Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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повний	інформаційний	короткий

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The use of the HPLC method for the quantitative determination of cetylpyridinium hexafluorosilicate in a dental gel [Текст] / V. Yu. Anisimov [et al.] // Вісн. фармації. - 2017. - № 4. - С. 3-9

MeSH-головна:
ЛЕКАРСТВЕННЫЕ СРЕДСТВА СТОМАТОЛОГИЧЕСКИЕ -- PHARMACEUTICAL PREPARATIONS, DENTAL (анализ)
ГЕЛИ -- GELS (анализ)
ЦЕТИЛПИРИДИНИЙ -- CETYLPYRIDINIUM (анализ, выделение и очистка)
ХРОМАТОГРАФИЯ ЖИДКОСТНАЯ -- CHROMATOGRAPHY, LIQUID (использование, методы)
Анотація: Cetylpyridinium hexaﬂuorosilicate has been proposed as a caries preventive and antibacterial agent for use as a gel for oral application, which requires development of quality control methods. Aim. To develop the method for the quantitative determination of cetylpyridinium hexaﬂuorosilicate in a dosage form using HPLC. The object of the study is the experimental dosage form – a gel proposed for use in dental practice. The research method is HPLC. The method for the quantitative determination of the active component, which allows determining cetylpyridinium hexaﬂuorosilicate in the gel in the presence of excipients of the dosage form, has been developed. It is recommended to carry out this determination by the HPLC method using the column of 150 × 4.6 mm in size flled with octadecyl silica gel for chromatography, the sorbent particle size of 3.5 μm, a mixture of perchlorate buffer solution (pH 3.0) and acetonitrile (30 : 70) as a mobile phase and UV detection at the wavelength of 254 nm
Цетилпіридинію гексафлуоросилікат запропонований як карієс-профілактичний та антибактеріальний засіб для застосування у вигляді гелю з метою оральних аплікацій, який потребує розробки методик контролю якості. Мета роботи: розробка методики кількісного визначення цетилпіридинію гексафлуоросилікату методом ВЕРХ у лікарській формі. Об’єктом дослідження є експериментальна лікарська форма гель, запропонована для використання у стоматологічній практиці. Метод дослідження – ВЕРХ. У ході дослідження розроблена методика кількісного визначення діючого компоненту, яка дозволяє визначити цетилпіридинію гексафлуоросилікат у гелі у присутності допоміжних речовин лікарської форми. Визначення рекомендовано проводити методом ВЕРХ на колонці розміром 150 ×4,6 мм, заповненій силікагелем октадецилсилільним для хроматографії з розміром зерен сорбенту 3,5 мкм з використанням як рухомої фази суміші перхлоратного буферного розчину рН 3,0 і ацетонітрилу (30 : 70) та УФ-детектуванням за довжини хвилі 254 нм
Дод.точки доступу:
Anisimov, V. Yu.
Gelmboldt, V. O.
Gubar, S. M.
Myhal, A. V.
Bevz, N. Yu.
Georgiyants, V. A.

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Serdiukova, Yu. Yu.
Development of a novel kinetic spectrophotometric method for the quantitative determination of Cefuroxime using Caro’s acid [Текст] / Yu. Yu. Serdiukova, S. G. Leonova, Yu. S. Kolisnyk // Вісн. фармації. - 2017. - № 4. - С. 10-14

MeSH-головна:
ЦЕФУРОКСИМ -- CEFUROXIME (анализ, выделение и очистка)
СПЕКТРОФОТОМЕТРИЯ -- SPECTROPHOTOMETRY (методы)
ХРОМАТОГРАФИЯ ЖИДКОСТНАЯ -- CHROMATOGRAPHY, LIQUID (использование, методы, стандарты)
Анотація: Development of new simple and economically profitable methods for the quantitative determination of Cefuroxime substance is of a great interest.Aim. To study the reaction of Cefuroxime with Caro’s acid and develop a new method for the quantitative determination of Cefuroxime based on the product of S-oxidation and perhydrolysis.Materials and methods. To determine Cefuroxime substance the triple potassium salt of Caro’s acid was used as an oxidizing agent. The procedure was developed as a kinetic spectrophotometric method. Results and discussion. The initial rate method can be easily applied to determine Cefuroxime substance. The data obtained showed good results in accuracy, precision, LOQ and LOD. The RSD for the substance was 1.53-2.35 %, δ = 0.55-1.40 %. The direct linear dependence was observed in a wide range of concentrations 1-7 µg·mL-1.Conclusions. The possibility of Cefuroxime analytical determination by the biologically active part of the molecule, reproducible results and accuracy are the advantages of the method proposed. The data obtained are in good agreement with the standard pharmacopoeial HPLC method
Розробка нових простих і економічно вигідних методик кількісного визначення цефуроксиму субстанції становить великий інтерес. Мета даної роботи полягає у вивченні реакції цефуроксиму з кислотою Каро та у розробці нової методики кількісного визначення цефуроксиму за продуктом S-окиснення та пергідролізу. Матеріали та методи. Потрійна калієва сіль кислоти Каро була використана як окисник для визначення субстанції цефуроксиму. Методика розроблена у кінетико-спектрофотометричному варіанті. Результати та їх обговорення. Метод початкової швидкості може бути застосований для визначення цефуроксиму субстанції. Отримані добрі результати точності, відтворюваності, LOQ та LOD. RSD для субстанції становить 1,53-2,35 %, δ = 0,55-1,40 %. Пряма лінійна залежність спостерігається у широкому діапазоні концентрацій 1-7 мкг/мл. Висновки. Можливість аналітичного визначення цефуроксиму за біологічно активною частиною молекули, відтворюваність і точність є перевагами запропонованої методики. Отримані дані добре узгоджуються зі стандартною фармакопейною ВЕРХ методикою
Дод.точки доступу:
Leonova, S. G.
Kolisnyk, Yu. S.

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Tomarovska, L. Yu.
Development of the UV-spectrophotometric and extraction-spectrophotometric methods of the atomoxetine quantitative determination suitable for the chemical and toxicological analysis [Текст] / L. Yu. Tomarovska, S. V. Baiurka, S. A. Karpushyna // Вісн. фармації. - 2017. - № 4. - С. 15-19

Рубрики: Атомоксетин

MeSH-головна:
АНТИДЕПРЕССАНТЫ -- ANTIDEPRESSIVE AGENTS (анализ, выделение и очистка, отравления)
СУДЕБНАЯ ТОКСИКОЛОГИЯ -- FORENSIC TOXICOLOGY (методы, стандарты)
СПЕКТРОФОТОМЕТРИЯ УЛЬТРАФИОЛЕТОВАЯ -- SPECTROPHOTOMETRY, ULTRAVIOLET (использование, методы, стандарты)
Анотація: The acute and lethal antidepressant poisonings have the tendency to grow, therefore, development of the methods for its chemical and toxicological analysis is a topical issue
Кількість гострих та летальних отруєнь лікарськими препаратами антидепресивної дії має тенденцію до зростання, що робить актуальним розробку методів їх хіміко-токсикологічного аналізу
Дод.точки доступу:
Baiurka, S. V.
Karpushyna, S. A.

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The synthesis of 3,5-dibromo-2-chlorobenzoic acid hydrazides as potential antituberculous drugs [Текст] / D. O. Alferova [et al.] // Вісн. фармації. - 2017. - № 4. - С. 20-24

MeSH-головна:
ХЛОРБЕНЗОАТЫ -- CHLOROBENZOATES (химический синтез)
ПРОТИВОТУБЕРКУЛЕЗНЫЕ СРЕДСТВА -- ANTITUBERCULAR AGENTS (химический синтез)
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (методы)
Анотація: Antitubercular drugs are used for a number of decades. In each country where research is conducted strains of mycobacteria that are resistant to one or more drugs have been registered, and it causes tuberculosis with multi-drug resistance (MDR-TB). These strains of M. tuberculosis at least are not sensitive to isoniazid and rifampicin – two most powerful first-line antitubercular drugs. MDR-TB can be treated and cured using the second choice drugs. However, these treatment options are limited and require extensive chemotherapy (the treatment duration is up to two years) with drugs which are of high cost and toxicity. In some cases, a more dangerous drug resistance may develop. Tuberculosis with extensive drug resistance (EDR-TB) is more severe form of MDR-TB caused by bacteria that do not respond to the most effective antitubercular drugs of the second choice with which there are often no any further treatment options for patients. Therefore, the search and development of drugs with the antitubercular activity are important today. Aim. To synthesize and study dibromo-substituted derivatives of ortho-chlorobenzoic acids as potential substances with the antitubercular action. Materials and methods. Hydrazides of 3,5-dibromo-2-chlorobenzoic acid were obtained by two methods – by hydrazinolysis of acid chlorides of the corresponding acids (method 1) and by interaction of 3,5-dibromo-2-chlorobenzoic acid with hydrazines in the presence of carbonyldiimidazole (method 2). Results and discussion. It has been found that the synthesis of hydrazides by method 2 allows obtaining the target compounds with a high yield. Conclusions. According to the literature data the compounds synthesized are promising for the pharmacological screening on the antitubercular activity
Дод.точки доступу:
Alferova, D. O.
Gritsenko, I. S.
Rebryk, A. O.
Kobzar, N. P.
Altukhov, O. O.
Shapovalova, O. V.
Kaliuzhnaia, O. S.
Suleiman, M. M.

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The phytochemical profile and antibacterial activity of fluid extracts of Galium verum L. herb [Текст] / I. L. Shynkovenko [et al.] // Вісн. фармації. - 2017. - № 4. - С. 25-28

MeSH-головна:
РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS (фармакология)
ПОДМАРЕННИК -- GALIUM (химия)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (фармакология)
Анотація: Aim. To obtain and study the qualitative composition and the content of the main groups of biologically active substances (BAS) of fluid extracts (FEs) of Galium verum L. herb and to assess their antibacterial activity. Materials and methods. FEs of Galium verum L. herb were obtained by three-fold water extraction or ethanol (20 %, 60 %, 96 %) extraction of the raw material when heating, followed by the concentration of the combined extracts. Phenolic compounds of FEs were studied by the methods of paper and thin-layer chromatography, and spectrophotometry. The content of polysaccharides was determined gravimetrically. The antibacterial activity of FEs was determined in vitro by the agar diffusion method. Results and discussion. The chromatographic study of FEs of Galium verum L. herb revealed the presence of chlorogenic acid and rutin in all FEs, the fluid 96 % ethanol extract contains chlorogenic acid, cyanoside, quercetin and rutin. Hydroxycinnamic acids, flavonoids and the amount of phenolic compounds were quantified in all extracts, and polysaccharides were determined in the aqueous extract and 20 % ethanol extract. When studying the antimicrobial activity of FEs it has been found that the fluid 96 % ethanol extract exhibits the highest activity. Bacillus subtilis was the most susceptible to all the extracts under study. Proteus vulgaris showed insignificant sensitivity to the test concentration of fluid extracts obtained with water and 60 % ethanol. The rest of the microorganism test strains used were sufficiently sensitive to the FEs under study. Conclusions. The results obtained indicate the prospects of further in-depth study of the antimicrobial activity of fluid extracts of Galium verum L. herb in order to develop antibacterial agents on their basis
Дод.точки доступу:
Shynkovenko, I. L.
Ilyina, T. V.
Goryacha, O. V.
Kovalyova, A. M.
Osolodchenko, T.Р.
Komisarenko, A. M.

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Lyapunova, A. M.
The study of o/w emulsions using the rotating viscometer method and the method of spin probes [Текст] / A. M. Lyapunova, O. P. Bezugla, O. M. Lyapunov // Вісн. фармації. - 2017. - № 4. - С. 29-34

MeSH-головна:
ТЕХНОЛОГИЯ ФАРМАЦЕВТИЧЕСКАЯ -- TECHNOLOGY, PHARMACEUTICAL (методы)
ЭМУЛЬСИИ -- EMULSIONS (анализ, стандарты)
ВЯЗКОСТЬ -- VISCOSITY
РЕОЛОГИЯ -- RHEOLOGY
Анотація: Study of the interaction of surfactants with poloxamer 338 (P338) and the effect of P338 on the properties of cream bases. Materials and methods. Solutions of the surfactants and P338 as well as cream bases were under study. The average hydrodynamic diameter (Dh) and zeta potential (ζ‑potential) were determined by the light scattering intensity and electrophoretic mobility of micelles. The electron paramagnetic resonance (EPR) spectra of spin probes in micelles, solvents and bases were obtained; the type of spectrum, isotropic constant (AN), rotational correlation times (τ) and anisotropy parameter (ε) were determined. Liquids and cream bases were studied by capillary and rotational viscometry; the flow behaviour and yield stress (t0), dynamic and apparent viscosity (η) as well as the hysteresis (thixotropic) area (AH) were determined. The microstructure of the bases was examined by optical microscopy. The strength of adhesion (Sm) was assessed by the pull-off test, and the absorption of water was studied by dialysis. Results. Under the impact of P338 the hydrodynamic diameters of micelles formed by cationic, anionic and nonionic surfactants decreased as well as the absolute values of their ζ‑potential became lower, but the microviscosity of the micelle nuclei increased. There was also a change in the structure of the aggregates of surfactant with fatty alcohols; EPR spectra, which were superpositions characteristic for the lateral phase separation, converted into triplets that indicated the uniform distribution of lipophilic probes in the surfactant phase. When the content of P338 increased to 17 %, the rheological parameters of the bases increased drastically, the flow behaviour and the microstructure changed. The bases had the consistency of cream within temperature range from 25 °C to 70 °C and completely restored their apparent viscosity, which had decreased under shear stress. P338 enhances the adhesive properties of the bases. Due to their microstructure, cream bases have a lower ability to absorb water compared to a solution and gel containing 17 % and 20 % P338, respectively. Conclusions. The structure of surfactant micelles and aggregates of surfactants with fatty alcohols changed under impact of P338 due to the interaction of surfactants with P338. As a result of this interaction, at a sufficiently high concentration of P338, the microstructure and flow behaviour of bases changed, their rheological parameters, which remain high at temperatures from 25 °C to 70 °C, increased significantly, and water absorption parameters decreased. The bases with P338 were more adhesive
Дод.точки доступу:
Bezugla, O. P.
Lyapunov, O. M.

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Development of the composition and technology of a soap with sapropel [Текст] / O. Y. Strus [et al.] // Вісн. фармації. - 2017. - № 4. - С. 35-40

MeSH-головна:
ТЕХНОЛОГИЯ ФАРМАЦЕВТИЧЕСКАЯ -- TECHNOLOGY, PHARMACEUTICAL (методы)
МЫЛА -- SOAPS (стандарты)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS
Кл.слова (ненормовані):
САПРОПЕЛИ
Анотація: Hygienic treatment of hands is an effective means of reducing the spread of transient microflora and is considered as one of the most important procedures for preventing the infection transmission by the contact-household way. Hygienic treatment of hands is necessary in public catering establishments, treatment and prevention institutions, for immunity compromised patients, in the period of seasonal diseases, etc. Most antibacterial soaps are based on synthetic surfactants using such synthetic antibacterial additives as triclosan, triclocarbanum, farnesol, benzalkonium chloride, pyroctonolamine. Therefore, development of soaps containing natural substances in their composition is relevant. Aim. To develop a soap with sapropel, which would have the antibacterial effect and satisfactory sensory properties. Materials and methods. To make the soap the liquid corn and castor oils, solid palm and coconut oils, as well as argan oil were selected as a superfatting agent. Oil saponification was carried out with sodium hydroxide solution. The quality of the samples obtained was assessed by the organoleptic and physicochemical parameters (the qualitative number (the mass of fatty acids calculated with reference to the nominal weight of a soap bar of 100 g), the mass fraction of free caustic alkali, the mass fraction of sodium products calculated with reference to Na2O, the temperature of fatty acid (titer) gelation, the mass fraction of sodium chloride). Results and discussion. By the indicators of the saponification value of the selected components of the soap fatty base containing 43.8 % of palm oil and 25 % of coconut oil, 6.2 % of corn oil and 25 % of castor oil, and with the necessary consistency properties, soap ductility, high solubility and foaming in cold water the amount of alkali needed for making soap has been calculated. According to the results of determination of the soap consumer properties the concentration of argan oil has been chosen. As a result of studying the organoleptic and physicochemical parameters of the soap with 5 and 10 % of sapropel it has been found that the soap obtained by the cold method meets the standards for soap of the brand “Special” with disinfectants or therapeutic additives. Conclusions. The soap composition containing 5 and 10 % of sapropel has been proposed. In the laboratory conditions the cold and hot methods for obtaining the soap with sapropel have been tested. It has been found that the samples obtained by the cold method meet the requirements of the normative documentation in contrast to the soap with the unsatisfactory organoleptic parameters obtained by the hot method
Дод.точки доступу:
Strus, O. Y.
Polovko, N. P.
Filipska, A. M.
Rekhletska, O. V.

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The general methodological approach to development of modern foam washing [Текст] / I. I. Baranova [et al.] // Вісн. фармації. - 2017. - № 4. - С. 41-44

MeSH-головна:
ДЕТЕРГЕНТЫ -- DETERGENTS (стандарты)
ПОВЕРХНОСТНО-АКТИВНЫЕ ВЕЩЕСТВА -- SURFACE-ACTIVE AGENTS (стандарты)
Анотація: As the results of the analysis of the modern Ukrainian market for personal care products show, there is a clear tendency of the increased consumer interest, in particular to detergent-based liquid hygiene products. Aim. To develop a methodological unified approach for creation of foaming agents in two pH intervals of 3.5-4.5 and 5.0-6.0. Materials and methods. The methodological basis of this research is general scientific and applied methods of research, including methods of logical, historical, physicochemical, technological and analytical analysis. The modern Ukrainian market of foam washing agents and various types of detergents for obtaining satisfactory consumer properties were analyzed. Results and discussion. A wide production range of foam washing agents of the foreign and domestic origin has been analyzed, and the active functional groups, as well as excipients and biologically active substances have been systematized. The conceptual differences in the approaches to development of parapharmaceutical cleansing agents and the tendency to use modern surfactants with the “soft” action have been revealed. It has been found that creation of uniform foaming agents in two pH intervals of 3.5-4.05 and 5.0-6.0 when applied to sensitive areas of the skin and mucous membranes determines the selection of detergents that would combine sufficient functional properties and dermatological characteristics. The analysis has shown that there is a need to develop new approaches to the use of multifunctional complexes of modern detergents. Conclusions. A methodological unified approach for creation of foam washing agents in two pH intervals of 3.5-4.05 and 5.0-6.0 has been offered. It allows facilitating development of products and their introduction into domestic production
Дод.точки доступу:
Baranova, I. I.
Petrovska, L. S.
Bespalaya, Yu. O.
Zaika, S. V.

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Stadnichenko, O. V.
The study of liophilization parameters in the liposomal irinotecan development [Текст] / O. V. Stadnichenko, Yu. M. Krasnopolsky, T. G. Yarnykh // Вісн. фармації. - 2017. - № 4. - С. 45-49

Рубрики: Иринотекан

MeSH-головна:
ЛИПОСОМЫ -- LIPOSOMES
ТЕХНОЛОГИЯ ФАРМАЦЕВТИЧЕСКАЯ -- TECHNOLOGY, PHARMACEUTICAL (методы)
(методы)
КРИОПРОТЕКТОРЫ -- CRYOPROTECTIVE AGENTS
НАНОЧАСТИЦЫ -- NANOPARTICLES
Анотація: To optimize the content of the cryoprotector in the liposomal irinotecan, and develop lyophilization parameters to produce liposomes with the maximum encapsulation of irinotecan in them, alongside while maintaining the nanosize. Materials and methods. Egg phosphatidylcholine from Lipoid (Germany) was used for preparation of liposomes. Lyophilization was carried out in a Quarco device (PR China). The encapsulation degree was determined on a Shimadzu LC-20 instrument (Japan) by HPLC method developed earlier. Results and discussion. The optimal content of the cryoprotector – trehalose dihydrate has been studied. It has been found that the optimal content of trehalose dihydrate is 8 % (w/w). The modes of the product lyophilization have been studied. The secondary drying temperature in the range of 10-20 °C has been determined. At the secondary drying temperature of 10 °C the residual moisture content was 5-8 %, which was beyond the target range. At 20 °C the water content in the lyophilizate was 0.5-0.8 %, the loss of encapsulation was up to 20 %. The mode of drying at 15 °C was optimal, while the residual water content in the lyophilizate was 1.5-2.8 %, the loss of encapsulation was 13 %, the size of the liposomes after lyophilization and rehydration did not change significantly compared to the initial one. Сonclusions. As a result of the studies, liposomes with irinotecan have been obtained. The content of trehalose dihydrate as a cryoprotector in the range of 4-10 % has been studied. It has been shown that the optimum content of trehalose dihydrate is 8 % (w/w); moreover, the encapsulation decrease in lyophilization is 13 %. The modes of the liposomal irinotecan lyophilization have been studied at the final drying temperature of 10, 15 and 20 °C. It has been found that the optimum final drying temperature is 15
Дод.точки доступу:
Krasnopolsky, Yu. M.
Yarnykh, T. G.

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10.

Savchenkova, L. V.
The DDD-monitoring of consumption of fluoroquinolones when treating community-acquired pneumonia in a multi-specialty hospital in the Republic of Tajikistan [Текст] / L. V. Savchenkova, M. N. Saidova, N. S. Sanginova // Вісн. фармації. - 2017. - № 4. - С. 50-55

MeSH-головна:
ПНЕВМОНИЯ -- PNEUMONIA (лекарственная терапия)
СТАЦИОНАРНОЕ ЛЕЧЕНИЕ ДНЕВНОЕ -- DAY CARE (использование, методы)
ФТОРХИНОЛОНЫ -- FLUOROQUINOLONES (терапевтическое применение)
ФАРМАКОЭПИДЕМИОЛОГИЯ -- PHARMACOEPIDEMIOLOGY (методы)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (терапевтическое применение)
Анотація: Community-acquired pneumonia is one of the most common diseases and is still the leading cause of death among infectious diseases. Such drugs as β-lactam antibiotics, new macrolides (azithromycin, clarithromycin) and respiratory fluoroquinolones are of the greatest importance in the treatment of community-acquired pneumonia in adult patients worldwide. Aim. To analyze and assess the dynamics of consumption of fluoroquinolones for the treatment of communityacquired pneumonia in a multi-specialty hospital in the Republic of Tajikistan using the DDD-methodology. Materials and methods. A retrospective descriptive analysis of medical prescriptions for pharmacotherapy of patients treated in the Pulmonology department of the Sogdigh Regional Clinical Hospital (Khujand, Republic of Tajikistan) was performed. The consumption of fluoroquinolones was estimated according to the ATC/DDD index of the WHO. The unit of measurement used was the number of grams of the active substance with further calculation of the DDD/100 beddays and % of the total DDD. Results and discussion. The DDD analysis of consumption of fluoroquinolones in the Pulmonology department of the multi-specialty hospital showed a significant change in the structure of consumption of this group of drugs for the initial antibiotic therapy of community-acquired pneumonia in the last five years. A clear tendency was observed to reduce the consumption of this class of drugs in 2011-2015. There is a significant reduction in the consumption of ofloxacin and levofloxacin against the background of a slight tendency to increase the demand for ciprofloxacin in the treatment of pneumonia in the inpatient drug treatment. Conclusions. Monitoring of the consumption of antimicrobial drugs from the fluoroquinolone group for the treatment of community-acquired pneumonia in the Pulmonology department of the multi-specialty hospital using the ATS/DDD-methodology makes it possible to assess the tactics of community-acquired pneumonia treatment in this region, its compliance with the international standards and the risks of developing the drug-resistant microflora, in particular to fluoroquinolones
Дод.точки доступу:
Saidova, M. N.
Sanginova, N. S.

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11.

The study of hypolipidemic properties of Ginger extract on the model of type 2 diabetes induced by dexamethasone [Текст] / N. M. Kononenko [et al.] // Вісн. фармації. - 2017. - № 4. - С. 56-61

MeSH-головна:
ДИАБЕТ САХАРНЫЙ, ТИП 2 -- DIABETES MELLITUS, TYPE 2 (лекарственная терапия)
ГИПОЛИПИДЕМИЧЕСКИЕ СРЕДСТВА -- HYPOLIPIDEMIC AGENTS (фармакология)

РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS (фармакология)
Анотація: To study experimentally the hypolipidemic properties of Ginger extract against the background of type 2 diabetes. Materials and methods. The study of the hypolipidemic properties of Ginger extract was performed by the lipid metabolism indices on the model of type 2 diabetes induced by dexamethasone in rats aged 18 months. Results and discussion. Experimental type 2 diabetes was accompanied with disorder of the lipid metabolism, it was confirmed by the increase of the content triacylglycerides, atherogenic apoB-lipoproteins with simultaneous reduction of high-density lipoproteins and increased release of free fatty acids from the adipose tissue. Under the effect of Ginger extract in the doses of 50 and 80 mg/kg the level of free fatty acids in the blood serum decreased by 38.4 % and 38.9 %, probably due to correction of insulin resistance manifestations and preservation of the insulin control effect on lipolysis. The reliable inhibition of hypertriacylglycerolemia severity by Ginger extract in the dose of 80 mg/kg by 35.1% correlated with a decrease of apoB-LP production in the liver, and it indicated correction of diabetic dyslipidemia. At the same time, the level of the antiatherogenic fraction – high-density lipoproteins – significantly increased by 26.1 and 29.5 % under the effect of the extract in the doses of 50 and 80 mg/kg, respectively, compared to the values of animals of the control pathology. Ginger extract in the dose of 80 mg/kg showed a more expressive ability to normalize the lipid metabolism at the level of the reference drug – “Arphasetin” herbal medicinal product. Conclusions. Introduction of Ginger extract for 14 days in the doses of 50 and 80 mg/kg on the model of type 2 diabetes induced by dexamethasone was accompanied with a reliable normalization of the lipid metabolism. The use of Ginger extract in the dose of 80 mg/kg is most pronounced at the level of the reference drug – “Arphasetin” herbal medicinal product, corrected the pathological changes in the lipid metabolism characteristic for type 2 diabetes. It allows making a conclusion concerning the feasibility of further studies of the extract exactly in this dose and the prospects of its use as an antiatherogenic drug in the complex treatment of type 2 diabetes
Дод.точки доступу:
Kononenko, N. M.
Chikitkina, V. V.
Sorokina, M. V.
Ostapets, M. O.

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12.

The effect of the new combined cream on the protein synthetic activity of cells on the model of the thermal skin damage in rats [Текст] / N. M. Kononenko [et al.] // Вісн. фармації. - 2017. - № 4. - С. 62-66

MeSH-головна:
(лекарственная терапия)
КРЕМ ДЛЯ КОЖИ -- SKIN CREAM (фармакология)
ТИОКТОВАЯ КИСЛОТА -- THIOCTIC ACID (фармакология)
МАСЛА РАСТИТЕЛЬНЫЕ -- PLANT OILS (фармакология)
РАНЫ ЗАЖИВЛЕНИЕ -- WOUND HEALING (действие лекарственных препаратов)
Анотація: To study the mechanisms of the reparative action of a new combined cream on the model of thermal burn injury in rats. Materials and methods. On the model of thermal burn in rats the reparative properties of the new combined cream under the conditional name “Dermalipoin” containing α-lipoic acid, urea, olive oil, tea tree oil, PEG-400 were studied. To determine the level of the protein synthetic activity of cells (epitheliocytes of the stratified squamous epithelium in the epidermis and cells of the fibroblast cell in the edges of healing of thermal damage) the content of ribonucleoproteins (RNP) in the cytoplasm and deoxyribonucleoproteins (DNP) in the nuclei of the cells was assessed by the cytometric method. Results and discussion. On the model of thermal burn in rats “Dermalipoin” cream showed a more active effect on reparative processes compared to the reference drugs – methyluracil ointment and “Titriol” gel. It indicates a significant increase in the protein synthetic function of epitheliocytes of the stratified squamous epithelium in the epidermis and cells of the fibroblastic series at the healing edges. The reparative activity of the cream was, first of all, provided by the presence of thiol (sulfhydryl) groups in the molecule of lipoic acid, giving it the properties of an antioxidant. The antioxidant effect of lipoic acid promotes more efficient DNA molecule reparation after damage as a result of the oxidative stress. Conclusions. “Dermalipoin” cream shows a marked reparative effect due to the increase of the protein synthetic activity and acceleration of reparation of DNA molecules of epithelial cells after damage; as a result, the process of healing burns accelerates
Дод.точки доступу:
Kononenko, N. M.
Sheikhali, A. M.
Ostapets, M. O.
Loboda, V. S.

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