Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Down regulation of u-PA by a nutrient mixture in hemangioma (EOMA) cells by inducing caspase-dependent apoptosis [Text] / M. W. Roomi [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 90-94. - Bibliogr. at the end of the art.

MeSH-main:
НОВОРОЖДЕННЫЙ, БОЛЕЗНИ -- INFANT, NEWBORN, DISEASES (патофизиология, терапия, этиология)
ГЕМАНГИОМА -- HEMANGIOMA (патофизиология, терапия, этиология)
КОМПЛЕКСНЫЕ СМЕСИ -- COMPLEX MIXTURES (анализ, терапевтическое применение, фармакология)
ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА -- EXPERIMENTAL MEDICINE
МОРФОЛОГИЧЕСКИЕ И МИКРОСКОПИЧЕСКИЕ ПОКАЗАТЕЛИ -- MORPHOLOGICAL AND MICROSCOPIC FINDINGS
КАСПАЗЫ ИНИЦИИРУЮЩИЕ -- CASPASES, INITIATOR (анализ, иммунология)
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Key words(unnormalized):
питательную смесь состав : лизин, пролин, аскорбиновая кислота и экстракт зелено чая -- клетки EOMA
Annotation: Hemangiomas are the most common congenital vascular and benign tumor in infants and children. Most hemangiomas do not cause major symptoms to require intervention, however, the larger hemangiomas have tendency to bleed and may require surgical removal. Experimental studies have demonstrated the role of urokinase plasminogen activator (u-PA), especially cell surface u-PA, as an initiator of extra-cellular matrix proteolysis and associated tumor cell invasion. Aim: To examine, whether the antitumor effects of a specific nutrient mixture are due to induction of apoptosis by inhibition of u-PA. Materials and Methods: A nutrient mixture containing lysine, proline, ascorbic acid, and green tea extract which has showed anticancer activity against a number of cancer cell lines was used as an experimental composition. EOMA cells were grown in appropriate media with antibiotics in 24-well tissue culture plates. At near confluence, the cells were treated with nutrition mixture at 10, 100, 1000 µg/ml in triplicate. Analysis of u-PA activity was carried out by fibrin zymography. Morphological changes and caspase activation associated with apoptosis induction was checked by H&E staining and Live Green caspase assay, respectively. Apoptosis inducing anticancer drug camptothecin (10 µM) was used as positive control. Results: The nutrition mixture exhibited dose response toxicity with maximum toxicity 55% (p < 0.001) at 1000 µg/ml. EOMA cells expressed u-PA, which was inhibited by nutrition mixture in a dose-dependent manner. The caspase analysis revealed a dose dependent increase in apoptosis of EOMA hemangioma cells, with an increasing apoptosis observed at 100 μg/ml, and maximum at 1000 μg/ml. Cells treated with nutrition mixture showed significantly more apoptotic changes than the control or camptothecin-treated cells. Conclusion: These results suggest that NM may induce apoptosis of hemangioma cells in vitro thus warranting further investigation. Key Words: nutrient mixture, urokinase plasminogen activators, hemangioma, EOMA, caspase, apoptosis
Additional Access Points:
Roomi, M. W.
Bhanap, B.
Niedzwiecki, A.
Rath, M.

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Sanaei, M.
Effect of valproic acid in comparison with vorinostat on cell growth inhibition and apoptosis induction in the human colon cancer SW48 cells in vitro [Text] / M. Sanaei, F. Kavoosi, O. Mansoori // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 95-100. - Bibliogr. at the end of the art.

Rubrics: Вориностат--тер прим

MeSH-main:
ЭНТЕРОЭНДОКРИННЫЕ КЛЕТКИ -- ENTEROENDOCRINE CELLS (ультраструктура)
ГИСТОН-АЦЕТИЛТРАНСФЕРАЗЫ -- HISTONE ACETYLTRANSFERASES (анализ, диагностическое применение)
ГИСТОН-ДЕАЦЕТИЛАЗЫ -- HISTONE DEACETYLASES (анализ, диагностическое применение)
АПОПТОЗ-ИНДУЦИРУЮЩИЙ ФАКТОР -- APOPTOSIS INDUCING FACTOR (анализ)
ВАЛПРОЕВАЯ КИСЛОТА -- VALPROIC ACID (анализ, диагностическое применение)
РОСТА ИНГИБИТОРЫ -- GROWTH INHIBITORS (анализ)
ПАРНЫЙ СРАВНИТЕЛЬНЫЙ АНАЛИЗ -- MATCHED-PAIR ANALYSIS
Annotation: Acetylation levels of histones are the result of the balance between histone acetyltransfrases and histone deacetylases activities, which plays an important role in chromatin remodeling and regulation of gene expression. Histone deacetylases inhibitors such as valproic acid, vorinostat have attracted interest because of their ability to induce differentiation and apoptosis of cancer cells. The current study was designed to assess the effect of valproic acid in comparison to and in combination with vorinostat on cell growth inhibition and apoptosis induction in the human colon cancer SW48 cells. Materials and Methods: The colon cancer SW48 cells were seeded and treated with various doses of valproic acid and vorinostat and MTT assay and flow cytometric assay were done to determine cell viability and cell apoptosis, respectively. Results: All concentrations of both agents reduced viability significantly in a dose- and time-dependent fashion (p 0.004). Both compounds, either single or combined agents, induced apoptosis significantly, whereas the ratio of the apoptotic cells treated with combined agents was more significant than the single. Conclusion: Our findings suggest that vaproic acid and vorinostat can significantly inhibit cell growth and induce apoptosis in colon cancer SW48 cells. Key Words: valproic acid, vorinostat, apoptosis, colon cancer
Additional Access Points:
Kavoosi, F.
Mansoori, O.

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Expression of steroid and peptide hormone receptors, metabolic enzymes and EMT-related genes in prostate tumors in relation to the presence of the TMPRSS2/ERG fusion [Text] / G. V. Gerashchenko [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 101-108. - Bibliogr. at the end of the art.

MeSH-main:
АДЕНОКАРЦИНОМА -- ADENOCARCINOMA (генетика, патофизиология, ультраструктура, этиология)
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (патофизиология, этиология)
ПЕПТИДНЫЕ ГОРМОНЫ -- PEPTIDE HORMONES (анализ, диагностическое применение, физиология)
ГЕННАЯ ЭКСПРЕССИЯ -- GENE EXPRESSION (физиология)
РЕЦЕПТОРЫ АНДРОГЕНОВ -- RECEPTORS, ANDROGEN (анализ)
КЛАСТЕРНЫЙ АНАЛИЗ -- CLUSTER ANALYSIS
Annotation: To analyze an expression pattern of the steroid and peptide hormone receptors, metabolic enzymes and EMT-related genes in prostate tumors in relation to the presence of the TMPRSS2/ERG fusion; and to examine a putative correlation between gene expression and clinical characteristics, to define the molecular subtypes of prostate cancer. Materials and Methods: The relative gene expression (RE) of 33 transcripts (27 genes) and the presence/absence of the TMPRSS2/ERG fusion were analyzed by a quantitative PCR. 37 prostate cancer tissues (T) paired with conventionally normal prostate tissue (CNT) and 21 samples of prostate adenomas were investigated. RE changes were calculated, using different protocols of statistics. Results: We demonstrated differences in RE of seven genes between tumors and CNT, as was calculated, using the 2−ΔCT model and the Wilcoxon matched paired test. Five genes (ESR1, KRT18, MKI67, MMP9, PCA3) showed altered expression in adenocarcinomas, in which the TMPRSS2/ERG fusion was detected. Two genes (INSR, isoform B and HOTAIR) expressed differently in tumors without fusion. Comparison of the gene expression pattern in adenomas, CNT and adenocarcinomas demonstrated that in adenocarcinomas, bearing the TMPRSS2/ERG fusion, genes KRT18, PCA3, and SCHLAP1 expressed differently. At the same time, we detected differences in RE of AR (isoform 2), MMP9, PRLR and HOTAIR in adenocarcinomas without the TMPRSS2/ERG fusion. Two genes (ESR1 and SRD5A2) showed differences in RE in both adenocarcinoma groups. Fourteen genes, namely AR (isoforms 1 and 2), CDH1, OCLN, NKX3-1, XIAP, GCR (ins AG), INSR (isoform A), IGF1R, IGF1R tr, PRLR, PRL, VDR and SRD5A2 showed correlation between RE and tumor stage. RE of four genes (CDH2, ESR2, VDR and SRD5A2) correlated with differentiation status of tumors (Gleason score). Using the K-means clustering, we could cluster adenocarcinomas in three groups, according to gene expression profiles. A specific subtype of prostate tumors is characterized by the activated ERG signaling, due to the presence of TMPRSS2/ERG fusion, and also by high levels of the androgen receptor, prolactin, IGF, INSR and PCA3. Conclusions: We have found the specific differences in expression of the steroid and peptide hormone receptors, metabolic enzymes and EMT-related genes, depending on the presence/absence of the TMPRSS2/ERG fusion in prostate adenocarcinomas, CNT and adenomas. We showed three different gene expression profiles of prostate adenocarcinomas. One of them is characteristic for adenocarcinomas with the TMPRSS2/ERG fusion. Further experiments are needed to confirm these data in a larger cohort of patients. Key Words: prostate tumors, TMPRSS2/ERG fusion, gene expression patterns, steroid receptors, peptide receptors, EMT regulation
Additional Access Points:
Gerashchenko, G. V.
Mevs, L. V.
Chashchina, L. I.
Pikul, M. V.
Gryzodub, O. P.
Stakhovsky, E. O.
Kashuba, V. I.

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The analysis of methylation of DNA promoter of SFRP2 gene in patients with hyperplastic processes of the endometrium [Text] / V. G. Marichereda [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 109-113. - Bibliogr. at the end of the art.

MeSH-main:
ЖЕНЩИН ЗДОРОВЬЕ -- WOMEN'S HEALTH (тенденции)
ЭНДОМЕТРИЯ ГИПЕРПЛАЗИЯ -- ENDOMETRIAL HYPERPLASIA (патофизиология, этиология)
ГЕНЫ НОВООБРАЗОВАНИЙ -- GENES, NEOPLASM (физиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Key words(unnormalized):
ген SFRP2
Annotation: The hyperplastic processes of the endometrium can arise not only against the background of excessive influence of estrogen, but also against the background of epigenetic damages that affect apoptosis, cell proliferation, differentiation, and adhesion, and DNA reparation. The aim of our study was to investigate and analyze the status of methylation of the promoter of SFRP2 gene in patients with hyperplastic processes of the endometrium. Materials and Methods: The study groups were the following: I — patients with endometrial hyperplasia (EH, n = 9); II — patients with endometrial intraepithelial neoplasia (EIN, n = 10), III — control groups: 1) with endometrial cancer (EC, n = 4), and 2) healthy women (n = 4). Determination of promoter methylation of SFRP2 gene was carried out by the semiquantitative method of methylation-specific PCR assay. Results: The maximum level of methylation of SFRP2 gene promoter had been revealed in patients with EC — 42.80 ± 3.55% (р < 0.05). The patients of the I group had the lowest values of methylation of SFRP2 gene promoter — 10.66 ± 0.85%, while in patients of the II group this indicator was higher — 20.60 ± 0.95% (р < 0.05). In healthy women of the control group, methylation of SFRP2 gene promoter was detected in none of the samples. Conclusion: The content of the methylated SFRP2 gene in endometrial tissue of patients with hyperplastic processes higher than 20–25% allows relate these women to the risk group of EC development and dictates the need of intensive observation of such patients. Key Words: methylation, SFRP2 gene, hyperplastic processes of the endometrium
Additional Access Points:
Marichereda, V. G.
Bykovа, N. A.
Bubnov, V. V.
Manasova, G. S.
Moskalenko, T. Y.
Volyanska, A. G.
Shevchenko, I. M.
Adamovska, T. M.

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Increased homocysteine plasma levels in breast cancer patients of a Mexican population [Text] / Almanza K. M. Varela [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 114-118. - Bibliogr. at the end of the art.

MeSH-main:
ГИПЕРГОМОЦИСТЕИНЕМИЯ -- HYPERHOMOCYSTEINEMIA (диагностика, этиология)
ПРОДРОМАЛЬНЫЕ СИМПТОМЫ -- PRODROMAL SYMPTOMS
ЖЕНЩИН ЗДОРОВЬЕ -- WOMEN'S HEALTH (тенденции)
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика, этиология)
МЕКСИКА -- MEXICO (этнология)
Annotation: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population
Additional Access Points:
Varela, Almanza K. M.
Puebla-Pérez, A. M.
Delgado-Saucedo, J. I.
Rodríguez-Arévalo, F.
Zúñiga-González, G. M.
Figuera, L. E.
Morán-Mendoza, A.
Gallegos-Arreola, M. P.

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Yakovlev, P.
Lymphocyte count in peripheral blood is a sensitive tool in pretreatment assessment of patients with urological cancer [Text] / P. Yakovlev, D. Klyushin // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 119-123. - Bibliogr. at the end of the art.

MeSH-main:
РЕТРОСПЕКТИВНЫЕ ИССЛЕДОВАНИЯ -- RETROSPECTIVE STUDIES
ЛИМФОЦИТЫ, ИНФИЛЬТРИРУЮЩИЕ ОПУХОЛЕВЫЕ КЛЕТКИ -- LYMPHOCYTES, TUMOR-INFILTRATING (ультраструктура)
МОЧЕПОЛОВОЙ СИСТЕМЫ НОВООБРАЗОВАНИЯ -- UROGENITAL NEOPLASMS (диагностика, кровь, патофизиология, этиология)
ПРЕДРАСПОЛОЖЕННОСТЬ БОЛЬНОГО К ЛЕЧЕНИЮ, ОЦЕНКА -- PROPENSITY SCORE
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (анализ)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: Cancer, inflammation and immune surveillance recruit lymphocytes as common key cellular players. The aim of the study was to assess a utility of the absolute and relative lymphocyte counts (ALC and RLC) in peripheral blood of patients with urological cancer as sensitive tool in pretreatment assessment of patient, which correlates with postoperative outcome of the disease, and outlines the overall reactivity of the patient. Materials and Methods: We retrospectively studied correlation between lymphocyte count in peripheral blood of the patients with urological cancer (n = 789) and number of clinical parameters: cancer localization, stage of the disease, treatment outcome, complications. Mann — Whitney two-tailed test and logistic regression models were used. Results: Lymphocyte counts (both absolute and relative) correlate with the cancer stage, and status of the disease, allowing differentiate patients with urological cancer, from healthy individuals, and from the cancer patients after radical surgery. In patients with kidney and bladder cancer, lymphocyte count allowed differentiate the stages of the disease. Lower rate of the reactivity of the patient to the cancer treatment is accurately predicted by the ALC and RLC: those in highest quartile for lymphocytes count have shorter postoperative recovery. Patients in lowest quartile demonstrated worst postoperative performance, including cases of early postoperative mortality due to weak somatic status. Conclusion: The study presents evidence that pretreatment lymphocyte count in the peripheral blood of patients with urological cancer is a sensitive marker of cancer stage, and the reactivity of the patient to the cancer treatment, which can be used in the pretreatment assessment of the patient. Key Words: urological cancer, lymphocytes, postoperative morbidity, reactivity, immune status assessment, treatment outcome
Additional Access Points:
Klyushin, D.

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Kryzhanivska, A. E.
Clinical and immunohistochemical features of primary breast cancer and metachronous ovarian and endometrial tumors [Text] / A. E. Kryzhanivska, I. B. Dyakiv, I. Kyshakevych // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 124-127. - Bibliogr. at the end of the art.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика, осложнения, патофизиология, этиология)
МЕНОПАУЗА -- MENOPAUSE (физиология)
ЯИЧНИКОВ НОВООБРАЗОВАНИЯ -- OVARIAN NEOPLASMS (диагностика, этиология)
РЕЦЕПТОР ЭПИДЕРМАЛЬНОГО ФАКТОРА РОСТА -- RECEPTOR, EPIDERMAL GROWTH FACTOR (анализ, диагностическое применение)
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY (использование, тенденции)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: The aim of the study was to assess the patterns of development of metachronous cancer (endometrial cancer, EC, and ovarian cancer, OC) in breast cancer (BC) patients dependent of receptor phenotype of breast tumors. Materials and Methods: In the study, 63 patients with ВС, who developed metachronous EC (n = 47) or OC (n = 16) were enrolled. Expression of estrogen receptor (ER), progesterone receptor (PR), HER/2neu was assessed using immunohistochemical approach. Results: BC in patients with metachronous EC and OC was characterized by a different frequency of molecular subtypes with the dominance of luminal A (36%) and B (43%) subtypes. In primary BC, we have established a correlation between ER expression and regional lymph nodes status (r = −0.50, p 0.05); negative correlation between HER2/neu expression and tumor stage (r
Additional Access Points:
Dyakiv, I. B.
Kyshakevych, I.

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Differentiated thyroid carcinomas associated with chronic thyroiditis: biological and clinical properties [Text] / T. M. Myshunina [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 128-131. - Bibliogr. at the end of the art.

MeSH-main:
ЩИТОВИДНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- THYROID NEOPLASMS (классификация, патофизиология, этиология)
КАРЦИНОМА ПАПИЛЛЯРНАЯ -- CARCINOMA, PAPILLARY (диагностика, патофизиология, этиология)
ГРАНУЛЕЗОКЛЕТОЧНОЕ НОВООБРАЗОВАНИЕ -- GRANULOSA CELL TUMOR (диагностика, патофизиология, этиология)
РЕТРОСПЕКТИВНЫЕ ИССЛЕДОВАНИЯ -- RETROSPECTIVE STUDIES
ТИРЕОИДИТ АУТОИММУННЫЙ -- THYROIDITIS, AUTOIMMUNE (этиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To determine biological and clinical features of papillary and follicular thyroid carcinomas associated or not associated with chronic thyroiditis. Materials and Methods: The study was conducted by retrospective analysis of medical histories of 2,459 patients with thyroid cancer. Tumor size, its category according to the TNM system, multi-focal properties of tumor growth, carcinoma invasiveness, as well as disease stage, rates of relapses and metastasis, and also cumulative survival rates were analyzed. Results: The tumor size in patients with papillary or follicular carcinoma associated with thyroiditis was smaller compared to the patients without thyroiditis. In the first case, the invasion frequency into extrathyroid structure and into the capsule was also lower. Multi-focal growth of both carcinoma types was registered more frequently in the presence of thyroiditis. The frequency of papillary carcinoma metastasis to lateral cervical lymph nodes was lower in the presence of thyroiditis, the frequency being equal for metastasis into lymph nodes of the VI lymph outflow zone in both groups of patients (with and without thyroiditis). In the presence of thyroiditis, the frequency of distant papillary carcinoma metastasis was decreased, no metastases were detected in patients with follicular carcinoma. In the group of patients with papillary carcinoma there was found no relation between the presence of thyroiditis and disease stage, relapse rates, and mortality levels; however, the risk of follicular carcinoma relapse was significantly lower in patients with thyroiditis. Conclusions: The presence of chronic thyroiditis in papillary carcinoma patients showed a certain positive impact on the course of the disease, in particular, primary tumor growth, invasion, and metastasis. Such effect is even more expressed in the patients with follicular thyroid carcinoma. Key Words: papillary and follicular thyroid carcinomas, autoimmune thyroiditis
Additional Access Points:
Myshunina, T. M.
Guda, B. D.
Bolgov, M. Yu.
Mikhailenko, N. I.
Tronko, N. D.

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Vakil, Monfared R.
OX40L gene polymorphism and breast cancer in Iranian population [Text] / Monfared R. Vakil, F. Mashayekhi // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 132-135. - Bibliogr. at the end of the art.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (генетика, патофизиология, этиология)
ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙ -- POLYMORPHISM, GENETIC (физиология)
OX40 ЛИГАНД -- OX40 LIGAND (анализ, диагностическое применение)
ПОЛИМЕРАЗНАЯ ЦЕПНАЯ РЕАКЦИЯ -- POLYMERASE CHAIN REACTION (использование, тенденции)
ИРАН -- IRAN (этнология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: The immune system plays an important role in the breast cancer development. OX40L (also known as TNFSF4), a membrane protein, which is a member of the tumor necrosis factor super family binds to its receptor OX40 and this co-stimulation has a crucial role in T cell proliferation, survival and cytokine release. Previous studies have shown that OX40L is associated with cancer. Due to the importance of the T cells in antitumor activities of OX40L we studied the association of rs3850641 (A→G) polymorphism of OX40L gene with the breast cancer. Materials and Methods: The study included 123 women with breast cancer and 126 healthy volunteers with no signs of cancer. Genomic DNA was extracted from blood leucocytes. Genotype and allele frequencies were determined in patients and control cases with the method of polymerase chain reaction-restriction fragment length polymorphism and the statistical analysis was performed by Med Calc. Results: The prevalence of genotype frequencies of AA/AG/GG were 60.9%, 30.08% and 8.9% in patients with breast cancer cases and 74.6%, 18.25% and 7.14% in healthy volunteers while the A and G allelic frequency was 76.01 and 23.98% in patients and 83.73 and 16.26% in healthy controls, respectively. Statistical analysis has shown signiﬁcant difference from the comparison of genotype (p = 0.03). Conclusion: It is concluded that the rs3850641 SNP is significantly associated with the breast cancer susceptibility in Iranian population. However, further studies in larger populations including other genetic and environmental factors are required to achieve conclusion. Key Words: OX40L, gene polymorphism, breast cancer, PCR-RFLP
Additional Access Points:
Mashayekhi, F.

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10.

The state of bone metabolism in lung cancer patients [Text] / Y. V. Dumanskyy [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 136-139. - Bibliogr. at the end of the art.

MeSH-main:
ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS (осложнения, патофизиология, этиология)
КОМОРБИДНОСТЬ -- COMORBIDITY (тенденции)
КОСТЕЙ БОЛЕЗНИ МЕТАБОЛИЧЕСКИЕ -- BONE DISEASES, METABOLIC (патофизиология, этиология)
ЛЕЧЕБНО-ДИАГНОСТИЧЕСКАЯ ТАКТИКА -- CRITICAL PATHWAYS (использование, тенденции)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: In recent years, we have discussed the correlation of malignant tumor process with the development of osteoporosis, which can be exacerbated by ongoing chemotherapy and radiation therapy. The aim of the work was to assess the status of bone metabolism in 32 untreated patients with lung cancer without metastasis. Materials and Methods: Patients underwent dual-energy X-ray osteodensitometry of proximal part of femoral bone. Osteopontin (OP), osteocalcin (OC) and alkaline phosphatase (AP) parameters were studied in blood, as well as osteo-associated chemical elements. Results: Lung cancer proceeds with severe disorders of bone metabolism, which is accompanied by an increase in blood levels of OP, OС, AP, phosphorus, lithium, lead, strontium and cobalt against a decrease of calcium, magnesium and manganese, which were observed in 75; 78; 31; 100; 66; 47; 44; 3; 100; 100, and 6% of patients, respectively; such disorder was associated with a morphological variant of the tumor (cobalt) and stage of disease (calcium, magnesium, manganese, strontium), development of osteodeficit (OP, OC, AR, strontium, zinc). Osteodeficit in the form of osteopenia and osteoporosis is observed more common in women, in every second patient, and osteodensimetric T-score depends on the age of patients, directly correlates with the values of the OP and OC, and inversely — with a zincemia rate. Conclusions: The disorders of bone metabolism in patients with lung cancer indicate the need for the development of antiosteoporosis treatment for cancer patients. Key Words: lung cancer, bone metabolism
Additional Access Points:
Dumanskyy, Y. V.
Syniachenko, O. V.
Stepko, Ph. A.
Taktashov, G. S.
Chernyshova, O. Y.
Stoliarova, O. Y.

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11.

Souchelnytskyi, S.
Intersection between genes controlling vascularization and angiogenesis in renal cell carcinomas [Text] / S. Souchelnytskyi // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 140-143. - Bibliogr. at the end of the art.

MeSH-main:
КРОВЕНОСНЫХ СОСУДОВ БОЛЕЗНИ -- VASCULAR DISEASES (патофизиология, этиология)
НОВООБРАЗОВАНИЯ ПО ЛОКАЛИЗАЦИИ (ВНЕШ) -- NEOPLASMS BY SITE (NON MESH)
НЕОВАСКУЛЯРИЗАЦИЯ ПАТОЛОГИЧЕСКАЯ -- NEOVASCULARIZATION, PATHOLOGIC (патофизиология, этиология)
СИСТЕМНЫЙ АНАЛИЗ -- SYSTEMS ANALYSIS
Annotation: To show that application of the systemic analysis may significantly improve comparison of different datasets. Different genes and proteins may converge on the same functional outputs. A comparison of 2 datasets by only identification names of affected molecules may miss that, leading to a conclusion that there is nothing in common for these datasets. Systemic analysis may overcome this limitation, by focusing on functions represented by the identification names. Materials and Methods: Datasets were retrieved from open sources. Systemic analysis of vascularization features and angiogenesis signature was performed by using Cytoscape and its plugs-in. Results: In contrary to the initial statement of the lack of overlap between the vascularization features and the angiogenesis genes-signature in renal carcinomas, we observed an intersection on the functional level. Analysis of the networks built with identification names of vascularization and angiogenesis datasets showed an intersection, which included potent regulators of vessel formation and growth. Conclusion: Analysis of networks may expose functional links, which may be missed by a direct identification names comparison. Key Words: cancer, vascularization, angiogenesis, systemic analysis
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12.

    Clinical case of a patient undergoing radium-223 treatment following treatment with abiraterone acetate and enzalutamide [Text] / Romero M. E. Jiménez [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 144-148. - Bibliogr. at the end of the art.

Rubrics: Абиратерон--тер прим

   энзалутамид--тер прим

MeSH-main:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ КАСТРАЦИОННО-РЕЗИСТЕНТНЫЕ -- PROSTATIC NEOPLASMS, CASTRATION-RESISTANT (патофизиология, терапия, этиология)
ОПИСАНИЕ СЛУЧАЕВ -- CASE REPORTS
РАДИЙ -- RADIUM (анализ, терапевтическое применение)
ЛЕЧЕБНО-ДИАГНОСТИЧЕСКАЯ ТАКТИКА -- CRITICAL PATHWAYS (тенденции)
БИОЛОГИЧЕСКИЕ МАРКЕРЫ -- BIOLOGICAL MARKERS (анализ)
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Key words(unnormalized):
Радий-223
Annotation: Over the last decade, significant advances have been made in the development of therapies for patients with metastatic castration-resistant prostate cancer. Abiraterone and enzalutamide were approved as treatments based on data supporting improved overall survival compared to placebo. Radium-223 became the first approved radiopharmaceutical which decreased skeletal-related events, palliated pain, and showed improved overall survival in symptomatic patients with castration-resistant prostate cancer and bone metastasis only. Materials and Methods: We present the case of an eighty-two year old man with metastatic castration-resistant prostate cancer who was treated with sequential therapy (abiraterone — enzalutamide — radium-223). The sequencing and treatment used for our patient was viable because of his clinical characteristics, which have allowed for longer survival time with an acceptable quality of life. These actions must be agreed on by the Multidisciplinary Tumour Board, in order to optimize the use of available courses of treatment. Results: The treatment of these patients is changing rapidly, but many questions remain regarding the optimal sequencing of the available drugs. Sequential or concomitant use of the next generation hormonal agents — abiraterone and enzalutamide — cannot currently be recommended. Data regarding the safety of concomitant abiraterone, enzalutamide or denosumab with radium-223 is reassuring and timely. However, we cannot advocate the general use of combined radium-223 therapy at this time, irrespective of prior therapy. Conclusion: A better understanding of active mechanisms, the genetic characteristics of each metastatic castration-resistant prostate cancer and the development of new prognostic and predictive biomarkers will help determine sequencing or different combination treatments for each individual patient. Key Words: castration-resistant prostate cancer, treatment sequence, abiraterone acetate, enzalutamide, radiopharmaceutic
Additional Access Points:
Jiménez, Romero M. E.
Díez, Farto S.
Navarro, Serrato J. C.
Canelón Castillo, E.
Revelo Cadena, I.

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13.

Gastric signet-ring cell carcinoma with hypersecretion of β-Human chorionic gonadotropin and review of the literature [Text] / Kridis W. Ben [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 149-151. - Bibliogr. at the end of the art.

MeSH-main:
РЕЦЕПТОРЫ ЛЮТРОПИНА -- RECEPTORS, LH (анализ, ультраструктура)
ДИАГНОСТИКА ДИФФЕРЕНЦИАЛЬНАЯ -- DIAGNOSIS, DIFFERENTIAL
АНОМАЛИИ ВРОЖДЕННЫЕ -- CONGENITAL ABNORMALITIES (патофизиология, этиология)
БЕЛКИ НОВООБРАЗОВАНИЙ -- NEOPLASM PROTEINS (анализ, диагностическое применение)
ЖЕЛУДКА НОВООБРАЗОВАНИЯ -- STOMACH NEOPLASMS (диагностика, этиология)
КАРЦИНОМА -- CARCINOMA (этиология)
Annotation: β-Human chorionic gonadotropin (β-HCG) is an embryonic protein secreted by the syncytiotrophoblast of the placenta. The determination of the plasma β-HCG level is routinely used for the diagnosis and the follow-up of germ cell tumors. Some adenocarcinomas have been described as being rarely associated with β-HCG hypersecretion. We report a case of gastric signet-ring cell carcinoma with β-HCG hypersecretion and propose hypotheses to explain the pathogenesis of such hypersecretion
Additional Access Points:
Ben, Kridis W.
Ben, Hassena R.
Charfi, S.
Toumi, N.
Boudawara, T.
Khanfir, A.
Frikha, M.

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14.

Anagrelide and the CALR mutation allele burden in essential thrombocythemia [Text] / E. Atkinson [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 152-153. - Bibliogr. at the end of the art.

Rubrics: анагрелид--тер прим

MeSH-main:
МИЕЛОДИСПЛАСТИЧЕСКИЕ-МИЕЛОПРОЛИФЕРАТИВНЫЕ БОЛЕЗНИ -- MYELODYSPLASTIC-MYELOPROLIFERATIVE DISEASES (диагностика, патофизиология, этиология)
ТРОМБОЦИТЕМИЯ ЭССЕНЦИАЛЬНАЯ -- THROMBOCYTHEMIA, ESSENTIAL (осложнения, этиология)
МИЕЛОФИБРОЗ ПЕРВИЧНЫЙ -- PRIMARY MYELOFIBROSIS (патофизиология, терапия, этиология)
ТРОМБОЦИТОВ АГРЕГАЦИИ ИНГИБИТОРЫ -- PLATELET AGGREGATION INHIBITORS (анализ, терапевтическое применение, фармакология)
1-ФОСФАТИДИЛИНОЗИТОЛ-4-КИНАЗА -- 1-PHOSPHATIDYLINOSITOL 4-KINASE (анализ, терапевтическое применение, фармакология)
ИНТЕРФЕРОНЫ -- INTERFERONS (анализ, терапевтическое применение, фармакология)
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Annotation: The myeloproliferative neoplasm of essential thrombocythemia is characterized by a sustained peripheral blood thrombocytosis, increased numbers of morphologically abnormal megakaryocytes in the bone marrow and clinically by episodes of thrombosis or hemorrhage and the propensity to transform into myelofibrosis or acute myeloid leukemia. The main treatment goals are therefore to prevent thrombotic events and to inhibit transformation with antiplatelet and myelosuppressive drugs, respectively. The pathogenesis of essential thrombocythemia is largely defined by three types of driver mutation, namely the JAK2 V617F, CALR exon 9 and MPL exon 10 mutations. Significant improvements have been in the treatment of the related myeloproliferative neoplasm of primary myelofibrosis with JAK1/2 inhibitors, but agents such as interferon and anagrelide remain relevant therapeutic options in the modern treatment algorithm for essential thrombocythemia
Additional Access Points:
Atkinson, E.
Bakri, M.
Hayat, A.
Langabeer, S. E.

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15.

Materials of symposium and summer school “Fundamental Principles of Cancer Biotherapy”, May 21–23, 2018, Kyiv, Ukraine [Text] // Экспериментальная онкология. - 2018. - Т. 40, № 2. - С. 154-176

MeSH-main:
СЪЕЗДЫ, СИМПОЗИУМЫ -- CONVENTIONS, SYMPOSIUMS
БИОЛОГИЧЕСКАЯ ТЕРАПИЯ -- BIOLOGICAL THERAPY (использование, методы, тенденции)
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS (анализ, терапевтическое применение)
Annotation: The International Scientific Symposium “Fundamental Principles of Cancer Biotherapy” was held on May 21–23, 2018 in Kyiv, Ukraine. It was organized by R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (IEPOR) of the National Academy of Sciences of Ukraine (NASU). The symposium was supported by the VACTRAIN project (TWINNING on DNA-based Cancer Vaccines, No 692293) in the frame of the European Union’s Horizon 2020 Research and Innovation Program
Additional Access Points:
Международный научный симпозиум «Фундаментальные принципы биотерапии рака».

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