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Search inquiry: (<.>S=Лимфома<.>)
Total number of found documents : 91
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1.


    Ильин, Н. В.
    7-й Международный симпозиум по лимфоме Ходжкина [Text] / Н. В. Ильин // Вопросы онкологии. - 2008. - Т. 54, № 2. - С. 241-242

Rubrics: Лимфома

   Ходжкина болезнь

   Конгрессы

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2.


   
    Effects of thiazole derivatives on intracellular structure and functions in murine lymphoma cells / V. P. Hreniukh [et al.] // The Ukrainian biochemical journal. - 2020. - Vol. 92, № 2. - P121-131


MeSH-main:
ЛИМФОМА -- LYMPHOMA (лекарственная терапия)
ТИАЗОЛЫ -- THIAZOLES (фармакокинетика)
Annotation: Thiazole derivatives have cytotoxic effects towards tumor cells, such as glioblastoma, melanoma, leukemia and lymphoma. However, the intracellular mechanism of this action is not clear. The aim of our study was to investigate the action of N-(5-benzyl-1,3-thiazol-2-yl)-3,5-dimethyl-1-benzofuran-2-carboxamide (BF1) and 7-benzyl-8-methyl-2-propylpyrazolo[4,3-e]thiazolo[3,2-a]pyrimidin-4(2H)-one (PP2) on cellular structure, and bioenergetic functions of mitochondria in Nemeth-Kellner lymphoma cells (NK/Ly). The structure of treated NK/Ly cells and their mitochondria was examined using electron microscopy. The rate of oxygen uptake by isolated mitochondria was recorded by a polarographic method using a Clark electrode. The mitochondrial potential relative values were registered using fluorescence dye rhodamine 123. In the short-term (15 min), incubation with BF1 and PP2 in 10 and 50 µM concentrations induced apoptotic and necrotic changes in the structure of NK/Ly cells, such as fragmentation and disintegration of the nucleus, destruction of the plasma membrane, and an increase in numbers of lysosomes and mitochondria. A polarographic method did not show significant metabolic shifts in lymphoma mitochondria, in either in vitro or ex vivo actions of the thiazole derivatives. However, fluorescent microscopy showed a significant decrease in mitochondria potential, following a 15 min incubation of cells with 50 µM of PP2. Thus, the electron and fluorescent microscopy data suggest that mitochondria are involved in the mechanism of cytotoxic action of the studied thiazole derivatives
Additional Access Points:
Hreniukh, V. P.
Finiuk, N. S.
Shalai, Ya. R.
Manko, B. O.
Manko, B. V.
Ostapiuk, Yu. V.
Kulachkovskyy, O. R.
Obushak, M. D.
Stoika, R. S.
Babsky, A. M.

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3.


   
    Impact of N-acetylcysteine on antitumor activity of doxorubicin and landomycin A in NK/Ly lymphoma-bearing mice / Yu. S. Kozak [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 2. - P46-55


MeSH-main:
АЦЕТИЛЦИСТЕИН -- ACETYLCYSTEINE (фармакология)
ДОКСОРУБИЦИН -- DOXORUBICIN (фармакология)
ЛИМФОМА -- LYMPHOMA
ЭУКАРИОТЫ -- EUKARYOTA
Annotation: N-acetylcysteine (NAC) is a dietary supplement demonstrating antioxidant and liver protecting effects that is widely used in clinics. NAC is considered to possess potential therapeutic activity for health disorders characterized by generation of free oxygen radicals, as well as potential for decreasing negative side effects of various drugs. However, the mechanisms of such tissue-protective actions of NAC remain poorly understood. The main aim of this work was to study therapeutic effects of NAC applied together with the “gold standard” of chemotherapy doxorubicin (Dx) or the novel experimental drug landomycin A (LA) to mice bearing NK/Ly lymphoma. It was revealed that NAC significantly decreased the nephrotoxicity of Dx (measured as creatinine level), possessed moderate immunomodulating activity (as revealed by an increase in number of cytotoxic T-lymphocytes), and partially increased survival of NK/Ly lymphoma-bearing animals treated with Dx. On the contrary, there was little tissue-protective effect of NAC towards LA due to the weak side effects of this anticancer drug, however, the combined use of NAC and LA significantly increased survival (60+ days) of LA-treated animals with NK/Ly lymphoma. Summarizing, NAC possesses a moderate tissue-protective activity towards Dx action but lacks a major therapeutic effect. However, in the case of LA action, NAC significantly increases its anticancer activity with no impact on its negative side effects. Further studies of the molecular mechanisms underlying that activity of NAC towards the action of LA are in progress
Additional Access Points:
Kozak, Yu. S.
Panchuk, R. R.
Skorokhyd, N. R.
Lehka, L. V.
Stoika, R. S.

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4.


    Новик, А. А.
    MALT-лимфома -новая разновидность опухоли желудка [Text] / А. А. Новик, Н. Л. Денисов, И. В. Городкин // Вестник хирургии им. И.И. Грекова. - 2002. - Т. 161, № 5. - С. 101-106


MeSH-main:
ЖЕЛУДКА НОВООБРАЗОВАНИЯ -- STOMACH NEOPLASMS (патофизиология)
ЛИМФОМА -- LYMPHOMA (патофизиология)
Additional Access Points:
Денисов, Н. Л.
Городкин, И. В.


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5.


   
    MALT-лимфома тонкой кишки, осложненная перфорацией и перитонитом: клиническое наблюдение [Text] / Н. А. Дасаев [и др.] // Эндоскопическая хирургия. - 2012. - № 4. - С. 36-38

Rubrics: Тонкая кишка

   Лимфома

   Перитонит

Additional Access Points:
Дасаев, Н. А.
Ларин, С. В.
Курганов, И. А.
Байбакова, Т. И.

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6.


    Lakshita, Purushotham
    Recent studies in the field of oncological diseases in children [Text] / Purushotham Lakshita, Veetil Arjun Krishna Kanniradan // Український науково-медичний молодіжний журнал. - 2022. - № 1 спецвип. . - С. 9


MeSH-main:
ОНКОЛОГИЯ МЕДИЦИНСКАЯ -- MEDICAL ONCOLOGY (статистика, тенденции)
ДЕТИ -- CHILD
ЛЕЙКОЗЫ -- LEUKEMIA (смертность)
МОЗГА ГОЛОВНОГО НОВООБРАЗОВАНИЯ -- BRAIN NEOPLASMS (патофизиология, смертность)
ЛИМФОМА -- LYMPHOMA (патофизиология, смертность)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: According to WHO’s recent study, about 400,000 children and adolescents in between the age group of 0-19 years develop cancer. Some of the common types of childhood cancer are leukemia, cancer of brain and lymphomas. Certain tumors such as Wilms tumor and Neuroblastomas can also be seen. Various carcinogenic factors cause childhood cancer yet, according to studies, usually childhood cancers are not associated with their lifestyle or environmental factors. Childhood cancers are mostly caused due to some serious infections like HPV, AIDS, Hepatitis etc. The survival rate of childhood cancer changes from one country to another depending on its economy. As per WHO reports, the high income countries have about 80% cure rate while economically weak countries have about 30% cure rate. The deaths from childhood cancer in economically weak countries are usually due to lack of diagnosis, misdiagnosis or delayed diagnosis. Also not providing proper care or abandoning treatment leads to death
Additional Access Points:
Kanniradan, Veetil Arjun Krishna

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7.


    Мартина, З. В.
    V Российская конференция с международным участием "злокачественные лимфомы" Москва, 30-31 октября 2008 г. [Text] / З. В. Мартина, О. М. Костюкевич // Український журнал гематології та трансфузіології. - 2008. - № 6. - С. 44-46

Rubrics: Лимфома

   Конференции

Additional Access Points:
Костюкевич, О. М.

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8.


    Лебедь, Г. Б.
    Імунофенотипова діагностика зрілих В-клітинних злоякісних лімфом з ураженням селезінки [Text] / Г. Б. Лебедь, І. Й. Євстахевич, Я. І. Виговська // Український журнал гематології та трансфузіології. - 2002. - № 4. - С. 39-43


MeSH-main:
ЛИМФОМА -- LYMPHOMA (диагноз, иммунология, осложнения, этиология)
СЕЛЕЗЕНКИ НОВООБРАЗОВАНИЯ -- SPLENIC NEOPLASMS (диагноз, иммунология)
Additional Access Points:
Євстахевич, І. Й.
Виговська, Я. І.

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9.


    Кунгуров, Н. В.
    Алгоритмы клинико-лабораторной диагностики злокачественных лимфом кожи [Text] / Н. В. Кунгуров, М. М. Кохан, С. В. Сазонов // Вестник дерматологии и венерологии. - 2002. - № 6. - С. 16-19


MeSH-main:
КОЖИ НОВООБРАЗОВАНИЯ -- SKIN NEOPLASMS (диагностика)
ЛИМФОМА -- LYMPHOMA (диагностика)
Additional Access Points:
Кохан, М. М.
Сазонов, С. В.

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10.


   
    Анализ заболеваемости и контингентов больных злокачественными лимфомами в Российской Федерации [Text] / А. Г. Толкушин, Е. В. Огрызко, Р. И. Ягудина // Вопросы онкологии. - 2006. - Т. 52, № 4. - С. 392-397

Rubrics: Лимфома

   Заболеваемость

Additional Access Points:
Толкушин, А. Г.
Огрызко, Е. В.
Ягудина, Р. И.

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