Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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повний	інформаційний	короткий

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Загальна кількість знайдених документів : 4
Показані документи з 1 по 4

Назва журналу :Вісник фармації -2016р.,N 4
Цікаві статті :
Determination of the content of benzocaine and penicillin-G-procaine in combined finished dosage forms using tropaeolin O azo dye , M. Ya. Smolinska, I. Ya. Kotsiumbas (стр.3-8)
Blazheyevskiy M. The quantitative determination of hydrogen peroxide by voltammetry on the carbositall electrode / M. Blazheyevskiy, O. Mozgova (стр.9-13)
Grytsan L. D. Some applications of physicochemical analysis in pharmacy/ L. D. Grytsan (стр.14-16)
The synthesis and the antimicrobial activity of the substituted arylamides of 3-arylmethyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7-carboxylic acids , K. Yu. Krolenko, S. V. Vlasov (стр.17-21)
The use of analytical methods for quality control of promising active pharmaceutical ingredients among derivatives of 4-oxo-quinoline-3-propanoic acids , V. O. Zubkov, N. I. Ruschak (стр.22-30)
Stremoukhov O. O. The study of fatty and organic acids of Vaccinium uliginosum leaves / O. O. Stremoukhov, O. M. Koshovyi, O. I. Zalyubovs’ka (стр.31-33)
Stadnichenko O. V. The study of the lipid membrane charge effect when creating liposomes with oxaliplatin/ O. V. Stadnichenko, Yu. M. Krasnopolsky, T. G. Yamykh (стр.34-37)
Fedorovska M. Development of the composition of the gel base for treating telogen effluvium / M. Fedorovska, N. PoIovko (стр.38-42)
Shmalko O. O. The study on the choice of flavours for the herbal syrup with the hepatotropic action / O. O. Shmalko, L. I. Vyshnevska, V. A. Megalinskyi (стр.43-45)
Development of the original method for determination of diclofenac sodium in different drug dosage forms , V. A. Khanin, O. M. Kotenko (стр.46-49)
Petravska L. S. Assessment of the main trends of developing the market of foaming detergents in Ukraine/ L. S. Petravska (стр.50-53)
Zarichkova M. V. The scientific summary of monitoring results of expenditure for social protection in the European union and Ukraine/ M. V. Zarichkova (стр.54-58)
Determination of toxicity of new benzilic acid derivatives , N. M. Tryshchuk, I. V. Kireyev (стр.59-61)
The effect of the mixtures with biologically active substances from Fraxinus excelsior and Phlomis pungens on the resistance to hypoxia in white rats compared to the action of a-tocopherol and mexidol , I. A. Takhirov, V. Y. Asmetov (стр.62-65)
The anti-allergic and antihistaminic properties of hydrobromide 2-[4-(4’-chlorophenyl)-2-phenyliminothiazol-3-yl]-ethanol , O. Yu. Koshova, H. O. Ieryomina (стр.66-69)
Derkach N. M. The antimicrobial action of decamethoxinum substance at different pH values/ N. M. Derkach, Z. S. Suvorova (стр.70-75)
До 60-річчя професора кафедри технології ліків Національного фармацевтичного університету, доктора фармацевтичних наук Котенка Олександра Михайловича (стр.76-77)
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Назва журналу :Вісник фармації -2016р.,N 3
Цікаві статті :
Vlasov S. V. Synthesis, the anti-inflammatory and antimicrobial activity of 6-(1H-benzimidazol-2-yl)-5-methyl-4-(alkylthio)thienо[2,3-d] pyrimidines / S. V. Vlasov, V. P. Chernykh (стр.9-16)
Romanenko M. I. The synthesis, physicochemical and biological properties of 8-amino-7-(2-hydroxy-2-phenylethyl)-3-methylxanthines/ M. I. Romanenko [et al.] (стр.17-21)
Suleimanov T. A. Development and determination of validation parameters for the HPLC method of thymol quantification in “Kalinol plus” syrup / T. A. Suleimanov, E. Z. Balaeva, E. Yu. Akhmedov (стр.22-27)
Kyslychenko V. S. The anatomical study of shepherd’s purse herb/ V. S. Kyslychenko [et al.] (стр.28-31)
Upyr T. V. The study of the chemical composition and the pharmacological activity of the polysaccharide complex obtained from Ledum palustre/ T. V. Upyr [et al.] (стр.32-35)
Komisarenko M. A. The composition of volatile substances of cowberry leaves/ M. A. Komisarenko (стр.36-38)
Lenchyk L. V. Development of the composition of tablets with the extract of bird cherry and their standardisation/ L. V. Lenchyk [et al.] (стр.39-42)
Kudrik B. T. Development of the composition and technology of the capsulated drug based on bee bread and honey powder. Report 2. The study of pharmacotechnological properties of the mixtures of active pharmaceutikal ingredients with excipients of “Api-immuno-vit” capsules/ B. T. Kudrik, O. I. Tikhonov, O. S. Shpychak (стр.43-48)
Omelchenko I. O. Substantiation of the choice of excipients of “Corvalol” in the form of sublingual tablets/ I. O. Omelchenko, T. G. Yamykh, H. I. Borshchevsky (стр.49-50)
Strus O. Ye. The studies on development of the composition of masks with the sapropel paste/ O. Ye. Strus, O. G. Geyderikh, L. F. Silaeva (стр.51-53)
Shmal’ko O. O. The study on development of the technology of the syrup with the hepatotropic and choleretic action/ O. O. Shmal’ko [и др.] ; O. O. Shmal’ko [et al.] (стр.54-56)
Balynska M. V. The expert evaluation of drugs as a basic factor for development of the socioeconomic lists recommended for treating enteritis of the viral origin in children/ M. V. Balynska (стр.57-60)
Lega D. O. Antimicrobial, anti-inflammatory and analgesic activities of 2-amino-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine 5,5-dioxides and triethylammonium 3-[1-(4-hydroxy-1-ethyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)-3-(het)arylmethyl]-1-ethyl-1H-2,1-benzothiazin-4-olat 2,2-dioxides/ D. O. Lega [et al.] (стр.61-69)
Derkach N. M. The study of the acute and chronic toxicity of the drug “Decasan”/ N. M. Derkach [et al.] (стр.70-75)
Bulyga L. The histological study of the effect of gels with silver nanoparticles and glucosamine on purulent wound healing/ L. Bulyga, Ya. Butko, Yu. Laryanovska (стр.76-80)
До 75-річчя заслуженого діяча науки і техніки України, доктора фармацевтичних наук, професора Ковальова Володимира Миколайовича (стр.81)
До 65-річчя доктора фармацевтичних наук, професора Ковальової Алли Михайлівни (стр.82)
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Форма документа : Стаття із журналу
Шифр видання :
Автор(и) : Derkach N. M., ShtrygoI’ S. Yu., Laryanovska Yu. B., Grashchenkova S. A.
Назва : The study of the acute and chronic toxicity of the drug “Decasan”
Місце публікування : Вісн. фармації. - Х., 2016. - № 3. - С. 70-75 (Шифр ВУ18/2016/3)
MeSH-головна: ТОКСИЧНОСТИ ТЕСТЫ -- TOXICITY TESTS
ЖИВОТНЫЕ ЛАБОРАТОРНЫЕ -- ANIMALS, LABORATORY
Ключові слова (''Вільн.індекс.''): декаметоксин--декасан
Анотація: The intestinal diseases of bacterial aetiology are characterized by high prevalence and a severe course, especially at a young age, concomitant immunity suppression or chronic diseases of the gastrointestinal system. Therefore, it is expedient to search for the new antimicrobial drugs, and it seems promising to use known antimicrobial agent decamethoxinum for the development of peroral medicinal forms, such as “Decasan” that is 0.02% decamethoxinum solution for peroral use worked out by “Yuria Pharm.” This study aimed to determine the parameters of acute toxicity of decamethoxinum substance and “Decasan,” as well as to study the possible toxic effects of the latter in chronic administration. The experiments on rats have shown that “Decasan” at the maximal allowable dose of 20 ml/kg does not cause lethality in rats. For decamethoxinum substance LD50 equals 586 (484:588) mg/kg in intragastric administration, corresponding to the IV class of low toxic substances (500 mg/kgLD505000 mg/kg). The single intragastric administration of decamethoxinum substance at a dose of 400 mg/kg after 2 days causes moderate reversible changes in the gastrointestinal system, in the thymus and adrenal glands. “Decasan” intragastric administration at doses of 3 ml/kg and 30 ml/kg for a period of 30 days to male and female rats does not causes pathological changes in biochemical parameters of the blood (only the decrease in content of albumins is seen in male rats receiving the drug at both doses) as well as in histological structure of the internal organs and functions of the kidney, heart, and CNS
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Форма документа : Стаття із журналу
Шифр видання :
Автор(и) : Derkach N. M., Suvorova Z. S.
Назва : The antimicrobial action of decamethoxinum substance at different pH values
Місце публікування : Вісн. фармації. - Х., 2016. - № 4. - С. 70-75 (Шифр ВУ18/2016/4)
MeSH-головна: АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS
ПРОТИВОГРИБКОВЫЕ СРЕДСТВА -- ANTIFUNGAL AGENTS
Ключові слова (''Вільн.індекс.''): декаметоксин
Анотація: This study considers the effect of pH on the specific activity of decamethoxinum substance under experimental conditions. It has been shown that the minimum inhibitory concentration (MIC) of this substance depends on the microorganism species and pH; the lowest MIC values for S. aureus, P. aeruginosa, E. coli are determined in the basic medium. The significant antimicrobial activity in both acidic and basic media was shown against S. paratyphi, and the antifungal effect against C. albicans increased in the basic medium. It has been determined that decamethoxinum inhibits formation of biofilms by E. coli and P. aeruginosa, the effect depends on the concentration pH 8.0±0.1 in the concentration of 10.0). Decamethoxinum-induced inhibition of the microorganism biomass accumulation is also pH-dependent. Thus, inhibition of the growth and reproduction of P. aeruginosa was observed in 6 hours of incubation with the substance at pH 6.3±0.4; inhibition of the vital activity of E. coli was registered in the basic medium (pH 8.0±0.1) in 1 hour of incubation; while inhibition of S. paratyphi was in 12 hours of incubation at pH 5.1±0.2; 6.3±0.4; 8.0±0.1. The most significant activity of decamethoxinum against the gram-positive bacteria (S. aureus) was revealed in 6 hours of incubation at pH 5.1±0.2. In the acidic medium mentioned the antifungal action against C. albicans was also observed with inhibition of the cell accumulation in 12 hours after the substance introduction
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