Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Total number of found documents : 10
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The pharmacological activity of derivatives of 4-oxo-3,4-dihydroquinazoline and anthranilamides containing a fragment of glycine / Yu. O. Ovsyanikova [et al.] // Вісн. фармації. - 2016. - № 1. - P62-66

MeSH-main:
ХИНАЗОЛИНЫ -- QUINAZOLINES (фармакология)
ГЛИЦИН -- GLYCINE (фармакология)
АНТИДЕПРЕССАНТЫ -- ANTIDEPRESSIVE AGENTS (фармакология)
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL
ПРОТИВОСУДОРОЖНЫЕ СРЕДСТВА -- ANTICONVULSANTS (фармакология)
Additional Access Points:
Ovsyanikova, Yu. O.
Levashov, D. V.
Kravchenko, V. M.
Chernykh, V. P.
Shemchuk, L. A.

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Cipher: ВУ18/2016/3
Journal

Вісник фармації
2016year № 3

Contents:
Vlasov, S. V. Synthesis, the anti-inflammatory and antimicrobial activity of 6-(1H-benzimidazol-2-yl)-5-methyl-4-(alkylthio)thienо[2,3-d] pyrimidines / S. V. Vlasov, V. P. Chernykh. - С.9-16
Romanenko, M. I. The synthesis, physicochemical and biological properties of 8-amino-7-(2-hydroxy-2-phenylethyl)-3-methylxanthines / M. I. Romanenko [et al.]. - С.17-21
Other authors: Ivanphenko D. G., Nazarenko M. V., Diachkov M. V., Kamyshnyi O. M., Polishchuk N. M.
Suleimanov, T. A. Development and determination of validation parameters for the HPLC method of thymol quantification in “Kalinol plus” syrup / T. A. Suleimanov, E. Z. Balaeva, E. Yu. Akhmedov. - С.22-27
Kyslychenko, V. S. The anatomical study of shepherd’s purse herb / V. S. Kyslychenko [et al.]. - С.28-31
Other authors: Kuznietsova V. Yu., Kolisnyk Yu. S., Sushchuk N. A.
Upyr, T. V. The study of the chemical composition and the pharmacological activity of the polysaccharide complex obtained from Ledum palustre / T. V. Upyr [et al.]. - С.32-35
Other authors: Tolmachova K. S., Koshovyi O. M., Komisarenko A. M., Kireyev I. V.
Komisarenko, M. A. The composition of volatile substances of cowberry leaves / M. A. Komisarenko. - С.36-38
Lenchyk, L. V. Development of the composition of tablets with the extract of bird cherry and their standardisation / L. V. Lenchyk [et al.]. - С.39-42
Other authors: Sichkar A. A., Gladukh Ye. V., Kyslychenko V. S.
Kudrik, B. T. Development of the composition and technology of the capsulated drug based on bee bread and honey powder. Report 2. The study of pharmacotechnological properties of the mixtures of active pharmaceutikal ingredients with excipients of “Api-immuno-vit” capsules / B. T. Kudrik, O. I. Tikhonov, O. S. Shpychak. - С.43-48
Omelchenko, I. O. Substantiation of the choice of excipients of “Corvalol” in the form of sublingual tablets / I. O. Omelchenko, T. G. Yamykh, H. I. Borshchevsky. - С.49-50
Strus, O. Ye. The studies on development of the composition of masks with the sapropel paste / O. Ye. Strus, O. G. Geyderikh, L. F. Silaeva. - С.51-53
Shmal’ko, O. O. The study on development of the technology of the syrup with the hepatotropic and choleretic action / O. O. Shmal’ko [и др.] ; O. O. Shmal’ko [et al.]. - С.54-56
Other authors: Vyshnevs’ka L. I., Piskovats’kiy Yu. G., Mehalins’kiy V. A.
Balynska, M. V. The expert evaluation of drugs as a basic factor for development of the socioeconomic lists recommended for treating enteritis of the viral origin in children / M. V. Balynska. - С.57-60
Lega, D. O. Antimicrobial, anti-inflammatory and analgesic activities of 2-amino-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine 5,5-dioxides and triethylammonium 3-[1-(4-hydroxy-1-ethyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)-3-(het)arylmethyl]-1-ethyl-1H-2,1-benzothiazin-4-olat 2,2-dioxides / D. O. Lega [et al.]. - С.61-69
Other authors: Filimonova N. I., Zupanets I. A., Shebeko S. K., Chernykh V. P., Shemchuk L. A.
Derkach, N. M. The study of the acute and chronic toxicity of the drug “Decasan” / N. M. Derkach [et al.]. - С.70-75
Other authors: ShtrygoI’ S. Yu., Laryanovska Yu. B., Grashchenkova S. A.
Bulyga, L. The histological study of the effect of gels with silver nanoparticles and glucosamine on purulent wound healing / L. Bulyga, Ya. Butko, Yu. Laryanovska. - С.76-80
До 75-річчя заслуженого діяча науки і техніки України, доктора фармацевтичних наук, професора Ковальова Володимира Миколайовича. - С.81
До 65-річчя доктора фармацевтичних наук, професора Ковальової Алли Михайлівни. - С.82
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Vlasov, S. V.
Synthesis, the anti-inflammatory and antimicrobial activity of 6-(1H-benzimidazol-2-yl)-5-methyl-4-(alkylthio)thienо[2,3-d] pyrimidines [Text] / S. V. Vlasov, V. P. Chernykh // Вісн. фармації. - 2016. - № 3. - P9-16

MeSH-main:
БЕНЗИМИДАЗОЛЫ -- BENZIMIDAZOLES (химический синтез)
ПИРИМИДИНЫ -- PYRIMIDINES (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL (химический синтез)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (химический синтез)
Additional Access Points:
Chernykh, V. P.

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Antimicrobial, anti-inflammatory and analgesic activities of 2-amino-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine 5,5-dioxides and triethylammonium 3-[1-(4-hydroxy-1-ethyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)-3-(het)arylmethyl]-1-ethyl-1H-2,1-benzothiazin-4-olat 2,2-dioxides [Text] / D. O. Lega [et al.] // Вісн. фармації. - 2016. - № 3. - P61-69

MeSH-main:
БЕНЗОТИАДИАЗИНЫ -- BENZOTHIADIAZINES (фармакология, химия)
ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL (фармакология, химия)
АНАЛГЕЗИРУЮЩИЕ СРЕДСТВА -- ANALGESICS (фармакология, химия)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (методы)
Additional Access Points:
Lega, D. O.
Filimonova, N. I.
Zupanets, I. A.
Shebeko, S. K.
Chernykh, V. P.
Shemchuk, L. A.

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Cipher: ВУ18/2018/2
Journal

Вісник фармації
2018year № 2

Contents:
Kolisnyk, S. V. The reactivity of ethyl esters of 2-(benzoylamino) (1-R-2-oxoindoline-3-ylidene) acetic acids / S. V. Kolisnyk [et al.]. - С.3-7
Other authors: Svechnikova O. M., Vinnyk O. F., Kolisnyk O. V., Altukhov O. O.
Yusifova, D. Yu. Determination of a number of indicators of “Venocoryl” ointment / D. Yu. Yusifova, T. A. Suleymanov. - С.8-11
Kovalevska, I. V. The spectrophotometric study of thioctic acid solutions to develop the method of its quantitative determination / I. V. Kovalevska, O. A. Ruban, V. O. Grud’ko. - С.12-18
Kerimov, Yu. B. The pharmacognostic study of the aerial part of Prangos ferulacea lindl. at the stage of the beginning of vegetation / Yu. B. Kerimov [et al.]. - С.19-23
Other authors: Isaev D. I., Kerimli E. G., Akhmedov E. Yu.
Redkin, R. G. The synthesis of spiro[indole-3,1’-pyrrolo[3,4-c]pyrrole]-2,4’,6’-trione derivatives, the study of their antimicrobial activity and the molecular docking on staphylococcal dehydrosqualene synthase / R. G. Redkin, K. V. Hlebova. - С.24-35
Sydora, N. V. The technological aspects for complex processing of hawthorn fruits / N. V. Sydora, A. M. Kovalyova, V. K. Iakovenko. - С.36-40
Kriukova, A. I. The study of the technological and microbiological parameters of a dietary supplement “Osteovert” / A. I. Kriukova, I. M. Vladymyrova. - С.41-47
Nemchenko, A. S. Analysis of approaches to pharmacotherapy of patients with cardiovascular diseases according to the data of the Ukrainian and British Formularies / A. S. Nemchenko, Yu. Ye. Kurylenko. - С.48-51
Kobets, M. M. A social significance of the pharmacogenetic testing in Ukraine on the example of the CYP2B6 gene participating in the nicotine metabolism / M. M. Kobets, O. V. Filiptsova, Yu. M. Kobets. - С.52-56
Syumka, Ye. I. The study of the antimicrobial activity of ethylene-N,N’- bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrole-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives / Ye. I. Syumka [et al.]. - С.57-62
Other authors: Osolodchenko T. P., Chernykh V. P., Shemchuk L. A.
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The study of the antimicrobial activity of ethylene-N,N’- bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrole-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives [Text] / Ye. I. Syumka [et al.] // Вісн. фармації. - 2018. - № 2. - С. 57-62

MeSH-main:
СПИРОСОЕДИНЕНИЯ -- SPIRO COMPOUNDS (химический синтез)
ИНДОЛЫ -- INDOLES (химический синтез)
ПИРРОЛЫ -- PYRROLES (химический синтез)
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (использование, методы)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
Annotation: To find compounds with the antimicrobial activity in the series of N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c] pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives. Materials and methods. The antimicrobial activity was studied by the agar diffusion method. Results and discussion. The antimicrobial screening data revealed the pronounced biological activity of ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives against gramnegative (Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa) and grampositive (Staphylococcus aureus, Bacillus subtilis) bacteria and as well as against Candida albicans fungi. Conclusions. The antibacterial activity of ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives has been studied. The compounds with a significant level of the antimicrobial activity against gramnegative bacteria (Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa), grampositive bacteria (Staphylococcus aureus, Bacillus subtilis), as well as against fungi (Candida albicans) have been found. According to the data of the microbiological screening the most active compounds appeared to be ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) 1 and ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-5′-methyl-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) 2
Additional Access Points:
Syumka, Ye. I.
Osolodchenko, T. P.
Chernykh, V. P.
Shemchuk, L. A.

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Cipher: ВУ18/2018/3
Journal

Вісник фармації
2018year № 3

Contents:
До 80-річчя з дня народження Лауреата Державної премії України в галузі науки і техніки, Заслуженого діяча науки і техніки України, заслуженого винахідника СРСР, академіка Української АН, доктора фармацевтичних наук, заслуженого професора НФаУ Тихонова Олександра Івановича. - С.3-4
Syumka, Y. I. The synthesis of mono-and bis-derivatives of spiro-2-oxindole[3,3’]pyrrole and the study of their antioxidant and anti-inflammatory activities / Y. I. Syumka [et al.]. - С.5-13
Other authors: Kravchenko A. B., Chernykh V. P., Shemchuk L. A.
Sydora, N. V. The study of the carbohydrate composition of hawthorn fruits / N. V. Sydora, A. M. Kovaleva, V. K. Iakovenko. - С.14-18
Shynkovenko, I. L. Phenolic compounds of the liquid extract from cleavers herb (Galium aparine L.) / I. L. Shynkovenko [et al.]. - С.19-24
Other authors: Ilyina T. V., Kovalyova A. M., Goryacha O. V., Golembiovska O. I., Shemchuk N. S., Komissarenko A. М.
Hordiei, K. R. The study on the elemental composition of the feverfew herb (Tanacetum parthenium (L.) Schultz bip.) / K. R. Hordiei, T. M. Gontova, M. Y. Zolotaikina. - С.25-29
Polischuk, I. M. The study of phenolic compounds and the antimicrobial action of the alcoholic extract from the cake of the red raspberry fruit / I. M. Polischuk [et al.]. - С.30-33
Other authors: Koshovyi O. M., Osolodchenko T. P., Komissarenko M. A.
Romanenko, Ye. A. The study of the chemical composition of the components of the motherwort herb / Ye. A. Romanenko [et al.]. - С.34-38
Other authors: Koshovyi O. M., Komissarenko A. M., Golembiovska O. I., Gladyish Yu. I.
Rybachuk, V. D. The choice of the quantitative composition of excipients when creating the natural zeolite paste / V. D. Rybachuk. - С.39-43
Nemchenko, A. S. The study of the state of pharmaceutical provision for patients with cardiovascular diseases using ABC- and VEN-analyses / A. S. Nemchenko, V. N. Nazarkina, Yu. Ye. Kurylenko. - С.44-48
Germanyuk, T. A. The study of the effectiveness of the combined therapy of diabetes mellitus based on the pharmacoeconomic analysis in Ukraine / T. A. Germanyuk, T. I. Ivko, L. A. Bobrytska. - С.49-53
Volkovoy, V. A. The study of the wound healing effect of ointment from the meal of black alder leaves (Alnus Glutinosa) on the model of planar wounds / V. A. Volkovoy [et al.]. - С.54-58
Other authors: Derkach N. V., Bahlai T. O., Yeromenko O. D., Karabut L. V.
Drachuk, V. M. The effect of derivatives of sulfur-containing amino acids (ademetionine, taurine and glutathione) on survival of animals with acute kidney injury of various genesis / V. M. Drachuk [et al.]. - С.59-63
Other authors: Zamorskii I. I., Shchudrova T. S., Goroshko O. M.
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The synthesis of mono-and bis-derivatives of spiro-2-oxindole[3,3’]pyrrole and the study of their antioxidant and anti-inflammatory activities [Text] / Y. I. Syumka [et al.] // Вісн. фармації. - 2018. - № 3. - С. 5-13

MeSH-main:
ПИРРОЛЫ -- PYRROLES (химический синтез)
СПИРОСОЕДИНЕНИЯ -- SPIRO COMPOUNDS (химический синтез)
АНТИОКСИДАНТЫ -- ANTIOXIDANTS (химический синтез)
ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ИНДОЛЫ -- INDOLES (химический синтез)
Annotation: To synthesize a series of mono- and bis-derivatives of spiro-2-oxindole[3,3’]pyrrole and study the antioxidant and anti-inflammatory activity of the compounds obtained
Current research proved that the preparatory method, namely, the three-component cascade transformation of isatin, α-amino acids and dipolarophils based on bis-maleimides is effective for synthesis of spiro-2-oxindole[3,3']pyrrole mono- and bis-derivatives. Series of hexamethylene- and ethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-2a,5a'-dihydro-2,2',6'(1H,1'H,5'H)-trione) symmetric derivatives were obtained. The structure of the obtained compounds was confirmed. Investigation of the antioxidant properties of the synthesized compounds revealed the most active substances: 1'-(hexamethylene-N-maleimido)-5'-benzyl-2a',5a'-dihydro-1'H-spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-2,2',6'(1H,3'H,5'H)-trione 1; ethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-5'-methyl-2a,5a'-dihydro-2,2',6'(1H,1'H,5'H)-trione) 6; hexamethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-5'-benzyl-2a,5a'-dihydro-2,2',6(1H,1'H,5'H)-trione) 7. Compound 6 also showed anti-inflammatory properties on the reference drug level
Additional Access Points:
Syumka, Y. I.
Kravchenko, A. B.
Chernykh, V. P.
Shemchuk, L. A.

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Cipher: ВУ18/2018/4
Journal

Вісник фармації
2018year № 4

Contents:
Grygoriv, G. V. The synthesis of 2-amino-4-aryl-4H-pyrano[3,2-c][1,2] benzoxathiine-3-carbonitrile 5,5-dioxides and the study of their effect on the blood coagulation process / G. V. Grygoriv [et al.]. - С.3-8
Other authors: Legа D. A., Shemchuk L. M., Maloshtan L. M., Kalenichenko G. S., Chernykh V. P., Shemchuk L. A.
Kovalev, V. M. The study of the elemental composition of Iris hungarica and varieties of irises / V. M. Kovalev [et al.]. - С.9-15
Other authors: Krechun A. V., Mykhailenko O. O., Gryshyna O. V.
Shynkovenko, I. L. Saponins of the extracts of Galium aparine and Galium verum / I. L. Shynkovenko [et al.]. - С.16-23
Other authors: Ilyina T. V., Kovalyova A. M., Goryacha O. V., Golembiovska O. I., Koshovyi O. M.
Polishchuk, I. M. The study of saponins of the raspberry cake alcoholic extract by HPLC / I. M. Polishchuk [et al.]. - С.24-27
Other authors: Komisarenko M. A., Golik M. Yu., Upyr T. V.
Bilous, S. B. The studies on the pharmaceutical development of dosage forms with silver and gold nanoparticles for use in dentistry and surgery / S. B. Bilous [et al.]. - С.28-36
Other authors: Rieznichenko L. S., Dybkova S. M., Rybachuk A. V., Kalyniuk T. H.
Rybachuk, V. D. The choice of fillers when creating natural zeolite tablets by the wet granulation method / V. D. Rybachuk. - С.37-42
Olkhovska, A. B. The conceptual bases of implementation of the controlling system of marketing communication management in pharmaceutical organizations / A. B. Olkhovska, V. V. Malyi. - С.43-51
Yakovenko, O. V. The marketing research of drugs for prevention and treatment of stress conditions at the pharmaceutical market of Ukraine / O. V. Yakovenko, O. A. Ruban, V. V. Hrynenko. - С.52-56
Zaychenko, G. V. Experimental study of the cream with cerium dioxide nanoparticles on the model of photodynamic injury in guinea pigs / G. V. Zaychenko, O. A. Pokotylo. - С.57-62
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10.

The synthesis of 2-amino-4-aryl-4H-pyrano[3,2-c][1,2] benzoxathiine-3-carbonitrile 5,5-dioxides and the study of their effect on the blood coagulation process [Text] / G. V. Grygoriv [et al.] // Вісн. фармації. - 2018. - № 4. - P3-8

MeSH-main:
БЕНЗАЛЬДЕГИДЫ -- BENZALDEHYDES (химический синтез)
ПИРАНЫ -- PYRANS (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
АНТИКОАГУЛЯНТЫ -- ANTICOAGULANTS (фармакология, химический синтез)
ГЕМОСТАТИЧЕСКИЕ СРЕДСТВА -- HEMOSTATICS (фармакология, химический синтез)
Annotation: To date, coumaric oral anticoagulants are the worldwide standard for thrombosis treatment. However, representatives of this group also possess a number of undesirable side effects; therefore, the search for novel anticoagulants are still in progress
Additional Access Points:
Grygoriv, G. V.
Legа, D. A.
Shemchuk, L. M.
Maloshtan, L. M.
Kalenichenko, G. S.
Chernykh, V. P.
Shemchuk, L. A.

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