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Total number of found documents : 23
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1.
Cipher: ЕУ12/2017/39/1
   Journal
Экспериментальная онкология [Text]
2017year Т. 39 № 1
Contents:
Circulating tumor cells in breast cancer : functional heterogeneity, pathogenetic and clinical aspects. - С.2-11 : il.
Kashuba, E. Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtag. - С.12-16 : цв. ил.
Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro. - С.17-24 : цв. ил.
Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics. - С.25-29 : табл.
Parthenolide reduces gene transcription of prosurvival mediators in U937 cells. - С.30-35 : il.
Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells. - С.36-41 : il.
Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma. - С.42-48 : табл.
EPR spectroscopy studies of changes in erythrocyte membranes in patients with laryngeal cancer. - С.49-52 : табл.
Auzina, D. Prognostic value of the bone turnover markers in multiple myeloma / D. Auzina, R. Erts, S. Lejniece. - С.53-56 : табл.
Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population. - С.57-64 : табл.
Chekhun, V. F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova. - С.65-68 : табл.
Satinder, K. Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women / K. Satinder, R. C. Sobti, K. Pushpinder. - С.69-74 : табл.
The impact of coloregional treatment on survival of patients with primary metastatic breast cancer. - С.75-77 : табл.
Diagnostic challenges with intraoral myeloid sarcoma : Report of two cases & review of world literature. - С.78-85 : цв. ил.
Trichilemmal cystis in metastatic melanoma : A case report. - С.86-87 : цв. ил.
Materials of international vactrain/ 3-rd Swedish-Ukrainian conference on cancer diseases, January 16-17, 2017, Stockholm, Sweden. - С.88-93
Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells. - С.88-89
The adaptor protein Ruk/CIN85 paradoxically enhances EMT of triple negative mouse breast adenocarcinoma 4T1 cells. - С.89
Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines. - С.89-90
Alternative direction of inhibition of malignant properties in tumor cells in vitro and in vivo by gene therapy with INF-beta gene in recombinant baculovirus vector. - С.90
CD150/SLAMF1 as a new potential target for anti-tumor therapy. - С.90-91
CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia. - С.91-92
Borikun, T. Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer / T. Borikun, N. Lukianova, V. Chekhun. - С.92
The MRPS 18-2 protein as a putative marker of carcinogenesis. - С.92
High expression levels of MRPS 18-2 and presence of the RB protein are required for the maintenance of stem cell phenotype. - С.92-93
Mankovska, O. Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors / O. Mankovska, V. Kashuba. - С.93
Brieieva, O. Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients / O. Brieieva, I. Nesina, L. Buchynska. - С.93
Kyiv, May 11-12, 2017 Workshop with international participation. New trends in cancer research and innovative tumor vaccines. - С.94
International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine. - С.95
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    Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics / V. F. Chekhun [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P25-29 : табл. - 21 ref.


MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия)
АРТЕМИЗИНИНЫ -- ARTEMISININS
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ -- DRUG RESISTANCE
Annotation: To explore effects of Artemisinin on a series of breast cancer cells with different sensitivity to typical cytotoxic drugs (doxorubicin — Dox; cisplatin — DDP) and to investigate possible artemisinin-induced modification of the mechanisms of drug resistance. Materials and Methods: The study was performed on wild-type breast cancer MCF-7 cell line (MCF-7/S) and its two sublines MCF-7/Dox and MCF-7/DDP resistant to Dox and DDP, respectively. The cells were treated with artemisinin and iron-containing magnetic fluid. The latter was added to modulate iron levels in the cells and explore its role in artemisinin-induced effects. The MTT assay was used to monitor cell viability, whereas changes of expression of selected proteins participating in regulation of cellular iron homeostasis were estimated using immunocytochemical methods. Finally, relative expression levels of miRNA-200b, -320a, and -34a were examined by using qRT-PCR. Results: Artemisinin affects mechanisms of the resistance of breast cancer cells towards both Dox and DDP at sub-toxic doses. The former drug induces changes of expression of iron-regulating proteins via different mechanisms, including epigenetic regulation. Particularly, the disturbances in ferritin heavy chain 1, lactoferrin, hepcidin (decrease) and ferroportin (increase) expression (р ≤ 0.05) were established. The most enhanced increase of miRNA expression under artemisinin influence were found for miRNA-200b in MCF-7/DDP cells (7.1 ± 0.98 fold change), miRNA-320a in MCF-7/Dox cells (2.9 ± 0.45 fold change) and miRNA-34a (1.7 ± 0.15 fold change) in MCF-7/S cells. It was observed that the sensitivity to artemisinin can be influenced by changing iron levels in cells. Conclusions: Artemisinin can modify iron metabolism of breast cancer cells by its cytotoxic effect, but also by inducing changes in expression of iron-regulating proteins and microRNAs (miRNAs), involved in their regulation. This modification affects the mechanisms that are implicated in drug-resistance, that makes artemisinin a perspective modulator of cell sensitivity towards chemotherapeutic agents in cancer treatment
Additional Access Points:
Chekhun, V.F.
Lukianova, N.Y.
Borikun, T.V.
Zadvornyi, T.V.
Mokhir, A.

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3.


    Borikun, T.
    Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer / T. Borikun, N. Lukianova, V. Chekhun // Experimental Oncology. - 2017. - Том 39, N 1. - P92


MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика)
БИОМАРКЕРЫ ФАРМАКОЛОГИЧЕСКИЕ -- BIOMARKERS, PHARMACOLOGICAL
Annotation: High heterogeneity and diversity of breast tumors make the molecular characterization based on new biological markers very important. Recent studies have shown that not only genes and proteins are important players in tumorigenesis, but also a new class of potential epigenetic tumor markers such as microRNAs (miRNAs). An important advantage of miRNA molecules is their stability in both plasma and tumor tissues
Additional Access Points:
Lukianova, N.
Chekhun, V.

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4.
Cipher: ЕУ12/2020/42/2
   Journal
Экспериментальная онкология [Text]
2020year Т. 42 № 2
Contents:
Shvets, Yu. V. Human microbiota and effectiveness of cancer chemotherapy / Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun. - С.82-93
Zadvornyi, T. V. Nanog as prognostic factor of prostate cancer course / T. V. Zadvornyi [et al.]. - С.94-100
Other authors: Lukianova N. Yu., Borikun T. V., Vitruk Yu. V., Stakhovsky E. O., Chekhun V. F.
Lamdan, H. Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin / H. Lamdan [et al.]. - С.101-108
Other authors: Garcia-Lazaro R. S., Lorenzo N., Galigiuri L. G., Alonso D. F., Farina H. G.
Antonenko, S. V. Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells / S. V. Antonenko, G. D. Telegeev. - С.109-114
Onyshchenko, K. V. Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma / K. V. Onyshchenko [et al.]. - С.115-119
Other authors: Voitsitskyi T. V., Grygorenko V. M., Saidakova N. O., Pereta L. V., Onyschuk A. P., Skrypkina I. Ya.
Stegantseva, M. V. Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model / M. V. Stegantseva [et al.]. - С.120-125
Other authors: Shinkevich V. A., Tumar E. M., Meleshko A. N.
Andreieva, S. V. Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias / S. V. Andreieva [et al.]. - С.126-129
Other authors: Kyselova O. A., Serbin I. M., Alkhimova O. G.
Bialik, P. HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer / P. Bialik [et al.]. - С.130-134
Other authors: Wysokinski D., Slomka M., Morawiec Z., Strapagiel D., Wozniak K.
Pankaj, D. Clinicopathological correlation of the expression of excision repair cross complementation group 1 (ERCC1) in oral cavity squamous cell carcinomas: an immunohistochemical study / D. Pankaj, V. Guddattu, M. C. Solomon. - С.135-139
Lyalkin, S. A. Prognostic role of androgen receptor expression in patients with metastatic triple negative breast cancer / S. A. Lyalkin [et al.]. - С.140-143
Other authors: Verevkina N. O., Alekseyenko O. O., Syvak L. A.
Perekhrestenko, T. Expression of Ki-67 and CD34 on blood and bone marrow cells of CML patients with different response to imatinib and nilotinib therapy / T. Perekhrestenko [et al.]. - С.144-147
Other authors: Melnyk U., Goryainova N., Diagil I.
Glavatskyi, O. Ya. Temozolomide in glioblastoma treatment: 15-year clinical experience and analysis of its efficacy / O. Ya. Glavatskyi [et al.]. - С.148-156
Other authors: Zemskova O. V., Khmelnytskyi H. V., Kardash K. A., Shuba I. M., Stuley V. A.
Kliusov, O. M. Specialized care provided to patients with rectal cancer in Kyiv city / O. M. Kliusov. - С.157-160
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    Nanog as prognostic factor of prostate cancer course / T. V. Zadvornyi [et al.] // Experimental Oncology. - 2020. - Том 42, N 2. - P94-100


MeSH-main:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (терапия)
Annotation: The variability of the clinical course of prostate cancer (PC) indicates the need to find factors that could predict the aggressive potential of neoplasms accounting the biological characteristics of tumor cells. In this context, the role of NANOG, a transcription factor involved in maintaining pluripotency and one of the markers of cancer stem cells (CSCs), is being actively studied today. Aim: To investigate the level of NANOG mRNA in tumor tissue of patients with PC and to analyze the possibility of its use as a marker of the disease course. Materials and Methods: The study involved 85 patients with PC of stages II–IV. Morphological and immunohistochemical studies were performed on serial paraffin sections of resected PC using monoclonal antibodies to Ki-67 and androgen receptor. NANOG and miR-214 mRNA expression in tumor cells was analyzed by real-time reverse transcription polymerase chain reaction. The identification of CSCs was performed by double-labeled immunohistochemical method using primary antibodies to CD24 and CD44. Results: We have revealed notable variability of NANOG mRNA levels in tumor tissue of patients with PC (mean 4.18 ± 0.65 a.u. with individual deviations from 0.11 ± 0.03 a.u. to 15.24 ± 0.36 a.u.). According to NANOG mRNA levels, two groups of the PC patients were delineated: group 1 and group 2, with the average NANOG mRNA levels of 2.12 ± 0.16 a.u., and 8.68 ± 1.24 a.u., respectively. The NANOG mRNA levels in tumor tissue of PC patients of groups 1 and 2 correlated with preoperative serum prostate-specific antigen level (r = 0.58; p 0.05 and r
Additional Access Points:
Zadvornyi, T. V.
Lukianova, N. Yu.
Borikun, T. V.
Vitruk, Yu. V.
Stakhovsky, E. O.
Chekhun, V. F.

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6.
Cipher: ЕУ12/2018/40/4
   Journal
Экспериментальная онкология [Text]
2018year Т. 40 № 4
Contents:
Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F Chekhun. - С.258-260
Tari, K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia / K. Tari [et al.]. - С.261-267
Other authors: Shamsi Z., Ghafari H. R., Atashi A., Shahjahani M., Abroun S.
Chekhun, V. F. Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.]. - С.268-274
Other authors: Todor I. N., Lukianova N. Yu., Horbyk D. M., Lozovskaya Yu. V., Burlaka A. P., Borikun T. V.
Symchych, T. V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model / T. V. Symchych [et al.]. - С.275-281
Other authors: Fedosova N. I., Karaman O. M., Voyeykova I. M., Didenko G. V.
Yakymenko, I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation / I. Yakymenko [et al.]. - С.282-287
Other authors: Burlaka A., Tsybulin O., Brieieva O., Buchynska L., Tsehmistrenko S., Chekhun V.
Smal, M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer / M. P. Smal [et al.]. - С.288-298
Other authors: Kuzhir T. D., Savina N. V., Nikitchenko N. V., Rolevich A. I., Krasny S. A., Goncharova R. I.
Abooshahab, R. Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer / R. Abooshahab [et al.]. - С.299-302
Other authors: Niyazi E., Yaghmaie P., Chadaksaz H. G., Hedayati M.
Buchynska, L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.]. - С.303-308
Other authors: Iurchenko N. P., Kashuba E. V., Brieieva O. V., Glushchenko N. M., Mints M., Lukianova N. Yu., Chekhun V. F.
Arabpour, F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients / F. Arabpour [et al.]. - С.309-314
Other authors: Shafizad A., Rahimzadeh M., Norouzian M., Naderi N.
Gerashchenko, G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer / G. V. Gerashchenko [et al.]. - С.315-322
Other authors: Grygoruk O. V., Kononenko O. A., Gryzodub O. P., Stakhovsky E. O., Kashuba V. I.
Tas, F. Clinical significance of serum caveolin-1 levels in gastric cancer patients / F. Tas [et al.]. - С.323-327
Other authors: Karabulut S., Erturk K., Duranyildiz D.
Shvachko, L. P. Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells / L. P. Shvachko [et al.]. - С.328-331
Other authors: Zavelevich M. P., Gluzman D. F., Kravchuk I. V., Telegeev G. D.
Kuzyk, P. V. Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis / P. V. Kuzyk, M. A. Savchyna, S. G. Gychka. - С.332-335
Zakhartseva, L. M. Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart / L. M. Zakhartseva [et al.]. - С.336-342
Other authors: Zakharova L. P., Shatrova K. M., Chitaeva G. E., Vitovsky R. M.
Langabeer, S. E. The JAK2 V617F mutation in lung cancer: caveat emptor / S. E. Langabeer. - С.343-344
Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary). - С.345
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    Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P268-274


MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (метаболизм, патофизиология)
Annotation: To study the effect of Ferroplat (FrP) on the indexes of pro/antioxidant balance and energy metabolism in breast cancer cells of different malignancy degree and different sensitivity to drug therapy. Materials and Methods: The study was carried out on breast cancer cells of low (T47D, MCF-7) and high malignancy degree (MCF-7/DDP (cisplatin-resistant), MDA-MB-231, MDA-MB-468) using cell culture techniques, immunocytochemical, biochemical, biophysical methods, flow cytometry and polarography. Results: We established that the addition of FrP to the culture medium reduces the activity of glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD) and the level of non-protein thiols by 32–41% (p 0.05). At the same time, there was an increase of the total level of ROS and the rate of NO generation by inducible NO synthase by 1.7–2.5 times (p 0.05). This testifies that FrP disturbs the antioxidant balance in cells, resulting in their death. Also, the use of FrP led to a decrease in the rate of oxygen absorption in MCF-7 and T47D cells by 26% and 25%, respectively (p 0.05). In cells of high malignancy degree this index decreased by 38–40% under the influence of FrP. Incubation of MCF-7 and T47D cells with the indicated agent also reduced the content of phospholipid cardiolipin by 15–16% (p 0.05), and in MDA-MB-231, MCF-7/DDP, MDA-MB-468 cells — by 29%, 30% and 32%, respectively. In addition, the effect of FrP caused a decrease in the levels of Mg2+ and lactate in MCF-7 and T47D cells by 21–29% and 14–24%, respectively, whereas in MDA-MB-231, MDA-MB-468, MCF-7/DDP cells — by 34–38% and 32–35%, respectively. In this case, the agent raised the level of glucose in the cells of low malignancy degree by 20–23% (p 0.05), and in the cells of high malignancy degree and with the phenotype of drug resistance — by 31–36%. However, the nanocomposite did not affect the activity of lactate dehydrogenase in all studied breast cancer cells. Conclusion: The study has shown that FrP has an effect on the pro/antioxidant balance and energy metabolism of cancer cells. In addition, the denoted effect of FrP was more pronounced in the breast cancer cells with a high malignancy degree and the phenotype of drug resistance
Additional Access Points:
Chekhun, V. F.
Todor, I. N.
Lukianova, N. Yu.
Horbyk, D. M.
Lozovskaya, Yu. V.
Burlaka, A. P.
Borikun, T. V.

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8.
Cipher: ЕУ12/2021/43/2
   Journal
Экспериментальная онкология [Text]
2021year Т. 43 № 2
Contents:
Vitruk, Yu. V. Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302a and -377 in tumor tissue / Yu. V. Vitruk [et al.]. - С.98-103
Other authors: Semko S. L., Voylenko O. A., Pikul M. V., Borikun T. V., Zadvornyi T. V., Yalovenko T. M., Stakhovsky E. O., Rossylna O. V.
Pyaskovskaya, O. N. Role of tumor/endothelial cell interactions in tumor growth and metastasis / O. N. Pyaskovskaya [et al.]. - С.104-110
Other authors: Kolesnik D. L., Garmanchouk L. V., Yanish Yu. V., Solyanik G. I.
Akalovich, S. 5-FU resistens colorectal cancer cells possess improved invasiveness and βIII-tubulin expression / S. Akalovich [et al.]. - С.111-117
Other authors: Portyanko A., Pundik A., Mezheyeuski A., Doroshenko T.
Bychkov, V. A. In vitro modeling of tumor interclonal interactions using breast cancer cell lines / V. A. Bychkov [et al.]. - С.118-124
Other authors: Pevzner A. M., Nebova J. A., Ermakova N. N., Ibragimova M. K., Tsyganov M. M., Lyapunova L. S., Litviakov N. V.
Ayyildiz, A. Co-administration of apigenin with doxorubicin enhanges anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells / A. Ayyildiz [et al.]. - С.125-134
Other authors: Koc H., Turkekul K., Erdogan S.
Buchynska, L. G. Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium / L. G. Buchynska, O. M. Movchan, N. P. Iurchenko. - С.135-141
Yakovlev, P. G. Expression of TLR4 and major inflammatory cytokines in patients with bladder cancer of different grade and stage / P. G. Yakovlev [et al.]. - С.142-148
Other authors: Gorbach O. I., Ostapchenko L. I., Garmanchuk L. V., Skachkova O. V., Khranovska N. M., Senchylo N. V.
Zoubi, M. S. RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population / M. S. Zoubi [et al.]. - С.149-154
Other authors: Al-Eitan L. N., Rababa D. M., Al-Batayneh K., Farzand R., Quinn G. A., Tambuwala M. M., Bakshi H. A.
Kornatska, A. G. A variant of TP53 gene (RS 1625895, 13494G>A) is associated with neoplasm localization in patients with uterine leiomyoma / A. G. Kornatska [et al.]. - С.155-158
Other authors: Flaksemberg M. A., Chubei G. V., Trokhymovych O. V., Rossokha Z. I., Fishchuk L. Ye., Medvedieva N. L., Vershyhora V. O., Gorovenko N. G.
Mohamed, Yusoff A. A. Significance of BRAFv600E mutation in intra-axial brain tumor in Malaysian patients: case series and literature review / A. A. Mohamed Yusoff [et al.]. - С.159-167
Other authors: Abd Radzak S. M., Mohd Khair S. Z. N., Abdullah J. M.
Ben, Kridis W. Therapeutic results of laryngeal preservation: a retrospective study / W. Ben Kridis [et al.]. - С.168-172
Other authors: Werda I., Mnejja W., Toumi N., Charfeddine I., Daoud J., Khanfir A.
Pilinska, M. A. Study of modifyng effects of astaxanthin on cytogenetic manifestations of bystander response in human peripheral blood lymphocytes in vitro / M. A. Pilinska [et al.]. - С.173-176
Other authors: Shemetun O. V., Talan O. O., Dibska O. B., Talko V. V.
De, Giorgi V. Scrotal cutaneous metastasis from rectal squamous cell carcinoma: a rare evolution into a rare tumor / V. De Giorgi [et al.]. - С.177-179
Other authors: Venturi F., Portelli F., Maida P., Scarfi F., Trane L., Gori A., Silvestri F., Massi D.
Liubota, R. Systemic chemotherapeutic treatment of patients with breast cancer brain metastases / R. Liubota [et al.]. - С.180-184
Other authors: Vereshchako R., Anikusko M., Liubota I., Vakulenko G.
Pasichnyk, S. M. Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model / S. M. Pasichnyk [et al.]. - С.185-188
Other authors: Pasichnyk M. S., Lychkovsky A. E., Stakhovsky E. O., Gozhenko A. I., Shatnyi S. V., Pasichnyk M. A.
Gluzman, D. F. Long-term exposure to low doses of ionizing radiation and COVID-19 pandemic: oncohematological aspects / D. F. Gluzman [et al.]. - С.189-192
Other authors: Zavelevich M. P., Philchenkov A. A., Koval S. V., Guslitser L. N., Zinchenko V. N., Bezhenar T. O.
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    Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302a and -377 in tumor tissue [Text] / Yu. V. Vitruk [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P98-103


MeSH-main:
КАРЦИНОМА ПОЧЕЧНО-КЛЕТОЧНАЯ -- CARCINOMA, RENAL CELL (генетика, патофизиология, терапия)
РЕЦЕПТОРНЫЕ ПРОТЕИН-ТИРОЗИН-КИНАЗЫ (стандарты)
РНК -- RNA (генетика)
Annotation: Renal cell carcinoma (RCC) is one of the most common solid tumors in adults highly resistant to conventional therapies. The expression profile of a number of miRNAs correlates with RCC response to chemotherapeutic agents. Aim: To identify the association of tumor miRNAs expression with neoadjuvant treatment response in patients with RCC. Materials and Methods: We analyzed the expression levels of tumor miR-99b, -144, -155, -210, -222, -302а, -377 in 93 RCC patients who received pazopanib or sunitinib in neoadjuvant regimen using RT-PCR. RNU48 was used as a reference miRNA. Results: The levels of expression of miR-99b and -377 are associated with the RCC response to pazopanib, and microRNA-210 and -377 to sunitinib. The characteristic expression profile of miR-99b, -144, -222, -377, and miR-302a determined in 90% of cases was delineated in pazopanib responders as opposed to nonresponders. Similarly, the characteristic expression profile of miR-210, -222, -302a and -377 was suggested for sunitinib responders. Conclusions: Levels of miR-99b, -210 and -377 expression in RCC tumor tissue might be used as a basis for future predictive panel intended for the assessment of the sensitivity to the regimens of neoadjuvant RCC treatment
Additional Access Points:
Vitruk, Yu. V.
Semko, S. L.
Voylenko, O. A.
Pikul, M. V.
Borikun, T. V.
Zadvornyi, T. V.
Yalovenko, T. M.
Stakhovsky, E. O.
Rossylna, O. V.

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10.
Cipher: ЕУ12/2021/43/1
   Journal
Экспериментальная онкология [Text]
2021year Т. 43 № 1 . - 51.32, р.
Contents:
Cavalli, M. A non-coding cancer mutation disrupting an HNF4α binding motif affects an enhancer regulating genes associated to the progression of liver cancer / M. Cavalli [та ін.]. - С.2-7. - Bibliogr. at the end of the art.
Other authors: Diamanti K.1., Pan G., Dabrowski M. J., Komorowski J., Wadelius C.
Yakovlev, P. G. Changes in expression of TLR-4, TGF-β, INF-γ, TNF-α in cultured T24/83 cells of invasive bladder cancer treated with cisplatin and/or polyphenolic adjuvant melanin / P. G. Yakovlev [та ін.]. - С.7-14. - Bibliogr. at the end of the art.
Other authors: Gorbach O. I., Khranovska N. M., Beliayeva A. V., Skachkova O. V., Skaterna T. D., Kalachniuk L. G., Ostapchenko L. I., Garmanchuk L. V.
Chumak, A. V. Macrophage polarization in dynamics of Lewis lung carcinoma growth and metastasis / A. V. Chumak [та ін.]. - С.15-20. - Bibliogr. at the end of the art.
Other authors: Fedosova N.I., Cheremshenko N. L., Symchych T. V., Voyeykova I. M., Chekhun V. F.
Yushko, L. A. Comparative study of biochemical and morphological parameters in rats with Walker 256 and Walker 256/DOX carcinosarcoma / L. A. Yushko [та ін.]. - С.21-25. - Bibliogr. at the end of the art.
Other authors: Sarnatskaya V. V., Sakhno L. A., Hudenko N. V., Paziuk L. M., Maslenny V. N., Melnyk V. O., Nikolaev V. G.
Prokhorova, I. V. ROS production by circulating phagocytes and Guerin carcinoma resistance to cisplatin / I. V. Prokhorova [та ін.]. - С.26-30. - Bibliogr. at the end of the art.
Other authors: Gorbach O. I., Yakshibaeva Yu. R., Shliakhtova N. А., Solyanik G. I.
Elemam, O. Emergency oncology admissions during COVID-19 pandemic: a major institution experience from Saudi Arabia / O. Elemam [та ін.]. - С.31-35. - Bibliogr. at the end of the art.
Other authors: Tashkandi E., Abdelkhalek S., Shalaby I., Baraka R.
Kravets, O. V. Significance of expression of tumor-associated microRNA-21 and -375 for predicting the course of cancer of oral cavity / O. V. Kravets [та ін.]. - С.36-40. - Bibliogr. at the end of the art.
Other authors: Burtyn O. V., Borikun T. V., Zadvornyi T. V., Yalovenko T. M., Kolesnik O. O.
Boyko, O. Erythropoietin as an independent prognostic factor in myelodysplastic syndromes / O. Boyko [та ін.]. - С.41-45. - Bibliogr. at the end of the art.
Other authors: Simonova M., Knysh N., Danysh O., Vygovska Y., Masliak Z.
Samoylenko, O. A. Ornithine decarboxylase activity in prostate cancer / О. А. Samoylenko [та ін.]. - С.46-51. - Bibliogr. at the end of the art.
Other authors: Stakhovsky E. O., Vitruk Y. V., Shlyakhovenko V. O.
Gervas, P. New germline mutations in BRCA1, ATM, MUTYH, and RAD51D genes in Tuvans early-onset breast cancer patients / P. Gervas [та ін.]. - С.52-55. - Bibliogr. at the end of the art.
Other authors: Molokov A., Ivanova A., Panferova Ye., Kiselev A., Chernyshova A., Pisareva L., Choynzonov E., Cherdyntseva N.
Lobanova, O. E. Prevalence of BRCA1 and BRCA2 genes promoter hypermethylation in breast cancer tissue / O. E. Lobanova [та ін.]. - С.56-60. - Bibliogr. at the end of the art.
Other authors: Rossokha Z. I., Medvedieva N. L., Cheshuk V. E., Vereshchako R. I., Vershyhora V. O., Fishchuk L. Ye., Zakhartseva L. M., Gorovenko N. G.
Hergebue, K. Therapeutic results and prognostic factors of stage III NSCLC: a population-based study in Tunisia / K. Hergebue [та ін.]. - С.61-66. - Bibliogr. at the end of the art.
Other authors: Mejri N., Berrazega Y., Rachdi H., El Benna H., Labidi S., Boussen H.
Tsip, N. P. Experience with the use of HIPEC in advanced serous ovarian cancer after complete and optimal cytoreduction / N. P. Tsip [та ін.]. - С.67-72. - Bibliogr. at the end of the art.
Other authors: Kopetskiy V. I., Polentsov Yu. O., Yegorov M. Yu., Vakulenko G. O., Svintsitskiy V. S.
Gurianov, D. S. Nuclear localization of BCR and cortactin indicates their potential role in regulation of actin branching in nucleus / D. S. Gurianov, S. V. Antonenko, G. D. Telegeev. - С.73-76. - Bibliogr. at the end of the art.
Yanish, Yu. V. Application of gold and silver nanoparticles for selective assay of spermine in mixture with spermidine / Yu. V. Yanish [та ін.]. - С.77-81. - Bibliogr. at the end of the art.
Other authors: Zaletok S. P., Vityuk N. V., Mukha Yu. P.
Drogovoz, S. M. Experience and prospects for the use of off-label drugs in oncology / S. M. Drogovoz [та ін.]. - С.82-86. - Bibliogr. at the end of the art.
Other authors: Starikov V. I., Ivantsyk L. B., Shchokina K. G.
Gluzman, D. F. Immunodeficiency-associated lymphoproliferative disorders and lymphoid neoplasms in post-COVID-19 pandemic era / D. F. Gluzman [та ін.]. - С.87-91. - Bibliogr. at the end of the art.
Other authors: Zavelevich M. P., Philchenkov A. A., Koval S. V., Bezhenar T. O.
Moreno, M. An uncommon case of vulvar cancer metastatic to breast / M. Moreno [та ін.]. - С.92-95. - Bibliogr. at the end of the art.
Other authors: Matschinski G. N., Czarnobai I., Oliveira A., Boff T. C.
Ada Leonidivna Vorontsova (1934–2020). - С.96
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11.


   
    Significance of expression of tumor-associated microRNA-21 and -375 for predicting the course of cancer of oral cavity [Text] = Значення експресії пухлиноасоційованих мікрорнк-21 та -375 для прогнозування перебігу раку порожнини рота / O. V. Kravets [та ін.] // Экспериментальная онкология. - 2021. - Т. 43, № 1. - P36-40. - Bibliogr. at the end of the art.


MeSH-main:
РОТОВОЙ ПОЛОСТИ НОВООБРАЗОВАНИЯ -- MOUTH NEOPLASMS (терапия)
МИКРО-РНК -- MICRORNAS (агонисты)
ПОЛИМЕРАЗНАЯ ЦЕПНАЯ РЕАКЦИЯ -- POLYMERASE CHAIN REACTION (тенденции)
Annotation: To investigate the features of expression of miRNA-21 and miRNA-375 in tumor cells of patients with cancer of oral cavity (COC) and to determine the possibility of their use to predict the aggressiveness of COC course. Materials and Methods: The work is based on the results of examination and treatment of 50 patients with stage II–IV COC. miRNA expression in tumor cells was analyzed by real time reverse transcription polymerase chain reaction. Results: High levels of miRNA-21 expression ( 0.26 a.u.) and miRNA-375 ( 0.36 a.u.) were determined in 72.0% and 63.0% of cases. We revealed a tendency to decreased miRNA-21 expression and increased miRNA-375 expression in tumors of patients with recurrence-free survival less than 12 months and the presence of metastatic lesions in regional lymph nodes. In patients with COC of low differentiation grade, the level of miRNA-21 was 2.0 times lower compared with tumors of moderate differentiation grade (p 0.05), while the expression of miRNA-375, on the contrary, was higher in tumors of low differentiation grade. A decreased expression of miRNA-21 ( 0.26 a.u.) against the background of decreased levels of miRNA-375 ( 0.36 a.u.) in tumor cells was associated with worse recurrence-free survival. Conclusions: The obtained results indicate the relation between the main clinical and pathological characteristics of patients with COC and the levels of miRNA-21 and -375 expression in tumor tissue, which indicates the involvement of these miRNAs in the formation of COC malignancy evidencing on their potential usefulness as additional prognostic markers
Дослідити особливості експресії мікроРНК-21 та мікроРНК-375 у пухлинних клітинах хворих на рак порожнини рота (РПР) та визначити можливість їх використання для прогнозування агресивності перебігу РПР. Матеріали та методи: Робота заснована на результатах обстеження та лікування 50 хворих з ІІ–IV стадією РПР. Експресію мікроРНК у клітинах пухлини аналізували за допомогою кількісної полімеразної ланцюгової реакції. Результати: Високий рівень експресії мікроРНК-21 ( 0.26 у.о.) та мікроРНК-375 ( 0.36 у.о.) було визначено у 72.0% та 63.0% випадків відповідно. Ми виявили тенденцію до зниження експресії мікроРНК-21 та підвищення експресії мікроРНК-375 у пухлинах пацієнтів з безрецидивною виживаністю менше 12 міс та наявністю метастатичних уражень у регіонарних лімфатичних вузлах. У пацієнтів з РПР низького ступеня диференціювання рівень мікроРНК-21 був у 2.0 рази нижчим порівняно з пухлинами помірного ступеня диференціювання (р 0.05), тоді як експресія мікроРНК-375, навпаки, була вищою у пухлинах низького ступеня диференціювання. Зниження експресії мікроРНК-21 ( 0.26 у.о.) на тлі зниженого рівня мікроРНК-375 ( 0.36 у.о.) в пухлинних клітинах асоціювалося з гіршою безрецидивною виживаністю. Висновки: Отримані результати вказують на зв’язок між основними клініко-патологічними характеристиками пацієнтів з РПР та рівнем експресії мікроРНК-21 та -375 у тканині пухлини, що свідчить про участь цих мікроРНК у формуванні злоякісності РПР та про їх потенційну практичну значимість як додаткових прогностичних маркерів
Additional Access Points:
Kravets, O. V.
Burtyn, O. V.
Borikun, T. V.
Zadvornyi, T. V.
Yalovenko, T. M.
Kolesnik, O. O.

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12.
Cipher: ЕУ12/2022/44/1
   Journal
Экспериментальная онкология [Text]
2022year Т. 44 № 1 . - 55.65, р.
Contents:
Ebru, Nur Ay. Therapeutic targeting of molecular pathways in colorectal cancer / Nur Ay Ebru. - С.2-6. - Bibliogr. at the end of the art.
Kumar, M. Current therapeutic strategies and challenges in nsclc treatment: a comprehensive review / M. Kumar, A. Sarkar. - С.7-16. - Bibliogr. at the end of the art.
Bolgova, L. S. On the origin of lung cancer development / L. S. Bolgova [та ін.]. - С.17-22. - Bibliogr. at the end of the art.
Other authors: Tuganova T. N., Alekseenko O. I., Ponomarenko A. A.
Kannan, S. A long-term 10G-hypergravity exposure promotes cell-cell contacts and reduces adhesiveness to a substrate, migration, and invasiveness of MCF-7human breast cancer cells / S. Kannan [та ін.]. - С.23-30. - Bibliogr. at the end of the art.
Other authors: Shailesh H., Mohamed H., Souchelnytskyi N., Souchelnytskyi S.
Horak, I. R. Adaptor protein Ruk/CIN85regulates redox balance in 4T1 mouse breast cancer cells exposed to plasmin(ogen) / I. R. Horak [та ін.]. - С.31-38. - Bibliogr. at the end of the art.
Other authors: Latyshko N. V., Hudkova O. O., Tokarchuk K. O., Kishko T. O., Yusova O. I., Drobot L. B., Tykhomyrov A. A.
Lukianova, N. Expression of markers of bone tissue remodeling in breast cancer and prostate cancer cells in vitro / N. Lukianova [та ін.]. - С.39-46. - Bibliogr. at the end of the art.
Other authors: Zadvornyi T., Kashuba E., Borikun T., Mushii О., Chekhun F.
Kovalevska, L. Differential expression pattern of AIP, UCKL1, and PKN1 genes in prostate cancer patients / L. Kovalevska [та ін.]. - С.47-51. - Bibliogr. at the end of the art.
Other authors: Zadvornyj T., Lukianova N., Kashuba E.
Lozynska, L. NOD2c.3019-3020insC and c.2104C>T gene variants among patients from western Ukraine with Crohn’s disease and colorectal cancer / L. Lozynska [та ін.]. - С.52-59. - Bibliogr. at the end of the art.
Other authors: Pinyazhko R., Lozynska M., Plawski A., Makukh H., Lukavetskyy O., Grzegotsky M., Pinyazhko O.
Moghaddam, Zhaleh Karimi. Evaluation of 5-fluorouracil-induced cardiotoxicity: role of cardiac biomarkers / Zhaleh Karimi Moghaddam [та ін.]. - С.60-66. - Bibliogr. at the end of the art.
Other authors: Rostami Mina, Zeraatchi Alireza, Abadi Hamidreza Fallah, Karamitanha Farzaneh, Amirmoghaddami Hamidreza
Grygorenko, V. Long-term radical prostatectomy oncologic outcomes in patients with clinically locally advanced prostate cancer: a single-center study / V. Grygorenko [та ін.]. - С.67-74. - Bibliogr. at the end of the art.
Other authors: Afanasiev Ye., Danylets R., Vikarchuk M., Kosyuchno M., Pasichnyk S.
Holotiuk, I. S. Evaluation of the efficiency of alpha-lipoic acid and ipidacrine hydrochloride for the prevention of paclitaxel-induced peripheral neuropathy according to the total neuropathy score / I. S. Holotiuk [та ін.]. - С.75-82. - Bibliogr. at the end of the art.
Other authors: Kryzhanivska A. Ye., Holotiuk S. I., Maliborska S. V., Holotiuk V. V.
Dybkov, M. V. Rapid low-cost detection of type 2CALR mutation by allele-specific RT-PCR for diagnosis of myeloproliferative neoplasms / M. V. Dybkov [та ін.]. - С.83-86. - Bibliogr. at the end of the art.
Other authors: Zavelevich M. P., Gluzman D. F., Telegeev G. D.
Danylo Fishelevych Gluzman (1936–2022). - С.87-88
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13.


   
    Expression of markers of bone tissue remodeling in breast cancer and prostate cancer cells in vitro [Text] = Експресія маркерів ремоделювання кісткової тканини у клітинах раку молочної залози та раку передміхурової залози in vitro / N. Lukianova [та ін.] // Экспериментальная онкология. - 2022. - Т. 44, № 1. - P39-46. - Bibliogr. at the end of the art.


MeSH-main:
ГЕННАЯ ЭКСПРЕССИЯ -- GENE EXPRESSION (действие лекарственных препаратов, иммунология)
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика, иммунология, кровь, метаболизм)
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (диагностика, иммунология, кровь, метаболизм)
КОСТИ МОРФОГЕНЕТИЧЕСКИЕ БЕЛКИ -- BONE MORPHOGENETIC PROTEINS (диагностическое применение, иммунология, кровь, метаболизм, секреция)
ОСТЕОПОНТИН -- OSTEOPONTIN (диагностическое применение, иммунология, метаболизм, секреция)
ОСТЕОНЕКТИН -- OSTEONECTIN (диагностическое применение, иммунология, метаболизм, секреция)
ФЕНОТИП -- PHENOTYPE
Annotation: The aim of the study was to compare the expression of markers of bone remodeling in vitro in breast cancer (BCa) cells and prostate cancer (PCa) cells varying in their malignancy phenotype. Materials and Methods: The study was performed on human BCa cells (MCF-7 and MDA-MB-231 lines) and PCa cells (LNCaP and DU-145 lines). Expression levels of bone tissue remodeling proteins (osteopontin (OPN), osteonectin (ON) and bone morphogenetic protein 7 (BMP-7) were determined immunocytochemically. The mRNA levels of bone tissue remodeling proteins OPN (SPP1), ON (SPARC), BMP-7 (BMP7)) and miRNA-10b, -27a, -29b, -145, -146a were assessed by quantitative reverse transcription polymerase chain reaction. To search for miRNAs involved in the regulation of target genes, miRNet v. 2.0 resource was used. Results: We have shown that highly malignant MDA-MB-231 cells are characterized by significantly higher expression of OPN and ON on the background of decreased SPARC and BMP7 mRNA expression. In highly malignant DU-145 cells, ON and SPP1, SPARC, and BMP7 mRNA expression was significantly higher compared with low malignant LNCaP cells. MDA-MB-231 line was characterized by significantly higher expression of miRNA-10b, -27a, -29b, -145 and -146a. In DU-145 cells, significantly lower levels of expression of miRNAs-27a and -145 against the background of increasing levels of miRNAs-29b and -146a were recorded. Conclusion: High malignancy phenotype of the BCa and PCa cells is characterized by high levels of expression of bone remodeling proteins, which may be caused by impaired regulation of their expression at the epigenetic level
Провести порівняльне дослідження експресії маркерів ремоделювання кісткової тканини у клітинах раку молочної залози (РМЗ) та раку передміхурової залози (РПЗ) різного ступеня злоякісності в системі in vitro. Матеріали та методи: Дослідження проводили на клітинах РМЗ людини (лінії MCF-7 та MDA-MB-231) та клітинах РПЗ (лінії LNCaP та DU-145) різного ступеня злоякісності. Рівні експресії білків ремоделювання кісткової тканини (остеопонтин (osteopontin — OPN), остеонектин (osteonectin — ON) і кістковий морфогенетичний протеїн 7 (Bone morphogenetic protein 7 — BMP-7) визначали з використанням імуноцито­хімічного аналізу. Рівні мРНК OPN (SPP1), ON (SPARC), BMP-7 (BMP7) та мікроРНК-10b, -27а, -29b, -145, -146а оцінювали за допомогою кількісної полімеразної ланцюгової реакції. Для пошуку мікроРНК, залучених до регуляції цільових генів, використовували ресурс miRNet v. 2.0. Результати: Встановлено, що клітини високого ступеня злоякісності лінії MDA-MB-231 РМЗ людини характеризуються значно вищими рівнями експресії OPN та ON на тлі зниження експресії мРНК SPARC та BMP7. У клітинах високого ступеня злоякісності DU-145 експресія мРНК ON, SPP1, SPARC та BMP7 була значно вищою порівняно з клітинами LNCaP. Лінія MDA-MB-231 характеризувалася значно вищою експресією мікроРНК-10b, -27a, -29b, -145 та -146a. У клітинах DU-145 зафіксовано достовірно нижчі рівні експресії мікроРНК-27a і -145 на тлі підвищення рівня мікроРНК-29b і -146a. Висновок: Встановлено, що формування високого ступеня злоякісності у клітинах РМЗ та РПЗ асоціюється з високим рівнем експресії білків ремоделювання кісткової тканини, що може бути зумовлено порушенням регуляції їх експресії на епігенетичному рівні
Additional Access Points:
Lukianova, N.
Zadvornyi, T.
Kashuba, E.
Borikun, T.
Mushii, О.
Chekhun, F.

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14.
Cipher: ЕУ12/2017/39/3
   Journal
Экспериментальная онкология [Text]
2017year Т. 39 № 3 . - 34.76, р.
Contents:
Chekhun, V. F. On the 40th anniversary of the international symposium “The role of stem cells in leukemo-and carcinogenesis»: in Kyiv again / V. F. Chekhun. - С.162-163
Kalynychenko, T. O. Umbilical cord blood banking in the worldwide hematopoietic stem cell transplantation system: perspectives for Ukraine / T. O. Kalynychenko. - С.164-170. - Bibliogr. at the end of the art.
Vasyliev, R. G. Large-scale expansion and characterization of human adult neural crest-derived multipotent stem cells from hair follicle for regenerative medicine applications / R. G. Vasyliev [та ін.]. - С.171-180. - Bibliogr. at the end of the art.
Other authors: Rodnichenko A. E., Gubar O. S., Zlatska A. V., Gordiienko I. M., Novikova S. N., Zubov D. O.
Kozub, M. M. Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure / M. M. Kozub [та ін.]. - С.181-185. - Bibliogr. at the end of the art.
Other authors: Prokopiuk V. Y., Skibina K. R., Prokopiuk О. V., Kozub N. I.
Gubar, O. S. Postnatal extra-embryonic tissues as a source of multiple cell types for regenerative medicine applications / O. S. Gubar [та ін.]. - С.186-190. - Bibliogr. at the end of the art.
Other authors: Rodnichenko A. E., Vasyliev R. G., Zlatska A. V., Zubov D. O.
Vasyliev, R. G. Tissue-engineered bone for treatment of combat related limb injuries / R. G. Vasyliev [та ін.]. - С.191-196. - Bibliogr. at the end of the art.
Other authors: Oksymets V. M., Rodnichenko A. E., Zlatska A. V., Gubar O. S., Gordiienko I. M., Zubov D. O.
Zlatska, A. V. Endometrial stromal cells: isolation, expansion, morphological and functional properties / A. V. Zlatska [та ін.]. - С.197-202. - Bibliogr. at the end of the art.
Other authors: Rodnichenko A. E., Gubar O. S., Zubov D. O., Novikova S. N., Vasyliev R. G.
Chekhun, V. F. Association of CD44+CD24-/low with markers of aggressiveness and plasticity of cell lines and tumors of patients with breast cancer / V. F. Chekhun [та ін.]. - С.203-211. - Bibliogr. at the end of the art.
Other authors: Lukianova N. Y., Chekhun S. V., Bezdieniezhnykh N. O., Zadvomiy T. V., Borikun T. V., Polishchuk L. Z., Klyusov O. M.
Karlitepe, A. Anti-cancer efficiency of natural killer cells differentiated from human adipose tissue-derived mesenchymal stem cells and transfected with miRNA150 / A. Karlitepe [та ін.]. - С.212-218. - Bibliogr. at the end of the art.
Other authors: Kabadayi H., Vatansever S., Gurdal M., Gunduz C., Ercan G.
Lisyaniy, N. I. Content of stem tumor CD133+ cells in brain neoplasms of different histological type / N. I. Lisyaniy [та ін.]. - С.219-223. - Bibliogr. at the end of the art.
Other authors: Stanetskaya D. N., Lisyaniy A. N., Belskaya L. N.
Ryspayeva, D. E. Are CD44+CD24- cells the assumed cancer stem cells in breast cancer? / D. E. Ryspayeva [та ін.]. - С.224-228. - Bibliogr. at the end of the art.
Other authors: Smolanka I. I., Dudnichenko A. S., Lyashenko A. A., Grinevich Yu. A., Gurianov V. G., Koshubarova M. V., Seleznev A. A.
Bezdieniezhnykh, N. O. Scientific-practical and legal problems of implementation of the personalized medicine / N. O. Bezdieniezhnykh, V. V. Reznikova, O. V. Rossylna. - С.229-233
Normal and cancer stem cells: discovery diagnosis and therapy international scientific conference. R. E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology National Academy of Sciences of Ukraine Kyiv October 5–6 2017. - С.234-256
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15.


   
    Association of CD44+CD24-/low with markers of aggressiveness and plasticity of cell lines and tumors of patients with breast cancer [Text] / V. F. Chekhun [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 3. - С. 203-211. - Bibliogr. at the end of the art.


MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (осложнения, патофизиология, этиология)
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (анализ)
ЦИТОСТАТИЧЕСКИЕ СРЕДСТВА -- CYTOSTATIC AGENTS (анализ, терапевтическое применение)
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ НОВООБРАЗОВАНИЙ -- DRUG RESISTANCE, NEOPLASM (физиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To search for additional molecular-biological markers of cancer stem cell (CSC) involved in the development of intra-tumor heterogeneity for the detection of features of the breast cancer (BC) pathogenesis. Materials and methods: Expression of estrogen receptors (ER), progesterone receptors (PR), Her2/neu, E- and N-cadherin, CD24, CD44, Bcl-2, Bax, Slug, P-gp, glutathione-S-transferase (GST) and metallothionein in cell lines was determined by the immunocytochemical method. Expression of ER, PR, Her2/neu, CD24 and CD44 in the surgical material of BC patients were determined by the immunohistochemical method. The levels of the miRNA were determined using real-time polymerase chain reaction. Results: Cells of high-grade malignancy (HGM), MDA-MB-231 and MDA-MB-468 are characterized by high expression of stem cell markers compared to the cells of low-grade malignancy (LGM), T47D and MCF-7: CD44 levels in T47D and MCF-7 cells were in range of 72-79 points, which is significantly lower than in HGM cells (p 0.05). Also, HGM cells with the properties of CSC were characterized by high expression of antiapoptotic proteins, the transcription factor Slug, and low levels of proapoptotic protein Bax (p 0.05) compared to LGM cells. In cells with CSC characteristics an increased expression of transferrin and its receptor, ferritin, fentorin and hepcidin was revealed indicating activation of the endogenous iron metabolism. The characteristic feature of HGM cells with CSC phenotype were the increased levels of oncogenic miR-221, -155 and -10b by 60%, 92% and 78%, respectively, and decreased levels of oncosuppressive miR-29b, -34a and -200b by 8.4 ± 0.3, 4.6 ± 0.2, and 3.4 ± 0.6 times compared to MCF-7 line cells. It has been established that the development of resistance to cytostatics is accompanied by increased aggressiveness of tumor cells, loss of expression of hormonal receptors and acquiring of stem phenotype. In particular, increased expression of P-gp was observed in BC cells during the development of resistance to doxorubicin, of GST during the development of resistance to cisplatin along with increased CD44 expression (p 0.05). We have revealed the relation between the presence of cells with the CSC phenotype (CD44+CD24-/low) and clinical and pathological characteristics of BC patients, their survival and BC sensitivity to neoadjuvant therapy (p > 0.05). Conclusions: The dependence between the expression of CSC markers and the degree of malignancy of tumor cells, development of resistance to cytostatics in vitro was established as well as the predictive value of the detection of the CSC for the individual prognosis of the BC course and sensitivity of the tumors to the treatment
Additional Access Points:
Chekhun, V. F.
Lukianova, N. Y.
Chekhun, S. V.
Bezdieniezhnykh, N. O.
Zadvomiy, T. V.
Borikun, T. V.
Polishchuk, L. Z.
Klyusov, O. M.

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16.
Cipher: ЕУ12/2018/40/3
   Journal
Экспериментальная онкология [Text]
2018year Т. 40 № 3
Contents:
Akbarzadeh, A. Role of dendrimers in advanced drug delivery and biomedical applications: a review / A. Akbarzadeh [та ін.]. - С.178-183. - Bibliogr. at the end of the art.
Other authors: Khalilov R., Mostafavi E., Annabi N., Abasi E., Kafshdooz T., Herizchi R., Kavetskyy T., Saghfi S., Nasibova A., Davaran S.
Zadvornyi, T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro / T. V. Zadvornyi [та ін.]. - С.184-189. - Bibliogr. at the end of the art.
Other authors: Lukianova N. Y., Borikun T. V., Chekhun V. F.
Harper, P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies / P. Harper [та ін.]. - С.190-193. - Bibliogr. at the end of the art.
Other authors: Hald O., Lwaleed B. A., Kyyaly A., Johnston D., Cooper A. J., Birch B.
Apykhtina, О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles / О. L. Apykhtina [та ін.]. - С.194-199. - Bibliogr. at the end of the art.
Other authors: Dybkova S. M., Sokurenko L. M., Chaikovsky Yu. B.
Chekhun, V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats / V. F. Chekhun [та ін.]. - С.200-204. - Bibliogr. at the end of the art.
Other authors: Storchai D. M., Todor I. N., Borikun T. V., Lukianova N. Yu.
Prokhorova, I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6 / I. V. Prokhorova [та ін.]. - С.205-210. - Bibliogr. at the end of the art.
Other authors: Pyaskovskaya O. N., Kolesnik D. L., Solyanik G. I.
Abramenko, I. V. Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients / I. V. Abramenko [та ін.]. - С.211-217. - Bibliogr. at the end of the art.
Other authors: Bilous N. I. , Chumak A. A., Dyagil I. S., Martina Z. V.
Nesina, I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I. P. Nesina, N. P. Iurchenko, L. G. Buchynska. - С.218-222. - Bibliogr. at the end of the art.
Vernygorodskyi, S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction / S. Vernygorodskyi, T. Rekun, P. Zhuchenko. - С.223-227. - Bibliogr. at the end of the art.
Gerashchenko, T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles / T. S. Gerashchenko [та ін.]. - С.228-234. - Bibliogr. at the end of the art.
Other authors: Denisov E. V., Novikov N. M., Tashireva L. A., Kaigorodova E. V., Savelieva O. E., Zavyalova M. V., Cherdyntseva N. V., Perelmuter V. M.
Agishev, T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury / T. T. Agishev [та ін.]. - С.235-238. - Bibliogr. at the end of the art.
Other authors: Topuzov E. E., Кrasnozhon D. A., Petrachkov A. O., Pavlov R. V., Doniyarov S. H.
Dumansky, Yu. V. Paraneoplastic syndrome in lung cancer / Yu. V. Dumansky [та ін.]. - С.239-242. - Bibliogr. at the end of the art.
Other authors: Syniachenko O. V., Stepko P. A., Yehudina Ye. D., Stoliarova O. Yu.
Grybach, S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome / S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun. - С.243-248. - Bibliogr. at the end of the art.
Chrysanthakopoulos, N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study / N. A. Chrysanthakopoulos, N. S. Dareioti. - С.249-250. - Bibliogr. at the end of the art.
Tkachenko, R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy / R. Tkachenko, A. Golovko, O. Kuryk. - С.251-253
Svitlana Pavlivna Sidorenko (1953–2018). - С.254-255
Yurii Yosypovych Kudryavets (1946–2018). - С.256-257
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17.


   
    Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro [Text] / T. V. Zadvornyi [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 184-189. - Bibliogr. at the end of the art.


MeSH-main:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (патофизиология, этиология)
ЛАКТОФЕРРИН -- LACTOFERRIN (анализ, терапевтическое применение, фармакология)
ТКАНЕЙ ВЫЖИВАЕМОСТЬ -- TISSUE SURVIVAL (действие лекарственных препаратов)
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY (использование, тенденции)
ГЕННОЙ ЭКСПРЕССИИ РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION (действие лекарственных препаратов)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To investigate the biological effects of exogenous lactoferrin (LF) on phenotypic profile and invasiveness of human prostate cancer (PC) cells in vitro. Materials and Methods: Human PC cell lines (LNCaP, DU-145) were cultured with an exogenous LF at a dose corresponding to IC30. The expression levels of steroid hormone receptors (androgen receptor, estrogen receptor, progesterone receptor), Her2/neu, Ki-67, E- and N-cadherin, were monitored by immunohistochemical analysis. The levels of miRNAs were assessed using q-PCR. The invasive activity of the cells was examined in a standard invasion test. Results: Exogenous LF reduced expression of steroid hormone receptors (ERα and PR) and Ki-67 in both PC cell lines. The expression of E-cadherin increased significantly in LF-treated DU-145 cells. Also, we established the decrease in invasive activity upon LF treatment by 40% and 30% in DU-145 and LNCaP cells, respectively. In DU-145 cells, incubation with exogenous LF resulted in an increase in the expression of oncosuppressive (miR-133a and miR-200b) miRNAs. Conclusions: Exogenous LF causes the changes in phenotypic characteristics of PC cells and levels of oncogenic and oncosuppressive miRNAs involved in the regulation of key cellular processes. Key Words: prostate cancer, exogenous lactoferrin, DU145, LNCaP, miRNA
Additional Access Points:
Zadvornyi, T. V.
Lukianova, N. Y.
Borikun, T. V.
Chekhun, V. F.

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18.


   
    Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats [Text] / V. F. Chekhun [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 200-204. - Bibliogr. at the end of the art.


MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (патофизиология, этиология)
КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER (патофизиология, этиология)
ЛАКТОФЕРРИН -- LACTOFERRIN (анализ, метаболизм, терапевтическое применение, физиология)
РОСТА ИНГИБИТОРЫ -- GROWTH INHIBITORS (анализ, диагностическое применение)
МУТАГЕНЫ -- MUTAGENS (анализ)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF. Materials and Methods: The study was performed on Walker-256 tumor-bearing rats. Total lipids and phospholipids were determined by thin-layer chromatography. Comet assay was used to investigate the genotoxic effects of LF. Results: Daily i.p. administrations of exogenous LF at concentrations of 1 mg/kg and 10 mg/kg starting from the 4th day after tumor transplantation suppressed growth of Walker-256 carcinosarcoma by almost 44%. After treatment with recombinant LF in both doses, the phospholipid composition of Walker-256 carcinosarcoma cells was changed (3-fold increase of phosphatidylethanolamine, 3.4-fold increase of phosphatidylcholine, and 1.8-fold increase of sphingomyelin, while the cardiolipin content decreased by 67%. Exogenous LF was not genotoxic for bone marrow cells (as assessed by the ratio of PCE/NCE, number of micronuclei) and peripheral blood lymphocytes (percentage of DNA in the tail of a comet) in Walker-256 carcinosarcoma-bearing rats. Conclusion: Exogenous LF caused the inhibition of Walker-256 carcinosarcoma growth and a decrease in the microviscosity of plasma cell membranes, and exerted no genotoxicity toward bone marrow cells and peripheral blood of experimental animals. Key Words: lactoferrin, breast cancer, Walker-256 carcinosarcoma, phospholipid content, genotoxicity
Additional Access Points:
Chekhun, V. F.
Storchai, D. M.
Todor, I. N.
Borikun, T. V.
Lukianova, N. Yu.

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19.
Cipher: ЕУ12/2019/41/3
   Journal
Экспериментальная онкология [Text]
2019year Т. 41 № 3 . - 45.41, р.
Contents:
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine: 25 years with the OECI. - С.187
Chekhun, V. F. MicroRNAs are a key factor in the globalization of tumor-host relationships / V. F. Chekhun. - С.188-194. - Bibliogr. at the end of the art.
Shlyakhovenko, V. O. The dual role of ribonucleases in tumor-host relationship / V. O. Shlyakhovenko, O. A. Samoylenko. - С.195-199. - Bibliogr. at the end of the art.
Shuba, Ya. M. Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? / Ya. M. Shuba. - С.200-206. - Bibliogr. at the end of the art.
Ivanivska, T. S. Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia / T. S. Ivanivska [та ін.]. - С.207-209. - Bibliogr. at the end of the art.
Other authors: Sklyarenko L. M., Zavelevich M. P., Philchenkov A. A., Koval S. V., Polishchuk A. S., Gluzman D. F.
Holotiuk, V. V. Role of nitric oxide in pathogenesis of tumor growth and its possible application in cancer treatment / V. V. Holotiuk [та ін.]. - С.210-215. - Bibliogr. at the end of the art.
Other authors: Kryzhanivska A. Y., Churpiy I. K., Tataryn B. B., Ivasiutyn D. Ya.
Oshyvalova, O. Modern view on epidermal dysplasia carcinogenesis / O. Oshyvalova, Z. Rossokha. - С.216-223. - Bibliogr. at the end of the art.
Bazalytska, S. V. Моlecular mechanisms of initiation of carcinogenesis in the testis / S. V. Bazalytska, Y. Persidsky, A. M. Romanenko. - С.224-234. - Bibliogr. at the end of the art.
Bogdanova, T. Histopathological characteristics and post-operative follow-up of patients with potentially radiogenic papillary thyroid carcinoma depending on oncocytic changes availability in the tumor cells / T. Bogdanova [та ін.]. - С.235-241. - Bibliogr. at the end of the art.
Other authors: Zurnadzhy L., Masiuk S., Burko S., Degtyaryova T., Kovalenko A., Bolgov M., Chernyshov S., Gulevatyi S., Thomas G., Tronko M.
Lukianova, N. Yu. Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer / N. Yu. Lukianova, T. V. Borikun, V. F. Chekhun. - С.242-247. - Bibliogr. at the end of the art.
Patysheva, M. Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes / M. Patysheva [та ін.]. - С.248-253. - Bibliogr. at the end of the art.
Other authors: Stakheyeva M., Larionova I., Fedorov A., Kzhyshkowska J., Cherdyntseva N.
Sakhno, L. A. Adsorptive therapy as a modificator for tumor-host interaction / L. A. Sakhno [та ін.]. - С.254-257. - Bibliogr. at the end of the art.
Other authors: Sarnatskaya V. V., Yushko L. A., Snezhkova E. A., Bardakhivskaya K. I., Shevchuk O. O., Sidorenko A. S., Nikolaev V. G.
Materials of the II International Conference “Tumor and Host: Novel Aspects of Old Problem” (November 21–22, 2019, Kyiv, Ukraine). - С.258-280
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20.


    Lukianova, N. Yu.
    Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer [Text] / N. Yu. Lukianova, T. V. Borikun, V. F. Chekhun // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 242-247. - Bibliogr. at the end of the art.

Annotation: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) were analyzed in tissue of BC using immunohistochemical method. Relative expression levels of the miR-155, -320a, and -205 were examined in tissue and sera from BC patients using quantitative reverse transcription polymerase chain reaction. Results: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. Nevertheless, we established the relation of circulating and tissue miR-155, -320a, and -205 to lymph node metastases and basal breast cancer subtype. Conclusions: Changes of miR-155, -320a, and -205 expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC
Additional Access Points:
Borikun, T.V.
Chekhun, V. F.

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