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Total number of found documents : 110
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1.


   
    Indicators of the immune system after correction of climacteric syndrome in women with uterine leiomyoma and endometrial hyperplasia [Text] / L. A. Butina [et al.] // Здоров’я жінки. - 2020. - № 5/6. - С. 72-79. - Бібліогр. в кінці ст.


MeSH-main:
КЛИМАКТЕРИЧЕСКОГО ПЕРИОДА РАССТРОЙСТВА -- CLIMACTERIC DISORDERS
ЛЕЙОМИОМА -- LEIOMYOMA (патофизиология)
ЭНДОМЕТРИЯ ГИПЕРПЛАЗИЯ -- ENDOMETRIAL HYPERPLASIA (патофизиология)
ПРЕМЕНОПАУЗА -- PREMENOPAUSE (действие лекарственных препаратов)
ПОСТМЕНОПАУЗА -- POSTMENOPAUSE (действие лекарственных препаратов)
ИММУННАЯ СИСТЕМА -- IMMUNE SYSTEM (действие лекарственных препаратов)
АДЪЮВАНТЫ ИММУНОЛОГИЧЕСКИЕ -- ADJUVANTS, IMMUNOLOGIC (терапевтическое применение)
Annotation: The objective: to evaluate the effectiveness of the correction of climacteric syndrome (CS) with the use the method of sequential prevention and treatment of CS in women with uterine leiomyoma (UL) and endometrial hyperplasia (EH) based on studies of indicators of the immune system. Materials and methods. On the basis of prognosis using a mathematical model some groups of women with UL and EH in the period of before and after menopause, with the risk of development of disorders in menopause were chosen and the state of the immune system before and after the correction of climacteric syndrome with the use the method of sequential prevention and treatment of CS were evaluated. The prevention of CS was carried out in 184 women aged 40 to 53 years with the presence of signs of UL and EH, in which after menstruation was delayed for 3–6 months, uterine bleeding and symptoms of CS were observed. These women underwent CS prevention for one year with the use of a contraceptive containing of the natural estrogen estradiol valerate and gestagen dienogest. The women were divided into groups depending on the presence or absence of signs of CS, UL and EH: women with UL and CS (n=60), women with UL without CS (n=37), women with EH and CS (n=37), women with EH without CS (n=25), women with CS without UL and EH (n = 25). Women with UL and CS who constituted the main group (n=60), additionally used an immunomodulator that contains meglumine acridonacetate and suppositories containing recombinant alpha interferon 2b. The control group consisted 50 women of the same age category without the presence of CS, UL and EH. After the prevention in 24 women of the main group (n=60), the menstrual function was recovered and the symptoms of CS disappeared. In remaining 36 women the menopause was developed and they amounted to 1 treatment-and-prophylactic (1-T-P) group of women who were prescribed the treatment complex developed and proposed by us. In these women we investigated the effectiveness of the correction of climacteric syndrome with the use the method of sequential prevention and treatment of symptoms of CS. The treatment of CS, which included a complex of drugs: a combined herbal preparation containing cimicifuga, a preparation from the microalgae Spirulina platensis, pectin and a drug with the active substance mebicar, was carried out for one year in 193 women aged 48 to 60 years. These women consisted of women with UL and CS after prophylaxis – 1 treatment-and-prophylactic (1-T-P) group (n=36), of women without prior prevention: women with UL, CS and natural menopause – 1-treatment (1-T) group (n=31), women of 2 – treatment (2-T) group with UL without CS (n=40), women of 3 – treatment (3-T) group with EH and CS (n=25), women of 4 – treatment (4-T) group with EH without CS (n=27), women of 5 – treatment (5-T) group with CS without UL and EH (n=34). The control group consisted of 35 women of the same age category without the presence of UL, EH and CS. The signs of uterine leiomyoma (UL) and endometrial hyperplasia (EH) were determined according to ultrasound examination of the uterine and the results of histological investigations of the endometrium. The intensity of the symptoms of CS was evaluated using a modified Cooperman index (MCI). To assess the effectiveness of correction of CS in women with UL and EH by an enzyme immunoassay, the level of Ig A, G, M, interleukins 1 and 2 (IL-1, IL-2) of tumor necrosis factor (TNF) was studied before and after the use of prevention and treatment of CS. Group comparisons were performed using the angular Fischer transform. Parametric indicators at normal distribution were compared using Student’s t criterion. In the work, their quantitative values are given in the form of arithmetic mean and its error. Results. After the treatment in women with EH and CS (n=25) in women with CS without UL and EH (n=34) indicators of humoral immunity IgA, IgM, IgG, IL-1, IL-2 and TNF did not significantly differ from those in healthy women in the menopause (р0,05). In women after consistent prevention and treatment of CS of 1 T-P group (n=36), we observed the increase of the level of IgA for 29%, IgM for 25%, decrease the level of IL-1 to 1,3 times, and TNF level – to 1,8 times. In women without prophylaxis of CS of 1-T group (n=31) we observed the increase of the level of IgA for 25%, IgM for 19%, compared with the indicators before the treatment (р0.05), and the IgG and TNF level after the treatment does not differ from the indicators in healthy women in the menopause (р0.05), the level of the IL-1 remained to 1,6 times higher compared with healthy women (р0.05). The consistent use of prevention and treatment by our worked out method allows to reduce the intensity of CS in women with UL and CS after prevention (n
Мета дослідження: оцінювання ефективності корекції клімактеричного синдрому (КС) шляхом застосування методу послідовної профілактики та лікування КС у жінок з лейоміомою матки (ЛМ) та гіперплазією ендометрія (ГЕ) на підставі дослідження показників імунної системи
Корекція КС шляхом застосування запропонованого методу послідовної профілактики та лікування дозволяє зменшити інтенсивність симптомів КС у жінок з ЛМ та КС за даними МІК в 1,26–1,39 разу, відновити показники гуморальної ланки імунної системи і попередити виснаження факторів протипухлинного захисту
Additional Access Points:
Butina, L. A.
Shelestova, L. P.
Khancha, F. A.
Ostroukh, A. L.
Shahanov, P. F.

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2.


   
    New approaches to prophylaxis of endometrium hyperplasia relaps in premenopausal women / V. O. Beniuk [et al.] // Репродуктивна ендокринологія = Reproductive endocrinology. - 2021. - N 2. - P67-72


MeSH-main:
ЭНДОМЕТРИЯ ГИПЕРПЛАЗИЯ -- ENDOMETRIAL HYPERPLASIA (профилактика и контроль)
РЕЦИДИВ -- RECURRENCE
ПРЕМЕНОПАУЗА -- PREMENOPAUSE
Annotation: Depapilin® inclusion in the basic therapy of endometrial hyperplasia in premenopausal aged women is pathogenetically justified due to the complex effect of the drug components on the extragonadal estrogens synthesis and the antiproliferative effect on the endometrium
Additional Access Points:
Beniuk, V. O.
Ginzburg, V. H.
Govsieiev, D. O.
Oleshko, V. F.
Kovaliuk, T. V.
Kravchenko, Y. V.
Luchko, A. S.

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3.


    Parazzini, F.
    Застосування ацетату гозереліну для запобігання гістеректомії в жінок з фіброміомами матки до менопаузи, які потребують хірургічного лікування. Скорочений виклад [Text] / F. Parazzini, A. Bortolotti, V. Chaiantera // Медицина світу. - 2004. - Т. 17, № 10. - С. 301-303

Rubrics: Пременопауза

   Матки новообразования--лек тер

   Гистерэктомия

Additional Access Points:
Bortolotti, A.
Chaiantera, V.

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4.


    Rozhkovska, N. M.
    Immunohistochemical features of benign endometrial hyperplasia in premenopausal women / N. M. Rozhkovska, I. S. Lomakina // Репродуктивна ендокринологія = Reproductive endocrinology. - 2020. - N 4. - P42-45


MeSH-main:
ПРЕМЕНОПАУЗА -- PREMENOPAUSE (иммунология, физиология)
ЭНДОМЕТРИЯ ГИПЕРПЛАЗИЯ -- ENDOMETRIAL HYPERPLASIA (иммунология, патофизиология)
Annotation: Hyperproliferative diseases of the endometrium play an important role in the structure of gynecological pathology, which are a spectrum of irregular morphological changes. Particularly difficult is evaluation of the phenotypic characteristics of the endometrium hyperplastic processes (EHP) in premenopausal women in the presence of an unstable menstrual cycle. Diagnosis and EHP prognosis remains a difficult task given that it can occur as focal or diffuse lesions with various structural and cytological differences. Objective of the study: to evaluate the immunohistochemical features (phenotypic variants) of benign endometrial hyperplasia in premenopausal women. Material and methods. 33 premenopausal women with abnormal uterine bleeding and verified benign endometrial hyperplasia were examined. Expression of the α-receptors for estrogens type 1 (ER1), progesterone receptors and Ki-67 nuclear protein in the endometrium stroma and glands was analyzed. Micromorphometry was performed and the D-score was calculated. Results. Prevalence of comorbid lesions in patients was the combination of endometrial hyperplasia and fibroids (51.4%), cases of abnormal uterine bleedings against submucosal fibroids (13.5%), endometrial polyps (8.1%), combinations of EHP and peritoneal endometriosis (10.8%), adenomyosis and myoma (8.1%), or other combinations of endometrial and myometrial proliferative pathology. D-score for surgery averaged 1.78 ± 0.11 indicating a low risk of malignancy. There were changes after treatment in the quantitative presentation of the studied proteins in stroma and endometrial glands. Thus, before treatment in the glands was determined up to 100% of cells containing ER1 in large quantities, while after treatment their number decreased by an average of 20%. Similar dynamics was observed with progesterone receptors activity. Conclusions. The main prognostic significant phenotypes of endometrial proliferative pathology have been identified. After removing of pathologically chanced endometrium and subsequent treatment with dydrogesterone during 6 months there is prognostically positive decreasing in the ER1 density as well as the Ki-67 protein expression
Additional Access Points:
Lomakina, I. S.

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5.


   
    Активность матриксных металлопротеиназ ММП-2 и ММП-9 в сыворотке крови у пациенток с гиперплазией эндометрия в периоде перименопаузы [Text] / Н. В. Стрижова [и др.] // Акушерство и гинекология. - 2010. - № 1. - С. 65-66

Rubrics: Эндометрия гиперплазия--диагн--патолог

   Желатиназа А--кровь

   Желатиназа В--кровь

   Пременопауза

Additional Access Points:
Стрижова, Н. В.
Соболева, Г. М.
Ибрагимов, А. И.
Рейснер, Е. А.

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6.


    Астахов, В. М.
    Фитотерапия дисгормональных заболеваний молочных желез у женщин в период перименопаузы [Text] / В. М. Астахов, С. Н. Пернаков, Е. С. Гомон // Здоровье женщины. - 2009. - № 7. - С. 185-188

Rubrics: Мастопатия фиброзно-кистозная--лек тер

   Мастодинон

   Пременопауза

   Фитотерапия

Additional Access Points:
Пернаков, С. Н.
Гомон, Е. С.

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7.


    Барна, О. М.
    Лікування артеріальної гіпертензії у жінок у перименопаузі [Text] / О. М. Барна // Медицинские аспекты здоровья женщины. - 2009. - № 1/2. - С. 10-12

Rubrics: Гипертензия--женск

   Пременопауза

   Антигипертензивные средства

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8.


   
    Биоценоз влагалища с точки зрения количественной полимеразной цепной реакции: что есть норма? [Text] / Е. С. Ворошилина [и др.] // Акушерство и гинекология. - 2011. - № 1. - С. 57-65

Rubrics: Влагалище--берем--микроб

   Полимеразная цепная реакция

   Пременопауза

   Постменопауза

Additional Access Points:
Ворошилина, Е. С.
Тумбинская, Л. В.
Донников, А. Е.
Плотко, Е. Э.
Хаютин, Л. В.

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9.


    Вебер, В. Р.
    Структурно-функциональные изменения сердца у больных артериальной гипертонией женщин в перименопаузе при антигипертензивной терапии [Text] / В. Р. Вебер, М. П. Рубанова, С. В. Жмайлова // Российский медицинский журнал. - 2003. - № 6. - С. 12.

Rubrics: Гипертензия--диагн--лек тер

   Сердечно-сосудистые болезни--диагн--лек тер

   Пременопауза

   Антигипертензивные средства

Additional Access Points:
Рубанова, М. П.
Жмайлова, С. В.

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10.


    Верещако, Г. В.
    Опыт лечения неспецифических вульвовагинитов у женщин старшей возрастной группы [Text] / Г. В. Верещако, Н. В. Лазарева // Український медичний часопис. - 2010. - № 1. - С. 75-77

Rubrics: Вульвовагинит--сравн исслед--диагн--лек тер

   Пременопауза

   Постменопауза

   Повидон-иод--тер прим

   Колпосептин

   Овестин

Additional Access Points:
Лазарева, Н. В.

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