Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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повний	інформаційний	короткий

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Загальна кількість знайдених документів : 10
Показані документи з 1 по 10

Obtaining of the pharmacopoeial reference sample of the mandelic acid isopropyl ester [Текст] / O. V. Bevz [et al.] // Вісн. фармації. - 2018. - № 1. - С. 3-11

MeSH-головна:
ФАРМАКОПЕИ -- PHARMACOPOEIAS
МИНДАЛЬНЫЕ КИСЛОТЫ -- MANDELIC ACIDS (анализ, стандарты)
(стандарты)
Анотація: In accordance with the requirements of the International Council on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) each monograph for a drug must include the test for related impurities. Impurities in a medicinal product may appear as initial, intermediate or side products of the synthesis and during storage
Дод.точки доступу:
Bevz, O. V.
Ukrainets, I. V.
Vashchenko, O. V.
Georgiyants, V. A.
Budianska, L. V.

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Development of the methods for the quantitative determination of fusidic acid and panthenol in the composition of “Fuzipam-derma” dermatological gel [Текст] / P. P. Baiva [et al.] // Вісн. фармації. - 2018. - № 1. - С. 12-16

Рубрики: Фузидиевая кислота

MeSH-головна:
ДЕРМАТОЛОГИЧЕСКИЕ СРЕДСТВА -- DERMATOLOGIC AGENTS (анализ)
ГЕЛИ -- GELS (анализ)
АКНЕ ОБЫКНОВЕННЫЕ -- ACNE VULGARIS (лекарственная терапия)
Анотація: To develop and validate the methods for the quantitative determination of fusidic acid and panthenol in “Fuzipam-derma” gel. Materials and methods. The determination was performed by high performance liquid chromatography (HPLC) according to the requirements of the State Pharmacopoeia of Ukraine (SPhU) 1.0 on a Prostar-210 liquid chromatograph, (Varian Chromatography System, USA). Results and discussion. The methods for the quantitative determination of fusidic acid and panthenol in “Fuzipam-derma” gel have been developed. The appropriate chromatographic conditions have been chosen, due to them the peaks of fusidic acid and panthenol are completely separated from other gel components. The validation of the methods for the quantitative determination of fusidic acid and panthenol has been performed. The data obtained have shown that the methods are stable and reproducible in different days. Conclusions. The methods for the quantitative determination of fusidic acid and panthenol in the composition of the new dermatological gel “Fuzipam-derma” for the treatment of grade І-ІІ acne has been developed using the HPLC method
Дод.точки доступу:
Baiva, P. P.
Kovalenko, Sv. M.
Baranova, I. I.
Mamedova, S. O.

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Fedorovska, M. I.
Development of methods for identification and quantitative determination of active substances in the medicated cosmetic cream for use in trichology [Текст] / M. I. Fedorovska, N. P. Polovko, V. O. Grudko // Вісн. фармації. - 2018. - № 1. - С. 17-22

MeSH-головна:
АЛОПЕЦИЯ -- ALOPECIA (лекарственная терапия)
КОСМЕТИЧЕСКИЕ СРЕДСТВА -- COSMETICS (анализ)
РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS (анализ)
СОФОРА -- SOPHORA
КРЕМ ДЛЯ КОЖИ -- SKIN CREAM (анализ)
Анотація: To prevent and treat androgenic alopecia (AA) a medicated cosmetic cream (MCC) with the saw palmetto extract and the Sophora japonica tincture has been developed. The introduction of MCC in production requires its standardization and development of its quality control methods
Дод.точки доступу:
Polovko, N. P.
Grudko, V. O.

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Rybachuk, . D..
The study of the kinetics of drying natural zeolite granules in a tray dryer [Текст] / . D. Rybachuk, O. A. Ruban ; . D. Rybachuk, O. A. Ruban // Вісн. фармації. - 2018. - № 1. - С. 23-27

MeSH-головна:
ТЕХНОЛОГИЯ ФАРМАЦЕВТИЧЕСКАЯ -- TECHNOLOGY, PHARMACEUTICAL (методы)
ЦЕОЛИТЫ -- ZEOLITES
ДЕГИДРАТАЦИОННЫЕ МЕТОДЫ -- DESICCATION (оборудование)
Кл.слова (ненормовані):
ГРАНУЛЫ
Анотація: Determination of the main drying parameters for choosing the optimal ones is obligatory when developing the drug technology, which uses wet granulation operations
The kinetics and basic parameters of drying of natural zeolite granules obtained by the wet granulation method in a tray dryer have been studied. The optimal temperature and time modes of drying have been determined. The data obtained can be used when developing the technology of granules and tablets with natural zeolite
Дод.точки доступу:
Ruban, O. A.

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Masliy, Yu. S.
The study of biopharmaceutical and adhesive characteristics of a dental gel [Текст] / Ju. S. Masliy, O. A. Ruban // Вісн. фармації. - 2018. - № 1. - С. 28-32

MeSH-головна:
ТЕХНОЛОГИЯ ФАРМАЦЕВТИЧЕСКАЯ -- TECHNOLOGY, PHARMACEUTICAL (методы)
ЛЕКАРСТВЕННЫЕ СРЕДСТВА СТОМАТОЛОГИЧЕСКИЕ -- PHARMACEUTICAL PREPARATIONS, DENTAL
ГЕЛИ -- GELS
АДГЕЗИВНОСТЬ -- ADHESIVENESS
БИОДОСТУПНОСТЬ -- BIOLOGICAL AVAILABILITY
Анотація: Significant prevalence of dental pathologies among different age groups of the population of Ukraine dictates the need to find new effective medicines used in the treatment of oral cavity diseases. The choice of a dosage form and the optimal composition of the active pharmaceutical ingredients introduced in it to provide the necessary therapeutic effect is of importance in the treatment of periodontal diseases. For local treatment in dentistry gels are widely used; due to formation of aqueous internal structures they can include various chemotherapeutic substances in their composition, which makes it possible to obtain a dosage form with the multi-profile action. Considering the above, the research on developing the composition and technology of the dental gel with “Phytodent” tincture (PJSC “CPP Red Star”, Ukraine), choline salicylate 80 % (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy) has been conducted
Дод.точки доступу:
Ruban, O. A.

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Kutsanian, A. S.
The study of stability of suppositories with the glifazin herbal complex during storage [Текст] / A. S. Kutsanian, N. A. Shram, D. I. Dmitrievskiy // Вісн. фармації. - 2018. - № 1. - С. 33-37

MeSH-головна:
СУППОЗИТОРИИ -- SUPPOSITORIES (стандарты)
РАСТИТЕЛЬНЫЕ ПРЕПАРАТЫ -- PLANT PREPARATIONS (стандарты)
ЛЕКАРСТВ ХРАНЕНИЕ -- DRUG STORAGE
ЛЕКАРСТВ ХИМИЧЕСКАЯ СТАБИЛЬНОСТЬ -- DRUG STABILITY
(химия)
ГИПОГЛИКЕМИЧЕСКИЕ СРЕДСТВА -- HYPOGLYCEMIC AGENTS (стандарты)
Анотація: The result of the search in the direction of creating an effective and save drug for the treatment of type 2 diabetes mellitus (DM) was development of suppositories with the glifazin herbal complex obtained from the herb of bean (Phaseolus vulgaris) and mung bean (Phaseolus aureus). Aim. To study stability of suppositories with glifazin during storage. Materials and methods. The study objects were rectal suppositories with the hypoglycemic activity containing the glifazin herbal complex in its composition and made on the hydrophilic polyethylene oxide base by the molding method. While storing suppositories their quality parameters (description, uniformity of mass, average weight, dissolution time, pH, microbiological purity, quantitative content of phenolic compounds) were determined using physical, physicochemical, pharmacotechnological and microbiological methods in accordance with the requirements of the State Pharmacopeia of Ukraine (SPhU). Results and discussion. It has been experimentally proven that all quality parameters of the drug meet the requirements of the draft of the Quality Control Methods (QCM). Conclusions. The results of the studies conducted have shown that suppositories are stable when stored in a dry, dark cool place for 2 years
Дод.точки доступу:
Shram, N. A.
Dmitrievskiy, D. I.

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Postoy, М. M.
The marketing research of the Ukrainian market of drugs for the treatment of arthritis [Текст] / М. M. Postoy, L. I. Vyshnevska // Вісн. фармації. - 2018. - № 1. - С. 38-42

MeSH-головна:
АРТРИТ РЕВМАТОИДНЫЙ -- ARTHRITIS, RHEUMATOID (лекарственная терапия)
ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL (снабжение и распределение, терапевтическое применение, экономика)
Анотація: Rheumatoid arthritis (RA) is a chronic systematic disease of the connective tissue with peripheral joints damage and characteristic non-arterial effects. Rheumatic diseases affect the national economy, lead to considerable expenses for their treatment and reduce the quality of the patients’ life
According to the ATC-classification data there are approximately 60 drugs presented at the pharmaceutical market of Ukraine for the treatment of rheumatic diseases. This market segment includes different pharmacotherapeutic groups, a wide range of manufacturing countries and pharmaceutical companies. However, there is no original combined gel of the complex national production at the pharmaceutical market of Ukraine
Дод.точки доступу:
Vyshnevska, L. I.

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The study of acute toxicity of 1,3-oxazole-4-il-phosphonic acid derivative in intraperitoneal administration [Текст] / I. V. Nizhenkovska [et al.] // Вісн. фармації. - 2018. - № 1. - С. 43-48

MeSH-головна:
ОКСАЗОЛЫ -- OXAZOLES (фармакология, химический синтез)
(фармакология, химический синтез)
ТОКСИЧНОСТИ ОСТРОЙ ТЕСТЫ -- TOXICITY TESTS, ACUTE (использование, методы)
ЛЕКАРСТВ ПУТИ ВВЕДЕНИЯ -- DRUG ADMINISTRATION ROUTES
Анотація: The derivative of 1,3-oxazole-4-yl-phosphonic acid (OVP-1) has the vasodilatory activity and is studied as a potential antihypertensive agent. The toxicological assessment plays an important role in the preclinical study of new drugs
It has been determined that LD50 of OVP-1 derivative in intraperitoneal administration to mice of both sexes is 3350.67 ± 54.62 mg/kg and belongs to the toxicity class VI – relatively harmless compounds, which makes this compound promising for further preclinical pharmacological studies
Дод.точки доступу:
Nizhenkovska, I. V.
Sedko, V. K.
Golovchenko, O. V.
Golovchenko, O. I.

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The effect of the Ginger dry extract on the indicators of the carbohydrate metabolism under conditions of the experimental metabolic syndrome in Syrian golden hamsters [Текст] / N. M. Kononenko [et al.] // Вісн. фармації. - 2018. - № 1. - С. 49-53

MeSH-головна:
МЕТАБОЛИЧЕСКИЙ СИНДРОМ X -- METABOLIC SYNDROME X (лекарственная терапия, метаболизм)
УГЛЕВОДНЫЙ ОБМЕН -- CARBOHYDRATE METABOLISM (действие лекарственных препаратов)
(химия)
РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS (фармакология)
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
Анотація: To study the effect of the ginger dry extract on the indicators of the carbohydrate metabolism in the experimental metabolic syndrome
On the experimental model of the metabolic syndrome the use of the ginger dry extract normalized blood glucose, insulinemia, decreased insulin resistance and restored the glycogen content in the liver at the level of metformin. By the intensity of the pharmacological action the ginger extract exceeded the reference herbal drug “Arphasetin”. This fact is the basis for its further pharmacological study as a promising agent for the treatment of the metabolic syndrome and type 2 diabetes
Дод.точки доступу:
Kononenko, N. M.
Chikitkina, V. V.
Sorokyna, M. V.
Ostapets, M. O.

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10.

Kononenko, N. M.
The effect of the Brassica oleracea extract on the structural components of mucous cells of the stomach in its ulcerative damage [Текст] / N. M. Kononenko, M. T. Mirzaliev, M. O. Ostapets // Вісн. фармації. - 2018. - № 1. - С. 54-57

MeSH-головна:
(химия)
ПРОТИВОЯЗВЕННЫЕ СРЕДСТВА -- ANTI-ULCER AGENTS (фармакология)
РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS (фармакология)
ЖЕЛУДКА СЛИЗИСТОЙ ГЛАВНЫЕ КЛЕТКИ -- CHIEF CELLS, GASTRIC (действие лекарственных препаратов)
Анотація: To study the effect of the Brassica oleracea extract on the total content of proteins and lipids of mucous cells of the stomach in the experimental ulcer. Materials and methods. On the model of alcohol-prednisolone ulcer in rats the effect of the Brassica oleracea extract on the content of proteins and lipids of the mucous cells of the stomach was studied. To study the phospholipid content of membranes the lipid fraction was separated by Folch method. Separation of phospholipids into separate fractions was carried out by thin layer chromatography on silica gel. The protein spectrum of the stroma was studied by gel chromatography. Results and discussion. The mechanism of the reparative action of the Brassica oleracea extract in the experimental gastric ulcer consisted in formation of a new fraction of proteins with the molecular mass of 36 kDa and restoration of the lipid content of the gastric mucosa. It was accompanied with normalization of the structural and functional state of the mucosa by the restitution type with complete restoration of the mucous membrane. Conclusions. The Brassica oleracea extract in ulcerative damage of the stomach promotes the processes of regeneration of proteins and lipids on the mucous cells of the stomach leading to reparation
Дод.точки доступу:
Mirzaliev, M. T.
Ostapets, M. O.

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© Міжнародна Асоціація користувачів і розробників електронних бібліотек і нових інформаційних технологій
(Асоціація ЕБНІТ)