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Search inquiry: (<.>S=Спиросоединения<.>)
Total number of found documents : 9
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1.


    Федірко, Н. В.
    Вплив еозину Y та ортованадату на базальну секрецію та стаціонарний вхід Са2+ у секреторні клітини екзокринних залоз [Text] / Н. В. Федірко, М. Ю. Клевець // Фізіологічний журнал. - 2000. - Т. 46, № 5. - С. 3-8


MeSH-main:
ЭКЗОКРИННЫЕ ЖЕЛЕЗЫ -- EXOCRINE GLANDS (метаболизм, секреция, химия)
СПИРОСОЕДИНЕНИЯ -- SPIRO COMPOUNDS (классификация, метаболизм)
ЖИДКОСТИ И СЕКРЕТЫ (ВНЕШ) -- FLUIDS AND SECRETIONS (NON MESH) (метаболизм, секреция, химия)
ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА -- EXPERIMENTAL MEDICINE
Additional Access Points:
Клевець, М. Ю.

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2.


    Буторов, С. И.
    Эффективность фенспирида в лечении больных хронической обструктивной болезнью легких [Text] / С. И. Буторов, В. И. Мунтяну // Клиническая медицина : Научно-практический журнал. - 2007. - № 5. - С. 43-47

Rubrics: Легких болезни обструктивные--лек тер

   Спиросоединения

Additional Access Points:
Мунтяну, В. И.

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3.


   
    Клинико-функциональное состояние и качество жизни больных хронической обструктивной болезнью легких до и после лечения фенспиридом в амбулаторных условиях [Text] / С. И. Буторов [и др.] // Терапевтический архив. - 2008. - Т. 80, № 3. - С. 24-28

Rubrics: Легких болезни обструктивные--лек тер--психол

   Спиросоединения

   Качество жизни

Additional Access Points:
Буторов, С. И.
Буторов, И. В.
Бодруг, Н. И.
Крушка, С. И.
Тофан, Е. Ф.

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4.


    Гляделова, Н. П.
    Инспирон: новый этап в патогенетической противовоспалительной фармакотерапии респираторных инфекций у детей [Text] / Н. Л. Гляделова, Н. К. Унич // Современная педиатрия. - 2009. - № 6. - С. 115-117

Rubrics: Респираторные инфекции--дети--лек тер

   Инспирон

   Спиросоединения

Additional Access Points:
Унич, Н. К.

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5.


    Багаурі, О. В.
    Скринінг антигіпоксичної активності в ряду нових похідних 3,2--спіро-піроло-2-оксіндолу [Text] / О. В. Багаурі, Р. Г. Редькін, О. А. Ходаківський // Вісник фармації. - 2013. - № 2. - С. 63-65


MeSH-main:
(анализ, химия)
АНОКСИЯ -- ANOXIA (лекарственная терапия)
МОЗГОВОГО КРОВООБРАЩЕНИЯ РАССТРОЙСТВА -- CEREBROVASCULAR DISORDERS (лекарственная терапия)
Additional Access Points:
Редькін, Р. Г.
Ходаківський, О. А.

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6.


   
    The synthesis, spectral properties and the biological activity of 7-arenesulfonyl-3-arylmethyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione derivatives [Text] / K. Yu. Krolenko [et al.] // Вісн. фармації. - 2017. - № 1. - P3-9


MeSH-main:
СПИРОСОЕДИНЕНИЯ -- SPIRO COMPOUNDS (химический синтез)
ГИДАНТОИНЫ -- HYDANTOINS (химический синтез)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
Key words(unnormalized):
ТРУДЫ СОТРУДНИКОВ НФаУ
Annotation: To synthesize the series of 7-arenesulfonyl-3-arylmethyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione, to study their spectral properties and antibacterial activity. Materials and methods. The methods of organic synthesis, instrumental methods of organic compounds analysis, as well as the agar diffusion method were used. Results and discussion. By the interaction of 3-arymethyl-1,3,7-triazaspiro[4.4]nonane-2,4-diones with arenesulfonyl cholrides in the presence of triethylamine the series of 7-arenesulfonyl-3-arylmethyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione was obtained. For the compounds containing the fragments of 1-sulfonylamido-(2,4)- and 3,4-difluorobenzene the1 H-1 H coupling constants in their 1Н{19F}-NMR fluorine decoupled spectra, as well as the 19 F-19 F coupling constants in the 19F{1Н}-NMR proton decoupled spectra were measured. The antimicrobial activity screening showed that the growth of such bacterial strains as Staphylococcus aureus and Bacillus subtilis was inhibited by the compounds of the series obtained. Conclusions. It has been found that the interaction of 3-arymethyl-1,3,7-triazaspiro[4.4]nonane-2,4-diones with arenesulfonyl cholrides is an effective way for the synthesis of 7-arenesulfonyl-3-arylmethyl-1,3,7-triazaspiro[4.4]nonane-2,4-diones with the promising biological activity against the strains of gram-positive bacteria such as Staphylococcus aureus and Bacillus subtilis. Among 7-renesulfonyl-3-arylmethyl-1,3,7-triazaspiro[4.4]nonane-2,4-dione derivatives 3-(3-methylbenzyl)-7-(toluene-4-sulfonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione exhibited the highest activity
Additional Access Points:
Krolenko, K. Yu.
Vlasov, S. V.
Zhuravel, I. O.
Osolodchenko, T. P.

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7.


    Redkin, R. G.
    The synthesis of spiro[indole-3,1’-pyrrolo[3,4-c]pyrrole]-2,4’,6’-trione derivatives, the study of their antimicrobial activity and the molecular docking on staphylococcal dehydrosqualene synthase [Text] / R. G. Redkin, K. V. Hlebova // Вісн. фармації. - 2018. - № 2. - С. 24-35


MeSH-main:
(химический синтез)
ПИРРОЛЫ -- PYRROLES (химический синтез)
МОЛЕКУЛЯРНОЙ СТЫКОВКИ МОДЕЛИРОВАНИЕ -- MOLECULAR DOCKING SIMULATION (использование, методы)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ИНДОЛЫ -- INDOLES (химический синтез)
Annotation: To synthesize the series of new spiro[indole-3,1’-pyrrolo[3,4-c]pyrrole]-2,4’,6’-trione derivatives, study their physicochemical characteristics, antibacterial activity and precision of the molecular docking on the model of staphylococcal dehydrosqualene synthase
Additional Access Points:
Hlebova, K. V.

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8.


   
    The study of the antimicrobial activity of ethylene-N,N’- bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrole-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives [Text] / Ye. I. Syumka [et al.] // Вісн. фармації. - 2018. - № 2. - С. 57-62


MeSH-main:
СПИРОСОЕДИНЕНИЯ -- SPIRO COMPOUNDS (химический синтез)
ИНДОЛЫ -- INDOLES (химический синтез)
ПИРРОЛЫ -- PYRROLES (химический синтез)
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (использование, методы)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
Annotation: To find compounds with the antimicrobial activity in the series of N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c] pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives. Materials and methods. The antimicrobial activity was studied by the agar diffusion method. Results and discussion. The antimicrobial screening data revealed the pronounced biological activity of ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives against gramnegative (Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa) and grampositive (Staphylococcus aureus, Bacillus subtilis) bacteria and as well as against Candida albicans fungi. Conclusions. The antibacterial activity of ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) derivatives has been studied. The compounds with a significant level of the antimicrobial activity against gramnegative bacteria (Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa), grampositive bacteria (Staphylococcus aureus, Bacillus subtilis), as well as against fungi (Candida albicans) have been found. According to the data of the microbiological screening the most active compounds appeared to be ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) 1 and ethylene-N,N’-bis(spiroindole-3,3’-pyrrolo[3,4-c]pyrrol-5′-methyl-2a’,5a’-dihydro-2,2’,6’(1H,1’H,5’H)-trione) 2
Additional Access Points:
Syumka, Ye. I.
Osolodchenko, T. P.
Chernykh, V. P.
Shemchuk, L. A.

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9.


   
    The synthesis of mono-and bis-derivatives of spiro-2-oxindole[3,3’]pyrrole and the study of their antioxidant and anti-inflammatory activities [Text] / Y. I. Syumka [et al.] // Вісн. фармації. - 2018. - № 3. - С. 5-13


MeSH-main:
ПИРРОЛЫ -- PYRROLES (химический синтез)
СПИРОСОЕДИНЕНИЯ -- SPIRO COMPOUNDS (химический синтез)
АНТИОКСИДАНТЫ -- ANTIOXIDANTS (химический синтез)
ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ИНДОЛЫ -- INDOLES (химический синтез)
Annotation: To synthesize a series of mono- and bis-derivatives of spiro-2-oxindole[3,3’]pyrrole and study the antioxidant and anti-inflammatory activity of the compounds obtained
Current research proved that the preparatory method, namely, the three-component cascade transformation of isatin, α-amino acids and dipolarophils based on bis-maleimides is effective for synthesis of spiro-2-oxindole[3,3']pyrrole mono- and bis-derivatives. Series of hexamethylene- and ethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-2a,5a'-dihydro-2,2',6'(1H,1'H,5'H)-trione) symmetric derivatives were obtained. The structure of the obtained compounds was confirmed. Investigation of the antioxidant properties of the synthesized compounds revealed the most active substances: 1'-(hexamethylene-N-maleimido)-5'-benzyl-2a',5a'-dihydro-1'H-spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-2,2',6'(1H,3'H,5'H)-trione 1; ethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-5'-methyl-2a,5a'-dihydro-2,2',6'(1H,1'H,5'H)-trione) 6; hexamethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-5'-benzyl-2a,5a'-dihydro-2,2',6(1H,1'H,5'H)-trione) 7. Compound 6 also showed anti-inflammatory properties on the reference drug level
Additional Access Points:
Syumka, Y. I.
Kravchenko, A. B.
Chernykh, V. P.
Shemchuk, L. A.

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