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Total number of found documents : 3
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1.
Cipher: МУ96/2017/3/1
   Journal

Міжнародний журнал медицини і медичних досліджень. - Published twice a year
2017year т.3 N 1
Contents:
Venger, O. P. Improvement in the approaches to the treatment of emigrants and re-emigrants with depressive disorders / O. P. Venger, Y. I. Mysula, L. V. Shkrobot. - С.5-10
Kedyk, A. V. Screening for dyslipidemia and expedience of statin therapy for the citizens of transcarpathia valley regions with overweight and obesity / A. V. Kedyk, M. V. Rishko, O. O. Kutsyn. - С.11-14
Oleshchuk, O. M. Leptin resistance and type 2 diabetes / O. M. Oleshchuk, H. Ya. Loi. - С.15-21
Martynyuk, L. Z. The effect of L-arginine on oxidative stress and microalbuminuria in patients with type 2 diabetes mellitus and chronic kidney disease / L. Z. Martynyuk, L. Z. Vons, O. O. Ruzhytska. - С.22-25
Sarapuk, I. M. Neurodevelopmental care of preterm infants and its key / I. M. Sarapuk [и др.]. - С.26-33
Other authors: Pavlyshyn H. A., Lacina L., Krolak-Olejnik B.
Vergun, A. R. Chronic mycotic-associated surgical nail pathology complicated with ingrown nail (nail incarnation): the analyses of clinical cases and complex treatment / A. R. Vergun [и др.]. - С.34-40
Other authors: Parashchuk B. M., Krasnyi M. R., Kit Z. M., Vergun O. M.
Hasiuk, N. V. Pathogenic mechanisms of generalized periodontitis from the position of polymorphism of nuclear transcription / N. V. Hasiuk [и др.]. - С.41-46
Other authors: Vesnina L. E., Shlykova O. A., Izmailova O. V.
Kostenko, Ye. Ya. The effectivness of chronic gingivites treatment in patients with non-removable orthodontic apparatus according to the results of periodontal tissues index assessment / Ye. Ya. Kostenko, V. S. Melnyk, L. F. Horzov. - С.47-49
Kalinichenko, S. V. Influence of lactobacillus spp. on colonization and anti-infectious resistance of the mucous membranes of the upper respiratory tract / S. V. Kalinichenko [и др.]. - С.50-59
Other authors: Korotkykh O. O., Pokhil S. I., Bakumenko M. G.
Melnyk, L. P. Awareness of lyme borreliosis of the patients of ternopil regional tb dispensary / L. P. Melnyk [и др.]. - С.60-63
Other authors: Hryshchuk L. A., Koziol-Montewka M., Tabas P. O., Klos R. O.
Nazarchuk, O. A. Research in sensitivity to antibiotics, antiseptics in pseudomonas aeruginosa strains isolated from patients with infectious complications / O. A. Nazarchuk, D. V. Paliy, N. I. Osadchuk. - С.64-69
Boiagina, O. D. Morphological study of communication between the longitudinal strips and the human corpus callosum / O. D. Boiagina. - С.70-74
Ilika, V. V. Morphological research on free-residue oxidation processes in cases of decidual cells of placenta in chorioamnionotis and basal deciduitis combined with iron-deficiency anemia in the pregnant / V. V. Ilika. - С.75-78
Khudobiak, M. M. Morphological changes in lungs, heart and liver caused by experimental associated chest and thighs trauma / M. M. Khudobiak, M. I. Marushchak, L. M. Holovatiuk. - С.79-83
Lykhatskyi, P. H. Free radicals and inflammation in rats of different age in cases of sodium nitrites and tobacco smoke poisoning / P. H. Lykhatskyi, L. S. Fira. - С.84-88
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2.


    Oleshchuk, O. M.
    Leptin resistance and type 2 diabetes [Text] / O. M. Oleshchuk, H. Ya. Loi // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P15-21


MeSH-main:
ДИАБЕТ САХАРНЫЙ, ТИП 2 -- DIABETES MELLITUS, TYPE 2
ЛЕПТИН -- LEPTIN
Annotation: Leptin is one of adipocyte-secreted hormones. It signals to the brain and other tissues about the status of body energy reserves. Circulating leptin levels are directly proportional to the amount of the body fat. Leptin concentration increases when surfeit and decreases during fasting. Obese patients are hyperleptinemic compared with thin persons and they are tolerant to the central hypothalamic effects of leptin. The reduced sensitivity toward exogenous and endogenous leptin is commonly referred to as leptin resistance. Alterations in the signaling of the long isoform of the leptin receptor play the crucial role in leptin resistance. Surfeit may induce leptin resistance and other metabolic sequelae of obesity. Leptin insensitivity and insulin resistance play a major role in the development of type 2 diabetes. Metformin remains the preferred first-line pharmacologic agent for the treatment of type 2 diabetes. It reduces hepatic glucose production, increases glucose uptake in peripheral tissue and can lead to weight loss. Metformin decreases both insulin and leptin concentration, restores the sensitivity to these hormones. But some studies have shown poor relationship between metformin action and leptin level. And the mechanism of metformin action on leptin resistance remains unclear. Thus, these issues should be studied as well as polymorphisms in genes encoding metformin action
Additional Access Points:
Loi, H. Ya.

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3.


   
    Metformin exerts cardioprotection in isoproterenol-induced cardiomyopathy in rats [Text] = Метформін проявляє кардіопротекцію при ізопротереноліндукованій кардіоміопатії в щурів / H. Ya. Loi [et al.] // Медична та клінічна хімія = Medical and clinical chemistry. - 2019. - Том 21, N 4. - С. 169-177


MeSH-main:
МЕТФОРМИН -- METFORMIN
КАРДИОМИОПАТИИ -- CARDIOMYOPATHIES (лекарственная терапия)
КРЫСЫ -- RATS
ИЗАДРИН -- ISOPROTERENOL (вредные воздействия)
Annotation: Due to neuropathy in diabetic patients, the dysfunction of the autonomic nervous system occurs, and cardiac activity undergone excess sympathetic stimulation which is named cardiac autonomic neuropathy. Patients with cardiac autonomic neuropathy are at higher risk of left ventricular hypertrophy and are predisposed to cardiovascular events. It was established that metformin, a first-line agent for the initial pharmacotherapy of type 2 diabetes mellitus, poses significant cardioprotective effects. Nevertheless, its activity in the myocardium, subjecting the increased sympathetic tone, remains poorly investigated
У хворих на цукровий діабет у зв’язку з нейропатією виникає дисфункція автономної нервової системи, внаслідок чого серцева діяльність піддається надмірній симпатичній стимуляції, що називають кардіальною автономною нейропатією. Пацієнти з нейропатією мають підвищений ризик виникнення гіпертрофії лівого шлуночка та більш схильні до розвитку серцево-судинних ускладнень. Встановлено, що метформін, препарат першої лінії для початкової фармакотерапії цукрового діабету 2 типу, проявляє виражені кардіопротекторні ефекти. Проте його активність у міокарді, що піддається надмірному симпатичному впливу, вивчено недостатньо
Additional Access Points:
Loi, H. Ya.
Pavliuk, B. V.
Kramar, S. B.
Korda, M. M.
Oleshchuk, O. M.

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