Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Аврущенко, М. Ш.
Действие нейропептидов на состояние нейрональных популяций в постреанимационном периоде: структурно-функциональные корреляции [Text] / М. Ш. Аврущенко, А. В. Волков // Патологическая физиология и экспериментальная терапия. - 1999. - № 2. - С. 7-11

MeSH-main:
НЕЙРОПЕПТИДЫ -- NEUROPEPTIDES (иммунология, метаболизм, секреция)
НЕЙРОНЫ -- NEURONS (метаболизм, ультраструктура)
КОРТИКАЛЬНАЯ СИНХРОНИЗАЦИЯ -- CORTICAL SYNCHRONIZATION (физиология)
РЕАНИМАЦИЯ -- RESUSCITATION (уход)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
Additional Access Points:
Волков, А. В.

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Дифференциальная активность генов у mycoplasma pneumoniae при острых и хронических формах экспериментальной инфекции [Text] // Журнал микробиологии, эпидемиологии и иммунобиологии. - 2000. - № 4 (прилож.). - С. 26-30

MeSH-main:
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ГЕНЫ МИКРОБНЫЕ -- GENES, MICROBIAL (генетика, иммунология)
БАКТЕРИАЛЬНЫЕ ИНФЕКЦИИ И МИКОЗЫ -- BACTERIAL INFECTIONS AND MYCOSES (генетика, микробиология)
ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА -- EXPERIMENTAL MEDICINE
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    Константы ионизации амидов N-замещенных антраниловых кислот в изучении связи структура-активность [Text] / Л. М. Коркодинова, О. Б. Кремлева, О. С. Ендальцева // Химико-фармацевтический журнал : Науч.-техн. и произв. журн. - 2005. - Т. 39, № 1. - С. 45-47

Rubrics: Амиды

   Антраниловые кислоты

   Структура-активность, взаимосвязь

Additional Access Points:
Коркодинова, Л. М.
Кремлева, О. Б.
Ендальцева, О. С.

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    Температурная зависимость структурированного состояния воды [Text] / О. Н. Савостикова [и др.] // Гигиена и санитария. - 2009. - № 5. - С. 18-20

Rubrics: Структура-активность, взаимосвязь

   Вода пресная

Additional Access Points:
Савостикова, О. Н.
Стехин, А. А.
Яковлева, Г. В.
Кочеткова, М. Г.

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    Паолетти, Серж
    Взаимодействие структуры и функции фасций [Text] / Серж Паолетти // Мануальная терапия : Наук. -практ. реценз. журнал. - 2009. - № 2. - С. 18-25

Rubrics: Медицина остеопатическая

   Фасция

   Структура-активность, взаимосвязь

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    Изучение взаимосвязи "Структура - антиаритмическая активность" в ряду производных N-фенилацетамида и амидов ароматических карбоновых кислот [Text] / В. Р. Хайруллина [и др.] // Биомедицинская химия. - 2010. - Т. 56, № 4. - С. 471-479

Rubrics: Противоаритмические средства--тер прим

   Структура-активность, взаимосвязь

   Карбоновые кислоты

Additional Access Points:
Хайруллина, В. Р.
Тарасов, Г. П.
Герчиков, А. Я.
Зарудий, Ф. С.
Тюрина, Л. А.

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    Изучение взаимосвязи структура — свойство в ряду природных и синтетических ингибиторов каталитической активности 15-липоксигеназы [Text] / В. Р. Хайруллина [и др.] // Химико-фармацевтический журнал. - 2011. - Т. 45, № 9. - С. 25-32

Rubrics: Арахидонат-15-липоксигеназа--анал

   Катализ

   Структура-активность, взаимосвязь

Additional Access Points:
Хайруллина, В. Р.
Герчиков, А. Я.
Таипов, И. Α.
Бегелъ, Х.
Зарудий, Ф. С.

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Афанасьев, Д. Е.
Катализ, структура, регуляция – известное и малоизвестное о значении цинка в организме… [Text] / Д. Е. Афанасьев // Новая медицина тысячелетия. - 2014. - № 3. - С. 3-10

MeSH-main:
ЦИНК -- ZINC (анализ, дефицит, кровь, метаболизм, терапевтическое применение)
ОБЗОР -- REVIEW
КАТАЛИЗ -- CATALYSIS
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
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Коробко, Д. Б.
Скринінг протимікробної активності ряду 8-R-1,3-диметил-7-(3-(4-(трифлюорометокси) феніл) проп-2-ініл)-1H-пурин-2,6(3H,7H)-діонів [Text] / Д. Б. Коробко // Фітотерапія.Часопис. - 2015. - № 4. - С. 69-73. - Бібліогр.: в кінці ст.

MeSH-main:
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (методы)
СТЕРИЛИЗУЮЩИЕ ХИМИЧЕСКИЕ ВЕЩЕСТВА -- CHEMOSTERILANTS (анализ, фармакология, химия)
ЛЕКАРСТВА СОЗДАНИЕ -- DRUG DESIGN
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
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10.

Antimicrobial, anti-inflammatory and analgesic activities of 2-amino-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine 5,5-dioxides and triethylammonium 3-[1-(4-hydroxy-1-ethyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)-3-(het)arylmethyl]-1-ethyl-1H-2,1-benzothiazin-4-olat 2,2-dioxides [Text] / D. O. Lega [et al.] // Вісн. фармації. - 2016. - № 3. - P61-69

MeSH-main:
БЕНЗОТИАДИАЗИНЫ -- BENZOTHIADIAZINES (фармакология, химия)
ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL (фармакология, химия)
АНАЛГЕЗИРУЮЩИЕ СРЕДСТВА -- ANALGESICS (фармакология, химия)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (методы)
Additional Access Points:
Lega, D. O.
Filimonova, N. I.
Zupanets, I. A.
Shebeko, S. K.
Chernykh, V. P.
Shemchuk, L. A.

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11.

The synthesis, physicochemical and biological properties of 8-amino-7-(2-hydroxy-2-phenylethyl)-3-methylxanthines [Text] / M. I. Romanenko [et al.] // Вісн. фармації. - 2016. - № 3. - P17-21

MeSH-main:
КСАНТИНЫ -- XANTHINES (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (химический синтез)
ПРОТИВОГРИБКОВЫЕ СРЕДСТВА -- ANTIFUNGAL AGENTS (химический синтез)
Additional Access Points:
Romanenko, M. I.
Ivanphenko, D. G.
Nazarenko, M. V.
Diachkov, M. V.
Kamyshnyi, O. M.
Polishchuk, N. M.

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12.

The use of analytical methods for quality control of promising active pharmaceutical ingredients among derivatives of 4-oxo-quinoline-3-propanoic acids FV. O. Zubkov [et al.] [Text] / V. O. Zubkov [] // Вісн. фармації. - 2016. - № 4. - P22-30

MeSH-main:
ХИНОЛИНЫ -- QUINOLINES (анализ)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (анализ)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
КАЧЕСТВА КОНТРОЛЬ -- QUALITY CONTROL
Additional Access Points:
Zubkov, V.O.
Ruschak, N. I.
Suleiman, M. M.
Devyatkina, A. O.
Gritsenko, I. S.

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13.

The synthesis and the antimicrobial activity of the substituted arylamides of 3-arylmethyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7-carboxylic acids [Text] / K. Yu. Krolenko [et al.] // Вісн. фармації. - 2016. - № 4. - P17-21

MeSH-main:
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (химический синтез)
КАРБОНОВЫЕ КИСЛОТЫ -- CARBOXYLIC ACIDS (химический синтез)
ГИДАНТОИНЫ -- HYDANTOINS (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ПИРРОЛИДИНОНЫ -- PYRROLIDINONES (химический синтез)
Additional Access Points:
Krolenko, K. Yu.
Vlasov, S. V.
Vlasova, O. D.
Zhuravel, I. O.

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14.

The study of the antihypoxic activity of new derivatives of benzilic acid [Text] / I. V. Kireyev [et al.] // Вісн. фармації. - 2016. - № 2. - P51-53

MeSH-main:
КАРБОНОВЫЕ КИСЛОТЫ -- CARBOXYLIC ACIDS
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
Key words(unnormalized):
БЕНЗИЛОВАЯ КИСЛОТА -- АНТИГИПОКСАНТЫ, химический синтез
Additional Access Points:
Kireyev, I. V.
Kolisnyk, S. V.
Tryshchuk, N. M.
Sytnik, K. M.

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15.

The synthesis of ω-(7-aryl-8-oxo-7,8-dihydro[1,2,4]-triazolo-[4,3-a]pyrazin-3-yl)alkylcarboxylic acids and their amides as promising pharmaceutical agents [Text] / K. Yu. Netyosova [et al.] // Вісн. фармації. - 2016. - № 2. - P15-23

MeSH-main:
ТРИАЗОЛЫ -- TRIAZOLES
ПИРАЗИНЫ -- PYRAZINES
КАРБОНОВЫЕ КИСЛОТЫ -- CARBOXYLIC ACIDS
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ЛИПИДНЫЙ ОБМЕН -- LIPID METABOLISM
Additional Access Points:
Netyosova, K. Yu.
Kovalenko, S. S.
Drushlyak, O. G.
Zhuravel, I. O.
Kovalenko, S. M.
Toryanik, E. L.

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16.

Vlasov, S. V.
Synthesis, the anti-inflammatory and antimicrobial activity of 6-(1H-benzimidazol-2-yl)-5-methyl-4-(alkylthio)thienо[2,3-d] pyrimidines [Text] / S. V. Vlasov, V. P. Chernykh // Вісн. фармації. - 2016. - № 3. - P9-16

MeSH-main:
БЕНЗИМИДАЗОЛЫ -- BENZIMIDAZOLES (химический синтез)
ПИРИМИДИНЫ -- PYRIMIDINES (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL (химический синтез)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (химический синтез)
Additional Access Points:
Chernykh, V. P.

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17.

Molecular parameters and the antimicrobial activity of functional derivatives of N-,R-amines [Text] / M. Yu. Golik [et al.] // Вісн. фармації. - 2016. - № 2. - P59-63

MeSH-main:
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS
РЕГРЕССИОННЫЙ АНАЛИЗ -- REGRESSION ANALYSIS
Additional Access Points:
Golik, M. Yu.
Kryskiv, O. S.
Dudka, K. I.
Kolisnyk, O. V.

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18.

Molecular parameters and the antimicrobial activity of some N-substituted amino acids [Text] / М. Yu. Golik [et al.] // Вісн. фармації. - 2017. - № 3. - P10-15

MeSH-main:
АМИНОКИСЛОТЫ -- AMINO ACIDS (фармакология)
БИОДОСТУПНОСТЬ -- BIOLOGICAL AVAILABILITY
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS
Annotation: The concept of “drug likeness” is used when developing drugs for a potential biologically active substance, which must meet some specific criteria, in particular it should be bioavailable. The traditional method of “drug likeness” assessment is verification of compliance with Lipinski’s rule. Aim. To determine the compliance of the “drug likeness” concept for some N-substituted amino acids and identify the quantitative “structure – microbiological activity” relationships. Materials and methods. Using ChemOffice 2016 software the physicochemical parameters determining the bioavailability of some N-substituted amino acids were calculated. Determination of the possible correlations and quantitative ratios of the biological activity data experimentally obtained with the molar refraction (MR) values calculated was conducted using STATISTIKA 8 program. Results and discussion. All compounds studied in their physicochemical properties meet the requirements for new BAS at the stage of testing their biological activity (correspond to Lipinski’s rule). The dependence of the microbiological action of some N-substituted amino acids on MR is maximal for compounds, which MR value is in the range of 2.13-4.53. The growth of all microorganisms was observed for unsubstituted amino acids (MR 2.8). The maximum activity of all compounds studied was observed against gram-positive (B. subtilis and S. aureus), and the less activity was against gram-negative microorganisms (E. coli, P. vulgaris, P. aeruginosa) and fungi (C. albicans). It may be associated with the structural peculiarities of the cellular wall. The MR values calculated correlate satisfactorily with the experimental data of the antimicrobial activity of compounds. Conclusions. Statistically significant values of MR correlation with the values of the antimicrobial activity of some N-substituted amino acids against the microorganisms studied have been determined. It quantitatively confirms the presence of the “structure – activity” relationship in this series of compounds
Additional Access Points:
Golik, М. Yu.
Kryskiv, О. S.
Komissarenko, A. M.
Kolisnyk, O. V.

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19.

The synthesis and the antimicrobial activity of N¹-substituted 5-amino-4-arylsulfonyl-3-N-phenylaminopyrazoles [Text] / P. V. Tkachenko [et al.] // Вісн. фармації. - 2017. - № 3. - P3-9

MeSH-main:
ПИРАЗОЛЫ -- PYRAZOLES (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (химический синтез)
Annotation: This article is continuation of the development of methods for the synthesis of small molecules based on the structure of 5-aminopyrazole. The synthesis and the antimicrobial activity for a series of new N1-subsituted 5-amino-4-arylsulfonyl-3-N-phenylaminopyrazoles have been described. Aim. To synthesize derivatives of 5-amino-4-arylsulfonyl-3phenylaminopyrazoles and study their antimicrobial and antifungal properties. Materials and methods. The methods of organic synthesis, instrumental methods of organic compounds analysis and methods of microbiological screening were used. Results and discussion. 5-Amino-4-arylsulfonyl-3-phenylaminopyrazoles were prepared by the reaction of arylsulfonylacetonitriles with isothiocyanates in the presence of NaOH and CH3I with further cyclization with hydrazine hydrate. The reaction of this compounds with N-arylchloroacetamides finished a series of N1-substituted 5-amino-4-arylsulfonyl-3-phenylaminopyrazoles. The antibacterial and antifungal properties of the compounds synthesized were studied. Some of the compounds obtained appeared to be potent inhibitors for several pathogenic bacterial and fungal lines. Conclusions. The synthetic scheme for obtaining of N1-substituted 5-amino-4-arylsulfonyl-3-phenylaminopyrazoles, which can be used for creation of a library of compounds for in vitro antimicrobial screening, has been proposed. Some of the compounds synthesized are of certain interest as potential pharmaceutical agents and can be used to develop new antifungal agents
Additional Access Points:
Tkachenko, P. V.
Tkachenko, O. V.
Netosova, K. Yu.
Borisov, O. V.
Zhuravel, I. O.
Kazmirchuk, V. V.

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20.

The synthesis of 3,5-dibromo-2-chlorobenzoic acid hydrazides as potential antituberculous drugs [Text] / D. O. Alferova [et al.] // Вісн. фармації. - 2017. - № 4. - С. 20-24

MeSH-main:
ХЛОРБЕНЗОАТЫ -- CHLOROBENZOATES (химический синтез)
ПРОТИВОТУБЕРКУЛЕЗНЫЕ СРЕДСТВА -- ANTITUBERCULAR AGENTS (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (методы)
Annotation: Antitubercular drugs are used for a number of decades. In each country where research is conducted strains of mycobacteria that are resistant to one or more drugs have been registered, and it causes tuberculosis with multi-drug resistance (MDR-TB). These strains of M. tuberculosis at least are not sensitive to isoniazid and rifampicin – two most powerful first-line antitubercular drugs. MDR-TB can be treated and cured using the second choice drugs. However, these treatment options are limited and require extensive chemotherapy (the treatment duration is up to two years) with drugs which are of high cost and toxicity. In some cases, a more dangerous drug resistance may develop. Tuberculosis with extensive drug resistance (EDR-TB) is more severe form of MDR-TB caused by bacteria that do not respond to the most effective antitubercular drugs of the second choice with which there are often no any further treatment options for patients. Therefore, the search and development of drugs with the antitubercular activity are important today. Aim. To synthesize and study dibromo-substituted derivatives of ortho-chlorobenzoic acids as potential substances with the antitubercular action. Materials and methods. Hydrazides of 3,5-dibromo-2-chlorobenzoic acid were obtained by two methods – by hydrazinolysis of acid chlorides of the corresponding acids (method 1) and by interaction of 3,5-dibromo-2-chlorobenzoic acid with hydrazines in the presence of carbonyldiimidazole (method 2). Results and discussion. It has been found that the synthesis of hydrazides by method 2 allows obtaining the target compounds with a high yield. Conclusions. According to the literature data the compounds synthesized are promising for the pharmacological screening on the antitubercular activity
Additional Access Points:
Alferova, D. O.
Gritsenko, I. S.
Rebryk, A. O.
Kobzar, N. P.
Altukhov, O. O.
Shapovalova, O. V.
Kaliuzhnaia, O. S.
Suleiman, M. M.

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