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Total number of found documents : 129
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1.

Type of document : Magazine article
Edition cipher :
Author(s) : Semko S., Pikul M., Voylenko O., Stakhovskyi O., Kononenko O., Vitruk Yu., Stakhovsky E.
Title : A case of synchronous bilateral calyx urothelial carcinoma: combined treatment approach
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 76-79 (Cipher ЕУ12/2019/41/1)
Notes : Bibliogr. at the end of the art.
Annotation: Upper urinary tract urothelial carcinoma is a rare tumor. Data about its correct management are controversial. Investigational technology development made it possible to diagnose asymptomatic small tumors, which can be successfully managed endoscopically. We report the case of bilateral urothelial cancer and hydronephrosis in patient aged 38. After management of acute post-renal kidney insufficiency, the neoadjuvant platinum-based chemotherapy was used followed by the kidney-sparing surgery split in two interventions on both sides. The patient does not have any relapse or further progression after one year of initial treatment with good performance status and high life quality level. We believe that the kidney preserving strategy can be considered as an option even in high-risk patients. The renal function in such cases is a crucial parameter affecting the outcome
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2.

Type of document : Magazine article
Edition cipher :
Author(s) : Ben Kridis W., Sghaier S., Toumi N., Boudawara Z., Khanfir A., Daoud J., Frikha M.
Title : A long survival of a patient with brain metastasis of unknown site of the primary tumor
Place of publication : Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 85-87 (Cipher ЕУ12/2018/40/1)
Notes : Bibliogr. at the end of the art.
MeSH-main: НОВООБРАЗОВАНИЯ НЕИЗВЕСТНОЙ ПЕРВИЧНОЙ ЛОКАЛИЗАЦИИ -- NEOPLASMS, UNKNOWN PRIMARY
МОЗГА ГОЛОВНОГО БОЛЕЗНИ -- BRAIN DISEASES
НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS
ОПИСАНИЕ СЛУЧАЕВ -- CASE REPORTS
ВЫЖИВАЕМОСТИ АНАЛИЗ -- SURVIVAL ANALYSIS
Annotation: Eighty percent of brain metastases (BM) are diagnosed in patients with known primary site of cancer. BM of unknown primary represents a difficult diagnosis. In up to 15% of patients with BM, the site of the primary tumor will not be detected despite investigations. The prognosis of this entity is very poor. We report here a case of a long survival of a patient with brain metastasis of unknown primary. The conclusion that can be drawn is that within BM of unknown primary exist patients with a very good prognosis that must be collected and published in order to base recommendations
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3.

Type of document : Magazine article
Edition cipher :
Author(s) : Dumanskiy Y. V., Stoliarova O. Y., Syniachenko O. V., Giulmamedova M. F., Potapov Y. A.
Title : Adsorption-rheological properties of blood serum in lung cancer patients
Place of publication : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 304-307 (Cipher ЕУ12/2017/39/4)
Notes : Bibliogr. at the end of the art.
Annotation: The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. Patients and Methods: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women. The parameters of surface (interfacial) viscosity, elasticity, viscoelasticity module, tension and relaxation of blood serum were studied by the oscillating drop method using a computer tensiometer “PAT2-Sinterface”, and its volumetric viscosity was investigated using a Low-Shear-30 rotational viscometer. ARPB parameters were also studied in a control group composed from 50 healthy donors. Results: Increased levels of volumetrical viscosity, surface tension, surface elasticity and the relaxation time of the blood are typical for patients with LC and depended on the localization of the tumor, its histological variant, differentiation grade, severity of the course of the disease, the number of metastases in the lymph nodes, distant organs and skeleton, involvement of the pleura and ribs, the development of compression pulmonary syndrome, metastasis into the spine, adrenals, brain, and pancreas. The surface-active, viscoelastic and relaxation properties of the blood correlated with the levels of tumor markers (TGFβ1, VEGF, C-reactive protein, α2-macroglobulin). Conclusions: Integral changes of ARPB observed in every fifth patient with LC are involved in the pathogenesis of the disease, have predictive value in relation to the clinical course of disease (volumetric viscosity) and the development of complications from radiochemotherapy (surface viscosity)
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4.

Type of document : Magazine article
Edition cipher :
Author(s) : Sakhno L. A., Sarnatskaya V. V., Yushko L. A., Snezhkova E. A., Bardakhivskaya K. I., Shevchuk O. O., Sidorenko A. S., Nikolaev V. G.
Title : Adsorptive therapy as a modificator for tumor-host interaction
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 254-257 (Cipher ЕУ12/2019/41/3)
Notes : Bibliogr. at the end of the art.
Annotation: The potential of one of the adsorption methods, enterosorption (ES), using the new generation of carbon adsorbents to correct the negative manifestations of tumor-host interaction in the framework of paraneoplastic syndrome (PNS) as well as systemic toxicity of chemo- and radiation therapy, is discussed. The ES influence on the development of PNS was demonstrated in C57/BL6 mice with transplanted Lewis lung carcinoma. Two-week administration of carbon enterosorbents resulted in a significant suppression of metastasis and correction of tumor-related anemia, activation of granulocytic line in the bone marrow with nearly 3-fold enhancement of its mitotic activity. ES exerted a positive influence on the structural-morphologic indexes and regenerative potential of kidneys and liver, mitigated manifestations of oxidative stress, decreased the level of endogenous intoxication, increased resistance of erythrocyte membranes and decreased ligand loading of blood plasma transport proteins. The effect of ES on anticancer activity and toxic reactions of cisplatin (CP) was evaluated in Guerin carcinoma-bearing rats. ES reduced significantly creatinine and other kidney biochemical indexes elevated in the blood plasma of rats after CP treatment. ES attenuated dystrophic changes in the histological structure of internal organs (kidney, liver, spleen), caused by tumor growth and significantly aggravated under the influence of CP. Such changes were specially traced in the kidneys and well reflect the nephroprotective potential of ES. In rats irradiated with X-ray in sublethal dose, highly activated granulated carbonic enterosorbents facilitated the restoration of white blood cells and lymphocyte count. The results obtained confirm the insights of academician R.E. Kavetsky predicting the future of adsorptive detoxification with activated carbons in the treatment of cancer patients
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5.

Type of document : Magazine article
Edition cipher :
Author(s) : Zabolotnyi D. I., Belousova A. A., Zabolotna D. D., SavchenkoT. D., Voroshylova N. M., Timchenko M. D., Tsvirinko I. R., Verevka S. V.
Title : Aggregated proteins in malignant and benign neoplasms
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 61-68 (Cipher ЕУ12/2019/41/1)
Notes : Bibliogr. at the end of the art.
Annotation: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology
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6.

Type of document : Magazine article
Edition cipher :
Author(s) : Alghamdi S., Tajaldeen A.
Title : Evaluation of dose calculation algorithms using different density materials for in-field and out-of-field conditions
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 46-52 (Cipher ЕУ12/2019/41/1)
Notes : Bibliogr. at the end of the art.
Annotation: The accuracy of the dose calculation is vital in the stereotactic ablative body radiotherapy (SABR) technique to achieve clinically effective dose distribution for better tumor control. Multiple commercial radiotherapy treatment planning systems (TPS) were implemented with different algorithms, such as Acuros XB in Eclipse and Superposition in XiO. The aim of this study is to investigate five different dose calculation algorithms, namely, pencil beam convolution (PBC), Acuros XB, AAA implemented in an Eclipse system, collapsed cone convolution (CCC) algorithm implemented in Mobius3D and superposition algorithms implemented in the XiO system, and then validate the results against measurements using an Institute of Physical Sciences in Medicine (IPSM) phantom with different density materials for in-field and out-of- field conditions. Material and Methods: The IPSM phantom was used to investigate the dose calculation algorithm performances in four different densities (water, lung, ribs, and dense bone) using different beam configurations, including small beam fields utilised in lung SABR. Five commercial algorithms implemented in two TPS (Eclipse and XiO) and one plan check (M3D) system were used for in-field and out-of-field measurement. Results: In the in-field condition, the Acuros XB algorithm had lower mean differences than the measured dose by the IC ranging from –0.46 to 0.24 for all the densities. In the out-of-field condition, the results of eclipse system: AAA, PBC and Acuros XB algorithms demonstrated underdose point’s measurements by –40% for all densities except for AAA calculations in lung density (overdosed by 40%). The measured points of the superposition algorithms were overestimated to the actual dose less than 30% in water, lung and dense bone. At the same densities, the CCC algorithms showed relatively the lowest differences in percentage compared to the superposition algorithms. Conclusion: Our results showed that the Acuros XB and superposition algorithms are closer to the actual measured dose than AAA, PBC and CCC for majority of the field conditions for water-equivalent, lung, rib and dense bone densities. The CCC algorithm resulted in a better agreement with the measurement of the out-of-field points compared with the other algorithms
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7.

Type of document : Magazine article
Edition cipher :
Author(s) : Caballero-Hernandez D., Najera-Valderrabano D., Valadez-Lira A., Franco-Molina M., Gomez-Flores R., Tamez-Guerra P., Tamez-Guerra R., Rodriguez-Padilla C.
Title : Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure
Place of publication : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 276-280 (Cipher ЕУ12/2017/39/4)
Notes : Bibliogr. at the end of the art.
Annotation: In stress research, reducing times of stress induction may contribute to improving the well-being of experimental animals, especially in cancer models, already under physiological distress. To support this idea, we evaluated the effects of a short-timed stress protocol on endocrine, metabolic and immune indicators in mice bearing the L5178Y-R lymphoma. Materials and Methods: A 30-minute daily stress protocol was applied for 28 days to healthy and lymphoma-bearing BALB/c mice; body weight, plasma levels of corticosterone, norepinephrine, Th1/Th2 cytokines, insulin, and leptin, were measured. Results: We found a 12% significant decrease in body weight in non-tumor bearing mice under stress (p 0.007). The disruption of weight evolution was accompanied by a stress induced 85% decrease in plasmatic leptin (p 0.01) and total reduction of insulin. Tumor burden alone was associated to an increase in more than two-fold of plasmatic levels of norepinephrine (p 0.008). Neither stress nor tumor or their combination, resulted in an elevation of systemic IL-6. IFN-γ levels were 20 times higher in lymphoma-bearing animals when compared with non-tumor bearing mice (p 0.01); however, under stress, this response was reduced by half, indicating a suppressing effect of chronic stress on the antitumor immune response. Conclusion: A short-timed stress induction is enough to cause significant alterations in the metabolism and immunity of healthy and tumor-bearing mice, supporting the use of short-timed protocols as an efficient way to induce chronic stress that also considers concerns regarding the well-being of experimental animals in biomedical research
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8.

Type of document : Magazine article
Edition cipher :
Author(s) : Atkinson E., Bakri M., Hayat A., Langabeer S. E.
Title : Anagrelide and the CALR mutation allele burden in essential thrombocythemia
Place of publication : Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 152-153 (Cipher ЕУ12/2018/40/2)
Notes : Bibliogr. at the end of the art.
Annotation: The myeloproliferative neoplasm of essential thrombocythemia is characterized by a sustained peripheral blood thrombocytosis, increased numbers of morphologically abnormal megakaryocytes in the bone marrow and clinically by episodes of thrombosis or hemorrhage and the propensity to transform into myelofibrosis or acute myeloid leukemia. The main treatment goals are therefore to prevent thrombotic events and to inhibit transformation with antiplatelet and myelosuppressive drugs, respectively. The pathogenesis of essential thrombocythemia is largely defined by three types of driver mutation, namely the JAK2 V617F, CALR exon 9 and MPL exon 10 mutations. Significant improvements have been in the treatment of the related myeloproliferative neoplasm of primary myelofibrosis with JAK1/2 inhibitors, but agents such as interferon and anagrelide remain relevant therapeutic options in the modern treatment algorithm for essential thrombocythemia
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9.

Type of document : Magazine article
Edition cipher :
Author(s) : Bilous N., Abramenko I., Chumak A., Dyagil I., Martina Z.
Title : Analysis of LPL gene expression in patients with chronic lymphocytic leukemia
Place of publication : Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 39-45 (Cipher ЕУ12/2019/41/1)
Notes : Bibliogr. at the end of the art.
Annotation: The IGHV mutational status is one of the most important markers for chronic lymphocytic leukemia (CLL) prognostication. Lipoprotein lipase (LPL) gene expression was found to correlate with IGHV status and was suggested as its surrogate marker. Recent data reported that LPL expression might be influenced by pivotal signalling pathways in CLL. This study aimed to assess LPL gene expression in relation to key immunogenetic and molecular markers of CLL, including IGHV mutational status, B-cell receptor (BCR) stereotypy, TP53, NOTCH1, and SF3B1 gene mutations. Materials and Methods: Expression of LPL mRNA was measured in peripheral blood mononuclear cells of 73 CLL patients by real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR). IGHV, NOTCH1, TP53, and SF3B1 gene mutation analysis was performed by PCR amplification and direct sequencing. Results: 44 of 73 (60%) CLL cases were categorized as LPL-positive based on the cut-off value established by ROC (receiver operating characteristic) curve analysis. LPL expression was significantly associated with IGHV mutation status (r = 0.684; p 0.0001) and tended to correlate with presence of NOTCH1 gene mutations (p
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10.

Type of document : Magazine article
Edition cipher :
Author(s) : Abramenko I. V. , Bilous N. I. , Chumak A. A., Dyagil I. S., Martina Z. V.
Title : Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients
Place of publication : Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 211-217 (Cipher ЕУ12/2018/40/3)
Notes : Bibliogr. at the end of the art.
Annotation: Deregulation of NOTCH1-signalling pathway is common in chronic lymphocytic leukemia (CLL). The most of studies are focused on detection of the hotspot c.7541_7542delCT NOTCH1 mutations in exon 34, while studies of mutations in the 3′UTR region are rare. The aims of work were to evaluate the frequencies of mutations in the 3′UTR region of the NOTCH1 gene (9:136,495553-136,495994) in Ukrainian CLL patients, the distribution of rs3124591 genotypes located in that area, and association of NOTCH1 mutations with structure of B-cell receptor. Materials and Methods: Detection of mutations in the 3′UTR region of the NOTCH1 was performed by direct sequencing in 87 previously untreated CLL patients (from the total group of 237 CLL patients) with unmutated immunoglobulin heavy-chain variable (UM IGHV) genes and without mutations in hotspot regions of TP53, SF3B1, and exon 34 of NOTCH1 genes. Results: Mutations in the 3′UTR region of the NOTCH1 were revealed in three of 87 CLL patients (3.4%). Two cases with non-coding mutations were related to subset #1 of stereotyped B-cell receptors, and one case belonged to stereotyped subset #28a. Analysis with inclusion of 30 UM IGHV cases with previously detected c.7544_7545delCT mutations revealed that the frequency of UM IGHV genes of I phylogenetic clan (except IGHV1-69) was significantly increased, and the frequency of UM IGHV3 and IGHV4 genes, on the contrary, was reduced in NOTCH1-mutated cases comparing with NOTCH1-unmutated cases (p = 0.002) and the general group (p = 0.013). SNP rs3124591 did not affect the risk of CLL and survival parameters of the patients. At the same time, differences were found in the frequency of IGHV gene usage and in the structure of HCDR3 in carriers of individual genotypes. Conclusion: The frequency of NOTCH1 mutations in 3′UTR region was low. Our findings confirmed current data on the association between the structure of the B-cell receptor and the appearance of NOTCH1 mutations. Some features of HCDR3 structure were identified in carriers of TT and CC genotypes of rs3124591. Key Words: NOTCH1 mutations, 3′UTR region of the NOTCH1, rs3124591, IGHV genes
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