Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Cipher: ЕУ12/2017/39/1
Journal

Экспериментальная онкология [Text]
2017year Т. 39 № 1

Contents:
Circulating tumor cells in breast cancer : functional heterogeneity, pathogenetic and clinical aspects. - С.2-11 : il.
Kashuba, E. Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtag. - С.12-16 : цв. ил.
Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro. - С.17-24 : цв. ил.
Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics. - С.25-29 : табл.
Parthenolide reduces gene transcription of prosurvival mediators in U937 cells. - С.30-35 : il.
Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells. - С.36-41 : il.
Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma. - С.42-48 : табл.
EPR spectroscopy studies of changes in erythrocyte membranes in patients with laryngeal cancer. - С.49-52 : табл.
Auzina, D. Prognostic value of the bone turnover markers in multiple myeloma / D. Auzina, R. Erts, S. Lejniece. - С.53-56 : табл.
Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population. - С.57-64 : табл.
Chekhun, V. F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova. - С.65-68 : табл.
Satinder, K. Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women / K. Satinder, R. C. Sobti, K. Pushpinder. - С.69-74 : табл.
The impact of coloregional treatment on survival of patients with primary metastatic breast cancer. - С.75-77 : табл.
Diagnostic challenges with intraoral myeloid sarcoma : Report of two cases & review of world literature. - С.78-85 : цв. ил.
Trichilemmal cystis in metastatic melanoma : A case report. - С.86-87 : цв. ил.
Materials of international vactrain/ 3-rd Swedish-Ukrainian conference on cancer diseases, January 16-17, 2017, Stockholm, Sweden. - С.88-93
Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells. - С.88-89
The adaptor protein Ruk/CIN85 paradoxically enhances EMT of triple negative mouse breast adenocarcinoma 4T1 cells. - С.89
Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines. - С.89-90
Alternative direction of inhibition of malignant properties in tumor cells in vitro and in vivo by gene therapy with INF-beta gene in recombinant baculovirus vector. - С.90
CD150/SLAMF1 as a new potential target for anti-tumor therapy. - С.90-91
CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia. - С.91-92
Borikun, T. Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer / T. Borikun, N. Lukianova, V. Chekhun. - С.92
The MRPS 18-2 protein as a putative marker of carcinogenesis. - С.92
High expression levels of MRPS 18-2 and presence of the RB protein are required for the maintenance of stem cell phenotype. - С.92-93
Mankovska, O. Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors / O. Mankovska, V. Kashuba. - С.93
Brieieva, O. Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients / O. Brieieva, I. Nesina, L. Buchynska. - С.93
Kyiv, May 11-12, 2017 Workshop with international participation. New trends in cancer research and innovative tumor vaccines. - С.94
International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine. - С.95
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Chekhun, V. F.
Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova // Experimental Oncology. - 2017. - Том 39, N 1. - P65-68 : табл. - 16 ref.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия)
ХИМИОТЕРАПИЯ АДЪЮВАНТНАЯ -- CHEMOTHERAPY, ADJUVANT
СИМПОРТЕРЫ -- SYMPORTERS
Annotation: The aim of the research was to study the relation between expression of Na⁺/I⁻symporter (NIS) in breast cancer (BC) of different molecular subtypes and sensitivity of BC cells to neoadjuvant chemotherapy (NACT) and to assess whether NIS expression may be used as a predictive marker of treatment efficacy. Materials and Methods: The study included 148 women with BC of stage II–III who were treated at the Precarpathian Clinical Oncology Center during 2012–2017. All patients were treated with NACT that included 2–6 cycles of chemotherapy by FAC, AC scheme with 21 day intervals. NACT efficacy was evaluated every 2 cycles by mammography according to RECIST criteria. Morphological and immunohistochemical study of NIS expression was performed by the standard methods on paraffin sections of surgically resected tumors. Results: The heterogeneity of different molecular BC subtypes regarding response to the NACT has been found. Her2/neu-positive and basal BC subtypes were the least susceptible to the NACT (p 0.05). It was shown that NIS expression is related to the sensitivity of luminal B and basal BC subtypes to the NACT. The highest expression of NIS and impairment of its functional activity was registered in the group of patients with tumors resistant to NACT (stabilization of the disease or its progression) of luminal B (220 ± 8.6 points) and basal subtypes (290 ± 11.3 points) (p 0.05). It was revealed that the disease-free survival of patients with BC of luminal B and basal subtypes was higher in the absence of NIS expression in tumor cells (p 0.05). Conclusions: The results indicate that NIS can be used as an objective criterion for predicting the sensitivity of luminal B and basal BC subtypes to NACT, which will provide improved treatment outcomes in this group of patients
Additional Access Points:
Andriiv, A.V.
Lukianova, N.Yu.

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Cipher: ЕУ12/2020/42/2
Journal

Экспериментальная онкология [Text]
2020year Т. 42 № 2

Contents:
Shvets, Yu. V. Human microbiota and effectiveness of cancer chemotherapy / Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun. - С.82-93
Zadvornyi, T. V. Nanog as prognostic factor of prostate cancer course / T. V. Zadvornyi [et al.]. - С.94-100
Other authors: Lukianova N. Yu., Borikun T. V., Vitruk Yu. V., Stakhovsky E. O., Chekhun V. F.
Lamdan, H. Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin / H. Lamdan [et al.]. - С.101-108
Other authors: Garcia-Lazaro R. S., Lorenzo N., Galigiuri L. G., Alonso D. F., Farina H. G.
Antonenko, S. V. Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells / S. V. Antonenko, G. D. Telegeev. - С.109-114
Onyshchenko, K. V. Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma / K. V. Onyshchenko [et al.]. - С.115-119
Other authors: Voitsitskyi T. V., Grygorenko V. M., Saidakova N. O., Pereta L. V., Onyschuk A. P., Skrypkina I. Ya.
Stegantseva, M. V. Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model / M. V. Stegantseva [et al.]. - С.120-125
Other authors: Shinkevich V. A., Tumar E. M., Meleshko A. N.
Andreieva, S. V. Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias / S. V. Andreieva [et al.]. - С.126-129
Other authors: Kyselova O. A., Serbin I. M., Alkhimova O. G.
Bialik, P. HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer / P. Bialik [et al.]. - С.130-134
Other authors: Wysokinski D., Slomka M., Morawiec Z., Strapagiel D., Wozniak K.
Pankaj, D. Clinicopathological correlation of the expression of excision repair cross complementation group 1 (ERCC1) in oral cavity squamous cell carcinomas: an immunohistochemical study / D. Pankaj, V. Guddattu, M. C. Solomon. - С.135-139
Lyalkin, S. A. Prognostic role of androgen receptor expression in patients with metastatic triple negative breast cancer / S. A. Lyalkin [et al.]. - С.140-143
Other authors: Verevkina N. O., Alekseyenko O. O., Syvak L. A.
Perekhrestenko, T. Expression of Ki-67 and CD34 on blood and bone marrow cells of CML patients with different response to imatinib and nilotinib therapy / T. Perekhrestenko [et al.]. - С.144-147
Other authors: Melnyk U., Goryainova N., Diagil I.
Glavatskyi, O. Ya. Temozolomide in glioblastoma treatment: 15-year clinical experience and analysis of its efficacy / O. Ya. Glavatskyi [et al.]. - С.148-156
Other authors: Zemskova O. V., Khmelnytskyi H. V., Kardash K. A., Shuba I. M., Stuley V. A.
Kliusov, O. M. Specialized care provided to patients with rectal cancer in Kyiv city / O. M. Kliusov. - С.157-160
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Shvets, Yu. V.
Human microbiota and effectiveness of cancer chemotherapy / Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun // Experimental Oncology. - 2020. - Том 42, N 2. - P82-93

MeSH-main:
НОВООБРАЗОВАНИЯ -- NEOPLASMS (лекарственная терапия, микробиология)
Annotation: This review presents up-to-date information on the effects of microbiota on the individual chemotherapy sensitivity in cancer treatment. Recent studies have shown that a fine balance between the intestinal microbiota and the immune system is crucial for maintaining an efficacy of cancer chemotherapy. A number of antitumor drugs have complex mechanisms of action involving not only direct effects but also the activity of the intestinal microbiota and the immune system. A unique combination of these factors contributes to the individual chemotherapy sensitivity
Additional Access Points:
Lukianova, N. Yu.
Chekhun, V. F.

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Nanog as prognostic factor of prostate cancer course / T. V. Zadvornyi [et al.] // Experimental Oncology. - 2020. - Том 42, N 2. - P94-100

MeSH-main:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (терапия)
Annotation: The variability of the clinical course of prostate cancer (PC) indicates the need to find factors that could predict the aggressive potential of neoplasms accounting the biological characteristics of tumor cells. In this context, the role of NANOG, a transcription factor involved in maintaining pluripotency and one of the markers of cancer stem cells (CSCs), is being actively studied today. Aim: To investigate the level of NANOG mRNA in tumor tissue of patients with PC and to analyze the possibility of its use as a marker of the disease course. Materials and Methods: The study involved 85 patients with PC of stages II–IV. Morphological and immunohistochemical studies were performed on serial paraffin sections of resected PC using monoclonal antibodies to Ki-67 and androgen receptor. NANOG and miR-214 mRNA expression in tumor cells was analyzed by real-time reverse transcription polymerase chain reaction. The identification of CSCs was performed by double-labeled immunohistochemical method using primary antibodies to CD24 and CD44. Results: We have revealed notable variability of NANOG mRNA levels in tumor tissue of patients with PC (mean 4.18 ± 0.65 a.u. with individual deviations from 0.11 ± 0.03 a.u. to 15.24 ± 0.36 a.u.). According to NANOG mRNA levels, two groups of the PC patients were delineated: group 1 and group 2, with the average NANOG mRNA levels of 2.12 ± 0.16 a.u., and 8.68 ± 1.24 a.u., respectively. The NANOG mRNA levels in tumor tissue of PC patients of groups 1 and 2 correlated with preoperative serum prostate-specific antigen level (r = 0.58; p 0.05 and r
Additional Access Points:
Zadvornyi, T. V.
Lukianova, N. Yu.
Borikun, T. V.
Vitruk, Yu. V.
Stakhovsky, E. O.
Chekhun, V. F.

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Cipher: ФУ6/2019/65/6
Journal

Фізіологічний журнал . - Published biomonthly
2019year Т. 65 № 6

Contents:
Полякова, Л. І. Андрогенна функція сім’яників і стан сперматозоїдів молодих і старіючих щурів після тривалого інгібування ароматази стероїдів та його відміни / Л. І. Полякова [та ін.]. - С.3-11
Other authors: Сачинська О. В., Фалюш О. А., Резніков О. Г.
Струтинська, Н. А. Аміногуанідин відновлює ендогенний синтез сірководню, конститутивний синтез оксиду азоту, ендотелійзалежну вазодилатацію та пригнічує відкривання мітохондріальної пори у серці старих щурів / Н. А. Струтинська [та ін.]. - С.12-21
Other authors: Лучкова А. Ю., Мись Л. А., Коркач Ю. В., Сагач В. Ф.
Телька, М. В. Вплив норадреналіну на електричну активність культивованих нейронів ганглія трійчастого нерва / М. В. Телька [та ін.]. - С.22-29
Other authors: Маслов В. Ю., Федулова С. А., Веселовський М. С.
Котлярова, А. Б. Функціонування катіонних каналів великої провідності ядерної мембрани під впливом модуляторів нікотинових холінорецепторів / А. Б. Котлярова [та ін.]. - С.30-37
Other authors: Котик О. А., Юришинець І. В., Харченко С. М.
Драчук, К. О. Ендотеліальний моноцитактивуючий фактор II відновлює ендотелійзалежне розслаблення судин при старінні / К. О. Драчук [та ін.]. - С.38-42
Other authors: Коркач Ю. П., Дорофеєва Н. О., Корнелюк О. І., Сагач В. Ф.
Грушка, Н. Г. Протективна дія цитрату германію на функціональний стан імунокомпетентних клітин та активність нейтрофілів при запаленні, індукованому ліпополісахаридом / Н. Г. Грушка [та ін.]. - С.43-50
Other authors: Павлович С. І., Кондрацька О. А., Пількевич Н. О., Янчій Р. І.
Ісаєнко, О. Ю. Протидифтерійні властивості структурно-метаболітних комплексів пробіотичних штамів лактобактерій і сахароміцетів у тестах in vitro та in vivo / О. Ю. Ісаєнко. - С.51-60
Деген, А. С. Розподіл FOXP3⁺- та ROR?t⁺-лімфоцитів у кишковоасоційованій лімфоїдній тканині щурів при цукровому діабеті та введенні неселективних блокаторів фактора некрозу пухлин ? / А. С. Деген, О. М. Камишний. - С.61-69
Lozovska, Yu. V. Relationship aggressiveness of prostate cancer with tumor-associated serum markers / Yu. V. Lozovska [et al.]. - С.70-80
Other authors: Naleskina L. A., Zadvorniy T. V., Andrusishina I. M., Zhulkevych I. V., Stakhovskiy E. O., Kunska L. M., Lukianova N. Yu.
Chernenko, O. Papillary thyroid cancer and thyroid stimulating hormone: does sex matter? / O. Chernenko, O. Sulaieva. - С.81-87
Бредун, О. Ю. Фактори природженого і антивірусного імунітету в ротоглотковому секреті, екстрактах тканин та лізатах клітин піднебінних мигдаликів дітей при їхній гіпертрофії та хронічному запаленні / О. Ю. Бредун [та ін.]. - С.88-93
Other authors: Мельников О. Ф., Тимченко М. Д., Фараон І. В.
Натрус, Л. В. Роль NF-κβ у диференціюванні та активації нейтрофілів під час загоєння опікової рани шкіри щурів / Л. В. Натрус [та ін.]. - С.94-104
Other authors: Рижко І. М., Лісаковська О. О., Тихомиров А. О., Лабудзинський Д. О., Панова Т. І.
Прудніков, І. М. Сучасні уявлення про міжклітинну везикулярну сигналізацію / І. М. Прудніков [та ін.]. - С.105-125
Other authors: Цивкін В. М., Смірнов А. М., Прісташ І. В., Черняк В. А., Селюк В. М., Музиченко П. Ф.
Про XX з’їзд Українського фізіологічного товариства ім. П.Г. Костюка, з міжнародною участю, присвяченого 95-річчю від дня народження академіка П.Г. Костюка (Київ, 27-30 травня 2019 р.). - С.126-130
До ювілею Олександра Григоровича Резнікова. - С.131-132
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Relationship aggressiveness of prostate cancer with tumor-associated serum markers [Text] / Yu. V. Lozovska [et al.] // Фізіологічний журнал. - 2019. - Том 65, N 6. - P70-80

MeSH-main:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (кровь)
ЛАКТОФЕРРИН -- LACTOFERRIN (кровь)
C-РЕАКТИВНЫЙ БЕЛОК -- C-REACTIVE PROTEIN (анализ)
АЛЬБУМИН СЫВОРОТОЧНЫЙ -- SERUM ALBUMIN (анализ)
Annotation: Досліджено вміст сироваткових пухлиноасоційованих маркерів: лактоферин (ЛФ), С-реактивний протеїн (СРП), альбумін, лактатдегідрогеназа (ЛДГ), співвідношення Ca/Mg та СРП/альбумін, у хворих на рак передміхурової залози залежно від клініко-патологічних характеристик захворювання. Крім того, визначено ступінь злоякісності новоутворень за Глісоном і наявність метастазів у регіонарні лімфатичні вузли. Показано, що у сироватці крові хворих на рак III стадії порівняно із II знижувався у 1,4 раза вміст ЛФ та зменшувалося співвідношення СРП/ альбумін на фоні достовірного збільшення вмісту СРП та співвідношення Ca/Mg (у 2,75 та 1,12 раза відповідно). Водночас у хворих із метастатичним ураженням регіонарних лімфатичних вузлів порівняно із пацієнтами без цих ознак виявлено зменшення у 1,3 раза вмісту ЛФ та альбуміну у 1,16 раза при одночасному зростанні вмісту СРП та співвідношення Ca/Mg (у 2,84 та 1,1 раза відповідно) та зниження СРП/альбумін. Показано, що у сироватці крові хворих із високим ступенем злоякісності новоутворень (8 та 9 балів за шкалою Глісона) та вмістом простатспецифічного антигена (ПСА) більш ніж 4 нг/мл, порівняно зі значеннями у пацієнтів з менш вираженими ознаками пухлинної прогресії, суттєво знижувався вміст сироваткового ЛФ та альбуміну на фоні підвищеного співвідношення Ca/Mg, СРП/альбумін і вмісту ЛДГ. Зазначені відмінності у різних ланках метаболічних шляхів в організмі хворих на рак передміхурової залози з більш агресивним проявом захворювання свідчать про несприятливий перебіг пухлинного процесу. Отримані результати дають підстави вважати, що сироватковий ЛФ може бути використаний як додатковий позапухлинний маркер для прогнозу цього захворювання.
Additional Access Points:
Lozovska, Yu. V.
Naleskina, L. A.
Zadvorniy, T. V.
Andrusishina, I. M.
Zhulkevych, I. V.
Stakhovskiy, E. O.
Kunska, L. M.
Lukianova, N. Yu.

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Cipher: ЕУ12/2018/40/4
Journal

Экспериментальная онкология [Text]
2018year Т. 40 № 4

Contents:
Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F Chekhun. - С.258-260
Tari, K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia / K. Tari [et al.]. - С.261-267
Other authors: Shamsi Z., Ghafari H. R., Atashi A., Shahjahani M., Abroun S.
Chekhun, V. F. Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.]. - С.268-274
Other authors: Todor I. N., Lukianova N. Yu., Horbyk D. M., Lozovskaya Yu. V., Burlaka A. P., Borikun T. V.
Symchych, T. V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model / T. V. Symchych [et al.]. - С.275-281
Other authors: Fedosova N. I., Karaman O. M., Voyeykova I. M., Didenko G. V.
Yakymenko, I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation / I. Yakymenko [et al.]. - С.282-287
Other authors: Burlaka A., Tsybulin O., Brieieva O., Buchynska L., Tsehmistrenko S., Chekhun V.
Smal, M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer / M. P. Smal [et al.]. - С.288-298
Other authors: Kuzhir T. D., Savina N. V., Nikitchenko N. V., Rolevich A. I., Krasny S. A., Goncharova R. I.
Abooshahab, R. Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer / R. Abooshahab [et al.]. - С.299-302
Other authors: Niyazi E., Yaghmaie P., Chadaksaz H. G., Hedayati M.
Buchynska, L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.]. - С.303-308
Other authors: Iurchenko N. P., Kashuba E. V., Brieieva O. V., Glushchenko N. M., Mints M., Lukianova N. Yu., Chekhun V. F.
Arabpour, F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients / F. Arabpour [et al.]. - С.309-314
Other authors: Shafizad A., Rahimzadeh M., Norouzian M., Naderi N.
Gerashchenko, G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer / G. V. Gerashchenko [et al.]. - С.315-322
Other authors: Grygoruk O. V., Kononenko O. A., Gryzodub O. P., Stakhovsky E. O., Kashuba V. I.
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Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P268-274

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (метаболизм, патофизиология)
Annotation: To study the effect of Ferroplat (FrP) on the indexes of pro/antioxidant balance and energy metabolism in breast cancer cells of different malignancy degree and different sensitivity to drug therapy. Materials and Methods: The study was carried out on breast cancer cells of low (T47D, MCF-7) and high malignancy degree (MCF-7/DDP (cisplatin-resistant), MDA-MB-231, MDA-MB-468) using cell culture techniques, immunocytochemical, biochemical, biophysical methods, flow cytometry and polarography. Results: We established that the addition of FrP to the culture medium reduces the activity of glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD) and the level of non-protein thiols by 32–41% (p 0.05). At the same time, there was an increase of the total level of ROS and the rate of NO generation by inducible NO synthase by 1.7–2.5 times (p 0.05). This testifies that FrP disturbs the antioxidant balance in cells, resulting in their death. Also, the use of FrP led to a decrease in the rate of oxygen absorption in MCF-7 and T47D cells by 26% and 25%, respectively (p 0.05). In cells of high malignancy degree this index decreased by 38–40% under the influence of FrP. Incubation of MCF-7 and T47D cells with the indicated agent also reduced the content of phospholipid cardiolipin by 15–16% (p 0.05), and in MDA-MB-231, MCF-7/DDP, MDA-MB-468 cells — by 29%, 30% and 32%, respectively. In addition, the effect of FrP caused a decrease in the levels of Mg2+ and lactate in MCF-7 and T47D cells by 21–29% and 14–24%, respectively, whereas in MDA-MB-231, MDA-MB-468, MCF-7/DDP cells — by 34–38% and 32–35%, respectively. In this case, the agent raised the level of glucose in the cells of low malignancy degree by 20–23% (p 0.05), and in the cells of high malignancy degree and with the phenotype of drug resistance — by 31–36%. However, the nanocomposite did not affect the activity of lactate dehydrogenase in all studied breast cancer cells. Conclusion: The study has shown that FrP has an effect on the pro/antioxidant balance and energy metabolism of cancer cells. In addition, the denoted effect of FrP was more pronounced in the breast cancer cells with a high malignancy degree and the phenotype of drug resistance
Additional Access Points:
Chekhun, V. F.
Todor, I. N.
Lukianova, N. Yu.
Horbyk, D. M.
Lozovskaya, Yu. V.
Burlaka, A. P.
Borikun, T. V.

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Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P303-308

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика, метаболизм, патофизиология)
ВНУТРИКЛЕТОЧНЫЕ СИГНАЛЬНЫЕ ПЕПТИДЫ И БЕЛКИ -- INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS (метаболизм)
Annotation: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients
Additional Access Points:
Buchynska, L. G.
Iurchenko, N. P.
Kashuba, E. V.
Brieieva, O. V.
Glushchenko, N. M.
Mints, M.
Lukianova, N. Yu.
Chekhun, V. F.

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