Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Назва журналу :The Ukrainian biochemical journal -2017р. т.89,N 6
Цікаві статті :
Osadchuk T. V. Synthesis and investigation of the derivatives of amidinohydrazonelated aromatic compounds as furin inhibitors/ T. V. Osadchuk [et al.] (стр.3-12)
Kolas I. K. Copurification of chicken liver soluble htiamine monophosphatase and low molecular weight acid phosphatase/ I. K. Kolas, A. F. Makarchikov (стр.13-21)
Kuznetsova T. Y. Antioxidant activity of melatonin and glutathione interacting with hydroxyl and superoxide anion radicals/ T. Y. Kuznetsova [et al.] (стр.22-30)
Chudina T. O. Changes in proHB-EGF expression after functional activation of the immune system cells/ T. O. Chudina [et al.] (стр.31-38)
Gonchar O. A. Time-dependent effect of severe hypoxia/reoxygenation on oxidative stress level, antioxidant capacity and p53 accumulation in mitochondria of rat heart/ O. A. Gonchar, I. N. Mankovska (стр.39-47)
Shahouzehi B. Effect of L-carnitine administration on serum insulin and adiponectin levels, and AMPK, APPL1 and PPAR? gene expression in STZ-induced diabetic rat liver/ B. Shahouzehi [et al.] (стр.48-55)
Pylypets A. Z. Effects of thiosulfonates on the lipid composition of rat tissues/ A. Z. Pylypets et al.] (стр.56-62)
Комісаренко С. В. Для чого потрібні циркадні ритми, або як змінити хід "біологічного годинника"/ С. В. Комісаренко, С. І. Романюк (стр.63-73)
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Форма документа : Стаття із журналу
Шифр видання :
Автор(и) : Shahouzehi B., Barkhordari K., Aminizadeh S., Masoumi-Ardakani Y.
Назва : Effect of L-carnitine administration on serum insulin and adiponectin levels, and AMPK, APPL1 and PPAR? gene expression in STZ-induced diabetic rat liver
Місце публікування : The Ukrainian Biochemical Journal. - Київ, 2017. - Том 89, N 6. - С. 48-55 (Шифр УУ60/2017/89/6)
MeSH-головна: ДИАБЕТ САХАРНЫЙ ЭКСПЕРИМЕНТАЛЬНЫЙ -- DIABETES MELLITUS, EXPERIMENTAL
КРОВЬ -- BLOOD
ПЕЧЕНЬ -- LIVER
КАРНИТИН -- CARNITINE
Анотація: Diabetes is considered as a metabolic disease in which insulin secretion and functions are disturbed and characterized by hyperglycemia. L-carnitine is synthesized in most mammals and plays critical role in fatty acid oxidation and energy production. Data about the L-carnitine hypoglycemic effects are controversial. We evaluated long-term oral L-carnitine administration effects on blood glucose, insulin and adiponectin levels, as well as expression of AMPK, APPL1 and PPARγ genes in liver of STZ-induced diabetic rats. Group 1 (control), did not receive any treatment, group 2 received 50 mg/kg STZ by i.p injection, group 3 received single dose of 50 mg/kg STZ by i.p injection and also 600 mg/kg/day L-carnitine orally for 5 weeks. Our results showed that L-carnitine long-term oral supplementation significantly reduced blood glucose and normalized insulin levels in diabetic rats. Also, we found that L-carnitine significantly increased AMPK and APPL1 expression, and showed a mild elevation of PPARγ expression. In sum, we suggest that long-term L-carnitine supplementation has beneficial effects on diabetic rats which showed hypoglycemic effects. Probably the beneficial effects of L-carnitine are contributed to the upregulation of insulin sensitizers such as AMPK and adiponectin
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Назва журналу :The Ukrainian biochemical journal -2018р. т.90,N 6
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Asmaa Missoum. The role of gene GJB2 and connexin 26 in hearing impairment/ Missoum Asmaa (стр.5-11)
Kolupaev Yu. E. Phenylalanine ammonia-lyase activity and content of flavonoid compounds in wheat seedlings at the action of hypothermia and hydrogen sulfide donor/ Yu. E. Kolupaev [et al.] (стр.12-20)
Chernyshenko V. O. Haemostasis modulation by calix[4]arene methylenebisphosphonic acid C-145 and its sulfur-containing analogue/ V. O. Chernyshenko [et al.] (стр.21-30)
Tykhomyrov A. A. Plasminogen modulates formation of reactive oxygen species in human platelets/ A. A. Tykhomyrov [et al.] (стр.31-40)
Siromolot A. A. Specificity and sensitivity of the new test for serological evaluation of tuberculosis using MPT83-MPT63 fusion antigen/ A. A. Siromolot [et al.] (стр.41-48)
Lylyk M. P. Effects of alpha-ketoglutarate on lifespan and functional aging. Of Drosophila melanogaster flies/ M. P. Lylyk [et al.] (стр.49-61)
Purkan P. Immunogenicity assay of KatG protein from Mycobacterium tuberculosis in mice: preliminary screening of TB vaccine/ P. Purkan [et al.] (стр.62-69)
Zavodovskyi D. O. Influence of C60 fullerene on the ischemia-reperfusion injury in the skeletal muscle of rat limb: mechanokinetic and biochemical analysis/ D. O. Zavodovskyi [et al.] (стр.70-81)
Nakonechna O. A. Disturbance of the transmembrane phosphatidylserine asymmetry in hepatocytes as an apoptosis marker under the action of xenobiotics on rats/ O. A. Nakonechna, L. A. Babijchuk, A. I. Bezrodna (стр.82-88)
Aminizadeh S. The effects of PDK4 inhibition on AMPK protein levels and PGC-1α gene expression following endurance training in skeletal muscle of Wistar rats/ S. Aminizadeh, Y. Masoumi-Ardakani, B. Shahouzehi (стр.89-96)
Horid’ko T. M. Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment/ T. M. Horid’ko [et al.] (стр.97-109)
Hurmach Y. The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma/ Y. Hurmach [et al.] (стр.110-119)
Marounek M. Long-term hypocholesterolemic effect of amidated alginate in rats/ M. Marounek [et al.] (стр.120-125)
Данилова В. М. Внесок Нобелівських лауреатів початку ХХ ст. в розвиток молекулярної імунології: Е. Берінг, І. І. Мечников, П. Ерліх, Ш. Ріше, Ж. Борде, К. Ландштейнер/ В. М. Данилова, Р. П. Виноградова, С. В. Комісаренко (стр.126-142)
Дмитро Олексійович Мельничук. До 75-річчя з дня народження (стр.143-144)
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Форма документа : Стаття із журналу
Шифр видання :
Автор(и) : Aminizadeh S., Masoumi-Ardakani Y., Shahouzehi B.
Назва : The effects of PDK4 inhibition on AMPK protein levels and PGC-1α gene expression following endurance training in skeletal muscle of Wistar rats
Місце публікування : The Ukrainian Biochemical Journal. - Київ, 2018. - Том 90, N 6. - С. 89-96 (Шифр УУ60/2018/90/6)
MeSH-головна: ФИЗИЧЕСКАЯ НАГРУЗКА У ЖИВОТНЫХ -- PHYSICAL CONDITIONING, ANIMAL
МЫШЦА СКЕЛЕТНАЯ -- MUSCLE, SKELETAL
КЛЕТОК КОНТАКТНОЕ ИНГИБИРОВАНИЕ -- CONTACT INHIBITION
Анотація: There are regulatory networks in cells which surveil the physiological and environmental states. These cellular regulations are conducted through gene expression modulation. Skeletal muscle is able to adapt shortly and produce ATP at different conditions. AMPK (AMP-activated protein kinase) and PGC-1α (peroxisome proliferator-activated receptor-gamma coactivator-1alpha) are important regulators of cellular energy homeostasis. We designed this study to examine the effects of interactions between endurance training and PDK4 (pyruvate dehydrogenase kinase 4) inhibition on AMPK and PGC-1α expression in rat skeletal muscle. Thirty-two male Wistar rats were randomly selected and divided into 4 groups (n = 8); Group 1 control which did not receive any treatment, Group 2 received dichloroacetic acid (DCA) (150 mg/kg/day), Group 3 (endurance training group), Group 4 which received DCA and performed endurance training. AMPK protein expression, PDK4 and PGC-1α gene expression were measured by western blotting and real-time PCR, respectively. Our data showed that PDK4 inhibition caused AMPK protein elevation. Endurance training (group 2) and PDK4 inhibition (group 4) induce significant enhancement of PGC-1α gene expression compared to control group. The group which received DCA showed significant elevation of PDK4 gene expression compared to control group (P = 0.001), also other two groups (groups 2 & 3) showed significant elevation of PDK4 gene expression compared to control (P = 0.006). It seems that the combination of endurance training and PDK4 inhibition by up-regulation of PGC-1α expression, effectively improves energy state and performance in skeletal muscle
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