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Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова
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Satinder, K.
Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women / K. Satinder, R. C. Sobti, K. Pushpinder> // Experimental Oncology. - 2017. -
Том 39
,
N 1
. - P69-74 : табл. - 33 ref.
MeSH-головна:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (радиотерапия, хирургия)
ВЫЖИВАНИЕ -- SURVIVAL
Анотація:
n the present study, we investigated the hypothesis whether exposure to wood smoke increases the risk of cervical cancer (CC) in North-Indian women who inherit different polymorphic forms of chemical metabolizing genes (GSTM1, GSTT1, GSTP1 and CYP1A1). Materials and Methods: One hundred fifty histologically confirmed CC patients and equal number of cancer-free age and ethnicity matched controls were genotyped for genetic polymorphism in chemical metabolizing genes by using polymerase chain reaction/restriction fragment length polymorphism method. The association of the different genotypes and exposure to wood smoke with the risk of CC in North-Indian women was estimated by doing statistical analysis using Statistical Package for the Social Science. Results: It was observed that the variant genotypes of GSTM1, GSTT1, GSTP1 and CYP1A1 did not significantly increase the risk of CC. However, statistically significant increased risk (odds ratio 3.6; 95% confidence interval, 1.34–9.78; p = 0.008) was observed for women who used wood for cooking and had GSTM1 (null) genotype. Conclusions: The present study suggests that genetic differences in the metabolism of wood smoke carcinogens, particularly by GSTM1, may increase the risk of CC
Дод.точки доступу:
Sobti, R.C.
Pushpinder, K.
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Шифр: ЕУ12/2017/39/1
Журнал
Экспериментальная онкология
[Текст]
2017р. Т. 39 № 1
Зміст:
Circulating tumor cells in breast cancer
: functional heterogeneity, pathogenetic and clinical aspects. - С.2-11 : il.
Kashuba, E. Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?
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Satinder, K.
Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women
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Mankovska, O. Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors
/ O. Mankovska, V. Kashuba. - С.93
Brieieva, O. Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients
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International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine
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