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Total number of found documents : 19
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 1-10    11-19 
1.

Type of document : Magazine article
Edition cipher :
Author(s) : Chekhun V.F., Andriiv A.V., Lukianova N.Yu.
Title : Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes
Place of publication : Experimental Oncology. - К., 2017. - Том 39, N 1. - С. 65-68: табл. (Cipher ЕУ12/2017/39/1)
Notes : 16 ref.
MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
ХИМИОТЕРАПИЯ АДЪЮВАНТНАЯ -- CHEMOTHERAPY, ADJUVANT
СИМПОРТЕРЫ -- SYMPORTERS
Annotation: The aim of the research was to study the relation between expression of Na⁺/I⁻symporter (NIS) in breast cancer (BC) of different molecular subtypes and sensitivity of BC cells to neoadjuvant chemotherapy (NACT) and to assess whether NIS expression may be used as a predictive marker of treatment efficacy. Materials and Methods: The study included 148 women with BC of stage II–III who were treated at the Precarpathian Clinical Oncology Center during 2012–2017. All patients were treated with NACT that included 2–6 cycles of chemotherapy by FAC, AC scheme with 21 day intervals. NACT efficacy was evaluated every 2 cycles by mammography according to RECIST criteria. Morphological and immunohistochemical study of NIS expression was performed by the standard methods on paraffin sections of surgically resected tumors. Results: The heterogeneity of different molecular BC subtypes regarding response to the NACT has been found. Her2/neu-positive and basal BC subtypes were the least susceptible to the NACT (p 0.05). It was shown that NIS expression is related to the sensitivity of luminal B and basal BC subtypes to the NACT. The highest expression of NIS and impairment of its functional activity was registered in the group of patients with tumors resistant to NACT (stabilization of the disease or its progression) of luminal B (220 ± 8.6 points) and basal subtypes (290 ± 11.3 points) (p 0.05). It was revealed that the disease-free survival of patients with BC of luminal B and basal subtypes was higher in the absence of NIS expression in tumor cells (p 0.05). Conclusions: The results indicate that NIS can be used as an objective criterion for predicting the sensitivity of luminal B and basal BC subtypes to NACT, which will provide improved treatment outcomes in this group of patients
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2.

Title of magazine :Экспериментальная онкология -2017year т.39,N 1
Interesting articles :
Circulating tumor cells in breast cancer (стр.2-11)
Kashuba E. Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?/ E. Kashuba, M. Mushtag (стр.12-16)
Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro (стр.17-24)
Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics (стр.25-29)
Parthenolide reduces gene transcription of prosurvival mediators in U937 cells (стр.30-35)
Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells (стр.36-41)
Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma (стр.42-48)
EPR spectroscopy studies of changes in erythrocyte membranes in patients with laryngeal cancer (стр.49-52)
Auzina D. Prognostic value of the bone turnover markers in multiple myeloma/ D. Auzina, R. Erts, S. Lejniece (стр.53-56)
Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population (стр.57-64)
Chekhun V.F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes/ V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova (стр.65-68)
Satinder K. Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women/ K. Satinder, R. C. Sobti, K. Pushpinder (стр.69-74)
The impact of coloregional treatment on survival of patients with primary metastatic breast cancer (стр.75-77)
Diagnostic challenges with intraoral myeloid sarcoma (стр.78-85)
Trichilemmal cystis in metastatic melanoma (стр.86-87)
Materials of international vactrain/ 3-rd Swedish-Ukrainian conference on cancer diseases, January 16-17, 2017, Stockholm, Sweden (стр.88-93)
Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells (стр.88-89)
The adaptor protein Ruk/CIN85 paradoxically enhances EMT of triple negative mouse breast adenocarcinoma 4T1 cells (стр.89)
Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines (стр.89-90)
Alternative direction of inhibition of malignant properties in tumor cells in vitro and in vivo by gene therapy with INF-beta gene in recombinant baculovirus vector (стр.90)
CD150/SLAMF1 as a new potential target for anti-tumor therapy (стр.90-91)
CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia (стр.91-92)
Borikun T. Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer/ T. Borikun, N. Lukianova, V. Chekhun (стр.92)
The MRPS 18-2 protein as a putative marker of carcinogenesis (стр.92)
High expression levels of MRPS 18-2 and presence of the RB protein are required for the maintenance of stem cell phenotype (стр.92-93)
Mankovska O. Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors/ O. Mankovska, V. Kashuba (стр.93)
Brieieva O. Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients/ O. Brieieva, I. Nesina, L. Buchynska (стр.93)
Kyiv, May 11-12, 2017 Workshop with international participation. New trends in cancer research and innovative tumor vaccines (стр.94)
International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine (стр.95)
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3.

Type of document : Magazine article
Edition cipher :
Author(s) : Chekhun V. F., Todor I. N., Lukianova N. Yu., Horbyk D. M., Lozovskaya Yu. V., Burlaka A. P., Borikun T. V.
Title : Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism
Place of publication : Experimental Oncology. - К., 2018. - Том 40, N 4. - С. 268-274 (Cipher ЕУ12/2018/40/4)
MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
Annotation: To study the effect of Ferroplat (FrP) on the indexes of pro/antioxidant balance and energy metabolism in breast cancer cells of different malignancy degree and different sensitivity to drug therapy. Materials and Methods: The study was carried out on breast cancer cells of low (T47D, MCF-7) and high malignancy degree (MCF-7/DDP (cisplatin-resistant), MDA-MB-231, MDA-MB-468) using cell culture techniques, immunocytochemical, biochemical, biophysical methods, flow cytometry and polarography. Results: We established that the addition of FrP to the culture medium reduces the activity of glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD) and the level of non-protein thiols by 32–41% (p 0.05). At the same time, there was an increase of the total level of ROS and the rate of NO generation by inducible NO synthase by 1.7–2.5 times (p 0.05). This testifies that FrP disturbs the antioxidant balance in cells, resulting in their death. Also, the use of FrP led to a decrease in the rate of oxygen absorption in MCF-7 and T47D cells by 26% and 25%, respectively (p 0.05). In cells of high malignancy degree this index decreased by 38–40% under the influence of FrP. Incubation of MCF-7 and T47D cells with the indicated agent also reduced the content of phospholipid cardiolipin by 15–16% (p 0.05), and in MDA-MB-231, MCF-7/DDP, MDA-MB-468 cells — by 29%, 30% and 32%, respectively. In addition, the effect of FrP caused a decrease in the levels of Mg2+ and lactate in MCF-7 and T47D cells by 21–29% and 14–24%, respectively, whereas in MDA-MB-231, MDA-MB-468, MCF-7/DDP cells — by 34–38% and 32–35%, respectively. In this case, the agent raised the level of glucose in the cells of low malignancy degree by 20–23% (p 0.05), and in the cells of high malignancy degree and with the phenotype of drug resistance — by 31–36%. However, the nanocomposite did not affect the activity of lactate dehydrogenase in all studied breast cancer cells. Conclusion: The study has shown that FrP has an effect on the pro/antioxidant balance and energy metabolism of cancer cells. In addition, the denoted effect of FrP was more pronounced in the breast cancer cells with a high malignancy degree and the phenotype of drug resistance
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4.

Title of magazine :Экспериментальная онкология -2018year т.40,N 4
Interesting articles :
Chekhun V. F. Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy/ ed. V. F Chekhun (стр.258-260)
Tari K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia/ K. Tari [et al.] (стр.261-267)
Chekhun V. F. Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism/ V. F. Chekhun [et al.] (стр.268-274)
Symchych T. V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model/ T. V. Symchych [et al.] (стр.275-281)
Yakymenko I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation/ I. Yakymenko [et al.] (стр.282-287)
Smal M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer/ M. P. Smal [et al.] (стр.288-298)
Abooshahab R. Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer/ R. Abooshahab [et al.] (стр.299-302)
Buchynska L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas/ L. G. Buchynska [et al.] (стр.303-308)
Arabpour F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients/ F. Arabpour [et al.] (стр.309-314)
Gerashchenko G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer/ G. V. Gerashchenko [et al.] (стр.315-322)
Tas F. Clinical significance of serum caveolin-1 levels in gastric cancer patients/ F. Tas [et al.] (стр.323-327)
Shvachko L. P. Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells/ L. P. Shvachko [et al.] (стр.328-331)
Kuzyk P. V. Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis/ P. V. Kuzyk, M. A. Savchyna, S. G. Gychka (стр.332-335)
Zakhartseva L. M. Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart/ L. M. Zakhartseva [et al.] (стр.336-342)
Langabeer S. E. The JAK2 V617F mutation in lung cancer: caveat emptor/ S. E. Langabeer (стр.343-344)
Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary) (стр.345)
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5.

Type of document : Magazine article
Edition cipher :
Author(s) : Buchynska L. G., Iurchenko N. P., Kashuba E. V., Brieieva O. V., Glushchenko N. M., Mints M., Lukianova N. Yu., Chekhun V. F.
Title : Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas
Place of publication : Experimental Oncology. - К., 2018. - Том 40, N 4. - С. 303-308 (Cipher ЕУ12/2018/40/4)
MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
ВНУТРИКЛЕТОЧНЫЕ СИГНАЛЬНЫЕ ПЕПТИДЫ И БЕЛКИ -- INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS
Annotation: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients
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6.

Type of document : Magazine article
Edition cipher :
Author(s) : Chekhun V. F., Storchai D. M., Todor I. N., Borikun T. V., Lukianova N. Yu.
Title : Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats
Place of publication : Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 200-204 (Cipher ЕУ12/2018/40/3)
Notes : Bibliogr. at the end of the art.
MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER
ЛАКТОФЕРРИН -- LACTOFERRIN
РОСТА ИНГИБИТОРЫ -- GROWTH INHIBITORS
МУТАГЕНЫ -- MUTAGENS
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF. Materials and Methods: The study was performed on Walker-256 tumor-bearing rats. Total lipids and phospholipids were determined by thin-layer chromatography. Comet assay was used to investigate the genotoxic effects of LF. Results: Daily i.p. administrations of exogenous LF at concentrations of 1 mg/kg and 10 mg/kg starting from the 4th day after tumor transplantation suppressed growth of Walker-256 carcinosarcoma by almost 44%. After treatment with recombinant LF in both doses, the phospholipid composition of Walker-256 carcinosarcoma cells was changed (3-fold increase of phosphatidylethanolamine, 3.4-fold increase of phosphatidylcholine, and 1.8-fold increase of sphingomyelin, while the cardiolipin content decreased by 67%. Exogenous LF was not genotoxic for bone marrow cells (as assessed by the ratio of PCE/NCE, number of micronuclei) and peripheral blood lymphocytes (percentage of DNA in the tail of a comet) in Walker-256 carcinosarcoma-bearing rats. Conclusion: Exogenous LF caused the inhibition of Walker-256 carcinosarcoma growth and a decrease in the microviscosity of plasma cell membranes, and exerted no genotoxicity toward bone marrow cells and peripheral blood of experimental animals. Key Words: lactoferrin, breast cancer, Walker-256 carcinosarcoma, phospholipid content, genotoxicity
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7.

Title of magazine :Экспериментальная онкология -2018year т.40,N 3
Interesting articles :
Akbarzadeh A. Role of dendrimers in advanced drug delivery and biomedical applications: a review/ A. Akbarzadeh [та ін.] (стр.178-183)
Zadvornyi T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro/ T. V. Zadvornyi [та ін.] (стр.184-189)
Harper P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies/ P. Harper [та ін.] (стр.190-193)
Apykhtina О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles/ О. L. Apykhtina [та ін.] (стр.194-199)
Chekhun V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats/ V. F. Chekhun [та ін.] (стр.200-204)
Prokhorova I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6/ I. V. Prokhorova [та ін.] (стр.205-210)
Abramenko I. V. . Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients/ I. V. Abramenko [та ін.] (стр.211-217)
Nesina I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma/ I. P. Nesina, N. P. Iurchenko, L. G. Buchynska (стр.218-222)
Vernygorodskyi S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction/ S. Vernygorodskyi, T. Rekun, P. Zhuchenko (стр.223-227)
Gerashchenko T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles/ T. S. Gerashchenko [та ін.] (стр.228-234)
Agishev T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury/ T. T. Agishev [та ін.] (стр.235-238)
Dumansky Yu. V. Paraneoplastic syndrome in lung cancer/ Yu. V. Dumansky [та ін.] (стр.239-242)
Grybach S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome/ S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun (стр.243-248)
Chrysanthakopoulos N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study/ N. A. Chrysanthakopoulos, N. S. Dareioti (стр.249-250)
Tkachenko R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy/ R. Tkachenko, A. Golovko, O. Kuryk (стр.251-253)
Svitlana Pavlivna Sidorenko (1953–2018) (стр.254-255)
Yurii Yosypovych Kudryavets (1946–2018) (стр.256-257)
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8.

Type of document : Magazine article
Edition cipher :
Author(s) : Lozovska Yu. V., Andrusishina I. M., Lukianova N. Yu., Burlaka A. P., Naleskina L. A., Todor I. N., Chekhun V. F.
Title : The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 20-25 (Cipher ЕУ12/2019/41/1)
Notes : Bibliogr. at the end of the art.
MeSH-main: КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER
ЛАКТОФЕРРИН -- LACTOFERRIN
ЦЕРУЛОПЛАЗМИН -- CERULOPLASMIN
ПЕРОКСИДАЗА -- PEROXIDASE
ТРАНСФЕРРИН -- TRANSFERRIN
ФЕРМЕНТОВ АКТИВАТОРЫ -- ENZYME ACTIVATORS
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To investigate the content of essential elements (EE): copper, zinc, magnesium, iron and calcium and the evaluation of the activity of metal-containing enzymes — ceruloplasmin (CP), myeloperoxidase (MPO) and the content of transferrin (TF) in blood plasma (BP) and tumor tissue (TT) of animals with Walker-256 carcinosarcoma treated with lactoferrin (LF). Materials and Methods: The study of the EE content and the activity of the abovementioned enzymes was carried out on rats with Walker-256 carcinosarcoma treated with LF at the doses of 1 and 10 mg/kg of body weight. The quantitative content of EE in BP and TT of animals was determined using the inductively coupled plasma atomic emission spectroscopy (ICP-AES). Determination of CP activity, content of TF and hemochromes was performed using the method of electron paramagnetic resonance (EPR), and MPO — by unified biochemical method. Results: The introduction of LF at the doses of 1 and 10 mg/kg resulted in a decrease in the ratio of Cu/Zn in BP and even more expressed decrease of Ca/Mg ratio in TT. Administration of LF, especially at a dose of 10 mg/kg, affected the increase in CP and MPO activity in BP. It has been shown that administration of LF at a dose of 10 mg/kg led to an increase in oxidative products of destruction of the hemoglobin-hemochrom system in the TT, against the background of lowering the TF content. Conclusions: The administration of LF, especially at a dose of 10 mg/kg, led to metabolic alterations associated with inhibition of the tumor process. The detected modulating effect of LF on the content of the EE and the activity of the CP and MPO may be a basis for correction of the elemental balance in carcinogenesis
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9.

Title of magazine :Экспериментальная онкология -2019year т.41,N 1
Interesting articles :
Solyanik G. I. Quinazoline compounds for antitumor treatment/ G. I. Solyanik (стр.3-6)
Mahmoudian J. Expression profiling of plac1 in murine cancer cell lines/ J. Mahmoudian [та ін.] (стр.7-13)
Kolesnik D. L. Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma/ D. L. Kolesnik [та ін.] (стр.14-19)
Lozovska Yu. V. The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma/ Yu. V. Lozovska [та ін.] (стр.20-25)
Burlaka A. A. DNA oxidation in patients with metastastic colorectal cancer: clinical significance of 8-hydroxy-deoxyguanosine as an independent prognostic factor/ A. A. Burlaka [та ін.] (стр.26-31)
Stakheyeva M. Integral characteristic of the immune system state predicts breast cancer outcome/ M. Stakheyeva [та ін.] (стр.32-38)
Bilous N. Analysis of LPL gene expression in patients with chronic lymphocytic leukemia/ N. Bilous [та ін.] (стр.39-45)
Alghamdi S. Evaluation of dose calculation algorithms using different density materials for in-field and out-of-field conditions/ S. Alghamdi, A. Tajaldeen (стр.46-52)
Poluben L. Copy number alterations and copy-neutral loss of heterozygosity in Ukrainian patients with primary myelofibrosis/ L. Poluben [та ін.] (стр.53-56)
Bakai O. A. Radiation research to determine local tumor invasion in patients with cervical cancer/ O. A. Bakai [та ін.] (стр.57-60)
Zabolotnyi D. I. Aggregated proteins in malignant and benign neoplasms/ D. I. Zabolotnyi [та ін.] (стр.61-68)
Shirin V. Assessment of trace elements in serum of acute lymphoblastic and myeloid leukemia patients/ V. Shirin [та ін.] (стр.69-71)
Tkachenko R. Parathyroid carcinoma: a case report/ R. Tkachenko [та ін.] (стр.72-75)
Semko S. A case of synchronous bilateral calyx urothelial carcinoma: combined treatment approach/ S. Semko [та ін.] (стр.76-79)
De Giorgi V. Cutaneous leiomyosarcoma: a clinical, dermoscopic, pathologic case study/ Giorgi V. De [та ін.] (стр.80-81)
Langabeer S. E. Suboptimal molecular response to tyrosine kinase inhibition associated with acquisition of a T240A ABL1 kinase domain mutation in a patient with chronic myeloid leukemia/ S. E. Langabeer [та ін.] (стр.82-83)
Brieieva O. Scientific and Practical Conference of Young Scientists “Fundamental Medicine: Integrated Approaches to Cancer Therapy”/ O. Brieieva (стр.84-86)
Tumor and Host: Novel Aspects of Old Problem (стр.87)
Ludmyla Zakharivna Polishchuk (1937–2019) (стр.88)
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10.

Type of document : Magazine article
Edition cipher :
Author(s) : Lukianova N. Yu., Borikun T.V., Chekhun V. F.
Title : Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 242-247 (Cipher ЕУ12/2019/41/3)
Notes : Bibliogr. at the end of the art.
MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY
МИКРО-РНК -- MICRORNAS
ГЕННАЯ ЭКСПРЕССИЯ -- GENE EXPRESSION
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) were analyzed in tissue of BC using immunohistochemical method. Relative expression levels of the miR-155, -320a, and -205 were examined in tissue and sera from BC patients using quantitative reverse transcription polymerase chain reaction. Results: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. Nevertheless, we established the relation of circulating and tissue miR-155, -320a, and -205 to lymph node metastases and basal breast cancer subtype. Conclusions: Changes of miR-155, -320a, and -205 expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC
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