Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia / I. Gordiienko [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P91-92

MeSH-main:
ЛЕЙКОЗ ЛИМФОЦИТАРНЫЙ ХРОНИЧЕСКИЙ B-КЛЕТОЧНЫЙ -- LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL (терапия)
АНТИГЕНЫ -- ANTIGENS
Annotation: Recent finding indicate that CD150 cell surface expression can be used as a surrogate prognostic marker of chronic lymphocytic leukemia (CLL) favorable outcome. It was shown that CLL patients with high CD150 expression level on malignant B cells has longer treatment free survival and overall survival compared to patients, which lost CD150 cell surface expression. However, the mechanisms that underlie dependent on CD150 expression biological properties of CLL B cells are not fully understood. Present study was focused on characterization of CD150 topology and isoforms expression, as well as study of CD150 mediated signaling pathways in CLL B cells
Additional Access Points:
Gordiienko, I.
Shlapatska, L.
Kholodniuk, V.
Sklyarenko, L.
Sidorenko, S.

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Sensitivity of chronic lymphocytic leukemia cells to chemotherapeutic drugs ex vivo depends on expression staus of cell surface receptors / V. Shcherbina [et al.] // Experimental Oncology. - 2020. - Том 42, N 1. - P16-24

MeSH-main:
ЛЕЙКОЗ-ЛИМФОМА ПРЕ-КЛЕТОЧНЫЙ ЛИМФОБЛАСТНЫЙ -- PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA (патофизиология)
Annotation: Response of chronic lymphocytic leukemia (CLL) patients to classical chemoimmunotherapy that remains the main strategy in treatment of this disease is strikingly variable. This issue requires the finding of biomarkers which could predict efficiency of drug administration and choose the best treatment option for each patient individually. The aim of this study was to find out association between cell surface receptors expression levels and CLL B cells sensitivity to chemotherapeutic drugs ex vivo. Materials and Methods: The study was performed on malignant B cells isolated from peripheral blood of primary CLL patients. Flow cytometry, qPCR, ex vivo drug sensitivity assay, and cell viability assay were used in this study. Results: The high CD5 expression level was linked to better bendamustine (BEN) and cyclophosphamide (CP) CLL B cells response in contrast to B cells with low CD5 expression. Sensitivity of CLL B cells to CP also could be predicted by high level of CD20 expression. Expression of CD38 and high levels of CD37 and CD40 showed CLL B cells resistance to BEN ex vivo. CLL B cells sensitivity to analyzed chemotherapeutic drugs was not dependent on CD22 expression status. The CD180 expression was detected in CLL B cells which were more susceptible to fludarabine and cyclophosphamide (FC) combinatory action. CLL B cells that coexpressed CD150 and CD180 on the cell surface were characterized by significantly decreased cell viability under fludarabine (FLU) exposure alone or FC in comparison with CD150-CD180- B cells. Cell surface expression level of CD150 was not associated with CLL B cells chemosensitivity. However, high mRNA expression level of mCD150 isoform in CLL B cells was linked to their FLU sensitivity and CP resistance, while high nCD150 mRNA expression level showed resistance to FLU. Simultaneous CD150 and CD180 ligation increased FLU resistance, but BEN susceptibility of CLL B cells. CD150 and CD180 alone or in combination are involved in upregulation of CD20 cell surface expression. Conclusion: Expression status of the CD5, CD20, CD37, CD38, CD40, CD150, and CD180 cell surface receptors could be used in prediction CLL B cells sensitivity to FLU, CP, BEN and FC ex vivo. Moreover, CD150 and CD180 receptors are involved in regulation of CLL B cells susceptibility to FLU and BEN. The CD150 and CD180 are positive regulators of CD20 expression that could make CD150+CD180+ CLL B cells more responsive to CD20-based immunotherapy
Additional Access Points:
Shcherbina, V.
Gordiienko, I.
Shlapatska, L.
Ivanivska, T.
Sidorenko, S.

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CD150/SLAMF1 as a new potential target for anti-tumor therapy / S. P. Sidorenko [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P90-91

MeSH-main:
НОВООБРАЗОВАНИЯ -- NEOPLASMS (лекарственная терапия, терапия)
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS
Annotation: CD150/SLAMF1 is a prototype member of SLAM family within the immunoglobulin superfamily of surface receptors that are widely expressed on cells within hematopoietic system. Six of nine SLAMF receptors have a paired unique immunoreceptor tyrosine-based switch motif (ITSM) that serves as a docking site for SH2-containing proteins. In T and B lymphocytes, natural killer cells, macrophages and dendritic cells CD150 is a co-receptor molecule that mediates different signal transduction pathways depending on the availability of downstream signaling elements, especially, the adaptor protein SH2D1A/SAP. Due to highly glycosylated and sialylated extracellular Ig domains, CD150 is involved in homotypic interactions and could be considered as a pattern-recognizing receptor. It is a major entry receptor for several Morbilliviruses, including measles virus, and also a bacterial sensor that control the killing of Gram-negative bacteria. Functionally it serves as a bridge between innate and adaptive immunity
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Sidorenko, S.P.
Romanets-Korbut, O.
Gordiienko, I.
Kovalevska, L.
Shlapatska, L.

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61
С 96

"Сьогодення та майбутнє медицини", міжнар. наук. конф. студ. та молодих вчених (2009 ; Вінниця)
Sidorenko, S.
Restless legs syndrome in correlation with emotional dysfunction in medical students [Text] / S. Sidorenko // Матеріали VI Міжнародної наукової конференції студентів та молодих вчених "Сьогодення та майбутнє медицини", 9-10 квіт. 2009 р. / гол. ред. Мороз В. М., ред.: В. В. Петрушенко, І. М. Макарчук, С. А. Мовчан ; відп. секр. С. Г. Полінкевич. - 2009. - С. 172

UDC

61(06)

Additional Access Points:
Мороз, В. М. \гол. ред.\
Петрушенко, В. В. \ред.\
Макарчук, І. М. \ред.\
Довгань, О. В. \ред.\
Мовчан, С. А. \ред.\
Полінкевич, С. Г. \відп. секр.\
"Сьогодення та майбутнє медицини", міжнар. наук. конф. студ. та молодих вчених(2009 ; Вінниця)

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Cipher: ЕУ12/2005/27/1
Journal

Экспериментальная онкология [Text]
2005year Т. 27 № 1

Contents:
Charalabopoulos, K. Рецепторы интегринов и компоненты внеклеточного матрикса при опухолях околоушной железы: Обзор=Integrin receptors and extracellular matrix components in parotid neoplasms: Rev. / K. Charalabopoulos [и др.] . - 2-6 (статья на англ.яз., резюме на рус.яз.). - References: P.4-6
Other authors: Mittari E., Golias Ch., Peschos D., Batistatou A.
Di, Micco P. Солитарная плазмоцитома и ее отличия от множественной миеломы: Обзор=Up-date on solitary plasmacytoma and its main differences with multiple myeloma: Rev. / Micco P. Di, Micco B. Di. - 7-12(статья на англ.яз., резюме на рус.яз.). - References: P.10-12
Giannakopoulos, X. Качество жизни больных раком простаты: Обзор=Quality of life survey in patients with advanced prostate cancer: Rev. / X. Giannakopoulos [и др.] . - 13-17 (статья на англ.яз., резюме на рус.яз.). - References: P.16-17
Other authors: Charalabopoulos K., Charalabopoulos A., Golias Ch., Peschos D., Sofikitis N.
Jordan, A. Селекция и характеристика терморезистентных вариантов клеточных линий рака желудка человека с множественной лекарственной резистентностью=Selection and characterization of heat-resistant variants of multidrug-resistant human gastric carcinoma cell lines / A. Jordan, R. Scholz. - 18-23(статья на англ.яз., резюме на рус.яз.). - References: P.22-23
Yurchenko, M. Y. Роль связывания CD150 и адапторного белка SH2D1A в опосредованных через CD150 сигнальных каскадах в линиях клеток лимфомы Ходжкина=The role of CD150-SH2D1A association in CD150 signaling in Hodgkin’s lymphoma cell lines / M. Y. Yurchenko [и др.] . - 24-30(статья на англ.яз., резюме на рус.яз.). - References: P.28-29
Other authors: Kashuba E.V., Shlapatska L.M., Sivkovich S.A., Sidorenko S.P.
Drobot, L. Преходящая активация Р21RAS в процессе эритроидной дифференцировки клеток человека линии К562, индуцированной гербимицином А=Transient activation of Ras-dependent signalling at the early stages Herbimycin A induced erythroid differentiation of human K562 cells / L. Drobot [и др.] . - 31-37(статья на англ.яз., резюме на рус.яз.). - References: P.35-37
Other authors: Husak Z, Ilnytska O., Igumentseva N., Oleksyn H., Kusen S.
Arutyunyan, R. Изучение резистентности теломер методом Comet-FISH в лейкоцитах человека при комбинированном действии цисплатина и блеомицина=Fragility of telomeres after bleomycin and cisplatin combined treatment measured in human leukocytes with the Comet-FISH technique / R. Arutyunyan [и др.] . - 38-42(статья на англ.яз., резюме на рус.яз.). - References: P.41-42
Other authors: Rapp A., Greulich K.O., Hovhannisyan G., Haroutiunian S., Gebhart E.
Svirnovski, A. Попытки воздействия на лекарственную резистентность опухолевых клеток в экспериментальной системе=Attempts to influence the drug resistance of tumor cells in experimental system / A. Svirnovski, V. Pasiukov. - 43-46(статья на англ.яз., резюме на рус.яз.). - References: P.45-46
Mikhailenko, V. M. Влияние экзогенных оксидов азота на состояние противоопухолевой резистентности у крыс =Effect of environmental nitric oxides on the antitumor resistance of rats / V. M. Mikhailenko [и др.] . - 65-70(статья на англ.яз., резюме на рус.яз.). - References: P.69-70
Other authors: Savtsova Z.D., Glavin O.A., Mikhailenko P.M., Voyeikova I.M., Evstratyeva L.N., Perepnyhatka N.P.
Ismail-zade, R. S. Общая гипертермия в сочетании с уротропином в лечении злокачественных опухолей =Whole body hyperthermia supplemented with urotropin in the treatment of malignant tumors / R. S. Ismail-zade. - 61-64(статья на англ.яз., резюме на рус.яз.). - References: P.64-64
Wu, J. Индукция апоптоза в клетках линии Нер G2 при воздействии 2-[(3-карбокси-1-оксопроги 1)амино]-2-дезокси-D-глюкозы =2-[(3-carboxy-1-oxoprogy 1) amino]-2-deoxy-D-glucose induces apoptosis in Hep G2 cells / J. Wu [и др.] . - 52-55(статья на англ.яз., резюме на рус.яз.). - References: P.55-55
Other authors: Qi D., Wei K., Li W., Chen X., Wang A., Liu W., Xue Q., Qiao L.
Hao, S. Новый подход к подавлению опухолевого роста микроинкапсулированными модифицированными клетками линии J558/TNF-a=A novel approach to tumor suppression using microencapsulated engineered J558/TNF-a cells / S. Hao [и др.] . - 56-60(статья на англ.яз., резюме на рус.яз.). - References: P.59-60
Other authors: Su L., Guo X., Moyana T., Xiang J.
Savitskiy, V. P. Накопление производных хлорида е6 в опухолевых клетках с различной экспрессией и функциональной активностью белка множественной лекарственной устойчивости Р-gp 170=Accumulation of chlorine e6 derivatives in cells with different level of expression and function activity of multidrug resistance protein P-gp 170 / V. P. Savitskiy, V. P. Zorin, M. P. Potapnev. - 47-51(статья на англ.яз., резюме на рус.яз.). - References: P.50-51
Klymenko, S. V. Перестройки гена MLL при радиационно-ассоциированных острых миелоидных лейкозах =MLL gene alterations in radiation-associated acute myeloid leukemia / S. V. Klymenko [и др.] . - 71-75(статья на англ.яз., резюме на рус.яз.). - References: P.74-75
Other authors: Bink K., Trott K.R., Bebeshko V.G., Bazyka D.A., Dmytrenko I.V., Abramenko I.V., Bilous N.I., Zitzelsberger H., Misurin A.V., Atkinson M.J., Rosemann M.
Unsal, D. Уровень перекисного окисления липидов и содержание сульфгидрильных групп и оксида азота в плазме крови онкологических больных при облучении различных полей: исследование методом "случай-контроль" =Plasma level of lipid peroxidation, total sulphydryl groups and nitric oxide levels in cancer patients irradiated on different anatomic fields: a case-control study / D. Unsal [и др.] . - 76-80(статья на англ.яз., резюме на рус.яз.). - References: P.79-79
Other authors: Akmansu M., Ozer C., Gonul B., Bora H.
Konac, E. Цитотоксическое действие госсипола на клетки плоскоклеточного рака гортани человека линии НЕр-2 in vitro =An in vitro study of cytotoxic effects of gossypol on human epidermoid larynx carcinoma cell line (HEp-2) / E. Konac [и др.] . - 81-83(статья на англ.яз., резюме на рус.яз.). - References: P.82-83
Other authors: Ekmekci A., Yurtcu E., Ergun M.A.
Инга Касьяненко к 80-летию со дня рождения=Inda Kasyanenko-80 th anniversary: Cronicle. - 84-84 (статья на анг.яз.)
Instructions to authors. - 85-85 (статья на англ.яз.)
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Cipher: ЕУ12/2020/42/1
Journal

Экспериментальная онкология [Text]
2020year Т. 42 № 1

Contents:
Bubnovskaya, L. Tumor microenvironment and metabolic factors: contribution to gastric cancer / L. Bubnovskaya, D. Osinsky. - С.2-10
Gong, Y. Rapamycin-induced autophagy plays a pro-survival role by enhancing up-regulation of intracellular ferritin expression in acute lymphoblastic leukemia / Y. Gong [et al.]. - С.11-15
Other authors: Wu J., Yang R., Zhang L., Ma Z.
Shcherbina, V. Sensitivity of chronic lymphocytic leukemia cells to chemotherapeutic drugs ex vivo depends on expression staus of cell surface receptors / V. Shcherbina [et al.]. - С.16-24
Other authors: Gordiienko I., Shlapatska L., Ivanivska T., Sidorenko S.
Siromolot, A. A. Antiproliferative and apoptotic effects of anti-human HB-EGF neutralizing polyclonal antibodies in vitro / A. A. Siromolot [et al.]. - С.25-30
Other authors: Krynina O. I., Kolybo D. V., Komisarenko S. V.
Shvachko, L. P. Aberrant expression of placental-like alkaline phosphatase in chronic myeloid leukemia cells in vitro and its modulation by vitamin E / L. P. Shvachko [et al.]. - С.31-34
Other authors: Zavelevich M. P., Gluzman D. F., Telegeev G. D.
Kolesnik, D. L. Metformin enhances cytotoxic action of dichloroacetate against lewis lung carcinoma cells in vitro / D. L. Kolesnik [et al.]. - С.35-39
Other authors: Pyaskovskaya O. N., Gorbach O., Solyanik G. I.
Sarnatskaya, V. V. Structural changes of serum albumin in response to oxidative stress caused by Walker-256 carcinosarcoma growth / V. V. Sarnatskaya [et al.]. - С.40-45
Other authors: Yushko L. A., Prokopenko I. V., Hudenko N. V., Maslenny V. N., Paziuk L. M., Bubnovskaya L. N., Nikolaev V. G.
Burlaka, A. A. Drag reducing polymers attenuate adverse effects of ischemia-reperfusion upon resection of liver metastases modeled by MC38 mouse colon adenocarcinoma / A. A. Burlaka [et al.]. - С.46-50
Other authors: Burlaka A. P., Krotevych M. S., Rudiuk T. O., Orel V. E.
Lifsics, A. Survival analysis of oropharyngeal squamous cell carcinoma patients linked to histopathology, disease stage, tumor stage, risk factors, and received therapy / A. Lifsics [et al.]. - С.51-59
Other authors: Rate E., Ivanova A., Tars J., Murovska M., Groma V.
Bilous, N. MYC copy number and mRNA expression in chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chornobyl NPP accident / N. Bilous [et al.]. - С.60-65
Other authors: Abramenko I., Chumak A., Dyagil I., Martina Z.
Fedorenko, Z. P. Incidence and long-term effects of treatment of malignant germ cell neoplasms in Ukraine / Z. P. Fedorenko [et al.]. - С.66-74
Other authors: Mikchailovich Yu. I., Goulak L. O., Ryzhov A. Yu., Gorokh Ye. L., Soumkina O. V.
Kozirovskis, V. High expression of GLI1 is associated with better survival in advanced SCLC / V. Kozirovskis [et al.]. - С.75-77
Other authors: Zandberga E., Magone M., Purkalne G., Line A., Vikmanis U.
Kearney, L. Frequency and spectrum of atypical BCR-ABL1 transcripts in chronic myeloid leukemia / L. Kearney, M. Grampe, S. E. Langabeer. - С.78-79
In commemoration of Dmitriy Vladimirovich Myasoyedov. - С.80
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