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Total number of found documents : 29
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1.


   
    Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population / M. Nikbakht [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P57-64 : табл. - 51 ref.


MeSH-main:
ЛЕЙКОЗ-ЛИМФОМА ПРЕ-КЛЕТОЧНЫЙ ЛИМФОБЛАСТНЫЙ -- PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA (генетика)
ЭПИГЕНОМИКА -- EPIGENOMICS
ДНК ФРАГМЕНТАЦИЯ -- DNA FRAGMENTATION
Annotation: Promoter hypermethylation mediates gene silencing in many neoplasms. Acute leukemia has been reported to harbor multiple genes aberrantly silenced by hypermethylation. Aim: In present study, we investigated the prevalence of hypermethylation of caspase-8 (CASP8), TMS1 and DAPK genes in correlation with clinicopathological factors in childhood acute lymphoblastic leukemia (ALL). Materials and Methods: A case-control study has been conducted based on bone marrow and peripheral blood samples from 125 ALL patients and 100 sex-age matched healthy controls. Methylation specific polymerase chain reaction (PCR) and bisulfite sequencing PCR was performed to analyze the methylation status of these genes. Reverse transcription PCR and real time PCR was carried out to determine changes in the mRNA expression level of the genes due to hypermethylation. Results: Hypermethylation of the 5´CpG islands of the CASP8, TMS1 and DAPK gene promoters was found in 3.2, 6.4, and 13.6% of 125 childhood ALL samples from north Indian population, respectively. There were significant differences in pattern of hypermethylation of TMS1 (p = 0.045) and DAPK (p 0.001) between patients and healthy controls. Down-regulation of mRNA expression was found in cases in which CASP8, TMS1 and DAPK were hypermethylated. Conclusions: The present study indicated the impact of hypermethylation-mediated inactivation of CASP8, TMS1 and DAPK genes, which is associated with risk of childhood ALL. This abnormality occurs in leukemogenesis and it may be used as a biomarker and for predicting the prognosis of ALL
Additional Access Points:
Nikbakht, M.
Jha, A.K.
Malekzadeh, K.
Askari, M.
Mohammadi, S.
Marwaha, R.K.
Kaul, D.
Kaur, J.

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2.


   
    Alternative direction of inhibition of malignant properties in tumor cells in vitro and in vivo by gene therapy with INF-beta gene in recombinant baculovirus vector / O. Lykhova [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P90


MeSH-main:
НОВООБРАЗОВАНИЯ -- NEOPLASMS (терапия)
ГЕННАЯ ТЕРАПИЯ -- GENETIC THERAPY
BACULOVIRIDAE -- BACULOVIRIDAE (генетика)
Annotation: The aim of the study was to investigate the influence of recombinant baculovirus containing the interferon-β gene (rBV/IFN) on phenotypic characteristics of tumor cells in vitro: morphology, growth, cytogenetic characteristics and expression of proteins associated with proliferative activity, cell cycle regulation, epithelial-mesenchymal transition (EMT), invasiveness, and the migration potential
Additional Access Points:
Lykhova, O.
Strokovska, L.
Kovaleva, O.
Bezdieniezhnych, N.
Semesiuk, N.
Adamenko, I.
Vorontsova, A.
Kudryavets, Yu.

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3.


   
    Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells / Yu. Kit [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P36-41 : il. - 34 ref.


MeSH-main:
ЛЕЙКОЗ T-КЛЕТОЧНЫЙ -- LEUKEMIA, T-CELL
ВОЛЧАНКА КРАСНАЯ СИСТЕМНАЯ -- LUPUS ERYTHEMATOSUS, SYSTEMIC
КРОВИ СЫВОРОТКА -- SERUM
КЛЕТКИ ПРОЛИФЕРАЦИЯ -- CELL PROLIFERATION
ПЕРЕКРЕСТНЫЕ РЕАКЦИИ -- CROSS REACTIONS
АУТОАНТИТЕЛА -- AUTOANTIBODIES
Annotation: The aim of this study was to characterize the proliferative activity of the anti-histone H1 IgGs towards human T-leukaemia CEM cells. Materials and Methods: Anti-histone H1 IgGs were purified from blood serum of systemic lupus erythematosus patients by precipitation of serum proteins with 50% ammonium sulfate followed by a sequential affinity chromatography on Protein GSepharose and histone H1-Sepharose columns. To avoid contamination with other proteins, anti-histone H1 IgGs were subjected to strongly acidic pH 2.0 during gel filtration through HPLC column. The effects of the anti-histone H1 IgGs on cell viability and cell cycle were tested by MTS-assay and flow cytometry, correspondingly. The cross-reactivity of the anti-histone H1 antibodies towards heterogenetic and cellular antigens was evaluated by Western-blot analysis. Results: It was found that incubation of CEM cells with the HPLC-purified anti-histone H1 IgGs resulted in significant stimulation of cell growth by 46% after 48 h of incubation. These IgGs possess an antigenic poly-specificity to positively charged heterogenetic antigens and different cellular antigens. FITC-labeled and biotinylated anti-histone H1 IgGs are internalized by CEM cells and preferentially accumulated in the cytoplasm. Conclusion: The anti-histone H1 IgGs are shown to internalize human T-leukemia CEM and stimulate their proliferation. These IgGs are polyspecific toward cellular antigens
Additional Access Points:
Kit, Yu.
Magorivska, I.
Bilyi, R.
Myronovskij, S.
Stoika, R.

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4.


   
    Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma / T. V. Symchych [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P42-48 : табл. - 27 ref.


MeSH-main:
КАРЦИНОМА, ЭРЛИХА ОПУХОЛЬ -- CARCINOMA, EHRLICH TUMOR (терапия)
ВАКЦИНЫ ПРОТИВООПУХОЛЕВЫЕ -- CANCER VACCINES (иммунология)
Annotation: To investigate anticancer and immunologic effects of chicken embryonic proteins (CEP) in mice bearing Ehrlich solid carcinoma. Materials and Methods: The study was carried out on male Balb/c mice bearing Ehrlich solid carcinoma. The immunizations were performed after the tumor transplantation. The immune status was assessed on days 7, 14, 21 and 28 after the tumor challenge. Cytotoxic activity (CAT) of macrophages (Mph), natural killer cells (NK), cytotoxic T-lymphocytes (CTL) and blood serum, as well as the influence of the blood serum on immune cells activity was checked in MTT-assay; Mph’s cytochemical activity was tested in NBT-assay; Ehrlich antigen-specific or CEP-specific antibodies were detected in ELISA-assay; medium size circulating immune complexes (CIC) were detected in reaction of 4.5% polyethylene glycol precipitation. Results: The immunization resulted in tumor growth suppression and significant 25.64% prolongation of the survival time. In both control and immunized mice with transplanted tumors antibodies specific to Ehrlich carcinoma antigens and to CEP were detected, but antibody response was more balanced in the treatment group. In the treatment group both cytochemical and CAT of Mph was moderately activated and well preserved until late stages of tumor development; CAT of NK and CTL remained in the range of the intact mice until day 28 after the tumor transplantation. The immunized mice were well protected from accumulation of CIC and suppressive activity of autologous blood serum. Conclusion: Collectively, our data indicate that CEP can elicit immunomodulating and immunoprotecting effects sufficient to provide tumor growth inhibition. The further elaboration of a xenogeneic anticancer vaccine based on CEP is warranted
Additional Access Points:
Symchych, T.V.
Fedosova, N.I.
Karaman, O.M.
Yevstratieva, L.M.
Voyeykova, I.M.
Potebnia, H.P.

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5.


   
    Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics / V. F. Chekhun [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P25-29 : табл. - 21 ref.


MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия)
АРТЕМИЗИНИНЫ -- ARTEMISININS
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ -- DRUG RESISTANCE
Annotation: To explore effects of Artemisinin on a series of breast cancer cells with different sensitivity to typical cytotoxic drugs (doxorubicin — Dox; cisplatin — DDP) and to investigate possible artemisinin-induced modification of the mechanisms of drug resistance. Materials and Methods: The study was performed on wild-type breast cancer MCF-7 cell line (MCF-7/S) and its two sublines MCF-7/Dox and MCF-7/DDP resistant to Dox and DDP, respectively. The cells were treated with artemisinin and iron-containing magnetic fluid. The latter was added to modulate iron levels in the cells and explore its role in artemisinin-induced effects. The MTT assay was used to monitor cell viability, whereas changes of expression of selected proteins participating in regulation of cellular iron homeostasis were estimated using immunocytochemical methods. Finally, relative expression levels of miRNA-200b, -320a, and -34a were examined by using qRT-PCR. Results: Artemisinin affects mechanisms of the resistance of breast cancer cells towards both Dox and DDP at sub-toxic doses. The former drug induces changes of expression of iron-regulating proteins via different mechanisms, including epigenetic regulation. Particularly, the disturbances in ferritin heavy chain 1, lactoferrin, hepcidin (decrease) and ferroportin (increase) expression (р ≤ 0.05) were established. The most enhanced increase of miRNA expression under artemisinin influence were found for miRNA-200b in MCF-7/DDP cells (7.1 ± 0.98 fold change), miRNA-320a in MCF-7/Dox cells (2.9 ± 0.45 fold change) and miRNA-34a (1.7 ± 0.15 fold change) in MCF-7/S cells. It was observed that the sensitivity to artemisinin can be influenced by changing iron levels in cells. Conclusions: Artemisinin can modify iron metabolism of breast cancer cells by its cytotoxic effect, but also by inducing changes in expression of iron-regulating proteins and microRNAs (miRNAs), involved in their regulation. This modification affects the mechanisms that are implicated in drug-resistance, that makes artemisinin a perspective modulator of cell sensitivity towards chemotherapeutic agents in cancer treatment
Additional Access Points:
Chekhun, V.F.
Lukianova, N.Y.
Borikun, T.V.
Zadvornyi, T.V.
Mokhir, A.

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6.


   
    Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines / N. Bezdieniezhnych [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P89-90


MeSH-main:
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS
ЦИТОКИНЫ -- CYTOKINES (действие лекарственных препаратов)
ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМНЫЙ ПЕРЕХОД -- EPITHELIAL-MESENCHYMAL TRANSITION (действие лекарственных препаратов)
Annotation: Formation of a highly malignant metastatic tumor cell phenotype and resistance to anticancer drugs are associated with the implementation of epithelial- mesenchymal transition (EMT). Thus, monitoring of EMT and the possible inhibition of this process could be helpful to inhibit the tumor progression. It is quite often that anti-tumor treatment is not effective, so new modalities and new targets to combat cancer should be developed. Established cell lines, primary cultures of malignant cells obtained from biopsies or ascites of patients with epithelial cancers (breast, colorectal and ovarian), immunohistochemistry, and statistical methods were used
Additional Access Points:
Bezdieniezhnych, N.
Lykhova, O.
Kocherga, R.
Kudryavets, Yu.

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7.


   
    CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia / I. Gordiienko [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P91-92


MeSH-main:
ЛЕЙКОЗ ЛИМФОЦИТАРНЫЙ ХРОНИЧЕСКИЙ B-КЛЕТОЧНЫЙ -- LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL (терапия)
АНТИГЕНЫ -- ANTIGENS
Annotation: Recent finding indicate that CD150 cell surface expression can be used as a surrogate prognostic marker of chronic lymphocytic leukemia (CLL) favorable outcome. It was shown that CLL patients with high CD150 expression level on malignant B cells has longer treatment free survival and overall survival compared to patients, which lost CD150 cell surface expression. However, the mechanisms that underlie dependent on CD150 expression biological properties of CLL B cells are not fully understood. Present study was focused on characterization of CD150 topology and isoforms expression, as well as study of CD150 mediated signaling pathways in CLL B cells
Additional Access Points:
Gordiienko, I.
Shlapatska, L.
Kholodniuk, V.
Sklyarenko, L.
Sidorenko, S.

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8.


   
    CD150/SLAMF1 as a new potential target for anti-tumor therapy / S. P. Sidorenko [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P90-91


MeSH-main:
НОВООБРАЗОВАНИЯ -- NEOPLASMS (лекарственная терапия, терапия)
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS
Annotation: CD150/SLAMF1 is a prototype member of SLAM family within the immunoglobulin superfamily of surface receptors that are widely expressed on cells within hematopoietic system. Six of nine SLAMF receptors have a paired unique immunoreceptor tyrosine-based switch motif (ITSM) that serves as a docking site for SH2-containing proteins. In T and B lymphocytes, natural killer cells, macrophages and dendritic cells CD150 is a co-receptor molecule that mediates different signal transduction pathways depending on the availability of downstream signaling elements, especially, the adaptor protein SH2D1A/SAP. Due to highly glycosylated and sialylated extracellular Ig domains, CD150 is involved in homotypic interactions and could be considered as a pattern-recognizing receptor. It is a major entry receptor for several Morbilliviruses, including measles virus, and also a bacterial sensor that control the killing of Gram-negative bacteria. Functionally it serves as a bridge between innate and adaptive immunity
Additional Access Points:
Sidorenko, S.P.
Romanets-Korbut, O.
Gordiienko, I.
Kovalevska, L.
Shlapatska, L.

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9.


    Borikun, T.
    Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer / T. Borikun, N. Lukianova, V. Chekhun // Experimental Oncology. - 2017. - Том 39, N 1. - P92


MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика)
БИОМАРКЕРЫ ФАРМАКОЛОГИЧЕСКИЕ -- BIOMARKERS, PHARMACOLOGICAL
Annotation: High heterogeneity and diversity of breast tumors make the molecular characterization based on new biological markers very important. Recent studies have shown that not only genes and proteins are important players in tumorigenesis, but also a new class of potential epigenetic tumor markers such as microRNAs (miRNAs). An important advantage of miRNA molecules is their stability in both plasma and tumor tissues
Additional Access Points:
Lukianova, N.
Chekhun, V.

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10.


   
    Circulating tumor cells in breast cancer : functional heterogeneity, pathogenetic and clinical aspects / N. V. Cherdyntseva [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P2-11 : il. - 84 ref.


MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
ЛЕКАРСТВЕННАЯ ТЕРАПИЯ -- DRUG THERAPY
НОВООБРАЗОВАНИЙ ЦИРКУЛИРУЮЩИЕ КЛЕТКИ -- NEOPLASTIC CELLS, CIRCULATING
БИОПСИЯ -- BIOPSY
Annotation: Each patient has a unique history of cancer ecosystem development, resulting in intratumor heterogeneity. In order to effectively kill the tumor cells by chemotherapy, dynamic monitoring of driver molecular alterations is necessary to detect the markers for acquired drug resistance and find the new therapeutic targets. To perform the therapeutic monitoring, frequent tumor biopsy is needed, but it is not always possible due to small tumor size or its regression during the therapy or tumor inaccessibility in advanced cancer patients. Liquid biopsy appears to be a promising approach to overcome this problem, providing the testing of circulating tumor cells (CTC) and/or tumor-specific circulating nucleic acids. Their genomic characteristics make it possible to assess the clonal dynamics of tumors, comparing it with the clinical course and identification of driver mutation that confer resistance to therapy. The main attention in this review is paid to CTC. The biological behavior of the tumor is determined by specific cancerpromoting molecular and genetic alterations of tumor cells, and by the peculiarities of their interactions with the microenvironment that can result in the presence of wide spectrum of circulating tumor clones with various properties and potentialities to contribute to tumor progression and response to chemotherapy and prognostic value. Indeed, data on prognostic or predictive value of CTC are rather contradictory, because there is still no standard method of CTC identification, represented by different populations manifesting various biological behavior as well as different potency to metastasis. Circulating clasters of CTC appear to have essentially greater ability to metastasize in comparison with single CTC, as well as strong association with worse prognosis and chemoresistance in breast cancer patients. The Food and Drug Administration (USA) has approved the CTC-based prognostic test for clinical application in patients with advanced breast cancer. Prospective clinical trials have demonstrated that measuring changes in CTC numbers during treatment is useful for monitoring therapy response in breast cancer patients. Molecular and genetic analysis of CTC gives the opportunity to have timely information on emergence of resistant tumor clones and may shed light on the new targets for pathogenetic antitumor therapy
Additional Access Points:
Cherdyntseva, N.V.
Litviakov, N.V.
Denisov, E.V.
Gervas , P.A.
Cherdyntsev, E.S.

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11.


   
    Diagnostic challenges with intraoral myeloid sarcoma : report of two cases & review of world literature / P. Kumar [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P78-85 : цв. ил. - 64 ref.


MeSH-main:
САРКОМА МИЕЛОИДНАЯ -- SARCOMA, MYELOID (диагностика)
ЛЕЙКОЗЫ -- LEUKEMIA
ГРАНУЛОЦИТЫ -- GRANULOCYTES
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY (методы)
Annotation: Myeloid sarcomas (MS) are rare extramedullary tumors composed of blasts of myeloid lineage that either precede, follow or present concomitantly with acute myeloid leukaemia (AML) or myeloproliferative neoplasms. The diagnosis of MS is especially challenging in patients without an antecedent history of leukemia. Methods: We present 2 cases of intraoral MS that presented as de novo lesions. A detailed review of cases of intraoral MS that either preceded or presented along with leukemia has been done with emphasis on diagnostic criteria used. Results: Two male patients aged 28 and 5 years presented with MS with one patient presenting with concomitant AML. A combination of morphological and immunohistochemical methods was used for diagnosis. A thorough review of world literature revealed 44 cases of intraoral MS that presented as de novo lesions. Conclusion: Intraoral MS is a rare tumor with poor prognosis. It may be diagnostically challenging due to its protean clinical manifestations and histological overlap with other tumors
Additional Access Points:
Kumar, P.
Singh, H.
Khurana, N.
Urs, A.B.
Augustine, J.
Tomar, R.

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12.


    Kashuba, E.
    Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtag // Experimental Oncology. - 2017. - Том 39, N 1. - P12-16 : цв. ил. - 21 ref.


MeSH-main:
МИТОХОНДРИАЛЬНЫЕ БЕЛКИ -- MITOCHONDRIAL PROTEINS
РЕТИНОБЛАСТОМЫ БЕЛОК -- RETINOBLASTOMA PROTEIN
СТВОЛОВЫЕ КЛЕТКИ -- STEM CELLS
Annotation: In childhood tumors, including retinoblastoma, osteosarcoma, and neuroblastoma, the RB-E2F1 pathway is inactivated, as a rule. These tumors arise from precursor cells that fail to undergo the terminal differentiation. Noteworthy, the RB1-encoded protein (RB) does not control the cell cycle in embryonic stem cells. It has not been yet well understood how RB controls cell stemness and differentiation. The question arises why “inactive” RB is required for the survival and stemness of cells? Recently, we have found that overexpression of the RB-binding protein MRPS18-2 (S18-2) in primary fibroblasts leads to their immortalization, which is accompanied by the induction of embryonic stem cell markers and, eventually, malignant transformation. We suggest that cell stemness may be associated with high expression levels of both proteins, RB and S18-2. There must be a strict regulation of the expression levels of S18-2 and RB during embryogenesis. Disturbances in the expression of these proteins would lead to the abnormalities in development. We think that the S18-2 protein, together with the RB, plays a crucial role in the control on cell stemness and differentiation. We hope to uncover the new mechanisms of the cell fate determination. The S18-2 may serve as a new target for anticancer medicines, which will help to improve human health
Additional Access Points:
Mushtag, M.

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13.


   
    Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro / N. Bezdieniezhnych [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P17-24 : цв. ил. - 27 ref.


MeSH-main:
ОБОДОЧНОЙ КИШКИ НОВООБРАЗОВАНИЯ -- COLONIC NEOPLASMS (лекарственная терапия)
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS
ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМНЫЙ ПЕРЕХОД -- EPITHELIAL-MESENCHYMAL TRANSITION (генетика)
Annotation: To estimate the impact of the low-dose anticancer drugs (ACD) with the different mechanisms of action and human interferon (IFN) alpha 2b on the biological properties, immunophenotypic and cytogenetic characteristics of colon cancer cells in vitro. Materials and Methods: The study was performed on human colon cancer cell lines COLO 205, HT-29 and 3C-P treated with ACD and IFN in subtoxic concentrations. Expression of CD44, N-cadherin, vimentin, β-catenin, ERCC1 and Slug was assessed by immunocytochemical method. Using cytogenetic analysis, the numbers of mitoses, cells with micronuclei, apoptotic cells and cells with nuclear protrusions were studied. Results: The prolonged exposure (up to 30 days) of colon cancer cells to low-dose ACD (0.2–0.5 µg/ml cisplatin and 0.1–0.2 µg/ml irinotecan) in combination with IFN (500–1000 IU/ml) led to 37-fold decreased colony-forming activity of these cell and 10-fold reduction of the number of cells expressing mesenchymal protein markers (N-cadherin, vimentin). Also, in COLO 205 cells treated with ACD and IFN the number of SLUG- and CD44-positive cells decreased by 92 and by 85%, respectively. Long-term cultivation of HT-29 cells in the presence of cisplatin and IFN resulted in 5-fold suppression of ERCC1 expression. The cytogenetic analysis has shown that the ACD, IFN and their combinations in subtoxic concentrations caused significant genotoxic effect, suppression of cell proliferation and accumulation of cells with micronuclei. The sensitivity of colon cancer cells to ACD in standard cytotoxic concentrations did not change after prolonged low-dose exposure. Conclusion: The data showed that the prolonged action of the low doses of ACD on human colon cancer cells resulted in the suppression of cell proliferation, colony-forming activity in soft agar, expression of epithelialmesenchymal transition-associated markers and significant cytogenetic changes
Additional Access Points:
Bezdieniezhnych, N.
Kovalova, O.
Lykhova, O.
Kocherga, R.
Vorontsova, A.
Zhylchuk, V.
Maksimyak, G.
Kudryavets, Yu.

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14.


   
    Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells / O. O. Ratushna [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P88-89


MeSH-main:
НОВООБРАЗОВАНИЯ -- NEOPLASMS
ЭНДОПЛАЗМАТИЧЕСКОГО РЕТИКУЛУМА СТРЕСС -- ENDOPLASMIC RETICULUM STRESS
Annotation: The endoplasmic reticulum (ER) stress represents the unfolded protein response to cope with the accumulation of unfolded or misfolded proteins. It is required to maintain the functional integrity of the ER, which is a dynamic intracellular organelle with exquisite sensitivity to alterations in homeostasis. The unfolded protein response is a key player in the development of different malignant tumors. Depending on the duration and severity of the ER stress, it leads to cell adaptation or demise. This stress is a fundamental phenomenon, which provides a secure protection of the cells from different environmental challenges and is transduced by three major ER resident stress sensors. Activation of these ER stress sensors leads to transcriptional reprogramming of the cells. The signaling pathways elicited by those stress sensors have connections with metabolic pathways and with other plasma membrane receptor signaling networks. As such, the ER has an essential position as a signal integrator in the cell and is instrumental in the different phases of tumor progression
Additional Access Points:
Ratushna, O.O.
Minchenko, D.O.
Riabovol, O.O.
Luzina, O.Y.
Minchenko, O.H.

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15.


   
    EPR spectroscopy studies of changes in erythrocyte membranes in patients with laryngeal cancer / Y. B. Burlaka [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P49-52 : табл. - 18 ref.


MeSH-main:
ГОРТАНИ НОВООБРАЗОВАНИЯ -- LARYNGEAL NEOPLASMS (диагностика)
ЭРИТРОЦИТЫ -- ERYTHROCYTES
ЭРИТРОЦИТА МЕМБРАНА -- ERYTHROCYTE MEMBRANE
ЭЛЕКТРОННОГО ПАРАМАГНИТНОГО РЕЗОНАНСА СПЕКТРОСКОПИЯ -- ELECTRON SPIN RESONANCE SPECTROSCOPY
Annotation: To evaluate microviscosity and sorption capacity of erythrocyte membranes (SCEM) from patients with laryngeal cancer (LC). Materials and Methods: Samples from 35 patients with LC of stages II and III and 20 healthy volunteers were investigated by electron paramagnetic resonance with Bis(1-oxyl-2,2,6,6-tetramethylpiperidinyl-4)-ester of 5,7-dimethyladamantane-1,3-dicarbonic acid (AdTEMPO) probe. SCEM was evaluated by amount of unabsorbed methylene blue. Results: Microviscosity of erythrocyte membranes was determined by the effective rotational diffusion correlation times (τeff) and a decrease in radical spectrum signal intensity per hour. The most apparent decrease in mobility of the AdTEMPO in erythrocytes was observed prior to washing of erythrocytes with 0.9% NaCl for 5 min after probe insertion. The deceleration after 60 min was observed only in stage II LC. τeff was at control values after washing of erythrocytes of stage II LC 5 min after probe insertion and was significantly reduced in stage III LC in comparison to control. Radical spectrum signal intensity per hour in samples of stage II and III patients prior to and after washing of erythrocytes was on average 1.5-fold higher than that of control. SCEM in samples of stage II and III LC was found in 40 and 33% cases, respectively and was on average significantly reduced in comparison to control. Conclusions: The initial interaction of AdTEMPO with erythrocyte membranes of stage II and III LC patients is accompanied by an increase in τeff, indicating deceleration of probe rotation. τeff of the probe in membranes remains unchanged in 60 min, indicating changes in the structural organization of lipid bilayer and its associated proteins in particular. The similarity of SCEM for both studied groups reflects the pathological changes in function of erythrocyte membranes
Additional Access Points:
Burlaka, Y.B.
Sukhoveev, O.V.
Grin, N.V.
Khilchevskyi, O.M.
Verevka, S.V.

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16.


    Brieieva, O.
    Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients / O. Brieieva, I. Nesina, L. Buchynska // Experimental Oncology. - 2017. - Том 39, N 1. - P93


MeSH-main:
ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
ГИДРОКСИЭСТРОНЫ -- HYDROXYESTRONES
ЛИМФОЦИТЫ -- LYMPHOCYTES
Annotation: The endometrial cancer (EC) pathogenesis to a large extent may be determined by genotoxic effects of estrogen metabolites, among which the 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. Genomic instability and sensitivity to genotoxic estrogen metabolites in cells of EC patients depend on the DNA repair efficiency. The aim of the study was to analyze the level of DNA damage in peripheral blood lymphocytes (PBL) of EC patients after treatment with the 4OHE2 and to evaluate the repair efficiency of induced DNA damag
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Nesina, I.
Buchynska, L.

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17.


   
    High expression levels of MRPS 18-2 and presence of the RB protein are required for the maintenance of stem cell phenotype / M. Mushtag [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P92-93


MeSH-main:
СТВОЛОВЫЕ КЛЕТКИ -- STEM CELLS
БЕЛКИ -- PROTEINS
Annotation: We have found that mitochondrial ribosomal protein MRPS18-2 (S18-2) is involved in regulation of the RB-dependent pathway. It binds to both hypo- and hyperphosphorylated RB. The binding between RB and S18-2 is promoted when cytoplasmic S18-2 is targeted to the nucleus, and this disrupts the association of E2F1 with RB, as indicated by the increased level of free E2F1 in the nucleus. This presumably enhances the RB-dependent block to S-phase entry in the cell cycle. We have also found overexpression of the human S18-2 in immortalized primary rat embryonic fibroblasts (REFs) that showed properties of embryonic stem cells. Elevated expression of S18-2 in stem cells (our findings and analysis of published microarray data) raises the question of whether this protein co-operates with the RB protein in differentiation and carcinogenesis
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Mushtag, M.
Kovalevska, L.
Klein, G.
Kashuba, E.

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18.


    Mankovska, O.
    Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors / O. Mankovska, V. Kashuba // Experimental Oncology. - 2017. - Том 39, N 1. - P93


MeSH-main:
НОВООБРАЗОВАНИЯ ЖЕЛЕЗИСТЫЕ И ЭПИТЕЛИАЛЬНЫЕ -- NEOPLASMS, GLANDULAR AND EPITHELIAL (диагностика)
ГЕНЕТИЧЕСКИЕ МАРКЕРЫ -- GENETIC MARKERS
Annotation: The main topic of our research is the identification of molecular and genetic markers for the early detection of epithelial tumors and prognosis of the course of disease. Early detection of carcinogenic process can lead to more successful treatment, thus, significantly increasing the chances for recovery. The investigation of non-invasive diagnostic tools, which can be used in clinical practice, is now the main focus of oncology. This problem can be solved by using of molecular nucleic acid markers that are present in biological fluids (serum, urine, semen etc)
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Kashuba, V.

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19.


    Satinder, K.
    Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women / K. Satinder, R. C. Sobti, K. Pushpinder // Experimental Oncology. - 2017. - Том 39, N 1. - P69-74 : табл. - 33 ref.


MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (радиотерапия, хирургия)
ВЫЖИВАНИЕ -- SURVIVAL
Annotation: n the present study, we investigated the hypothesis whether exposure to wood smoke increases the risk of cervical cancer (CC) in North-Indian women who inherit different polymorphic forms of chemical metabolizing genes (GSTM1, GSTT1, GSTP1 and CYP1A1). Materials and Methods: One hundred fifty histologically confirmed CC patients and equal number of cancer-free age and ethnicity matched controls were genotyped for genetic polymorphism in chemical metabolizing genes by using polymerase chain reaction/restriction fragment length polymorphism method. The association of the different genotypes and exposure to wood smoke with the risk of CC in North-Indian women was estimated by doing statistical analysis using Statistical Package for the Social Science. Results: It was observed that the variant genotypes of GSTM1, GSTT1, GSTP1 and CYP1A1 did not significantly increase the risk of CC. However, statistically significant increased risk (odds ratio 3.6; 95% confidence interval, 1.34–9.78; p = 0.008) was observed for women who used wood for cooking and had GSTM1 (null) genotype. Conclusions: The present study suggests that genetic differences in the metabolism of wood smoke carcinogens, particularly by GSTM1, may increase the risk of CC
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Sobti, R.C.
Pushpinder, K.

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20.


   
    International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine // Experimental Oncology. - 2017. - Том 39, N 1. - P95


MeSH-main:
НОВООБРАЗОВАНИЙ СТВОЛОВЫЕ КЛЕТКИ -- NEOPLASTIC STEM CELLS
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