Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Cipher: УУ1/2016/88/1
Journal

Український біохімічний журнал . - Published biomonthly
2016year Т. 88 № 1

Contents:
Uspenska, K. R. The effect of amixin and agmatine on cytochrome c release from isolated mitochondria / K. R. Uspenska [и др.]. - С.5-10. - Бібліогр.: в кінці ст.
Other authors: Gergalova G. L., Lykhmus O. Yu., Skok M. V.
Minchenko, O. H. Hypoxic regulation of the expression of cell proliferation related genes in U87 glioma cells upon inhibition of IRE1 signaling enzyme / O. H. Minchenko [и др.]. - С.11-21. - Бібліогр.: в кінці ст.
Other authors: Tsymbal D. O., Minchenko D. O., Riabovol O. O., Ratushna O. O., Karbovskyi L. L.
Sandeep, S. Multiple parametric approaches to assess acute radiation lung injury of rats / S. Sandeep [и др.]. - С.22-30. - Бібліогр.: в кінці ст.
Other authors: Mitra B., Priyanka A., Neeraj K., Aseem B., Neelam C.
Danylovych, H. V. Evaluation of functioning of mitochondrial electron transport chain with NADH and FAD autofluorescence / H. V. Danylovych. - С.31-43. - Бібліогр.: в кінці ст.
Franskevych, D. V. Modulation of cisplatin-induced reactive oxygen species production by fullerene C(60) in normal and transformed lymphoid cells / D. V. Franskevych [и др.]. - С.44-50. - Бібліогр.: в кінці ст.
Other authors: Grynyuk I. I., Prylutska S. V., Matyshevska O. P.
Kоbylinska, L. I. Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier / L. I. Kоbylinska [и др.]. - С.51-60. - Бібліогр.: в кінці ст.
Other authors: Havrylyuk D. Ya., Mitina N. E., Zаichenko A. S., Lesyk R. B., Zіmenkovsky B. S., Stoika R. S.
Rakhmetov, A. D. Prx II and CKBB proteins interaction under physiological and thermal stress conditions in A549 and HeLa cells / A. D. Rakhmetov [и др.]. - С.61-68. - Бібліогр.: в кінці ст.
Other authors: Lee Sang Pil, Ostapchenko L. I., Chae Ho Zoon
Olkhovych, N. V. Chitotriosidase activity as additional biomarker in the diagnosis of lysosomal storage diseases / N. V. Olkhovych. - С.69-78. - Бібліогр.: в кінці ст.
Gudkova, O. O. Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats / O. O. Gudkova, N. V. Latyshko, S. G. Shandrenko. - С.79-87. - Бібліогр.: в кінці ст.
Korneeva, K. L. Expression of genes, encoding the enzymes of cysteine metabolism in human placenta in the first and third trimesters of uncomplicated pregnancy / K. L. Korneeva [и др.]. - С.88-98. - Бібліогр.: в кінці ст.
Other authors: Rodriguez R. R., Ralchenko S. V., Martunovska O. V., Frolova A. О., Martsenyuk O. P., Manzhula L. V., Melnyk V. T., Shkoropad O. Y., Obolenska M. Yu.
Chekhun, V. F. Remodulating effect of doxorubicin on the state of iron-containing proteins, and redox characteristics of tumor with allowance for its sensitivity to cytostatic agents / V. F. Chekhun [и др.]. - С.99-108. - Бібліогр.: в кінці ст.
Other authors: Lozovska Yu. V., Burlaka A. P., Ganusevich I. I., Shvets Yu. V., Lukyanova N. Yu., Todor I. M., Tregubova N. A., Naleskina L. A.
Sokolik, V. V. Effect of β-amyloid peptide 42 on the dynamics of expression and formation of Аβ(40), IL-1β, TNFα, IL-6, IL-10 by peripheral blood mononuclear cells in vitro and its correction by curcumin / V. V. Sokolik, O. K. Koliada, S. M. Shulga. - С.109-118. - Бібліогр.: в кінці ст.
Bazalii, A. V. Transcriptional regulation of NOX genes expression in human breast adenocarcinoma MCF-7 cells is modulated by adaptor protein Ruk/CIN85 / A. V. Bazalii [и др.]. - С.119-125. - Бібліогр.: в кінці ст.
Other authors: Horak I. R., Pasichnyk G. V., Komisarenko S. V., Drobot L. B.
Данилова, В. М. Аналіз винахідницької діяльності відділу біохімії вітамінів і коензимів Інституту біохімії ім. О. В. Палладіна НАН України в 1980–2015 рр. / В. М. Данилова [и др.]. - С.126-140. - Бібліогр.: в кінці ст.
Other authors: Черниш І. Г., Виноградова Р. П., Луговська Г. Г., Юрасова С. П.
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Remodulating effect of doxorubicin on the state of iron-containing proteins, and redox characteristics of tumor with allowance for its sensitivity to cytostatic agents [Text] = Ремодулювальний вплив доксорубіцину на кількісні показники залізовмісних протеїнів та редоксзалежні характеристики пухлини з урахуванням її чутливості до цитостатика / V. F. Chekhun [et al.] // Український біохімічний журнал. - 2016. - Т. 88, № 1. - P99-108. - Бібліогр.: в кінці ст.

MeSH-main:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER (диагностика, кровь, патофизиология, ультраструктура, химия)
ДОКСОРУБИЦИН -- DOXORUBICIN (анализ, биосинтез, кровь, метаболизм, химия)
ФЕРРИТИНЫ -- FERRITINS (анализ, биосинтез, диагностическое применение, метаболизм)
ТРАНСФЕРРИНЫ -- TRANSFERRINS (анализ, биосинтез, диагностическое применение, метаболизм)
КИСЛОРОДА АКТИВНЫЕ ФОРМЫ -- REACTIVE OXYGEN SPECIES (анализ, метаболизм, химия)
Additional Access Points:
Chekhun, V. F.
Lozovska, Yu. V.
Burlaka, A. P.
Ganusevich, I. I.
Shvets, Yu. V.
Lukyanova, N. Yu.
Todor, I. M.
Tregubova, N. A.
Naleskina, L. A.

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Cipher: ЕУ12/2017/39/1
Journal

Экспериментальная онкология [Text]
2017year Т. 39 № 1

Contents:
Circulating tumor cells in breast cancer : functional heterogeneity, pathogenetic and clinical aspects. - С.2-11 : il.
Kashuba, E. Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtag. - С.12-16 : цв. ил.
Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro. - С.17-24 : цв. ил.
Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics. - С.25-29 : табл.
Parthenolide reduces gene transcription of prosurvival mediators in U937 cells. - С.30-35 : il.
Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells. - С.36-41 : il.
Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma. - С.42-48 : табл.
EPR spectroscopy studies of changes in erythrocyte membranes in patients with laryngeal cancer. - С.49-52 : табл.
Auzina, D. Prognostic value of the bone turnover markers in multiple myeloma / D. Auzina, R. Erts, S. Lejniece. - С.53-56 : табл.
Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population. - С.57-64 : табл.
Chekhun, V. F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova. - С.65-68 : табл.
Satinder, K. Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women / K. Satinder, R. C. Sobti, K. Pushpinder. - С.69-74 : табл.
The impact of coloregional treatment on survival of patients with primary metastatic breast cancer. - С.75-77 : табл.
Diagnostic challenges with intraoral myeloid sarcoma : Report of two cases & review of world literature. - С.78-85 : цв. ил.
Trichilemmal cystis in metastatic melanoma : A case report. - С.86-87 : цв. ил.
Materials of international vactrain/ 3-rd Swedish-Ukrainian conference on cancer diseases, January 16-17, 2017, Stockholm, Sweden. - С.88-93
Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells. - С.88-89
The adaptor protein Ruk/CIN85 paradoxically enhances EMT of triple negative mouse breast adenocarcinoma 4T1 cells. - С.89
Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines. - С.89-90
Alternative direction of inhibition of malignant properties in tumor cells in vitro and in vivo by gene therapy with INF-beta gene in recombinant baculovirus vector. - С.90
CD150/SLAMF1 as a new potential target for anti-tumor therapy. - С.90-91
CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia. - С.91-92
Borikun, T. Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer / T. Borikun, N. Lukianova, V. Chekhun. - С.92
The MRPS 18-2 protein as a putative marker of carcinogenesis. - С.92
High expression levels of MRPS 18-2 and presence of the RB protein are required for the maintenance of stem cell phenotype. - С.92-93
Mankovska, O. Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors / O. Mankovska, V. Kashuba. - С.93
Brieieva, O. Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients / O. Brieieva, I. Nesina, L. Buchynska. - С.93
Kyiv, May 11-12, 2017 Workshop with international participation. New trends in cancer research and innovative tumor vaccines. - С.94
International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine. - С.95
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Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics / V. F. Chekhun [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P25-29 : табл. - 21 ref.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия)
АРТЕМИЗИНИНЫ -- ARTEMISININS
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ -- DRUG RESISTANCE
Annotation: To explore effects of Artemisinin on a series of breast cancer cells with different sensitivity to typical cytotoxic drugs (doxorubicin — Dox; cisplatin — DDP) and to investigate possible artemisinin-induced modification of the mechanisms of drug resistance. Materials and Methods: The study was performed on wild-type breast cancer MCF-7 cell line (MCF-7/S) and its two sublines MCF-7/Dox and MCF-7/DDP resistant to Dox and DDP, respectively. The cells were treated with artemisinin and iron-containing magnetic fluid. The latter was added to modulate iron levels in the cells and explore its role in artemisinin-induced effects. The MTT assay was used to monitor cell viability, whereas changes of expression of selected proteins participating in regulation of cellular iron homeostasis were estimated using immunocytochemical methods. Finally, relative expression levels of miRNA-200b, -320a, and -34a were examined by using qRT-PCR. Results: Artemisinin affects mechanisms of the resistance of breast cancer cells towards both Dox and DDP at sub-toxic doses. The former drug induces changes of expression of iron-regulating proteins via different mechanisms, including epigenetic regulation. Particularly, the disturbances in ferritin heavy chain 1, lactoferrin, hepcidin (decrease) and ferroportin (increase) expression (р ≤ 0.05) were established. The most enhanced increase of miRNA expression under artemisinin influence were found for miRNA-200b in MCF-7/DDP cells (7.1 ± 0.98 fold change), miRNA-320a in MCF-7/Dox cells (2.9 ± 0.45 fold change) and miRNA-34a (1.7 ± 0.15 fold change) in MCF-7/S cells. It was observed that the sensitivity to artemisinin can be influenced by changing iron levels in cells. Conclusions: Artemisinin can modify iron metabolism of breast cancer cells by its cytotoxic effect, but also by inducing changes in expression of iron-regulating proteins and microRNAs (miRNAs), involved in their regulation. This modification affects the mechanisms that are implicated in drug-resistance, that makes artemisinin a perspective modulator of cell sensitivity towards chemotherapeutic agents in cancer treatment
Additional Access Points:
Chekhun, V.F.
Lukianova, N.Y.
Borikun, T.V.
Zadvornyi, T.V.
Mokhir, A.

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Chekhun, V. F.
Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova // Experimental Oncology. - 2017. - Том 39, N 1. - P65-68 : табл. - 16 ref.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия)
ХИМИОТЕРАПИЯ АДЪЮВАНТНАЯ -- CHEMOTHERAPY, ADJUVANT
СИМПОРТЕРЫ -- SYMPORTERS
Annotation: The aim of the research was to study the relation between expression of Na⁺/I⁻symporter (NIS) in breast cancer (BC) of different molecular subtypes and sensitivity of BC cells to neoadjuvant chemotherapy (NACT) and to assess whether NIS expression may be used as a predictive marker of treatment efficacy. Materials and Methods: The study included 148 women with BC of stage II–III who were treated at the Precarpathian Clinical Oncology Center during 2012–2017. All patients were treated with NACT that included 2–6 cycles of chemotherapy by FAC, AC scheme with 21 day intervals. NACT efficacy was evaluated every 2 cycles by mammography according to RECIST criteria. Morphological and immunohistochemical study of NIS expression was performed by the standard methods on paraffin sections of surgically resected tumors. Results: The heterogeneity of different molecular BC subtypes regarding response to the NACT has been found. Her2/neu-positive and basal BC subtypes were the least susceptible to the NACT (p 0.05). It was shown that NIS expression is related to the sensitivity of luminal B and basal BC subtypes to the NACT. The highest expression of NIS and impairment of its functional activity was registered in the group of patients with tumors resistant to NACT (stabilization of the disease or its progression) of luminal B (220 ± 8.6 points) and basal subtypes (290 ± 11.3 points) (p 0.05). It was revealed that the disease-free survival of patients with BC of luminal B and basal subtypes was higher in the absence of NIS expression in tumor cells (p 0.05). Conclusions: The results indicate that NIS can be used as an objective criterion for predicting the sensitivity of luminal B and basal BC subtypes to NACT, which will provide improved treatment outcomes in this group of patients
Additional Access Points:
Andriiv, A.V.
Lukianova, N.Yu.

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Cipher: УУ60/2017/89/2
Journal

The Ukrainian biochemical journal [Text]. - Published biomonthly
2017year Т. 89 № 2

Contents:
Shtemenko, A. V. Rhenium-platinum antitumor systems / A. V. Shtemenko, N. I. Shtemenko. - P.5-30
Minchenko, O. H. Effect of chromium disilicide and titanium nitride nanoparticles on the expression of NAMPT, E2F8, FAS, TBX3, IL13RA2, and UPS7 genes in mouse liver / О. Н. Minchenko [et al.]. - P.31-42
Other authors: Yavorovsky O. P., Solokha N. V., Minchenko D. O., Kuznetsova A. Y.
Tykhomyrov, A. A. Plasminogen and its fragments in rat brain: a plausible role for astrocytes in angiostatin generation / A. A. Tykhomyrov [et al.]. - P.43-54
Other authors: Nedzvetsky V. S., Agca C. A., Korsa V. V., Grinenko T. V.
Minchenko, O. H. IRE1 knockdown modifies hypoxic regulation of cathepsins and LONP1 genes expression in U87 glioma cells / О. Н. Minchenko [et al.]. - P.55-69
Other authors: Riabovol О. O., Halkin O. V., Minchenko D. O., Ratushna O. O.
Kaplia, A. A. Different sensitivity of Na+,K+-ATPase and Mg2+-ATPase to ethanol and arachidonic acid in rat colon smooth muscle under pretreatment of cellular membranes with Ds-Na / A. A. Kaplia. - P.70-77
Biliavska, L. O. Sterols biosynthesis by soil streptomycetes / L. O. Biliavska [et al.]. - P.78-84
Other authors: Ostapchuk A. M., Voychuk S. I., Iutynska G. O.
Kosyk, O. I. Phenylalanine ammonia-lyase activity and anthocyanin content in different varieties of lettuce under the cadmium influence / O. I. Kosyk [et al.]. - P.85-91
Other authors: Khomenko I. M., Batsmanova L. M., Taran N. Yu.
Kopylchuk, H. P. Rat liver arginase system under acetaminophen-induced toxic injury and protein deprivation / H. P. Kopylchuk, I. M. Nykolaichuk, O. M. Zhuretska. - P.92-98
Korol, L. V. Intensity of oxidative stress and activity of angiotensin converting enzyme in blood of patients with uncomplicated pyelonephritis / L. V. Korol, L. Ya. Mygal, N. M. Stepanova. - P.99-105
Kozachkova, O. M. Complexes of palladium(II) with 1-phenyl-1-hydroxymethylene bisphosphonic acid and their antitumor activity / O. M. Kozachkova [et al.]. - P.106-115
Other authors: Tsaryk N. V., Trachevskyi V. V., Rozhenko A. B., Shermolovich Yu. H., Guzyr O. I., Sharykina N. I., Chekhun V. F., Pekhnyo V. I.
Ellidag, H. Y. A novel method for negating cold agglutination interference by dithiothreitol during complete blood count and peripheral blood smear: a case study / H. Y. Ellidag [et al.]. - P.116-120
Other authors: Kulaksizoglu S., Eren E., Yilmaz N.
Данилова, В. М. Науково-практична діяльність відділу нейрохімії Інституту біохімії ім. О. В. Палладіна НАН України / В. М. Данилова, Р. П. Виноградова, Г. Г. Луговська. - P.121-134
Вельмишановна та дорога Валентино Михайлівно! (до 80-річчя від дня народження). - P.135
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Complexes of palladium(II) with 1-phenyl-1-hydroxymethylene bisphosphonic acid and their antitumor activity / O. M. Kozachkova [et al.] // The Ukrainian Biochemical Journal. - 2017. - Том 89, N 2. - P106-115

MeSH-main:
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS (терапевтическое применение)
ПАЛЛАДИЙ -- PALLADIUM (терапевтическое применение)
Annotation: Complex formation of K₂[PdCl₄] with 1-phenyl-1-hydroxymethylene bisphosphonic acid (PhHMBP, H₄L) has been studied by pH potentiometry, electron and NMR spectroscopy. It was found that in aqueous solution with physiological concentration of chlorine anions (0.15 mol/l KCl), anionic complexes of the equimolar compositions [PdHLCl₂]^3- (lgβ = 24.51 (0.3)) and [PdLCl₂]^4-(lgβ = 20.74 (0.02)) are formed. In the first coordination sphere palladium was surrounded by two oxygen atoms of two phosphonic groups of the bidentately coordinated ligand with closure of six-membered [O, O] ring, and two chlorine anions. The formation of palladium(II) equimolar complexes with PhHMBP and bidentate coordination of the ligand to the central metal cation was confirmed by³¹P NMR spectroscopy. Cytotoxic activity (IC₅₀ based on metal content) of the synthesized Pd(II) complexes with PhHMBP against human MG-63 osteosarcoma and MCF-7 mammary tumor cells was compared with cisplatin on in vitro models. It was established that cytotoxic activity of the Pd complexes was lower than that of cisplatin. The acute toxicity (LD₅₀ based on metal content) of solutions of Pd(II) complexes with PhHMBP was found to be lower compared to cisplatin. It was shown that the use of solutions of palladium(II) complexes with PhHMBP inhibited tumor growth in mice with sarcoma 180
Additional Access Points:
Kozachkova, O. M.
Tsaryk, N. V.
Trachevskyi, V. V.
Rozhenko, A. B.
Shermolovich, Yu. H.
Guzyr, O. I.
Sharykina, N. I.
Chekhun, V. F.
Pekhnyo, V. I.

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Cipher: ЕУ12/2019/41/4
Journal

Экспериментальная онкология [Text]
2019year Т. 41 № 4 . - 45.41, р.

Contents:
Karaman, O. M. Macrophages - a perspective target for antineoplastic immunotherapy / O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun. - С.282-290
Orel, V. E. Nоn-linear dynamics theory and malignant melanoma / V. E. Orel [et al.]. - С.291-299
Other authors: Korovin S. I., Molnair J., Orel V. B.
Lisyany, N. I. Cytomegaloviruses and malignant brain tumors / N. I. Lisyany [et al.]. - С.300-303
Other authors: Klyuchnikova A. A., Belskaya L. N., Lisyany A. A., Gnedkova I. A.
Woksepp, H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392 / H. Woksepp [et al.]. - С.304-311
Other authors: Saini R. K. R., Zakharchenko O., Gautier A., Souchelnytskyi N., Souchelnytskyi S.
Dehghan, Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression / Nayeri M. J. Dehghan [et al.]. - С.312-317
Other authors: Mahdavi M., Fazeli H., Hosseinpour Feizi M. A.
Albuquerque, A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation / A. P. B. Albuquerque [et al.]. - С.318-322
Other authors: Silva A. L. V., Lima C. A. D., Beltrao E. I. C.
Skuja, E. Deletions in metastatic colorectal cancer with chromothripsis / E. Skuja [et al.]. - С.323-327
Other authors: Butane D., Nakazawa-Miklasevica M., Daneberga Z., Purkalne G., Miklasevics E.
Burlaka, A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer / A. P. Burlaka [et al.]. - С.328-334
Other authors: Burlaka A. A., Virko S. V., Ganusevich I. I.
Buchynska, L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina. - С.335-341
Zelinskaya, A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer / A. Zelinskaya. - С.342-345
Moazeni-Roodi, A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls / A. Moazeni-Roodi, M. Taheri, M. Hashemi. - С.346-352
Skrypnyk, I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy / I. Skrypnyk [et al.]. - С.353-356
Other authors: Maslova G., Lymanets T., Gusachenko I.
Gavars, D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia / D. Gavars [et al.]. - С.357-362
Other authors: Perminov D., Tauckels E., Lindenberga I., Auce A., Lejniece S.
Prylutskyi, M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles / M. P. Prylutskyi, M. F. Starodub. - С.363-365
Shkatula, P. M. International scientific conference "Tumor and Host: novel aspects of old problem" / P. M. Shkatula. - С.366-367
To the 120th birthday anniversary of academician R. E. Kavetsky. - С.368-369
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Karaman, O. M.
Macrophages - a perspective target for antineoplastic immunotherapy / O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun // Experimental Oncology. - 2019. - Том 41, N 4. - P282-290

Annotation: The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity
Additional Access Points:
Ivanchenko, A. V.
Chekhun, V. F.

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10.

Cipher: ЕУ12/2020/42/2
Journal

Экспериментальная онкология [Text]
2020year Т. 42 № 2

Contents:
Shvets, Yu. V. Human microbiota and effectiveness of cancer chemotherapy / Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun. - С.82-93
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