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1.
Cipher: ЕУ12/2018/40/1
   Journal

Экспериментальная онкология [Text]
2018year Т. 40 № 1
Contents:
Kian, R. Role of components of microRNA machinery in carcinogenesis / R. Kian, S. Moradi, S. Ghorbian. - С.2-9. - Bibliogr. at the end of the art.
Patel, K. R. Clinical implications of p53 alterations in oral cancer progression: a review from India / K. R. Patel [та ін.]. - С.10-18. - Bibliogr. at the end of the art.
Other authors: Vajaria B. N., Singh R. D., Begum R., Patel P. S.
Varela-Castillo, O. Characterization of the cytotoxic effects of the combination of cisplatin and flavanol (-)-epicatechin on human lung cancer cell line A549. An isobolographic approach / O. Varela-Castillo [та ін.]. - С.19-23. - Bibliogr. at the end of the art.
Other authors: Cordero P., Gutierrez-Iglesias G., Palma I., Rubio-Gayosso I., Meaney E., Ramirez-Sanchez I., Villarreal F., Ceballos G., Najera N.
Chaves, K. C. B. Impact of endostatin gene therapy on myeloid-derived suppressor cells from a metastatic renal cell carcinoma / K. C. B. Chaves [та ін.]. - С.24-32. - Bibliogr. at the end of the art.
Other authors: Costa E. M., Teixeira L. F., Bellini M. H.
Sarnatskaya, V. V. Highly activated carbon enterosorbent mediates the suppression of paraneoplastic syndrome associated with lewis lung carcinoma in mice / V. V. Sarnatskaya [та ін.]. - С.33-41. - Bibliogr. at the end of the art.
Other authors: Sakhno L. A., Paziuk L. M., Yushko L. A., Rodionova N. K., Maslenny V. N., Sydorenko A. S., Nikolaev V.G.
Boroday, N. V. Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells / N. V. Boroday, V. F. Chekhun. - С.42-47. - Bibliogr. at the end of the art.
Kurtenkov, O. Signatures of anti-Thomsen — friedenreich antigen antibody diversity in colon cancer patients / O. Kurtenkov, M. Bubina, K. Klaamas. - С.48-58. - Bibliogr. at the end of the art.
Paliychuk, O. V. Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer / O. V. Paliychuk [та ін.]. - С.59-67. - Bibliogr. at the end of the art.
Other authors: Polishchuk L. Z., Rossokha Z. I., Chekhun V. F.
Buchynska, L. G. Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients / L. G. Buchynska, O. V. Brieieva. - С.68-72. - Bibliogr. at the end of the art.
Lozynska, L. Y. Variant of rare hermansky — pudlak syndrome associated with granulomatous colitis: diagnostics clinical course and treatment / L. Y. Lozynska [та ін.]. - С.73-78. - Bibliogr. at the end of the art.
Other authors: Plawski A., Lozynska M. R., Vytvytskyi I., Lozynskyi R. Y., Prokopchuk N., Tretiak B.
Zubenko, O. S. Effect of cytostatic agents on expression levels of human beta-defensins-1-4 in A431 and MCF-7 cell lines / O. S. Zubenko [та ін.]. - С.79-81. - Bibliogr. at the end of the art.
Other authors: Semeniuk D. O., Starenka I. O., Pogribnyy P. V.
Imaniar, R. Mediastinal yolk sac tumor infiltrating the heart / R. Imaniar [та ін.]. - С.82-84. - Bibliogr. at the end of the art.
Other authors: Syahruddin E., Soepandi P. Z., Putra A. C., Nurwidya F.
Ben, Kridis W. A long survival of a patient with brain metastasis of unknown site of the primary tumor / Kridis W. Ben [та ін.]. - С.85-87. - Bibliogr. at the end of the art.
Other authors: Sghaier S., Toumi N., Boudawara Z., Khanfir A., Daoud J., Frikha M.
Symposium and Summer School “Fundamental principles of cancer biotherapy” Kyiv Ukraine May 21-24 2018. - С.88
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2.


    Boroday, N. V.
    Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells [Text] / N. V. Boroday, V. F. Chekhun // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 42-47. - Bibliogr. at the end of the art.


MeSH-main:
КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER (осложнения, патофизиология, терапия, ультраструктура, этиология)
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ НОВООБРАЗОВАНИЙ -- DRUG RESISTANCE, NEOPLASM (физиология)
ТУЧНЫЕ КЛЕТКИ -- MAST CELLS (ультраструктура, физиология)
ДОКСОРУБИЦИН -- DOXORUBICIN (анализ)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Annotation: The mechanisms of drug resistance of cancer have not been yet elucidated in details. Recently, the role of mast cells (MCs) in the development of drug resistance has been brought in the limelight. The aim of the study was to examine the morphological features of doxorubicin (DOX)-resistant Walker 256 carcinosarcoma and to assess the response of MCs and histamine content in these cells in relation to the development of resistance to DOX as well as in DOX-resistant tumors. Materials and Methods: The DOX resistance was induced by serial passages of Walker 256 carcinosarcoma in rats in the setting of DOX treatment in vivo. MCs in tumors were detected in the sections by staining with Toluidine Blue O. Histamine content in MCs stained with solution of Water Blue-Orcein was assessed by Astaldi semiquantitative method taking into account different staining intensity. Results: Formation of DOX resistance in the course of serial passages of Walker 256 carcinosarcoma was accompanied by the increase in the number of MCs in tumors and histamine content. Nevertheless, in tumors with phenotype of complete DOX resistance the number of histamine-containing MCs decreased to the same level as in tumors of the original strain that are DOX-sensitive. Conclusion: MCs are involved in formation of DOX resistance in Walker 256 carcinosarcoma
Additional Access Points:
Chekhun, V. F.

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