Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Assessment of the quality of medical services to relatives of the mentally ill who are in inpatient treatment [Текст] = Оцінка якості медичних послуг родичам психічно хворих, які перебувають на стаціонарному лікуванні / V. V. Chorna [та ін.] // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 5-11. - Bibliogr. at the end of the art.

MeSH-головна:
ПСИХИЧЕСКИ БОЛЬНЫЕ ЛИЦА -- MENTALLY ILL PERSONS
ПСИХИЧЕСКОЕ ЗДОРОВЬЕ -- MENTAL HEALTH
СЕМЬИ ЗДОРОВЬЕ -- FAMILY HEALTH
ЭТИКА ПРОФЕССИОНАЛЬНАЯ -- ETHICS, PROFESSIONAL
СОЦИАЛЬНАЯ СТИГМА -- SOCIAL STIGMA
МЕДИЦИНСКОЙ ПОМОЩИ КАЧЕСТВО, ДОСТУПНОСТЬ И ОЦЕНКА (ВНЕШ) -- HEALTH CARE QUALITY, ACCESS, AND EVALUATION (NON MESH)
Анотація: The mental state of the mentally ill is one of the most important factors in the treatment of the patient by a medical professional. But aggression, high-pitched communication, indifference of a doctor or health care worker can negatively affect the outcome of treatment and recovery of a patient with mental and behavioral disorders. The problem of modern medical deontology in Ukraine is the stigmatization of health workers to patients with mental disorders, which lead to self-stigmatization of both patients and their families. The purpose of the study is to enable the relatives of mentally ill people undergoing long-term inpatient treatment, to determine the quality of medical services in a psychoneurological hospital, to identify ethical and deontological shortcomings in the doctor’s relationship with relatives of mentally ill person, to determine the level of self-stigmatization in relatives of the patient by medical staff. The analysis of domestic and foreign scientific sources, bibliosemantic, analytical and statistical research methods were used in the work. A questionnaire was conducted (using a specially designed questionnaire) with elements of interviews of 92 respondents (relatives of mentally ill patients who were treated at a psychoneurological hospital in Vinnytsia). The results were processed using the licensed standardized package "Statistica 6.1". The need to comply with state building codes for health care facilities in accordance with European requirements has been proven. This will eliminate the feeling of hopelessness during hospitalization in public psychoneurological hospitals, which are a great trauma for relatives of patients. It has been shown that in order to prevent stigmatization of relatives of patients in psychoneurological hospitals, it is necessary to conduct trainings and interviews after training, which will determine the degree of stigmatization and subsequent preventive measures. It is shown that for relatives of mentally ill on the basis of psychoneurological hospitals it is necessary to equip rooms for psychodiagnostics and further psychocorrection. Development of affordable correctional programs for relatives of patients will reduce maladaptation and improve life satisfaction
Дод.точки доступу:
Chorna, V. V.
Makhniuk, V. M.
Khliestova, S. S.
Gumeniuk, N. I.

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Features of the dental status of the Nogais who lived on the territory of Ukraine in the 15th century [Текст] = Особливості стоматологічного статусу ногайців, які мешкали на території України у XV столітті / L. F. Kaskova [та ін.] // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 12-16. - Bibliogr. at the end of the art.

MeSH-головна:
СТОМАТОГНАТИЧЕСКАЯ СИСТЕМА -- STOMATOGNATHIC SYSTEM (анатомия и гистология, патофизиология, повреждения, рост и развитие, физиология)
СТОМАТОГНАТИЧЕСКИЕ БОЛЕЗНИ -- STOMATOGNATHIC DISEASES (история)
ИСТОРИЯ 15 ВЕКА -- HISTORY, 15TH CENTURY
УКРАИНА -- UKRAINE (этнология)
Анотація: The condition of teeth in ancient populations living on the territory of Ukraine has been little studied. The aim of the work is to study the dental status of the 15th century Nogais, and to carry out a comparative analysis of the data obtained with the state of the dento-jaw system of medieval populations that lived on the territory of modern Ukraine in the 9th – early 15th centuries. The object of the study was 48 Nogai skeletons (main group) and 118 representatives of medieval cultures (control group). The research method was a method for analyzing the skeletal tissue of ancient people, developed by the authors. The prevalence and intensity of caries, the prevalence of dento-jaw anomalies, dental calculus and periodontal diseases were studied. Statistical analysis was performed using the Pearson χ2 test. It was found that the prevalence of dental caries in the main group is lower than in the control group (18.75 % and 37.28 % respectively, p0.05). It was also found that this indicator significantly differed in men of both groups (p0.05), while in women it did not differ (p0.1). It was found that in the main group, compared with the control group, the frequency of primary adentia was higher (16.67 % and 6.68 % respectively, p0.05), but the prevalence of anomalies in the position of individual teeth and occlusion was lower (4.17 % and 21.18 % respectively, p0.05,). It was found that the prevalence of dental calculus in the main group is two times higher than in the control group (89.50 % and 41.0 % respectively, p0.0001). Also, 15.0 % of Nogai men showed a decrease in the height of the alveolar process of the jaws, which is characteristic of periodontitis; in women, such changes were not found due to the low average age of survival. Thus, the 15th century Nogai population had a lower prevalence of caries and dento-maxillary anomalies than the medieval populations that lived on the territory of modern Ukraine in the 9th – early 15th centuries
Дод.точки доступу:
Kaskova, L. F.
Yanko, N. V.
Kulai, О. O.
Chupryna, L. F.
Artemyev, A. V.

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Development of a method for serial intravesical administration of drugs in experiment [Текст] = Розробка методу серійного внутрішньоміхурового введення ліків в експерименті / О. H. Kostiuk [та ін.] // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 17-23. - Bibliogr. at the end of the art.

MeSH-головна:
ВВЕДЕНИЕ ЛЕКАРСТВ ИНТРАВЕЗИКАЛЬНОЕ -- ADMINISTRATION, INTRAVESICAL
МОЧЕВОГО ПУЗЫРЯ НОВООБРАЗОВАНИЯ -- URINARY BLADDER NEOPLASMS (терапия)
КРЫСЫ -- RATS
ЭКСПЕРИМЕНТЫ НА ЖИВОТНЫХ -- ANIMAL EXPERIMENTATION
Анотація: The technical difficulties of serial intravesical administration of drugs are a significant problem in preclinical studies of the effectiveness of local chemotherapy for superficial bladder cancer. The aim of the study was to develop and evaluate the effectiveness of the method of serial intravesical administration of drugs in the experiment. The study included 49 Wistar rats of both sexes. Five proposed methods of intravesical administration of drugs were investigated: retrograde catheterization of the urinary bladder under anesthesia, method of transcutaneous puncture of the urinary bladder in rats, intraoperative puncture of the bladder, method of subcutaneous fixation of the bladder for subsequent puncture in the experiment, method of serial intravesical administration of drugs in female rats using special catheter. The obtained data were processed using a package of statistical programs SPSS 20.0 for Windows. The disadvantage of the first technique is its trauma – each insertion of the catheter is accompanied by trauma of the urethral mucosa and associated pain. The manipulations were failed because of edema of the urethral mucosa. The manipulation should be performed under general anesthesia. The second technique also requires general anesthesia. The aggressive cytostatic action of Doxorubicin prevented the closure of the puncture hole and caused the development of complications. Sealing the bladder with a collagen plate when performing the third technique prevents the release of the drug into the abdominal cavity, however, the adhesion of the tissues of the surrounding organs to the plate promotes the formation of an adhesive conglomerate and makes further manipulations impossible. The withdrawal of the bladder from the abdominal cavity during the implementation of the fourth technique, theoretically, should have helped to avoid the complications observed during the third technique. However, insufficiently reliable fixation of the urinary and adhesions in the area of the implanted ring make this technique such that it does not correspond to the tasks set. The fifth method was the only one proposed that met all the assigned tasks. This technique made it possible to perform a series of 5 intravesical injections of Doxorubicin without general anesthesia and without the development of postoperative complications from the postoperative wound and abdominal cavity. The proposed method of serial intravesical administration of drugs in female rats using a special catheter makes it technically easy to perform serial intravesical administration of drugs without the use of general anesthesia and without the development of complications from the postoperative wound and abdominal cavity
Дод.точки доступу:
Kostiuk, О. H.
Hodovan, N. L.
Taran, I. V.
Mashevska, О. V.
Grebeniuk, D. I.

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Features of social-psychological adaptation of girls and boys 15-17 years during the study period in senior classes of the modern school [Текст] = Особливості соціально-психологічної адаптації дівчат та хлопців 15-17 років протягом періоду навчання у старших класах сучасної школи / I. V. Serheta [та ін.] // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 24-29. - Bibliogr. at the end of the art.

MeSH-головна:
АДАПТАЦИЯ ПСИХОЛОГИЧЕСКАЯ -- ADAPTATION, PSYCHOLOGICAL (физиология)
СОЦИАЛЬНАЯ АДАПТАЦИЯ -- SOCIAL ADJUSTMENT
ШКОЛЬНИКИ -- SCHOOL STUDENTS
ПОЛОВЫЕ ХАРАКТЕРИСТИКИ -- SEX CHARACTERISTICS
ПОДРОСТКИ -- ADOLESCENT (физиология)
Анотація: Social-psychological adaptation is a process of active human adaptation to constantly changing environmental conditions, using various social means, an important component of a person’s specific attitude to the world, the main function of which is to ensure a stable and stable standard of living, an important component of development binding of both typical and atypical socially, educational and professionally significant tasks, formation of appropriate behavioral decisions. The purpose of the work is to establish the features of social and psychological adaptation of girls and boys aged 15-17 during their stay in the senior classes of a modern school. To determine the leading features of social-psychological adaptation during the scientific work used a personal questionnaire of Rogers and Diamond, the use of which involved the assessment of a number of both nominal and integrated indicators of adaptation processes, namely indicators of adaptation, self-acceptance, perception of others, internality, internality to dominance. Analysis of the obtained results led to the use of descriptive statistics procedures based on the use of a standard application package of multidimensional statistical analysis “Statistica 6.1 for Windows” (licensed №AXX910A374605FA). The results of the research show mainly the average level of expression of the leading nominal indicators of social-psychological adaptation of pupils 15-17 years old, who are in a modern school, and determine the features of the process of active adaptation of girls and boys to environmental conditions, their socially significant attitude to the world. from the standpoint of ensuring a stable and stable standard of living, the peculiarities of behavioral decisions that contribute to this. These trends are confirmed by the analysis of integrated indicators of the processes of social-psychological adaptation of pupils, especially the characteristics of adaptability and maladaptation, self-acceptance and acceptance of others, as well as emotional comfort and internality. These results should be further taken into account both in diagnostic (development and implementation of methods for comprehensive assessment of adaptive resources of boys and girls) and preventive (development and implementation of effective health technologies and measures of psychohygienic correction of existing changes in the functional state of the body to create preventive educational environment in the educational institution) context
Дод.точки доступу:
Serheta, I. V.
Bratkova, О. V.
Drezhenkova, I. L.
Cherkasova, L. A.
Dzevulska, I. V.

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Selskyy, P. R.
Structural changes in skeletal muscles of the hind limbs of rats in acute ischemia-reperfusion and its correction by carbacetam, detected by polarization microscopy [Текст] = Структурні зміни скелетних м’язів задніх кінцівок щурів при гострій ішемії-реперфузії та їх корекція карбацетамом, виявлені за допомогою поляризаційної мікроскопії / P. R. Selskyy, T. O. Veresiuk // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 30-35. - Bibliogr. at the end of the art.

MeSH-головна:
КРЫСЫ -- RATS
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
РЕПЕРФУЗИОННОЕ ПОВРЕЖДЕНИЕ -- REPERFUSION INJURY (терапия)
МЫШЦА СКЕЛЕТНАЯ -- MUSCLE, SKELETAL (патофизиология)
МИКРОСКОПИЯ ПОЛЯРИЗАЦИОННАЯ -- MICROSCOPY, POLARIZATION (использование, методы)
ГАМК МОДУЛЯТОРЫ -- GABA MODULATORS
КАРБОЛИНЫ -- CARBOLINES
Анотація: Arterial tourniquets are used in clinical practice for angioplasty and arthroplasty, and in case of limb injuries, their use often occurs according to vital signs. After removing the tourniquet and blood supply restoration to the limb arises a multifactorial lesion of tissues both ischemic and distant from the site of ischemia. A number of publications have been devoted to the study of morphological disorders in muscle tissue in acute ischemia-reperfusion in the medical literature. However, the researches for effective means for drug correction of these disorders still continues. The aim of the study was to explore peculiarities of skeletal muscle remodeling of the hind limbs of rats, detected by polarization microscopy, in acute ischemia-reperfusion, caused by the application of an arterial tourniquet, and in the correction of reperfusion disorders by carbacetam. Microscopic examination of histological sections of skeletal muscles of the hind limbs of 60 rats below the site of application of the tourniquet under conditions of experimental acute ischemia-reperfusion was performed. Acute ischemia for all animals was caused by application of SWAT rubber bands on the hind limbs of animals, 5–6 mm in width, at the inguinal fold level within 2 hours under thiopental anesthesia. A reperfusion was modeled by removing the tourniquet. Half of the experimental animals in the reperfusion period for the purpose of correction intraperitoneally was administered the nootropic drug 1-oxo-3.3.6-trimethyl-1.2.3.4-tetrahydroindolo[2.3-c]quinoline (carbacetam) at a dose of 5 mg per kilogram of body weight once a day during the entire reperfusion period. The histological specimens of the skeletal muscles were stained with hematoxylin and eosin, and were examined with a light microscope with polarization nozzle. Studies with using the polarization microscopy have shown that in the early reperfusion period morphological criteria for skeletal muscle remodeling expressed by deformation and anisotropy of muscle fibers, disappearance of their transverse striation, cracks and ruptures of fibers, and in the most severe cases there were signs of necrosis of the fibers with their fragmentation into separate lumps. Subject to the correction of reperfusion disorders by carbacetam, there is a decrease in the degree of damage and consistent acceleration of restoration of the skeletal muscles structure, which was the most pronounced in groups of animals with reperfusion terms after 1 and 14 days. Complex of features indicates, that at the tissue level the administration of carbacetam as reduces the ischemic-reperfusion lesion of the muscular fibers, as also accelerates the mechanisms of reparative rhabdomyohistogenesis. Thus, structural changes in the skeletal muscles of the limb after two-hour ischemia and subsequent reperfusion increased in the early reperfusion period and reached its peak after 1 day of reperfusion, and in the late period of reperfusion their reverse development took place. With the correction of disorders by carbacetam, the degree of damage was reduced and the recovery of the skeletal muscle structure of the limb was accelerated
Дод.точки доступу:
Veresiuk, T. O.

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Correlations of linear sizes of molars with cephalometric indicators of practically healthy men of the southern region of Ukraine [Текст] = Співвідношення лінійних розмірів молярів з цефалометричними показниками практично здорових чоловіків південного регіону України / J. S. Soboh [та ін.] // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 36-46. - Bibliogr. at the end of the art.

Рубрики: мужской

MeSH-головна:
ЦЕФАЛОМЕТРИЯ -- CEPHALOMETRY
ОДОНТОМЕТРИЯ -- ODONTOMETRY
УКРАИНА -- UKRAINE (этнология)
ЗУБ КОРЕННОЙ БОЛЬШОЙ -- MOLAR
ТОМОГРАФИЯ РЕНТГЕНОВСКАЯ КОМПЬЮТЕРНАЯ -- TOMOGRAPHY, X-RAY COMPUTED (методы)
Анотація: The high prevalence of pathologies of the dental and tooth-jaw system both in Ukraine and abroad requires scientists to search for new, fundamental discoveries, in particular, to identify patterns of the relationship between cephalometric and odontometric indicators within certain ethnic populations. The purpose of the study is to establish the features of the correlations of computed tomography sizes of molars with cephalometric parameters of practically healthy men in the southern region of Ukraine. 33 practically healthy men of the first mature age, inhabitants of the southern region of Ukraine (from Mykolayiv, Kherson, Odesa, Zaporizhia regions and the Autonomous Republic of Crimea) underwent cephalometry and cone-beam computed tomography followed by odontometry of molars. The correlations between odonto- and cephalometric parameters were assessed in the license package “Statistica 6.1” using non-parametric Spearman statistics. In almost healthy men of the southern region of Ukraine in the qualitative analysis of multiple nature, mostly direct reliable and medium unreliable correlations, found only between most sizes of molars on the lower jaw and the length and height of the nose. Quantitative analysis revealed the most significant correlations between computed tomography sizes of molars and face sizes (7.4 % on the upper jaw, most of which are inverse, and 13.2 % on the lower jaw, almost evenly straight and inverse). With the indicators of the skull, the relative majority of reliable, mostly inverse correlations are observed with the height of the teeth, their crowns and the length of the roots (on the upper jaw 11.4 %, on the lower jaw 5.4 %); and with indicators of the facial skull – almost evenly with the height of the teeth, their crowns and the length of the roots (on the upper jaw 6.4 %, on the lower jaw 14.6 %, in both cases mostly reverse) and with vestibular-lingual and mesio-distal dimensions (on the upper jaw 8.7 %, mostly reverse, on the lower jaw 11.8 %, mostly straight). The obtained results of correlation analysis of computed tomography sizes of molars with cephalometric indicators and indices confirm the population specificity of the features of the dental system and are necessary for the correct construction of regression models
Дод.точки доступу:
Soboh, J. S.
Cherkasova, O. V.
Gunas, V. I.
Babych, L. V.
Kotsyura, О. O.

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Prenosological screening of autonomic regulatory systems tension in secondary school students [Текст] = Донозологічний скринінг напруги вегетативних регуляторних систем у учнів загальноосвітніх шкіл / I. V. Redka [та ін.] // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 47-53. - Bibliogr. at the end of the art.

MeSH-головна:
ШКОЛЬНИКИ -- SCHOOL STUDENTS
НЕРВНАЯ СИСТЕМА ВЕГЕТАТИВНАЯ -- AUTONOMIC NERVOUS SYSTEM (физиология)
НЕРВНАЯ СИСТЕМА ЦЕНТРАЛЬНАЯ -- CENTRAL NERVOUS SYSTEM (физиология)
СЕРДЕЧНЫХ СОКРАЩЕНИЙ ЧАСТОТА -- HEART RATE
СТРЕСС ПСИХОЛОГИЧЕСКИЙ -- STRESS, PSYCHOLOGICAL
ПОДРОСТКИ -- ADOLESCENT (физиология)
Анотація: Adolescence is characterized by increased reactivity to stress factors, among the sources of which the educational environment plays a significant role. The content of education and educational process organization, as well as interpersonal relationships, is the predominant stress factors of the educational environment. In the context of education reform, new pedagogical projects are being introduced, in particular, on the basis of meritocratic education, providing for the intensification of the educational process. It may affect the state of the autonomic regulatory systems of students. The purpose of the research is to study the activity level of autonomic regulatory systems among students of secondary school, who are studying in meritocratic and traditional gymnasium education systems. The study involved 60 students: 42 studied in meritocratic system (19 in SG-1, 23 in SG-2), and 18 in traditional system (SG-3). Heart rate variability (HRV) was used as a physiological marker of stress. ECG was recorded during 5 minutes in a darkened room in a rest state with closed eyes in a sitting position at the 5th, 6th and 7th grades. Intergroup comparisons of HRV parameters were carried out according to the Mann-Whitney, Kruskell-Wallis, Dunnett criteria, and the φ-criterion of the angular Fisher transformation. Differences were considered significant at р≤0.05. In the 6th grade, there was a tendency (0.05р≤0.07) to lower values of Mean, SDNN, TR, ΔX, RMSSD, pNN50 among students in meritocratic system compared to the traditional one. However, this trend reached the level of statistical significance in the students of SG-1 compared to the control (SG-3). In meritocratic education different student groups differed in the level of school stress in 6th and 7th grades. Students in SG-1, compared to SG-2, characterized by lower values % HF, HFn, pNN50 against the background of higher values of % LF, LFn, LF/HF, IC, CC1, CC0. Thus, a higher level of school-based stress in conditions of meritocratic education is determined not so much by the intensification of the educational process as by social factors of the educational environment and/or individual typological traits of students
Дод.точки доступу:
Redka, I. V.
Danylenko, H. M.
Sotnikova-Meleshkina, Zh. V.
Mikhalchuk, O. Ya.

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    The role of the brain natriuretic peptide gene polymorphism in the diagnostic use of the biomarker in myocardial dysfunction in men, residents of Podillya with comorbid essential hypertension and type 2 diabetes mellitus [Текст] = Роль поліморфізму гена натрійуретичного пептидного гена в діагностичному застосуванні біомаркеру при дисфункції міокарда у чоловіків, мешканців Поділля з коморбідною есенціальною гіпертензією та цукровим діабетом 2 типу / Ya. O. Antoniuk [та ін.] // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 54-60. - Bibliogr. at the end of the art.

Рубрики: мужской

MeSH-головна:
ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙ -- POLYMORPHISM, GENETIC
НАТРИЙУРЕТИЧЕСКИЙ ПЕПТИД МОЗГОВОЙ -- NATRIURETIC PEPTIDE, BRAIN
ДИАБЕТ САХАРНЫЙ, ТИП 2 -- DIABETES MELLITUS, TYPE 2 (диагностика, патофизиология)
ГИПЕРТЕНЗИЯ -- HYPERTENSION (диагностика, патофизиология)
БИОЛОГИЧЕСКИЕ МАРКЕРЫ -- BIOLOGICAL MARKERS
УКРАИНА -- UKRAINE (этнология)
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Анотація: There is a growing interest in the early detection of signs of myocardial dysfunction, especially in comorbid patients for timely prevention of progression of disease, reducing the risk of complications, improving their quality of life. The aim of the work was to optimize the diagnosis of myocardial dysfunction in men, residents of Podillya, taking into account the plasma concentration of brain natriuretic peptide (BNP) and polymorphism of the corresponding gene under conditions of comorbidity of essential hypertension (EH) with left ventricular hypertrophy (LVH) and type 2 diabetes mellitus (T2D). We examined 211 men: 79 persons without the signs of cardiovascular diseases, 62 patients with EH 2 and chronic heart failure (CHF) 0-I functional classes (FC) according to NYHA Classification and 70 – with EH 2 combined with T2D and CHF FC I-II. The examination included the determination of plasma concentration of BNP, the brain natriuretic peptide gene polymorphism (polymorphic locus T-381C), indices of doppler-echocardiography. The mathematical processing was performed using the standard statistical package Statistica 10. During the study, we calculated the primary statistical indicators, identified differences between groups on statistical grounds, made correlation and discriminant analysis. Diastolic dysfunction (DD) of the left ventricle (LV) was diagnosed in 45.16% of patients in the group with EH 2, and 90% in the group of comorbid patients. It was determined that men, residents of Podillya, with presence and absence of T2D, have dominating T381C genotype of the BNP gene (p0.05). Lower plasma concentration of BNP that is peculiar for homozygous T381T genotype, in comparison with carriers of allele C of BNP gene and the average values of this biomarker in patients with DD may affect its informativeness in the diagnosis of myocardial dysfunction and requires a lower level of diagnosis. Appropriate borderline levels of BNP were determined for early diagnosis of DD in carriers of polymorphic variants of the BNP gene in men, residents of Podillya, with comorbid course of EH 2 and T2D. It is recommended to determine the genotype of the corresponding gene (polymorphic locus T-381C) and plasma level of BNP and focus on the calculated borderline levels of BNP to optimize the diagnosis of myocardial dysfunction in comorbid patients with EH 2 and T2D. For carriers of the T381T genotype it is ≥55.57 pg/ml, for carriers of the C allele (heterozygous T381C and homozygous C381C) of the BNP gene it is ≥69.13 pg/ml
Дод.точки доступу:
Antoniuk, Ya. O.
Gumeniuk, A. F.
Sakovych, О. O.
Zhebel, V. M.

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Kryvovyaz, Yu.
General clinical and anthropometric parameters in patients with type 1 diabetes [Текст] = Загальні клінічні та антропометричні показники у хворих на діабет 1 типу / Yu. Kryvovyaz // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 61-68. - Bibliogr. at the end of the art.

MeSH-головна:
ДИАБЕТ САХАРНЫЙ, ТИП 1 -- DIABETES MELLITUS, TYPE 1 (диагностика, патофизиология)
АНТРОПОМЕТРИЯ -- ANTHROPOMETRY (методы)
Анотація: Currently there are many experimental markers of diabetic nephropathy, but clinical practice focuses mainly on the presence of albuminuria, which usually manifests itself in both adults and children on average 5-7 years after the onset of diabetes. The aim of the study was to study the general clinical and anthropometric parameters in patients with type 1 diabetes mellitus (T1D) depending on the level of albumin in the urine. The study included 78 men and 62 women aged 22 to 26 years with T1D. The control group consisted of 8 healthy men and 13 healthy women of the same age. The level of microalbuminuria was determined in all patients by enzyme-linked immunosorbent assay. The assessment of general clinical (pulse, systolic, diastolic pressure) and anthropometric (height, weight, body surface area, waist circumference, body mass index) indicators was performed. Statistical processing of the obtained results was performed in the license package “Statistica 5.5”, using non-parametric evaluation methods. It was found that angio-, retino- and neuropathy occurred in all patients with T1D. Simultaneously with the increase in albuminuria, the percentage of patients with deeper degrees of these complications increased. It was found that with increasing levels of albumin in the urine in most cases increases the percentage of patients with a correspondingly severe degree of these complications. Thus, in patients with T1D men found: angiopathy of the III degree with normoalbuminuria – 12.5 %, with microalbuminuria – 40.0 %, with proteinuria – 53.8 %; retinopathy of the II-III degree with normoalbuminuria – 0 % and 7.5 %, with microalbuminuria – 4.0 % and 40.0 %, with proteinuria – 100 % and 0 %; II-III degree neuropathy with normoalbuminuria – 65.0 % and 0 %, with microalbuminuria – 92.0 % and 0 %, with proteinuria – 0 % and 92.3 %. In patients with T1D women were found: angiopathy of the III degree with normoalbuminuria – 29.0 %, with microalbuminuria – 13.0 %, with proteinuria – 62.5 %; retinopathy of the II-III degree with normoalbuminuria – 3.2 % and 9.7 %, with microalbuminuria – 4.3 % and 26.1 %, with proteinuria – 87.5 % and 0 %; II-III degree neuropathy with normoalbuminuria – 71.0 % and 0 %, with microalbuminuria – 91.3 % and 0 %, with proteinuria – 12.5 % and 75.0 %. In patients with T1D with normo-, microalbuminuria and proteinuria, the value of systolic, diastolic blood pressure and pulse, in most cases, significantly higher than in healthy subjects (respectively in men by 6.1-18.3 % – 3.6-20.3 % and 4.2-14.7 %; in women – by 5.0-20.0 % – 9.1-22.8 % and 8.0-31.6 %). The value of these indicators increased with the increase in the level of albumin in the urine (respectively in men by 11.4 % – 16.1 % and 10.1 %; in women –- by 13.3 % – 10.0 % and 21.8 %). Patients with T1D had lower values of growth (respectively in men by 4.6-9.2 %; in women – 2.2-4.1 %), weight (only in men by 9.0-26.4 %) and body surface area (respectively in men by 7.2-17.7 %, in women – 4.8 % only in the group of proteinuria). Body mass index in sick men, compared with healthy, was significantly lower only in the group of proteinuria (by 5.5 %); and in women it was higher in the groups of normo- and microalbuminuria (by 10.6 % and 11.2 %). Patients with T1D women compared to healthy women had a larger waist circumference (by 5.5-11.8 %), and in patients with T1D men – on the contrary, this figure was lower in the group of microalbuminuria (by 4.0 %). Thus, the differences in general clinical and anthropometric parameters between patients with T1D with different levels of albumin in the urine and the degree of complications from the vascular and nervous system allow to assess the severity and compensation of the disease, and comparison of these indicators with the control group possibilities of disease development and peculiarities of the pathological process
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10.

Maryenko, N. I.
Fractal dimension of the cortex and white matter of human cerebellum (magnetic resonance imaging study) [Текст] = Фрактальна розмірність кори та білої речовини мозочка людини (дослідження магнітно-резонансної томографії) / N. I. Maryenko, O. Yu. Stepanenko // Biomedical and Biosocial Anthropology. - 2020. - № 38. - С. 69-74. - Bibliogr. at the end of the art.

MeSH-головна:
МОЗЖЕЧКА КОРА -- CEREBELLAR CORTEX (анатомия и гистология, физиология)
БЕЛОЕ ВЕЩЕСТВО МОЗГА -- WHITE MATTER (анатомия и гистология, физиология)
МАГНИТНОГО РЕЗОНАНСА ИЗОБРАЖЕНИЕ -- MAGNETIC RESONANCE IMAGING (методы)
ФРАКТАЛИ -- FRACTALS
Анотація: The cerebellum is a typical structure with fractal properties, so fractal analysis is one of the main morphometric techniques that allow a comprehensive assessment of its morphofunctional state; the development of methods for differential measurement of the fractal dimension of various components of cerebellar tissue is necessary for complex morphological examination of the cerebellum using fractal analysis. The aim of the study was to develop an algorithm for differential fractal analysis and to determine the values of the fractal dimension of the cortex and white matter of human cerebellum using the study of magnetic resonance imaging scans. Digital T2 weighted magnetic resonance imaging scans of 30 conditionally healthy persons were used in the study. Fractal analysis of the distinct components of the cerebellar tissue was performed using the pixel dilation method. The fractal dimension values for all threshold brightness values (from 0 to 255) were determined. The confidence interval of the fractal dimension values based on the average values of the fractal dimension of the entire range of brightness values was calculated. Algorithms for image preprocessing were developed for an individual study of the different components of the cerebellum: cerebellar tissue as a whole, white matter, molecular and granular layers of the cortex. A differential fractal analysis technique has been developed to assess individual components of the cerebellar tissue. The values of the fractal dimension of white matter, granular and molecular layers of the cerebellar cortex were determined. The values of the fractal dimension of cerebellar tissue as a whole and the fractal dimension of the cerebellar cortex as a whole were the biggest. These values exceed the value of the fractal dimension of white matter. The average value of the fractal dimension (FD) for the threshold value of 80 (white matter) was 1.318±0.050, for the value of 90 (white matter and the granular layer of the cortex) was 1.568±0.028, for the value of 100 (cerebellar tissue as a whole) was 1.694±0.010. The average FD of the granular layer of the cortex (brightness range 81-90) was 1.377±0.020, the FD of the molecular layer of the cortex (brightness range 91-100) was 1.353±0.020, the average FD of the cerebellar cortex as a whole (brightness range 81-100) was 1.564±0.018. The obtained data can be used as diagnosis criteria to assess the morphofunctional state of the cerebellum using magnetic resonance imaging
Дод.точки доступу:
Stepanenko, O. Yu.

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