Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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A case of synchronous bilateral calyx urothelial carcinoma: combined treatment approach [Text] / S. Semko [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 76-79. - Bibliogr. at the end of the art.

Annotation: Upper urinary tract urothelial carcinoma is a rare tumor. Data about its correct management are controversial. Investigational technology development made it possible to diagnose asymptomatic small tumors, which can be successfully managed endoscopically. We report the case of bilateral urothelial cancer and hydronephrosis in patient aged 38. After management of acute post-renal kidney insufficiency, the neoadjuvant platinum-based chemotherapy was used followed by the kidney-sparing surgery split in two interventions on both sides. The patient does not have any relapse or further progression after one year of initial treatment with good performance status and high life quality level. We believe that the kidney preserving strategy can be considered as an option even in high-risk patients. The renal function in such cases is a crucial parameter affecting the outcome
Additional Access Points:
Semko, S.
Pikul, M.
Voylenko, O.
Stakhovskyi, O.
Kononenko, O.
Vitruk, Yu.
Stakhovsky, E.

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Tkachenko, R.
A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy [Text] / R. Tkachenko, A. Golovko, O. Kuryk // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 251-253

MeSH-main:
ОПИСАНИЕ СЛУЧАЕВ -- CASE REPORTS
КАРЦИНОМА АДРЕНОКОРТИКАЛЬНАЯ -- ADRENOCORTICAL CARCINOMA (диагностика, патофизиология, этиология)
АДРЕНАЛЭКТОМИЯ -- ADRENALECTOMY (тенденции)
НОВООБРАЗОВАНИЙ РЕЦИДИВ МЕСТНЫЙ -- NEOPLASM RECURRENCE, LOCAL (этиология)
НЕФРЭКТОМИЯ -- NEPHRECTOMY (использование, тенденции)
ВЫЖИВАЕМОСТИ АНАЛИЗ -- SURVIVAL ANALYSIS
Annotation: Adrenocortical cancer is an extremely rare tumor presenting with extensive locoregional spread at the time of diagnosis. Due to the diagnostic difficulties preoperatively and a lack of effective treatment options, patients have poor prognosis. Patients succumb to metastases within a couple of months. Only 20 cases have been so far reported in the literature with a medium disease-free survival up to 2 years. We present a case of a locoregional recurrence of adrenocortical cancer 18 years after left adrenalectomy. Key Words: аdrenocortical carcinoma, local relapse, adrenalectomy, long-term survival, nephrectomy
Additional Access Points:
Golovko, A.
Kuryk, O.

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A long survival of a patient with brain metastasis of unknown site of the primary tumor [Text] / Kridis W. Ben [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 85-87. - Bibliogr. at the end of the art.

MeSH-main:
НОВООБРАЗОВАНИЯ НЕИЗВЕСТНОЙ ПЕРВИЧНОЙ ЛОКАЛИЗАЦИИ -- NEOPLASMS, UNKNOWN PRIMARY (осложнения, патофизиология, этиология)
МОЗГА ГОЛОВНОГО БОЛЕЗНИ -- BRAIN DISEASES (осложнения, патофизиология, этиология)
НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS (диагностика, патофизиология)
ОПИСАНИЕ СЛУЧАЕВ -- CASE REPORTS
ВЫЖИВАЕМОСТИ АНАЛИЗ -- SURVIVAL ANALYSIS
Annotation: Eighty percent of brain metastases (BM) are diagnosed in patients with known primary site of cancer. BM of unknown primary represents a difficult diagnosis. In up to 15% of patients with BM, the site of the primary tumor will not be detected despite investigations. The prognosis of this entity is very poor. We report here a case of a long survival of a patient with brain metastasis of unknown primary. The conclusion that can be drawn is that within BM of unknown primary exist patients with a very good prognosis that must be collected and published in order to base recommendations
Additional Access Points:
Ben, Kridis W.
Sghaier, S.
Toumi, N.
Boudawara, Z.
Khanfir, A.
Daoud, J.
Frikha, M.

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Chrysanthakopoulos, N. A.
ABO blood group and the risk of lung cancer in Greek adults: a case — control study [Text] / N. A. Chrysanthakopoulos, N. S. Dareioti // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 249-250. - Bibliogr. at the end of the art.

MeSH-main:
ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS (диагностика, кровь, этиология)
ГРУППЫ КРОВИ, СИСТЕМА ABO -- ABO BLOOD-GROUP SYSTEM (анализ, диагностическое применение)
ВЗРОСЛЫЕ -- ADULT
ФАКТОРЫ РИСКА -- RISK FACTORS
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: The present study aimed to investigate any possible association between ABO blood groups and lung cancer. Materials and Methods: The study was conducted on 122 lung cancer patients and 1,255 matched-healthy individuals that were reviewed retrospectively. Chi-square and logistic regression models were used for statistical analysis. Results: No significant difference between lung cancer patients and the control group was recorded regarding ABO blood types and the risk of lung cancer (p = 0.055, OR = 0.79, 95% CI 0.61–1.03). Male gender (p = 0.006, OR = 2.08, 95% CI 1.24–3.49) and smoking (p = 0.000, OR = 3.13, 95% CI 1.72–5.69) were significantly associated with the risk of lung cancer. Conclusion: No association between ABO blood types and the risk of lung cancer was observed. Key Words: ABO blood types, lung cancer, adults, risk factor
Additional Access Points:
Dareioti, N. S.

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Adsorption-rheological properties of blood serum in lung cancer patients [Text] / Y. V. Dumanskiy [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 304-307. - Bibliogr. at the end of the art.

MeSH-main:
ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS (кровь, патофизиология, этиология)
КРОВИ ВЯЗКОСТЬ -- BLOOD VISCOSITY (физиология)
ГЕМОРЕОЛОГИЯ -- HEMORHEOLOGY (физиология)
АДСОРБЦИЯ -- ADSORPTION (физиология)
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (анализ)
ЦИРРОЗЫ ПЕЧЕНИ -- LIVER CIRRHOSIS (кровь, патофизиология, этиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. Patients and Methods: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women. The parameters of surface (interfacial) viscosity, elasticity, viscoelasticity module, tension and relaxation of blood serum were studied by the oscillating drop method using a computer tensiometer “PAT2-Sinterface”, and its volumetric viscosity was investigated using a Low-Shear-30 rotational viscometer. ARPB parameters were also studied in a control group composed from 50 healthy donors. Results: Increased levels of volumetrical viscosity, surface tension, surface elasticity and the relaxation time of the blood are typical for patients with LC and depended on the localization of the tumor, its histological variant, differentiation grade, severity of the course of the disease, the number of metastases in the lymph nodes, distant organs and skeleton, involvement of the pleura and ribs, the development of compression pulmonary syndrome, metastasis into the spine, adrenals, brain, and pancreas. The surface-active, viscoelastic and relaxation properties of the blood correlated with the levels of tumor markers (TGFβ1, VEGF, C-reactive protein, α2-macroglobulin). Conclusions: Integral changes of ARPB observed in every fifth patient with LC are involved in the pathogenesis of the disease, have predictive value in relation to the clinical course of disease (volumetric viscosity) and the development of complications from radiochemotherapy (surface viscosity)
Additional Access Points:
Dumanskiy, Y. V.
Stoliarova, O. Y.
Syniachenko, O. V.
Giulmamedova, M. F.
Potapov, Y. A.

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Adsorptive therapy as a modificator for tumor-host interaction [Text] / L. A. Sakhno [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 254-257. - Bibliogr. at the end of the art.

Annotation: The potential of one of the adsorption methods, enterosorption (ES), using the new generation of carbon adsorbents to correct the negative manifestations of tumor-host interaction in the framework of paraneoplastic syndrome (PNS) as well as systemic toxicity of chemo- and radiation therapy, is discussed. The ES influence on the development of PNS was demonstrated in C57/BL6 mice with transplanted Lewis lung carcinoma. Two-week administration of carbon enterosorbents resulted in a significant suppression of metastasis and correction of tumor-related anemia, activation of granulocytic line in the bone marrow with nearly 3-fold enhancement of its mitotic activity. ES exerted a positive influence on the structural-morphologic indexes and regenerative potential of kidneys and liver, mitigated manifestations of oxidative stress, decreased the level of endogenous intoxication, increased resistance of erythrocyte membranes and decreased ligand loading of blood plasma transport proteins. The effect of ES on anticancer activity and toxic reactions of cisplatin (CP) was evaluated in Guerin carcinoma-bearing rats. ES reduced significantly creatinine and other kidney biochemical indexes elevated in the blood plasma of rats after CP treatment. ES attenuated dystrophic changes in the histological structure of internal organs (kidney, liver, spleen), caused by tumor growth and significantly aggravated under the influence of CP. Such changes were specially traced in the kidneys and well reflect the nephroprotective potential of ES. In rats irradiated with X-ray in sublethal dose, highly activated granulated carbonic enterosorbents facilitated the restoration of white blood cells and lymphocyte count. The results obtained confirm the insights of academician R.E. Kavetsky predicting the future of adsorptive detoxification with activated carbons in the treatment of cancer patients
Additional Access Points:
Sakhno, L. A.
Sarnatskaya, V. V.
Yushko, L. A.
Snezhkova, E. A.
Bardakhivskaya, K. I.
Shevchuk, O. O.
Sidorenko, A. S.
Nikolaev, V. G.

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Aggregated proteins in malignant and benign neoplasms [Text] / D. I. Zabolotnyi [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 61-68. - Bibliogr. at the end of the art.

Annotation: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology
Additional Access Points:
Zabolotnyi, D. I.
Belousova, A. A.
Zabolotna, D. D.
SavchenkoT., D.
Voroshylova, N. M.
Timchenko, M. D.
Tsvirinko, I. R.
Verevka, S. V.

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Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure [Text] / D. Caballero-Hernandez [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 276-280. - Bibliogr. at the end of the art.

MeSH-main:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
СТРЕСС ФИЗИОЛОГИЧЕСКИЙ -- STRESS, PHYSIOLOGICAL (физиология)
ДИАГНОСТИЧЕСКИЕ МЕТОДЫ ЭНДОКРИННЫЕ -- DIAGNOSTIC TECHNIQUES, ENDOCRINE (использование, тенденции)
ИММУННОЙ СИСТЕМЫ ПРОЦЕССЫ -- IMMUNE SYSTEM PROCESSES (физиология)
МОРФОЛОГИЧЕСКИЕ И МИКРОСКОПИЧЕСКИЕ ПОКАЗАТЕЛИ -- MORPHOLOGICAL AND MICROSCOPIC FINDINGS
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Key words(unnormalized):
Прибор волнового воздействия (Патент Украины № 53568)
Annotation: In stress research, reducing times of stress induction may contribute to improving the well-being of experimental animals, especially in cancer models, already under physiological distress. To support this idea, we evaluated the effects of a short-timed stress protocol on endocrine, metabolic and immune indicators in mice bearing the L5178Y-R lymphoma. Materials and Methods: A 30-minute daily stress protocol was applied for 28 days to healthy and lymphoma-bearing BALB/c mice; body weight, plasma levels of corticosterone, norepinephrine, Th1/Th2 cytokines, insulin, and leptin, were measured. Results: We found a 12% significant decrease in body weight in non-tumor bearing mice under stress (p < 0.007). The disruption of weight evolution was accompanied by a stress induced 85% decrease in plasmatic leptin (p < 0.01) and total reduction of insulin. Tumor burden alone was associated to an increase in more than two-fold of plasmatic levels of norepinephrine (p < 0.008). Neither stress nor tumor or their combination, resulted in an elevation of systemic IL-6. IFN-γ levels were 20 times higher in lymphoma-bearing animals when compared with non-tumor bearing mice (p < 0.01); however, under stress, this response was reduced by half, indicating a suppressing effect of chronic stress on the antitumor immune response. Conclusion: A short-timed stress induction is enough to cause significant alterations in the metabolism and immunity of healthy and tumor-bearing mice, supporting the use of short-timed protocols as an efficient way to induce chronic stress that also considers concerns regarding the well-being of experimental animals in biomedical research
Additional Access Points:
Caballero-Hernandez, D.
Najera-Valderrabano, D.
Valadez-Lira, A.
Franco-Molina, M.
Gomez-Flores, R.
Tamez-Guerra, P.
Tamez-Guerra, R.
Rodriguez-Padilla, C.

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Anagrelide and the CALR mutation allele burden in essential thrombocythemia [Text] / E. Atkinson [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 152-153. - Bibliogr. at the end of the art.

Rubrics: анагрелид--тер прим

MeSH-main:
МИЕЛОДИСПЛАСТИЧЕСКИЕ-МИЕЛОПРОЛИФЕРАТИВНЫЕ БОЛЕЗНИ -- MYELODYSPLASTIC-MYELOPROLIFERATIVE DISEASES (диагностика, патофизиология, этиология)
ТРОМБОЦИТЕМИЯ ЭССЕНЦИАЛЬНАЯ -- THROMBOCYTHEMIA, ESSENTIAL (осложнения, этиология)
МИЕЛОФИБРОЗ ПЕРВИЧНЫЙ -- PRIMARY MYELOFIBROSIS (патофизиология, терапия, этиология)
ТРОМБОЦИТОВ АГРЕГАЦИИ ИНГИБИТОРЫ -- PLATELET AGGREGATION INHIBITORS (анализ, терапевтическое применение, фармакология)
1-ФОСФАТИДИЛИНОЗИТОЛ-4-КИНАЗА -- 1-PHOSPHATIDYLINOSITOL 4-KINASE (анализ, терапевтическое применение, фармакология)
ИНТЕРФЕРОНЫ -- INTERFERONS (анализ, терапевтическое применение, фармакология)
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Annotation: The myeloproliferative neoplasm of essential thrombocythemia is characterized by a sustained peripheral blood thrombocytosis, increased numbers of morphologically abnormal megakaryocytes in the bone marrow and clinically by episodes of thrombosis or hemorrhage and the propensity to transform into myelofibrosis or acute myeloid leukemia. The main treatment goals are therefore to prevent thrombotic events and to inhibit transformation with antiplatelet and myelosuppressive drugs, respectively. The pathogenesis of essential thrombocythemia is largely defined by three types of driver mutation, namely the JAK2 V617F, CALR exon 9 and MPL exon 10 mutations. Significant improvements have been in the treatment of the related myeloproliferative neoplasm of primary myelofibrosis with JAK1/2 inhibitors, but agents such as interferon and anagrelide remain relevant therapeutic options in the modern treatment algorithm for essential thrombocythemia
Additional Access Points:
Atkinson, E.
Bakri, M.
Hayat, A.
Langabeer, S. E.

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10.

Analysis of immunoglobulin heavy variable chain rearrangement in chronic lymphocytic leukemia patients among Chornobyl clean-up workers [Text] / I. V. Abramenko [та ін.] // Экспериментальная онкология. - 2020. - Т. 42, № 3. - С. 172-177. - Бібліогр.: в кінці ст.

MeSH-main:
ЛЕЙКОЗ ЛИМФОЦИТАРНЫЙ ХРОНИЧЕСКИЙ B-КЛЕТОЧНЫЙ -- LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL (патофизиология, этиология)
ИЗЛУЧЕНИЯ ВОЗДЕЙСТВИЕ -- RADIATION EFFECTS
ЧРЕЗВЫЧАЙНЫХ СИТУАЦИЙ ЛИКВИДАТОРЫ -- EMERGENCY RESPONDERS
ПОСЛЕДОВАТЕЛЬНОСТЕЙ АНАЛИЗ -- SEQUENCE ANALYSIS
ГЕНЫ НОВООБРАЗОВАНИЙ -- GENES, NEOPLASM
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Key words(unnormalized):
ген IGHV
Annotation: A number of epidemiological studies have shown an elevated radiation-associated risk for chronic lymphocytic leukemia (CLL). The aim of the paper was to analyze immunoglobulin heavy variable chain (IGHV) rearrangement and IGHV usage in CLL cases associated with ionizing radiation (IR) exposure. Materials and Methods: Samples of 76 clean-up workers of Chornobyl Nuclear Power Plant accident of 1986 (the main group) and 194 non-exposed patients (the control group) were analyzed. Two groups of CLL patients were comparable by gender (all patients were male), age, and place of residence (rural or urban). Results: Some features of IR-associated CLL cases as compared to CLL cases in patients without history of IR exposure were revealed. Among unmutated IGHV sequences, IGHV1 genes were less commonly used (29.4% vs 48.6%; p = 0.018), while the frequency of IGHD6 genes was higher (23.5% vs 10%; p = 0.029). The unmutated IGHV sequences did not use IGHD3-16 gene (0% vs 7.9%, p = 0.038). Mutated IGHV sequences were less frequently expressed IGHV3 genes (44% vs 68.5%; p = 0.037) due low representation of IGHV3-21 (4% vs 11.1%) and IGHV3-23 (0% vs 11.1%) genes; did not use IGHD3-22 gene (0% vs 18.5%, p = 0.025); and have signs of positive selection in the HCDR regions (Σ = 0.5029 ± 0.155 vs –0.0539 ± 0.14; p = 0.013). Conclusions: The revealed differences in IGHV gene usage and B-cell receptor structure in the main and the control groups of CLL patients indirectly indicate a change in the spectrum of antigens associated with CLL under IR exposure. The possible antigenic drivers associated with CLL associated with IR exposure are discussed
Additional Access Points:
Abramenko, I. V.
Bilous, N. I.
Chumak, A. A.
Dyagil, I. S.
Martina, Z. V.

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