] (стр.204-208)
Roomi M. W. A nutrient mixture reduced tumor growth of SK-UT-1 human leiomyosarcoma cells IN VIVO and IN VITRO by inhibiting MMPS and inducing apoptosis/ M. W. Roomi [et al.] (стр.209-216)
Khranovska N. Magnetically sensitive nanocomplex enhances antitumor efficacy of dendritic cell-based immunotherapy/ N. Khranovska [et al.] (стр.217-223)
Abramenko I. Association of lipoprotein lipase expression with TP53 gene polymorphisms in chronic lymphocytic leukemia cells/ I. Abramenko [et al.] (стр.224-228)
Zotova O. V. 11q23/MLL rearrangements in adult acute leukemia/ O. V. Zotova [et al.] (стр.229-233)
Horacek J. M. Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival/ J. M. Horacek [et al.] (стр.234-236)
Konovalenko V. F. Experimental substantiation of the use of hydroxyapatite - tricalcium phosphate bioceramics for replacing bone defects after tumor removal/ V. F. Konovalenko [et al.] (стр.237-241)
Ivankova V. S. Effects of brachytherapy on cytogenetic parameters and oxidative status in peripheral blood lymphocytes of gynecologic cancer patients/ V. S. Ivankova [et al.] (стр.242-246)
Rawoot S. Neutrophil to lymphocyte ratio as a prognostic marker for non-metastatic renal cell carcinoma - does it add to what we already know?/ S. Rawoot [et al.] (стр.247-251)
Vlachou M. S. Plasma ctDNA ras status selects patients for anti-EGER treatment rechallenge in metastatic colorectal cancer: a meta-analysis/ M. S. Vlachou [et al.] (стр.252-256)
Kukushkina M. Safety profile and clinical outcome of adjuvant radiation therapy and intermediate-dose interferon in comparison with intermediate dose interferon alone in patients with melanoma metastases in regional lymph nodes and unfavorable prognostic factors/ M. Kukushkina [et al.] (стр.252-260)
Burlaka A. P. Redox dependent features of tumors, adipose tissue. neutrophiles and platelets in patients with metastatic colorectal cancer/ A. P. Burlaka [et al.] (стр.261-265)
Kornatska A. G. ESR1 gene variants affect FSHR-depended risk of fibrocystic mastopapthy in infertile women/ A. G. Kornatska [et al.] (стр.266-269)
Solyanik G. I. Oxamate, an inhibitor of lactate dehydrogenase, can stimulate M2 polarization of peritoneal macrophages in mice with Lewis lung carcinoma/ G. I. Solyanik [et al.] (стр.270-276)
Chekhun V. F. Can SARS-CJV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical background)/ V. F. Chekhun, E. A. Domina (стр.277-280)
Interesting articles :
Find similar

Type of document : Magazine article
Edition cipher :
Author(s) : Chekhun V. F., Domina E. A.
Title : Can SARS-CJV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical backlground)
Place of publication : Experimental Oncology. - К., 2021. - Том 43, N 3. - С. 277-280 (Cipher ЕУ12/2021/43/3)
MeSH-main: КОРОНАВИРУСНЫЕ ИНФЕКЦИИ -- CORONAVIRUS INFECTIONS
РАДИОТОЛЕРАНТНОСТЬ -- RADIATION TOLERANCE
Annotation: R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Science of Ukraine has been studying the mechanisms and specificities of individual radiation sensitivity (IRS) formation in professionals who work in the field of ionizing radiation, cancer patients and representatives of other population groups. Our data based on the use of G2-test in in vitro irradiated blood lymphocytes in late G2-period of cell cycle indicated an increased carcinogenic risk in professionals with high IRS. We suggest that the COVID-19 pandemic could make significant adjustments in the formation of IRS in professionals who have survived the disease and continue to work with ionizing radiation (IR). Increased systemic inflammatory activity, which persists for a long time in COVID-19 patients, in combination with low-dose range irradiation (professionals who continue to work with IR) and with local irradiation in the high-dose range (radiation therapy for cancer patients) may affect IRS. Repeated determination of IRS in professionals who have had COVID-19 infection, using chromosomal G2-radiation sensitivity assay will answer the question: can SARS-CoV-2 coronavirus affect the IRS? The proposed hypothesis of the radiosensitivity evolution needs further experimental validation using a set of radiobiological indices to clarify the mechanism of IRS formation following COVID-19 infection. The detected changes (increase) of human IRS after COVID-19 must be taken into account for personalized planning of radiotherapy of COVID-19 cancer patients
Find similar

Type of document : Magazine article
Edition cipher :
Author(s) : Chumak A. V., Fedosova N.I., Cheremshenko N. L., Symchych T. V., Voyeykova I. M., Chekhun V. F.
Title : Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis
Parallel titles :Зміни поляризації макрофагів у динаміці росту метастазуючої карциноми Льюїс
Place of publication : Экспериментальная онкология. - 2021. - Т. 43, № 1. - С. 15-20 (Cipher ЕУ12/2021/43/1)
Notes : Bibliogr. at the end of the art.
MeSH-main: КАРЦИНОМА ЛЬЮИС ЛЕГКОГО -- CARCINOMA, LEWIS LUNG
НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS
МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL
Annotation: To assess the functional state of macrophages based on various manifestations of their activity at the different stages of metastatic tumor growth in C57Bl mice. Materials and Methods: On days 7, 14, 21 and 28 after Lewis lung carcinoma transplantation to C57Bl mice, macrophages from various anatomic sites were isolated and tested on their cytotoxicity, metabolic activity, NO production and arginase activity. Results: In the populations of peritoneal and splenic macrophages, on days 7 and 21 of tumor growth antitumor (M1) cells prevailed while on days 14 and 28 tumor-promoting (M2) macrophages predominated. In the population of lung macrophages, cells with M1 phenotype were in the majority in the early stages of tumor growth. On days 21 and 28, M1 cells were gradually substituted by cells exhibiting M2 phenotype. This shift correlated with metastasis to lungs. Conclusion: Lewis lung carcinoma growth is accompanied by the gradual change in macrophage polarization from antitumor (M1) towards tumor-promoting (M2) type. These changes were more evident in population of lung macrophages and correlated with the parameters of metastasisОцінити стан макрофагів мишей лінії С57Вl за різними проявами їх функціональної активності на різних стадіях росту метастазуючої пухлини. Матеріали та методи: У дослідженні використовували мишей лінії C57Bl з епідермоїдною метастазуючою карциномою легені Льюїс. На 7-, 14-, 21- та 28-й день після перещеплення пухлини макрофаги з різних ніш були виділені та піддані функціональному аналізу. Результати: Макрофаги, отримані з різних біологічних ніш у інтактних тварин, за дослідженими показниками функціональної активності мали фенотип М1. У популяціях макрофагів, отриманих з селезінки та перитонеальної порожнини мишей лінії С57Вl на 7-і 21-шу доби росту карциноми легені Льюїс переважали клітини з протипухлинними властивостями (М1), на 14- та 28-му добу — клітини з пропухлинними властивостями (М2). У популяції легеневих макрофагів на ранніх стадіях пухлинного процесу переважали клітини з фенотипом М1, до 28-ї доби спостерігали поступову їх поляризацію до фенотипу М2. Такі зміни корелювали з показниками метастазування в легені в ці терміни. Висновок: Aналіз показників функціональної активності макрофагів свідчить про їх поступову поляризацію від клітин з проти- (М1) до клітин з пропухлинними (М2) властивостями в динаміці росту карциноми легені Льюїс. Виявлені зміни були найбільш вираженими в популяції легеневих макрофагів та мали кореляційний зв’язок з показниками метастазування
Find similar

Title of magazine :Экспериментальная онкология -2021year т.43,N 1
Interesting articles :
Cavalli M. A non-coding cancer mutation disrupting an HNF4α binding motif affects an enhancer regulating genes associated to the progression of liver cancer/ M. Cavalli [та ін.] (стр.2-7)
Yakovlev P. G. Changes in expression of TLR-4, TGF-β, INF-γ, TNF-α in cultured T24/83 cells of invasive bladder cancer treated with cisplatin and/or polyphenolic adjuvant melanin/ P. G. Yakovlev [та ін.] (стр.7-14)
Chumak A. V. Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis/ A. V. Chumak [та ін.] (стр.15-20)
Yushko L. A. Comparative study of biochemical and morphological parameters in rats with Walker 256 and Walker 256/DOX carcinosarcoma/ L. A. Yushko [та ін.] (стр.21-25)
Prokhorova I. V. ROS production by circulating phagocytes and Guerin carcinoma resistance to cisplatin/ I. V. Prokhorova [та ін.] (стр.26-30)
Elemam O. Emergency oncology admissions during COVID-19 pandemic: a major institution experience from Saudi Arabia/ O. Elemam [та ін.] (стр.31-35)
Kravets O. V. Significance of expression of tumor-associated microRNA-21 and -375 for predicting the course of cancer of oral cavity/ O. V. Kravets [та ін.] (стр.36-40)
Boyko O. Erythropoietin as an independent prognostic factor in myelodysplastic syndromes/ O. Boyko [та ін.] (стр.41-45)
Samoylenko О. А. Ornithine decarboxylase activity in prostate cancer/ О. А. Samoylenko [та ін.] (стр.46-51)
Gervas P. New germline mutations in BRCA1, ATM, MUTYH, and RAD51D genes in Tuvans early-onset breast cancer patients/ P. Gervas [та ін.] (стр.52-55)
Lobanova O. E. Prevalence of BRCA1 and BRCA2 genes promoter hypermethylation in breast cancer tissue/ O. E. Lobanova [та ін.] (стр.56-60)
Hergebue K. Therapeutic results and prognostic factors of stage III NSCLC: a population-based study in Tunisia/ K. Hergebue [та ін.] (стр.61-66)
Tsip N. P. Experience with the use of HIPEC in advanced serous ovarian cancer after complete and optimal cytoreduction/ N. P. Tsip [та ін.] (стр.67-72)
Gurianov D. S. Nuclear localization of BCR and cortactin indicates their potential role in regulation of actin branching in nucleus/ D. S. Gurianov, S. V. Antonenko, G. D. Telegeev (стр.73-76)
Yanish Yu. V. Application of gold and silver nanoparticles for selective assay of spermine in mixture with spermidine/ Yu. V. Yanish [та ін.] (стр.77-81)
Drogovoz S. M. Experience and prospects for the use of off-label drugs in oncology/ S. M. Drogovoz [та ін.] (стр.82-86)
Gluzman D. F. Immunodeficiency-associated lymphoproliferative disorders and lymphoid neoplasms in post-COVID-19 pandemic era/ D. F. Gluzman [та ін.] (стр.87-91)
Moreno M. An uncommon case of vulvar cancer metastatic to breast/ M. Moreno [та ін.] (стр.92-95)
Ada Leonidivna Vorontsova (1934–2020) (стр.96)
Interesting articles :
Find similar

Type of document : Magazine article
Edition cipher :
Author(s) : Shvets Yu. V., Lukianova N. Yu., Chekhun V. F.
Title : Human microbiota and effectiveness of cancer chemotherapy
Place of publication : Experimental Oncology. - К., 2020. - Том 42, N 2. - С. 82-93 (Cipher ЕУ12/2020/42/2)
MeSH-main: НОВООБРАЗОВАНИЯ -- NEOPLASMS
Annotation: This review presents up-to-date information on the effects of microbiota on the individual chemotherapy sensitivity in cancer treatment. Recent studies have shown that a fine balance between the intestinal microbiota and the immune system is crucial for maintaining an efficacy of cancer chemotherapy. A number of antitumor drugs have complex mechanisms of action involving not only direct effects but also the activity of the intestinal microbiota and the immune system. A unique combination of these factors contributes to the individual chemotherapy sensitivity
Find similar

Title of magazine :Экспериментальная онкология -2020year т.42,N 2
Interesting articles :
Shvets Yu. V. Human microbiota and effectiveness of cancer chemotherapy/ Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun (стр.82-93)
Zadvornyi T. V. Nanog as prognostic factor of prostate cancer course/ T. V. Zadvornyi [et al.] (стр.94-100)
Lamdan H. Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin/ H. Lamdan [et al.] (стр.101-108)
Antonenko S. V. Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells/ S. V. Antonenko, G. D. Telegeev (стр.109-114)
Onyshchenko K. V. Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma/ K. V. Onyshchenko [et al.] (стр.115-119)
Stegantseva M. V. Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model/ M. V. Stegantseva [et al.] (стр.120-125)
Andreieva S. V. Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias/ S. V. Andreieva [et al.] (стр.126-129)
Bialik P. HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer/ P. Bialik [et al.] (стр.130-134)
Pankaj D. Clinicopathological correlation of the expression of excision repair cross complementation group 1 (ERCC1) in oral cavity squamous cell carcinomas: an immunohistochemical study/ D. Pankaj, V. Guddattu, M. C. Solomon (стр.135-139)
Lyalkin S. A. Prognostic role of androgen receptor expression in patients with metastatic triple negative breast cancer/ S. A. Lyalkin [et al.] (стр.140-143)
Perekhrestenko T. Expression of Ki-67 and CD34 on blood and bone marrow cells of CML patients with different response to imatinib and nilotinib therapy/ T. Perekhrestenko [et al.] (стр.144-147)
Glavatskyi O. Ya. Temozolomide in glioblastoma treatment: 15-year clinical experience and analysis of its efficacy/ O. Ya. Glavatskyi [et al.] (стр.148-156)
Kliusov O. M. Specialized care provided to patients with rectal cancer in Kyiv city/ O. M. Kliusov (стр.157-160)
Interesting articles :
Find similar

Type of document : Magazine article
Edition cipher :
Author(s) : Zadvornyi T. V., Lukianova N. Yu., Borikun T. V., Vitruk Yu. V., Stakhovsky E. O., Chekhun V. F.
Title : Nanog as prognostic factor of prostate cancer course
Place of publication : Experimental Oncology. - К., 2020. - Том 42, N 2. - С. 94-100 (Cipher ЕУ12/2020/42/2)
MeSH-main: ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS
Annotation: The variability of the clinical course of prostate cancer (PC) indicates the need to find factors that could predict the aggressive potential of neoplasms accounting the biological characteristics of tumor cells. In this context, the role of NANOG, a transcription factor involved in maintaining pluripotency and one of the markers of cancer stem cells (CSCs), is being actively studied today. Aim: To investigate the level of NANOG mRNA in tumor tissue of patients with PC and to analyze the possibility of its use as a marker of the disease course. Materials and Methods: The study involved 85 patients with PC of stages II–IV. Morphological and immunohistochemical studies were performed on serial paraffin sections of resected PC using monoclonal antibodies to Ki-67 and androgen receptor. NANOG and miR-214 mRNA expression in tumor cells was analyzed by real-time reverse transcription polymerase chain reaction. The identification of CSCs was performed by double-labeled immunohistochemical method using primary antibodies to CD24 and CD44. Results: We have revealed notable variability of NANOG mRNA levels in tumor tissue of patients with PC (mean 4.18 ± 0.65 a.u. with individual deviations from 0.11 ± 0.03 a.u. to 15.24 ± 0.36 a.u.). According to NANOG mRNA levels, two groups of the PC patients were delineated: group 1 and group 2, with the average NANOG mRNA levels of 2.12 ± 0.16 a.u., and 8.68 ± 1.24 a.u., respectively. The NANOG mRNA levels in tumor tissue of PC patients of groups 1 and 2 correlated with preoperative serum prostate-specific antigen level (r = 0.58; p 0.05 and r
Find similar

Type of document : Magazine article
Edition cipher :
Author(s) : Lukianova N. Yu., Borikun T.V., Chekhun V. F.
Title : Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 242-247 (Cipher ЕУ12/2019/41/3)
Notes : Bibliogr. at the end of the art.
Annotation: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) were analyzed in tissue of BC using immunohistochemical method. Relative expression levels of the miR-155, -320a, and -205 were examined in tissue and sera from BC patients using quantitative reverse transcription polymerase chain reaction. Results: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. Nevertheless, we established the relation of circulating and tissue miR-155, -320a, and -205 to lymph node metastases and basal breast cancer subtype. Conclusions: Changes of miR-155, -320a, and -205 expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC
Find similar

10.

Type of document : Magazine article
Edition cipher :
Author(s) : Lozovska Yu. V., Andrusishina I. M., Lukianova N. Yu., Burlaka A. P., Naleskina L. A., Todor I. N., Chekhun V. F.
Title : The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 20-25 (Cipher ЕУ12/2019/41/1)
Notes : Bibliogr. at the end of the art.
Annotation: To investigate the content of essential elements (EE): copper, zinc, magnesium, iron and calcium and the evaluation of the activity of metal-containing enzymes — ceruloplasmin (CP), myeloperoxidase (MPO) and the content of transferrin (TF) in blood plasma (BP) and tumor tissue (TT) of animals with Walker-256 carcinosarcoma treated with lactoferrin (LF). Materials and Methods: The study of the EE content and the activity of the abovementioned enzymes was carried out on rats with Walker-256 carcinosarcoma treated with LF at the doses of 1 and 10 mg/kg of body weight. The quantitative content of EE in BP and TT of animals was determined using the inductively coupled plasma atomic emission spectroscopy (ICP-AES). Determination of CP activity, content of TF and hemochromes was performed using the method of electron paramagnetic resonance (EPR), and MPO — by unified biochemical method. Results: The introduction of LF at the doses of 1 and 10 mg/kg resulted in a decrease in the ratio of Cu/Zn in BP and even more expressed decrease of Ca/Mg ratio in TT. Administration of LF, especially at a dose of 10 mg/kg, affected the increase in CP and MPO activity in BP. It has been shown that administration of LF at a dose of 10 mg/kg led to an increase in oxidative products of destruction of the hemoglobin-hemochrom system in the TT, against the background of lowering the TF content. Conclusions: The administration of LF, especially at a dose of 10 mg/kg, led to metabolic alterations associated with inhibition of the tumor process. The detected modulating effect of LF on the content of the EE and the activity of the CP and MPO may be a basis for correction of the elemental balance in carcinogenesis
Find similar

11.

Title of magazine :Экспериментальная онкология -2019year т.41,N 3
Interesting articles :
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine: 25 years with the OECI (стр.187)
Chekhun V. F. MicroRNAs are a key factor in the globalization of tumor-host relationships/ V. F. Chekhun (стр.188-194)
Shlyakhovenko V. O. The dual role of ribonucleases in tumor-host relationship/ V. O. Shlyakhovenko, O. A. Samoylenko (стр.195-199)
Shuba Ya. M. Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies?/ Ya. M. Shuba (стр.200-206)
Ivanivska T. S. Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia/ T. S. Ivanivska [та ін.] (стр.207-209)
Holotiuk V. V. Role of nitric oxide in pathogenesis of tumor growth and its possible application in cancer treatment/ V. V. Holotiuk [та ін.] (стр.210-215)
Oshyvalova O. Modern view on epidermal dysplasia carcinogenesis/ O. Oshyvalova, Z. Rossokha (стр.216-223)
Bazalytska S. V. Моlecular mechanisms of initiation of carcinogenesis in the testis/ S. V. Bazalytska, Y. Persidsky, A. M. Romanenko (стр.224-234)
Bogdanova T. Histopathological characteristics and post-operative follow-up of patients with potentially radiogenic papillary thyroid carcinoma depending on oncocytic changes availability in the tumor cells/ T. Bogdanova [та ін.] (стр.235-241)
Lukianova N. Yu. Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer/ N. Yu. Lukianova, T. V. Borikun, V. F. Chekhun (стр.242-247)
Patysheva M. Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes/ M. Patysheva [та ін.] (стр.248-253)
Sakhno L. A. Adsorptive therapy as a modificator for tumor-host interaction/ L. A. Sakhno [та ін.] (стр.254-257)
Materials of the II International Conference “Tumor and Host: Novel Aspects of Old Problem” (November 21–22, 2019, Kyiv, Ukraine) (стр.258-280)
Interesting articles :
Find similar

12.

Type of document : Magazine article
Edition cipher :
Author(s) : Chekhun V. F.
Title : MicroRNAs are a key factor in the globalization of tumor-host relationships
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 188-194 (Cipher ЕУ12/2019/41/3)
Notes : Bibliogr. at the end of the art.
Annotation: A new round of molecular oncology development in the post-genomic era significantly changes the conventional understanding of the nature and origin of the malignant process. Increasingly, fundamental phenomena are emerging that change the “canonical” views of the dominant role of gene mutations that contribute to the uncontrolled proliferation and emergence of heterogeneous malignant cells. Recent numerous studies have shown that significant variability in the initiation, proliferation and control of the apoptotic program of tumor cells is due to numerous epigenetic processes, including the level of expression of microRNAs (miRNAs). This paper reviews the literature data and presents the results of own research in which miRNAs have been found to form a molecular phenotype for malignancy. Their role as a “conductor” of the functioning of a genetic-epigenetic orchestra that coordinates various aspects of malignancy has been suggested. MiRNAs have been shown to be an active participant in balancing mechanisms in the development of controversial processes in breast cancer cell lines of varying degrees of malignancy. The analysis of the literature data and the own studies of the expression profile of only a few miRNAs suggests that scientists and clinicians have received a new marker and a target that simultaneously plays the role of an active insider in both the oncogene-oncosuppressor relationship and in the globalization of this process at the tumor-host level. Further investigation of the “alarm” marker in this network will allow to reconsider the molecular genetic classification of neoplastic disease, which will provide the development of a new strategy for cancer therapy
Find similar

13.

Title of magazine :Экспериментальная онкология -2019year т.41,N 1
Interesting articles :
Solyanik G. I. Quinazoline compounds for antitumor treatment/ G. I. Solyanik (стр.3-6)
Mahmoudian J. Expression profiling of plac1 in murine cancer cell lines/ J. Mahmoudian [та ін.] (стр.7-13)
Kolesnik D. L. Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma/ D. L. Kolesnik [та ін.] (стр.14-19)
Lozovska Yu. V. The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma/ Yu. V. Lozovska [та ін.] (стр.20-25)
Burlaka A. A. DNA oxidation in patients with metastastic colorectal cancer: clinical significance of 8-hydroxy-deoxyguanosine as an independent prognostic factor/ A. A. Burlaka [та ін.] (стр.26-31)
Stakheyeva M. Integral characteristic of the immune system state predicts breast cancer outcome/ M. Stakheyeva [та ін.] (стр.32-38)
Bilous N. Analysis of LPL gene expression in patients with chronic lymphocytic leukemia/ N. Bilous [та ін.] (стр.39-45)
Alghamdi S. Evaluation of dose calculation algorithms using different density materials for in-field and out-of-field conditions/ S. Alghamdi, A. Tajaldeen (стр.46-52)
Poluben L. Copy number alterations and copy-neutral loss of heterozygosity in Ukrainian patients with primary myelofibrosis/ L. Poluben [та ін.] (стр.53-56)
Bakai O. A. Radiation research to determine local tumor invasion in patients with cervical cancer/ O. A. Bakai [та ін.] (стр.57-60)
Zabolotnyi D. I. Aggregated proteins in malignant and benign neoplasms/ D. I. Zabolotnyi [та ін.] (стр.61-68)
Shirin V. Assessment of trace elements in serum of acute lymphoblastic and myeloid leukemia patients/ V. Shirin [та ін.] (стр.69-71)
Tkachenko R. Parathyroid carcinoma: a case report/ R. Tkachenko [та ін.] (стр.72-75)
Semko S. A case of synchronous bilateral calyx urothelial carcinoma: combined treatment approach/ S. Semko [та ін.] (стр.76-79)
De Giorgi V. Cutaneous leiomyosarcoma: a clinical, dermoscopic, pathologic case study/ Giorgi V. De [та ін.] (стр.80-81)
Langabeer S. E. Suboptimal molecular response to tyrosine kinase inhibition associated with acquisition of a T240A ABL1 kinase domain mutation in a patient with chronic myeloid leukemia/ S. E. Langabeer [та ін.] (стр.82-83)
Brieieva O. Scientific and Practical Conference of Young Scientists “Fundamental Medicine: Integrated Approaches to Cancer Therapy”/ O. Brieieva (стр.84-86)
Tumor and Host: Novel Aspects of Old Problem (стр.87)
Ludmyla Zakharivna Polishchuk (1937–2019) (стр.88)
Interesting articles :
Find similar

14.

Title of magazine :Экспериментальная онкология -2019year т.41,N 4
Interesting articles :
Karaman O. M. Macrophages - a perspective target for antineoplastic immunotherapy/ O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun (стр.282-290)
Orel V. E. Nоn-linear dynamics theory and malignant melanoma/ V. E. Orel [et al.] (стр.291-299)
Lisyany N. I. Cytomegaloviruses and malignant brain tumors/ N. I. Lisyany [et al.] (стр.300-303)
Woksepp H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392/ H. Woksepp [et al.] (стр.304-311)
Dehghan Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression/ Nayeri M. J. Dehghan [et al.] (стр.312-317)
Albuquerque A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation/ A. P. B. Albuquerque [et al.] (стр.318-322)
Skuja E. Deletions in metastatic colorectal cancer with chromothripsis/ E. Skuja [et al.] (стр.323-327)
Burlaka A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer/ A. P. Burlaka [et al.] (стр.328-334)
Buchynska L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma/ L. G. Buchynska, L. A. Naleskina, I. P. Nesina (стр.335-341)
Zelinskaya A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer/ A. Zelinskaya (стр.342-345)
Moazeni-Roodi A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls/ A. Moazeni-Roodi, M. Taheri, M. Hashemi (стр.346-352)
Skrypnyk I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy/ I. Skrypnyk [et al.] (стр.353-356)
Gavars D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia/ D. Gavars [et al.] (стр.357-362)
Prylutskyi M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles/ M. P. Prylutskyi, M. F. Starodub (стр.363-365)
Shkatula P. M. International scientific conference "Tumor and Host: novel aspects of old problem"/ P. M. Shkatula (стр.366-367)
To the 120th birthday anniversary of academician R. E. Kavetsky (стр.368-369)
Interesting articles :
Find similar

15.

Type of document : Magazine article
Edition cipher :
Author(s) : Karaman O. M., Ivanchenko A. V., Chekhun V. F.
Title : Macrophages - a perspective target for antineoplastic immunotherapy
Place of publication : Experimental Oncology. - К., 2019. - Том 41, N 4. - С. 282-290 (Cipher ЕУ12/2019/41/4)
Annotation: The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity
Find similar

16.

Title of magazine :Экспериментальная онкология -2018year т.40,N 1
Interesting articles :
Kian R. Role of components of microRNA machinery in carcinogenesis/ R. Kian, S. Moradi, S. Ghorbian (стр.2-9)
Patel K. R. Clinical implications of p53 alterations in oral cancer progression: a review from India/ K. R. Patel [та ін.] (стр.10-18)
Varela-Castillo O. Characterization of the cytotoxic effects of the combination of cisplatin and flavanol (-)-epicatechin on human lung cancer cell line A549. An isobolographic approach/ O. Varela-Castillo [та ін.] (стр.19-23)
Chaves K. C. B. Impact of endostatin gene therapy on myeloid-derived suppressor cells from a metastatic renal cell carcinoma/ K. C. B. Chaves [та ін.] (стр.24-32)
Sarnatskaya V. V. Highly activated carbon enterosorbent mediates the suppression of paraneoplastic syndrome associated with lewis lung carcinoma in mice/ V. V. Sarnatskaya [та ін.] (стр.33-41)
Boroday N. V. Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells/ N. V. Boroday, V. F. Chekhun (стр.42-47)
Kurtenkov O. Signatures of anti-Thomsen — friedenreich antigen antibody diversity in colon cancer patients/ O. Kurtenkov, M. Bubina, K. Klaamas (стр.48-58)
Paliychuk O. V. Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer/ O. V. Paliychuk [та ін.] (стр.59-67)
Buchynska L. G. Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients/ L. G. Buchynska, O. V. Brieieva (стр.68-72)
Lozynska L. Y. Variant of rare hermansky — pudlak syndrome associated with granulomatous colitis: diagnostics clinical course and treatment/ L. Y. Lozynska [та ін.] (стр.73-78)
Zubenko O. S. Effect of cytostatic agents on expression levels of human beta-defensins-1-4 in A431 and MCF-7 cell lines/ O. S. Zubenko [та ін.] (стр.79-81)
Imaniar R. Mediastinal yolk sac tumor infiltrating the heart/ R. Imaniar [та ін.] (стр.82-84)
Ben Kridis W. A long survival of a patient with brain metastasis of unknown site of the primary tumor/ Kridis W. Ben [та ін.] (стр.85-87)
Symposium and Summer School “Fundamental principles of cancer biotherapy” Kyiv Ukraine May 21-24 2018 (стр.88)
Interesting articles :
Find similar

17.

Type of document : Magazine article
Edition cipher :
Author(s) : Zadvornyi T. V., Lukianova N. Y., Borikun T. V., Chekhun V. F.
Title : Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro
Place of publication : Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 184-189 (Cipher ЕУ12/2018/40/3)
Notes : Bibliogr. at the end of the art.
Annotation: To investigate the biological effects of exogenous lactoferrin (LF) on phenotypic profile and invasiveness of human prostate cancer (PC) cells in vitro. Materials and Methods: Human PC cell lines (LNCaP, DU-145) were cultured with an exogenous LF at a dose corresponding to IC30. The expression levels of steroid hormone receptors (androgen receptor, estrogen receptor, progesterone receptor), Her2/neu, Ki-67, E- and N-cadherin, were monitored by immunohistochemical analysis. The levels of miRNAs were assessed using q-PCR. The invasive activity of the cells was examined in a standard invasion test. Results: Exogenous LF reduced expression of steroid hormone receptors (ERα and PR) and Ki-67 in both PC cell lines. The expression of E-cadherin increased significantly in LF-treated DU-145 cells. Also, we established the decrease in invasive activity upon LF treatment by 40% and 30% in DU-145 and LNCaP cells, respectively. In DU-145 cells, incubation with exogenous LF resulted in an increase in the expression of oncosuppressive (miR-133a and miR-200b) miRNAs. Conclusions: Exogenous LF causes the changes in phenotypic characteristics of PC cells and levels of oncogenic and oncosuppressive miRNAs involved in the regulation of key cellular processes. Key Words: prostate cancer, exogenous lactoferrin, DU145, LNCaP, miRNA
Find similar

18.

Type of document : Magazine article
Edition cipher :
Author(s) : Chekhun V. F., Storchai D. M., Todor I. N., Borikun T. V., Lukianova N. Yu.
Title : Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats
Place of publication : Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 200-204 (Cipher ЕУ12/2018/40/3)
Notes : Bibliogr. at the end of the art.
Annotation: To investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF. Materials and Methods: The study was performed on Walker-256 tumor-bearing rats. Total lipids and phospholipids were determined by thin-layer chromatography. Comet assay was used to investigate the genotoxic effects of LF. Results: Daily i.p. administrations of exogenous LF at concentrations of 1 mg/kg and 10 mg/kg starting from the 4th day after tumor transplantation suppressed growth of Walker-256 carcinosarcoma by almost 44%. After treatment with recombinant LF in both doses, the phospholipid composition of Walker-256 carcinosarcoma cells was changed (3-fold increase of phosphatidylethanolamine, 3.4-fold increase of phosphatidylcholine, and 1.8-fold increase of sphingomyelin, while the cardiolipin content decreased by 67%. Exogenous LF was not genotoxic for bone marrow cells (as assessed by the ratio of PCE/NCE, number of micronuclei) and peripheral blood lymphocytes (percentage of DNA in the tail of a comet) in Walker-256 carcinosarcoma-bearing rats. Conclusion: Exogenous LF caused the inhibition of Walker-256 carcinosarcoma growth and a decrease in the microviscosity of plasma cell membranes, and exerted no genotoxicity toward bone marrow cells and peripheral blood of experimental animals. Key Words: lactoferrin, breast cancer, Walker-256 carcinosarcoma, phospholipid content, genotoxicity
Find similar

19.

Title of magazine :Экспериментальная онкология -2018year т.40,N 3
Interesting articles :
Akbarzadeh A. Role of dendrimers in advanced drug delivery and biomedical applications: a review/ A. Akbarzadeh [та ін.] (стр.178-183)
Zadvornyi T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro/ T. V. Zadvornyi [та ін.] (стр.184-189)
Harper P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies/ P. Harper [та ін.] (стр.190-193)
Apykhtina О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles/ О. L. Apykhtina [та ін.] (стр.194-199)
Chekhun V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats/ V. F. Chekhun [та ін.] (стр.200-204)
Prokhorova I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6/ I. V. Prokhorova [та ін.] (стр.205-210)
Abramenko I. V. . Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients/ I. V. Abramenko [та ін.] (стр.211-217)
Nesina I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma/ I. P. Nesina, N. P. Iurchenko, L. G. Buchynska (стр.218-222)
Vernygorodskyi S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction/ S. Vernygorodskyi, T. Rekun, P. Zhuchenko (стр.223-227)
Gerashchenko T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles/ T. S. Gerashchenko [та ін.] (стр.228-234)
Agishev T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury/ T. T. Agishev [та ін.] (стр.235-238)
Dumansky Yu. V. Paraneoplastic syndrome in lung cancer/ Yu. V. Dumansky [та ін.] (стр.239-242)
Grybach S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome/ S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun (стр.243-248)
Chrysanthakopoulos N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study/ N. A. Chrysanthakopoulos, N. S. Dareioti (стр.249-250)
Tkachenko R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy/ R. Tkachenko, A. Golovko, O. Kuryk (стр.251-253)
Svitlana Pavlivna Sidorenko (1953–2018) (стр.254-255)
Yurii Yosypovych Kudryavets (1946–2018) (стр.256-257)
Interesting articles :
Find similar

20.

Type of document : Magazine article
Edition cipher :
Author(s) : Paliychuk O. V., Polishchuk L. Z., Rossokha Z. I., Chekhun V. F.
Title : Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer
Place of publication : Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 59-67 (Cipher ЕУ12/2018/40/1)
Notes : Bibliogr. at the end of the art.
MeSH-main: НОВООБРАЗОВАНИЯ -- NEOPLASMS
РЕПРОДУКТИВНОЕ ЗДОРОВЬЕ -- REPRODUCTIVE HEALTH
ЖЕНЩИН ЗДОРОВЬЕ -- WOMEN'S HEALTH
ЛИНЧА СИНДРОМ II -- LYNCH SYNDROME II
ГЕНЫ СУПРЕССОРЫ ОПУХОЛЕВОГО РОСТА -- GENES, TUMOR SUPPRESSOR
ГЕНЫ BRCA1 -- GENES, BRCA1
ГЕНЫ BRCA2 -- GENES, BRCA2
МУТАЦИЯ -- MUTATION
РИСКА СТЕПЕНИ ОЦЕНКА -- RISK ADJUSTMENT
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To develop a prognostic molecular genetic model for assessing the risk of development of benign and malignant tumors of female reproductive organs (FRO) in patients from cancer-affected families. Patients and Methods: The work presents the data on a comprehensive clinical examination of 210 women (90 patients with FRO cancer with aggregation of tumor pathology in families, 65 patients with benign pathology of FRO from cancer-affected families, 55 women — control group of healthy women without family history of cancer). Clinical genealogical analysis, morphological examination of tumors and molecular genetic studies of genomic DNA from peripheral blood and tumors were carried out. Results: It was established that in the families of patients with benign and malignant pathology of FRO, malignant tumors associated with Lynch II syndrome are observed. Based on the analysis of detected ESR-1, CYP 2D6*4 and mutations in BRCA1/2 genes in cancer patients and in patients with benign pathology, molecular genetic models have been developed to assess the individual risk of development of benign and malignant tumors of FRO. It has been established that these molecular genetic models and combinations of gene mutations and gene polymorphisms (SNP) by the intergene interaction that was analyzed, were found to be reliable in assessing the risk of benign and malignant pathology of the mammary gland and ovary. Conclusions: The model, which included the polymorphic variants of the T397C(ESR1)/CYP 2D6*4 genes was of the best predictive accuracy for the evaluation of the risk of benign tumors of the FRO (71.68%) and the highest reliability (p 0.001). At the same time, all identified models of intergene interaction in the development of malignant pathology of FRO were reliable, prognostically significant with high reproduction and almost identical accuracy (65.00–68.23%). The obtained results indicate a high informativeness of such molecular genetic indices as the polymorphism of ESR1 and CYP 2D6*4 genes and mutations in BRCA1/2 genes to assess the risk of benign or malignant tumors of FRO in families of patients with family history of cancer
Find similar

1-20 21-36

Standard

Advanced

Professional

Through the dictionary

UDC-navigator

Thematic navigator

Access statistics

© International Association of users and developers of electronic libraries and new information technology
(ELNIT Association)