Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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TGF-β1 expression by glioma C6 cells in vitro [Текст] / L. D. Liubich [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 258-263. - Bibliogr. at the end of the art.

MeSH-головна:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
ТРАНСФОРМИРУЮЩИЙ ФАКТОР РОСТА БЕТА1 -- TRANSFORMING GROWTH FACTOR BETA1 (анализ, диагностическое применение)
ГЛИОМА -- GLIOMA (эмбриология)
ГЕННОЙ ЭКСПРЕССИИ РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Кл.слова (ненормовані):
супернатанта клеток
Анотація: The aim of the work was to study the impact of fetal rat brain cell supernatant (FRBCS) on the expression of transforming growth factor β1 (TGF-β1) and p53 in C6 cells of rat glioma in vitro. Materials and Methods: FRBCS was obtained from suspensions of fetal rat brain cells on the 14th (E14) day of gestation. C6 glioma cells were cultured for 48 h in the presence of FRBCS or FRBCS + anti-TGF-β1 monoclonal antibody. Immunocytochemical staining for TGF-β1 and p53 was performed. Results: The proportion of TGF-β1-immunopositive tumor cells in C6 glioma cultures was statistically significantly higher than in the control cell cultures of normal fetal rat brain. FRBCS reduced the proportion of TGF-β1-immunopositive tumor cells and increased the proportion of p53-immunopositive cells in C6 glioma cultures. In cells cultured with FRBCS + anti-TGF-β1 monoclonal antibody, the above effects of FRBCS were abrogated. Conclusion: The obtained results suggest that TGF-β1 seems to be responsible for decrease in TGF-β1 expression and increase in p53 expression in C6 glioma cells treated with FRBCS
Дод.точки доступу:
Liubich, L. D.
Kovalevska, L. M.
Lisyany, M. I.
Semenova, V. M.
Malysheva, T. A.
Stayno, L. P.
Vaslovych, V. V.

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Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo [Текст] / O. N. Pyaskovskaya [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 264-268. - Bibliogr. at the end of the art.

MeSH-головна:
МЕТФОРМИН -- METFORMIN (анализ, терапевтическое применение, фармакология)
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS (анализ, терапевтическое применение, фармакология)
ГЛИОМА -- GLIOMA (лекарственная терапия, этиология)
МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Анотація: It is known that metformin is a hypoglycemic drug used to treat type II diabetes mellitus. Recently active studies of its antitumor activity in relation to different types of malignant cells are conducted. Aim: To determine the relationship between cytotoxic activity of metformin in vitro and its antitumor activity in vivo. Materials and Methods: The rat C6 glioma cell line and mouse Lewis lung carcinoma cells (LLC) were used in this work. The number of living cells in the cytotoxic test was evaluated using sulforhodamine B. Parameters of tumor cell susceptibility to metformin activity in vitro were calculated using nonlinear and linear regression of experimental data. The antitumor action of metformin in vivo was evaluated routinely by the extension of survival time (ST) (in rats with intracerebral C6 glioma) and its effect on the volume of the primary tumor, the number and volume of metastases (in mice with LLC). Results: In cultured LLC cells in vitro, the proportions of metformin-resistant (A₁, %) and metformin-sensitive (A₂, %) subpopulations were 10.0 ± 2.2% and 92.0 ± 3.5%, respectively, in terms of the total number of living cells. Parameter t, which characterizes the sensitivity of cancer cells to metformin action (the lower is the value of this parameter the higher is sensitivity of cells to metformin cytotoxicity), for metformin-resistant and metformin-sensitive subpopulations was: t1(mM) = ∞ and t2(mM) = 2.9 ± 0.3, correspondingly. For metformin-sensitive subpopulation of LLC cells IC₅₀ (mM) = 2.42 ± 0.34. The volume of the primary tumor, the amount and volume of metastases in mice receiving metformin at a dose of Dmin (0.15 g/kg) and Dmax (0.3 g/kg) values did not significantly differ from those in the control. However, in the case of Dmin, there was a tendency to increased volume of the primary tumor, in the case of Dmax, there was a tendency to increased volume of metastases. The analogical parameters (A₁, A₂, b₁, b₂, IC₅₀ (1), IC₅₀ (2)) characterizing cell sensitivity to the action of metformin in vitro were obtained in relation to C6 glioma cells. In metformin-resistant subpopulation, these parameters were: A₁ (%) = 72.3 ± 1.4; b1 (%/mM) = 0.43 ± 0.005; IC₅₀ (1) (mM) = 84.1 ± 2.4. For metformin-sensitive subpopulation, these parameters were: A₂ (%) = 30.8 ± 2.3; b2 (%/mM) = 2.87 ± 0.4; IC₅₀ (2) (mM) = 5.37 ± 0.45. In vivo, a statistically significant anti-glioma effect of metformin was observed: at a dose of Dmax (5.2 g/kg) administration of this preparation resulted in a prolongation of the mean ST of tumor-bearing rats by 23% (p 0.05) compared with that in the control. Conclusions: We found no correlation between the cytotoxic/cytostatic action of metformin in vitro and its antitumor activity in vivo on the two types of tumor cells; these results indicate a significant contribution of the tumor microenvironment to the implementation of the antitumor activity of the drug
Дод.точки доступу:
Pyaskovskaya, O. N.
Kolesnik, D. L.
Fedorchuk, A. G.
Gorbik, G. V.
Solyanik, G. I.

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Stress during puberty facilitates precancerous prostate lesions in adult rats [Текст] / D. Herrera-Covarrubias [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 269-275. - Bibliogr. at the end of the art.

MeSH-головна:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
СТРЕСС ФИЗИОЛОГИЧЕСКИЙ -- STRESS, PHYSIOLOGICAL (действие лекарственных препаратов)
ПОЛОВОЕ СОЗРЕВАНИЕ -- SEXUAL MATURATION (действие лекарственных препаратов)
ЛИПОПОЛИСАХАРИДЫ -- LIPOPOLYSACCHARIDES (анализ)
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ БОЛЕЗНИ -- PROSTATIC DISEASES (патофизиология, этиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Анотація: Puberty can be a critical period for the long-term development of diseases, especially for stress-related disorders that depend on neuroendocrine and immune responses. Some organs like the prostate are prone to diseases that result from neuroendocrine or immune challenges, such as cancer. Aim: In the present study, we assessed the long-term effects of an acute pubertal stressor (immune-challenge) on the development of precancerous lesions in adult rats, and compared them with testosterone-induced prostatic lesions. Materials and Methods: Pubertal male rats received a single injection of lipopolysaccharide (LPS) or saline during puberty (5 weeks old). At adulthood (8 weeks old) males were subcutaneously implanted with either an empty capsule or filled with testosterone propionate (100 mg/kg). This resulted in a total of five groups: 1) intact untreated, 2) saline-treated and implanted with a blank capsule, 3) saline-treated and implanted with a testosterone capsule, 4) LPS-treated and implanted with a blank capsule, 5) LPS-treated and implanted with a testosterone capsule. Four weeks later, the rats were sacrified and their prostates processed for histology (hematoxylin and eosin stain) and blood serum processed for hormone analysis (testosterone and corticosterone). Results: Males treated with LPS (stressed during puberty via immune challenge) expressed epithelium dysplasia (specially in the ventral prostate), anisocytosis, presence of mononuclear cells, anisokariosis, non-basal polarity, abnormal nucleus-cytoplasm ratio, proplastic myoepithelium, and granular content in the lumen. These histological alterations were similar, but less severe than those observed in males implanted with testosterone during adulthood. Conclusion: These results indicate that pubertal exposure to an immune challenge (stress) facilitates the long-term development of prostatic lesions in adult male rats
Дод.точки доступу:
Herrera-Covarrubias, D.
Coria-Avila, G. A.
Hernandez, M. E.
Ismail, N.

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Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure [Текст] / D. Caballero-Hernandez [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 276-280. - Bibliogr. at the end of the art.

MeSH-головна:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
СТРЕСС ФИЗИОЛОГИЧЕСКИЙ -- STRESS, PHYSIOLOGICAL (физиология)
ДИАГНОСТИЧЕСКИЕ МЕТОДЫ ЭНДОКРИННЫЕ -- DIAGNOSTIC TECHNIQUES, ENDOCRINE (использование, тенденции)
ИММУННОЙ СИСТЕМЫ ПРОЦЕССЫ -- IMMUNE SYSTEM PROCESSES (физиология)
МОРФОЛОГИЧЕСКИЕ И МИКРОСКОПИЧЕСКИЕ ПОКАЗАТЕЛИ -- MORPHOLOGICAL AND MICROSCOPIC FINDINGS
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Кл.слова (ненормовані):
Прибор волнового воздействия (Патент Украины № 53568)
Анотація: In stress research, reducing times of stress induction may contribute to improving the well-being of experimental animals, especially in cancer models, already under physiological distress. To support this idea, we evaluated the effects of a short-timed stress protocol on endocrine, metabolic and immune indicators in mice bearing the L5178Y-R lymphoma. Materials and Methods: A 30-minute daily stress protocol was applied for 28 days to healthy and lymphoma-bearing BALB/c mice; body weight, plasma levels of corticosterone, norepinephrine, Th1/Th2 cytokines, insulin, and leptin, were measured. Results: We found a 12% significant decrease in body weight in non-tumor bearing mice under stress (p < 0.007). The disruption of weight evolution was accompanied by a stress induced 85% decrease in plasmatic leptin (p < 0.01) and total reduction of insulin. Tumor burden alone was associated to an increase in more than two-fold of plasmatic levels of norepinephrine (p < 0.008). Neither stress nor tumor or their combination, resulted in an elevation of systemic IL-6. IFN-γ levels were 20 times higher in lymphoma-bearing animals when compared with non-tumor bearing mice (p < 0.01); however, under stress, this response was reduced by half, indicating a suppressing effect of chronic stress on the antitumor immune response. Conclusion: A short-timed stress induction is enough to cause significant alterations in the metabolism and immunity of healthy and tumor-bearing mice, supporting the use of short-timed protocols as an efficient way to induce chronic stress that also considers concerns regarding the well-being of experimental animals in biomedical research
Дод.точки доступу:
Caballero-Hernandez, D.
Najera-Valderrabano, D.
Valadez-Lira, A.
Franco-Molina, M.
Gomez-Flores, R.
Tamez-Guerra, P.
Tamez-Guerra, R.
Rodriguez-Padilla, C.

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Bebeshko, V.
Assessment of the effect of wave device application on morphological changes in organs and cells of irradiated animals [Текст] / V. Bebeshko, I. Homolyako, V. Grynchyshyn // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 281-285. - Bibliogr. at the end of the art.

MeSH-головна:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
ВНУТРЕННИЕ ОРГАНЫ -- VISCERA (анатомия и гистология, повреждения)
РАДИАЦИОННАЯ ОНКОЛОГИЯ -- RADIATION ONCOLOGY (тенденции)
МАГНИТНЫЕ ФЕНОМЕНЫ -- MAGNETIC PHENOMENA
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Кл.слова (ненормовані):
Изучить влияние Прибора волнового воздействия
Анотація: To study the effect of the Device for wave influence on biological objects on the prevention of the development of acute radiation sickness and chronic radiation syndrome in vivo. Materials and Methods: The studies were performed on white rats irradiated at a dose of 8 Gy. The experimental group of irradiated rats was treated with a wave Device (Patent of Ukraine No. 53568) once, for 2.5 min, 1.5 h after irradiation. Their organs were processed by standard histologic methods. Results: In the demagnetized rats, dystrophic changes in cells and tissues of liver, lungs, kidneys, brain, bone marrow and spleen were insignificant in 60 days compared to the control non-demagnetized group of animals. Conclusion: The Device reduced the magnetic charge of magneto-containing elements and their compounds in the organism of the irradiated animals, and decreased the formation of reactive oxygen species, which play a key role in the development of radiation-induced diseases
Дод.точки доступу:
Homolyako, I.
Grynchyshyn, V.

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The TGF-beta — SMAD pathway is inactivated in cronic lymphocytic leukemia cells [Текст] / A. Matveeva [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 286-290. - Bibliogr. at the end of the art.

MeSH-головна:
ЛЕЙКОЗ ЛИМФОЦИТАРНЫЙ ХРОНИЧЕСКИЙ B-КЛЕТОЧНЫЙ -- LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL (патофизиология, этиология)
ТРАНСФОРМИРУЮЩИЙ ФАКТОР РОСТА БЕТА2 -- TRANSFORMING GROWTH FACTOR BETA2 (анализ, диагностическое применение)
ГЕННОЙ ЭКСПРЕССИИ ПРОФИЛИРОВАНИЕ -- GENE EXPRESSION PROFILING (тенденции)
БИОИНЖЕНЕРИЯ -- BIOENGINEERING (тенденции)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Анотація: To study the status of the tumor growth factor beta (TGFB) pathway in chronic lymphocytic leukemia (CLL) cells and to uncover molecular details underlying CLL cell genesis. Objects and Methods: The study was conducted on peripheral blood samples of patients with CLL using the following methods: RNA isolation, analysis of expression of transcription factors using RT2 profiler assay, bioinformatics analysis of publicly available data bases on expression. Results: We have shown that the TGFB — SMAD canonical pathway is not active in CLL cells. SMAD-responsive genes, such as BCL2L1 (BCL-XL), CCND2 (Cyclin D2), and MYC, are down-regulated in CLL cells compared with peripheral blood B cells of healthy donors. Conclusions: The TGFB-mediated signaling is not active in CLL cells due to low (or absent) expression of SMAD1, -4, -5, -9, and ATF-3. Expression and phosphorylation status of SMAD2 and -3 should be further elucidated in the future studies
Дод.точки доступу:
Matveeva, A.
Kovalevska, L.
Kholodnyuk, I.
Ivanivskaya, T.
Kashuba, E.

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Gordiienko, I. M.
CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells [Текст] / I. M. Gordiienko, L. M. Shlapatska, V. M. Kholodniuk // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 291-298. - Bibliogr. at the end of the art.

MeSH-головна:
ТРАНСКРИПЦИИ ФАКТОР BRN-3B -- TRANSCRIPTION FACTOR BRN-3B (анализ, диагностическое применение)
ЛЕЙКОЗ ЛИМФОЦИТАРНЫЙ ХРОНИЧЕСКИЙ B-КЛЕТОЧНЫЙ -- LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL (патофизиология, этиология)
АНТИГЕНЫ ОПУХОЛЕВЫЕ -- ANTIGENS, NEOPLASM (анализ, диагностическое применение)
ГЕННОЙ ЭКСПРЕССИИ ЛЕЙКОЗА РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION, LEUKEMIC (физиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Анотація: Sequential stages of B-cell development is stringently coordinated by transcription factors (TFs) network that include B-lineage commitment TFs (Ikaros, Runx1/Cbfb, E2A, and FOXO1), B-lineage maintenance TFs (EBF1 and PAX5) and stage specific set of TFs (IRF4, IRF8, BCL6, BLIMP1). Deregulation of TFs expression and activity is often occurs in malignant B cells. The aim of this study was to evaluate TFs expression in chronic lymphocytic leukemia cells taking into consideration CD150 cell surface expression. From other side we attempted to regulate TFs expression via CD150 and CD180 cell surface receptors. Materials and Methods: Studies were performed on normal peripheral blood B-cell subpopulations and chronic lymphocytic leukemia (CLL) cells isolated from peripheral blood of 67 primary untreated patients with CLL. Evaluation of TFs expression was performed on mRNA level using qRT-PCR and on protein level by western blot analysis. Results: Median of PAX5 and EBF1 mRNA expression was higher in cell surface CD150 positive (csCD150⁺) compared to csCD150⁻ CLL cases or normal CD19⁺ and CD19⁺CD5⁺ B-cell subsets. Differences in mRNA expression of IRF8, IRF4 and BLIMP1 between studied groups of CLL and normal B cells were not revealed. All CLL cases were characterized by downregulated expression of PU.1 and BCL6 mRNAs in comparison to normal B cells. At the same time elevated SPIB mRNA expression level was restricted to CLL cells. Protein expression of IRF4, IRF8 and BCL6 was uniformly distributed between csCD150⁻ and csCD150⁺ CLL cases. PU.1 protein and CD20 that is direct PU.1 target gene positively correlated with CD150 cell surface expression on CLL cells. Ligation of CD150 and CD180 alone or in combination upregulated IRF8 and PU.1 while downregulated the IRF4 mRNA expression. Signaling via CD150 or CD180 alone elevated the level of BCL6 mRNA. Strong downregulation of IRF4 mRNA was observed after CD150, CD180 or CD150 and CD180 coligation on CLL cells. We found that in CLL cells CD150 is a negative regulator of SPIB while CD180 is involved in upregulation of EBF1 expression level. Moreover, CD180 ligation on CLL cells caused increase of CD150 mRNA level that is a one of the EBF1 target genes. Conclusions: Analysis of TFs expression profile revealed upregulated SPIB mRNA level and downregulated PU.1 in CLL cells. CD150 and CD180 receptors may modulate transcriptional program in CLL cells by regulating the TFs expression levels
Дод.точки доступу:
Shlapatska, L. M.
Kholodniuk, V. M.

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DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay [Текст] / L. G. Buchynska [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 299-303. - Bibliogr. at the end of the art.

MeSH-головна:
ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS (этиология)
ГЕНЫ СУПРЕССОРЫ ОПУХОЛЕВОГО РОСТА -- GENES, TUMOR SUPPRESSOR (физиология)
ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE (физиология)
ЛИМФОЦИТЫ, ИНФИЛЬТРИРУЮЩИЕ ОПУХОЛЕВЫЕ КЛЕТКИ -- LYMPHOCYTES, TUMOR-INFILTRATING (ультраструктура)
ПЕНЕТРАНТНОСТЬ -- PENETRANCE
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Анотація: To date, genome instability is considered to be a common feature not only of tumor cells, but also of non-malignant cells of cancer patients, including peripheral blood lymphocytes (PBLs). The issue of the association between genome instability in tumor cells and PBLs, as well as of its relationship with tumor progression remains poorly understood. Aim: To evaluate the level DNA damage in tumor cells and PBLs of endometrial cancer (EC) patients with regard to clinical and morphological characteristics of the patients. Materials and Methods: DNA damage was assessed in 106 PBLs samples and 42 samples of tumor cell suspension from EC patients by comet assay. PBLs from 30 healthy women were used as control. The level of DNA damage was expressed as the percentage of DNA in the comet tails (% tail DNA). Results: It was revealed that the amount of DNA damage in PBLs of EC patients was 2.2 times higher in comparison with that of healthy donors (8.3 ± 0.7 and 3.7 ± 0.4% tail DNA, respectively) (p 0.05). In this study, no association between the levels of DNA damage in endometrial tumor cells and PBLs was observed (r 0.05). The amounts of DNA damage both in tumor cells and PBLs were not related to the degree of tumor differentiation as well as the depth of myometrial invasion, but depended on the body mass index (BMI) of EC patients: high level of lesions was observed in patients with elevated BMI values. Furthermore, the level of DNA damage in tumor cells was associated to familial aggregation of cancer and was significantly higher in endometrial cells from patients with family history of cancer vs that from EC patients with sporadic tumors (32.3 ± 2.9 and 22.8 ± 1.8% tail DNA, respectively) (p 0.05). It was also found that for women who had high level of DNA damage in PBLs, the risk of EC was greater (odds ratio value of 3.5) compared to those with low level of such lesions. Conclusion: Genome instability that appears as an increased level of DNA damage in tumor cells and PBLs of EC patients is associated with BMI and family history of cancer and can reflect a predisposition to cancer
Дод.точки доступу:
Buchynska, L. G.
Brieieva, O. V.
Lurchenko, N. P.
Protsenko, V. V.
Nespryadko, S. V.

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Adsorption-rheological properties of blood serum in lung cancer patients [Текст] / Y. V. Dumanskiy [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 304-307. - Bibliogr. at the end of the art.

MeSH-головна:
ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS (кровь, патофизиология, этиология)
КРОВИ ВЯЗКОСТЬ -- BLOOD VISCOSITY (физиология)
ГЕМОРЕОЛОГИЯ -- HEMORHEOLOGY (физиология)
АДСОРБЦИЯ -- ADSORPTION (физиология)
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (анализ)
ЦИРРОЗЫ ПЕЧЕНИ -- LIVER CIRRHOSIS (кровь, патофизиология, этиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Анотація: The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. Patients and Methods: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women. The parameters of surface (interfacial) viscosity, elasticity, viscoelasticity module, tension and relaxation of blood serum were studied by the oscillating drop method using a computer tensiometer “PAT2-Sinterface”, and its volumetric viscosity was investigated using a Low-Shear-30 rotational viscometer. ARPB parameters were also studied in a control group composed from 50 healthy donors. Results: Increased levels of volumetrical viscosity, surface tension, surface elasticity and the relaxation time of the blood are typical for patients with LC and depended on the localization of the tumor, its histological variant, differentiation grade, severity of the course of the disease, the number of metastases in the lymph nodes, distant organs and skeleton, involvement of the pleura and ribs, the development of compression pulmonary syndrome, metastasis into the spine, adrenals, brain, and pancreas. The surface-active, viscoelastic and relaxation properties of the blood correlated with the levels of tumor markers (TGFβ1, VEGF, C-reactive protein, α2-macroglobulin). Conclusions: Integral changes of ARPB observed in every fifth patient with LC are involved in the pathogenesis of the disease, have predictive value in relation to the clinical course of disease (volumetric viscosity) and the development of complications from radiochemotherapy (surface viscosity)
Дод.точки доступу:
Dumanskiy, Y. V.
Stoliarova, O. Y.
Syniachenko, O. V.
Giulmamedova, M. F.
Potapov, Y. A.

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10.

L-arginine is an effective medication for prevention of endothelial dysfunction a predictor of anthracycline cardiotoxicity in patients with acute leukemia [Текст] / I. Skrypnyk [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 308-311. - Bibliogr. at the end of the art.

MeSH-головна:
АРГИНИН -- ARGININE (анализ, терапевтическое применение, фармакология)
ЭНДОТЕЛИАЛЬНЫЕ КЛЕТКИ -- ENDOTHELIAL CELLS (патология)
ЛЕЙКОЗЫ -- LEUKEMIA (осложнения, патофизиология, терапия, этиология)
КАРДИОМИОПАТИИ -- CARDIOMYOPATHIES (патофизиология, этиология)
АНТИОКСИДАНТНОЙ РЕАКЦИИ ЭЛЕМЕНТЫ -- ANTIOXIDANT RESPONSE ELEMENTS (действие лекарственных препаратов)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Анотація: To evaluate the effectiveness of L-arginine in the prevention of endothelial dysfunction, which may be a predictor of anthracycline-induced myocardial injury, in patients with acute leukemia (AL) on the background of anthracycline antibiotics low cumulative doses from 100 to 200 mg/m2. Materials and Methods: A total of 81 adult AL patients (38 males and 43 females with the age of 16–59 years) were studied. The patients were divided into two groups: group I (n = 34), AL patients treated with chemotherapy (CT) and L-arginine hydrochloride; group II (n = 47) — AL patients treated with CT only. Cardiac evaluation and endothelial function assessment were performed at baseline and after second CT. Electrocardiography (ECG) parameters, lipid peroxidation activity, antioxidant protection and NO system state were evaluated. Results: The bioelectric activity abnormalities of the myocardium were observed in studied patients with low cardiac risk after induction CT. In case of L-arginine administration, only minimal daily ECG changes were recorded. A significant difference in the lipid peroxidation and antioxidant defense system activity in patients of groups I and II was determined. We noticed deepening of endothelial dysfunction on the background of cytostatic therapy with anthracycline antibiotics compared with baseline values in patients of group II. It was found that prophylactic L-arginine increases superoxide dismutase level and reduces the total NOS activity due to its inducible isoform. Conclusion: The leading factor of anthracycline-induced cardiotoxicity is the imbalance between free radical generation and their inactivation that leads to endothelial dysfunction development. L-arginine eliminates the prooxidant-antioxidant imbalance and improves the endothelial function
Дод.точки доступу:
Skrypnyk, I.
Maslova, G.
Lymanets, T.
Gusachenko, I.

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11.

Phenotypic features of endometrial tumors in patients with family history of cancer [Текст] / L. G. Buchynska [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 312-318. - Bibliogr. at the end of the art.

MeSH-головна:
ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS (патофизиология, этиология)
ГЕНЕТИЧЕСКАЯ ПРЕДРАСПОЛОЖЕННОСТЬ К БОЛЕЗНИ -- GENETIC PREDISPOSITION TO DISEASE (этиология, этнология)
ФЕНОТИП -- PHENOTYPE
ГЕННОЙ ЭКСПРЕССИИ НОВООБРАЗОВАНИЙ РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION, NEOPLASTIC
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Анотація: To determine the peculiarities of expression of a number of proteins-regulators of the cell cycle in endometrial cancer (EC) cells in patients with a family history of oncological pathologies. Patients and Methods: 95 EC patients (stage І–ІІ) were included into the study. Clinical-genealogical analysis was performed. 54 patients (group I) had healthy relatives, and in families of 41 patients (group II) an aggregation of malignant tumors of different genesis (mainly tumors of the gastrointestinal tract and the female reproductive system) was recorded. p53, р21WAF1/CIP1, р16INK4a, and Ki-67 were assessed immunohistochemically in the surgical samples. Results: In the majority of patients, both from group I and II, moderately differentiated tumors were observed (in 38.9 and 46.3% of cases, respectively), mainly with deep myometrium invasion (64.8 and 58.5% of cases, respectively). In EC patients from group II, a significantly higher number of р16INK4a-positive cells (17.7 ± 1.7%; p = 0.001) and lower number of p53-positive (30.9 ± 3.2%; p = 0.05) and Ki-67-positive (26.9 ± 2.7%; p = 0.048) cells was observed compared to those in tumors of patients from group I (12.0 ± 1.6; 37.7 ± 2.8 and 36.7 ± 3.4%, respectively). Conclusion: Phenotypic features of the EC in the patients with family history of cancer differ from those in tumors of patients without such aggregation. The biological heterogeneity of EC seems to relate to the oncogenealogical history of patients. Also this biological heterogeneity is linked to the molecular features of EC cells, which affects cancer aggressiveness and the course of the disease
Дод.точки доступу:
Buchynska, L. G.
Lurchenko, N. P.
Glushchenko, N. M.
Nesina, I. P.

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12.

Consumptive hypothyroidism: an unusual paraneoplastic manifestation of a gastric gastrointestinal stromal tumor [Текст] / T. Patial [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 319-321. - Bibliogr. at the end of the art.

MeSH-головна:
ОПИСАНИЕ СЛУЧАЕВ -- CASE REPORTS
ГИПОТИРЕОЗ -- HYPOTHYROIDISM (патофизиология, этиология)
КОМОРБИДНОСТЬ -- COMORBIDITY (тенденции)
БРЮШНОЙ ПОЛОСТИ НОВООБРАЗОВАНИЯ -- ABDOMINAL NEOPLASMS (метаболизм, осложнения, хирургия, этиология)
ЛЕЧЕНИЯ РЕЗУЛЬТАТОВ АНАЛИЗ -- TREATMENT OUTCOME
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Кл.слова (ненормовані):
чахоточный гипотиреоз
Анотація: A 42-year-old hypothyroid shepherd presented with a progressive abdominal lump accompanied by nausea and abdominal fullness. In addition, he had worsening hypothyroidism, despite supranormal doses of thyroxine. Computed tomography of the abdomen was suggestive of a mass lesion in relation to the stomach. A resection of the mass was done and the histopathology was suggestive of gastrointestinal stromal tumor. After surgery, the patient became euthyroid. We believe the patient had consumptive hypothyroidism due to the tumor
Дод.точки доступу:
Patial, T.
Sharma, K.
Thakur, D.
Gupta, G.

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13.

Volodymyr Serhiiovych Mosiienko (1934–2017) [Текст] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 322

MeSH-головна:
ОНКОЛОГИЯ МЕДИЦИНСКАЯ -- MEDICAL ONCOLOGY (история, кадры)
Анотація: Dr. Mosiienko was generous and modest responding to the needs of others. The bright memory of Volodymyr Serhiiovych Mosiienko will live forever in the hearts of all who knew him
Дод.точки доступу:
Мосиенко, Владимир Сергеевич (онколог ; 1934-2017) \про нього\

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(Асоціація ЕБНІТ)