Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Venger, O. P.
Improvement in the approaches to the treatment of emigrants and re-emigrants with depressive disorders [Text] / O. P. Venger, Y. I. Mysula, L. V. Shkrobot // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P5-10

MeSH-головна:
ДЕПРЕССИВНЫЕ РАССТРОЙСТВА -- DEPRESSIVE DISORDER
Анотація: Social and clinical relevance of emigration and re-emigration is determined by a significant amount of Ukrainians that emigrate and re-emigrate. Clinical features of depressive disorders have not been studied; as well as risk factors and antiriscs of various forms of depression have not been established yet. Development of comprehensive approaches to the treatment and rehabilitation of these patients is an effective way of resolving of this problem and is of significant scientific, practical, medical and social importance. Objective. The development of measures for treatment of depressive disorders in emigrants and re-emigrants is based on investigation and analysis of clinical-psychopathological phenomenology of depression. Methods. We examined 196 emigrants, 191 re-emigrants and 198 not emigrants with final clinical diagnosis of depressive disorder according to ICD-10 criteria. Examination was conducted by means of depression rate according to M. Hamilton, the Montgomery-Asberg and Symptom Checklist-90-Revised and the scale of life quality by WHO QOL-26. Statistical analysis of the results was performed using nonparametric methods: Mann-Whitney test, Wilcoxon criterion of signs. Results. It was found that the maximum content of organic acids is accumulated in grass Hyssopus officinalis L. (Lamiaceae), and the minimal is in the leaves of Chrysánthemum xhortorum L. variety Apro (Asteraceae). The dominance of aliphatic acids was determined by means of gas chromatography. Benzoic is predominant among aromatic acids. Conclusions. The suggested therapy schemes proved higher effectiveness compared with the traditional one, and also allowed to improve the life quality of emigrants and re-emigrants
Дод.точки доступу:
Mysula, Y. I.
Shkrobot, L. V.

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Kedyk, A. V.
Screening for dyslipidemia and expedience of statin therapy for the citizens of transcarpathia valley regions with overweight and obesity [Text] / A. V. Kedyk, M. V. Rishko, O. O. Kutsyn // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P11-14

MeSH-головна:
ДИСЛИПИДЕМИЯ -- DYSLIPIDEMIAS
ОЖИРЕНИЕ -- OBESITY
ГИПОФИЗАРНЫХ ГОРМОНОВ ВЫСВОБОЖДЕНИЯ ИНГИБИТОРЫ -- PITUITARY HORMONE RELEASE INHIBITING HORMONES
Анотація: The lipid profiles of patients with overweight, obesity and healthy individuals, the citizens of Transcarpathia valley regions were analysed. Objective. The study was aimed at evaluation of dyslipidaemia frequency in patients with overweight and obesity, determination of expedience of statins prescription. Methods. All patients were divided into 2 groups: group 1 – patients with overweight; group 2 – patients with obesity of I and II degree. Estimation of lipid profile parameters was conducted by means of spectrophotometric device SIEMENS Dimension RxL Max. Statistical analysis of the data was conducted using Microsoft Excel 2007. Results. The patients with obesity had higher level of total cholesterol (6.03±0.53 mmol/l), lower HDL-C (1.15±0.07 mmol/l) and higher level of LDL-C (4.19±0.46 mmol/l) compare with overweight patients. In 46% of patients with overweight, dyslipidaemia was evidenced and required correction, 27% of them had high CVR and needed statin therapy, 19% of people with obesity had moderate CVR and didn’t need statins. 77% of obese patients needed lipid correction, 54% of them with very high and averagely high level of CVR required statin therapy; 23% of people with obesity had moderate CVR and did not need statins. Conclusions. In the studied overweight and obese patients, atherogenic dyslipidaemia was established in 46% and 77% of cases respectively. Correction of dyslipidaemia with statin was compulsory for 27% of patients with overweight and for 54% with obesity
Дод.точки доступу:
Rishko, M. V.
Kutsyn, O. O.

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Oleshchuk, O. M.
Leptin resistance and type 2 diabetes [Text] / O. M. Oleshchuk, H. Ya. Loi // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P15-21

MeSH-головна:
ДИАБЕТ САХАРНЫЙ, ТИП 2 -- DIABETES MELLITUS, TYPE 2
ЛЕПТИН -- LEPTIN
Анотація: Leptin is one of adipocyte-secreted hormones. It signals to the brain and other tissues about the status of body energy reserves. Circulating leptin levels are directly proportional to the amount of the body fat. Leptin concentration increases when surfeit and decreases during fasting. Obese patients are hyperleptinemic compared with thin persons and they are tolerant to the central hypothalamic effects of leptin. The reduced sensitivity toward exogenous and endogenous leptin is commonly referred to as leptin resistance. Alterations in the signaling of the long isoform of the leptin receptor play the crucial role in leptin resistance. Surfeit may induce leptin resistance and other metabolic sequelae of obesity. Leptin insensitivity and insulin resistance play a major role in the development of type 2 diabetes. Metformin remains the preferred first-line pharmacologic agent for the treatment of type 2 diabetes. It reduces hepatic glucose production, increases glucose uptake in peripheral tissue and can lead to weight loss. Metformin decreases both insulin and leptin concentration, restores the sensitivity to these hormones. But some studies have shown poor relationship between metformin action and leptin level. And the mechanism of metformin action on leptin resistance remains unclear. Thus, these issues should be studied as well as polymorphisms in genes encoding metformin action
Дод.точки доступу:
Loi, H. Ya.

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Martynyuk, L. Z.
The effect of L-arginine on oxidative stress and microalbuminuria in patients with type 2 diabetes mellitus and chronic kidney disease [Text] / L. Z. Martynyuk, L. Z. Vons, O. O. Ruzhytska // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P22-25

MeSH-головна:
ДИАБЕТ САХАРНЫЙ, ТИП 2 -- DIABETES MELLITUS, TYPE 2
ПОЧЕК БОЛЕЗНИ -- KIDNEY DISEASES
ОКСИДАТИВНЫЙ СТРЕСС -- OXIDATIVE STRESS
АРГИНИН -- ARGININE
АЛЬБУМИНУРИЯ -- ALBUMINURIA
Анотація: One of the severest complications of diabetes is diabetic kidney disease (DKD). Microalbuminuria (MAU) is one of the first signals of DKD and an important pathogenetic mechanism of disease progression. With diabetes dramatically antioxidant properties worsen. Objective. The aim was to investigate the effect of L-arginine on oxidative stress parameters and microalbuminuria in type 2 diabetes mellitus and chronic kidney disease patients. Methods. Total of 57 patients with type 2 diabetes mellitus and chronic kidney disease and 30 healthy subjects (control group) were included in the study. The patients were divided into 2 congruent groups. The 1-st group of patients (n=33), in addition to standard therapy, received L-arginine 4.2 g intravenously for 5 days, after that they took it 1,0 g orally three times a day during meals for 1 month. The second group of patients (n=24) received a standard therapy. The concentration of lipid peroxidation products was measured by a spectrophotometric method. The determination of MAU was carried out in morning portion of urine immunological semiquantitative using test strips. Results. Significant improvement in indexes of lipid peroxidation was observed in both groups after therapy (p˂0.01), but in patients treated with L-arginine it was more expressed (p˂0,01). The standard therapy did not significantly affect the level of MAU (p˃0,05). The patients treated with L-Arginine, showed a significant reduction in MAU (p˂0.01). Conclusions. The usage of L-arginine facilitates the correction of lipid peroxidation processes and reduces the severity of microalbuminuria in patients with diabetic kidney disease that slowing its progression
Дод.точки доступу:
Vons, L. Z.
Ruzhytska, O. O.

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Neurodevelopmental care of preterm infants and its key [Text] / I. M. Sarapuk [et al.] // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P26-33

MeSH-головна:
НОВОРОЖДЕННЫЙ, БОЛЕЗНИ -- INFANT, NEWBORN, DISEASES
Анотація: Over the past few decades, the advancements in the perinatal and neonatal intensive care have led to a significant survival of premature infants. However neurodevelopmental outcome still remains the topical issues of concern. Developmental care is an approach that is aimed to reduce the mismatches between extra- and intra-uterine environments, decrease the stress of preterm newborns in neonative intensive care units, and thus promote optimal neurobehavioral development of the infant. The Newborn Individualized Developmental Care and Assessment Program (NIDCAP) model was developed as a clinical framework for the implementation of developmental care. The model focuses on detailed reading of each individual infant’s behavioral cues. By observing the child during the routine manipulation performance (before, during and after) and a detailed description of his/her behavioral responses, a professional can assess the ability of the infant’s immature nervous system to tolerate the environment and care manipulations. Such evaluation will enable to determine the adequacy of environmental conditions and care manipulations to baby’s opportunities and needs, with their subsequent correction and adaptation. NIDCAP’s aim is to support the child in its increasing tolerance to stimuli and to minimize stressful events and manipulation. With the help of NIDCAP approaches in neonatal care, medical staff study how to read infants’ behavior, hear their voice and understand them
Дод.точки доступу:
Sarapuk, I. M.
Pavlyshyn, H. A.
Lacina, L.
Krolak-Olejnik, B.

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Chronic mycotic-associated surgical nail pathology complicated with ingrown nail (nail incarnation): the analyses of clinical cases and complex treatment [Text] / A. R. Vergun [et al.] // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P34-40

MeSH-головна:
НОГТИ ВРОСШИЕ -- NAILS, INGROWN
Анотація: Conservative treatment of secondary recurrent unguis incarnatus are not very effective and Dupuytren’s method, Emmert-Schmiden surgeries etc. are very traumatic, disfigure nail bone, distort anatomic and functional unity of a nail. Objective. The aim of our research was the optimal sequence of holiatry, surgical moving away from nails, local and system therapy after excision of the staggered nails in case of destructive onychomycosis complicated by secondary ingrown nail for some patients with complicated mycotic defeat of nails. Clinical options of surgical treatment were clarified; morphologic changes were studied; causes of unsatisfactory outcomes of chronic pathology complex treatment were analyzed for prospective approaches to preventing of relapses. Methods. The analysis justifies the feasibility of establishing of predictive relationships between clinical variants of chronic purulent necrotic infections and combined comorbidity. System therapy by itraconazole before operative treatment (basic onychial defeats sanation) and in a postoperative period was carried out. Types of operative treatment applied may be divided into five statistic groups. Results. Over a five-year period (2010-2015) 436 unguis incarnates diagnosis (325 cases of incarnated onychomycosis) in 259 men and 177 women aged 12-67 were performed, 38 of them with incarnated onychogryphosis had diabetes mellitus and 24 had metabolic syndrome. Analysis of subonychial scraping allowed stating the prevalence of red trichophytia in 31% of cases with the bacterial flora. Patients with combined pathology got 4-5 five-day system ‘pulses’ of 400 mg/day itraconazole therapy. In patients with primary advantage of providing low-impact methods of nail excision with access via onycholisation structure a nail extirpation and marginal matricectomy was carried out; dermatophytoms and stratification on a nail bed were deleted. Conclusions. Type of onychectomy wound cytograms in the study group on the 10th day was defined as regenerative-inflammatory in 24.81%, regeneratory in 75.19% (p=0.031). The methods of surgical treatment of mycotical recurrent nail incarnation have been improved considering patho- and morphogenetic properties of destructive onychomycosis
Дод.точки доступу:
Vergun, A. R.
Parashchuk, B. M.
Krasnyi, M. R.
Kit, Z. M.
Vergun, O. M.

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Pathogenic mechanisms of generalized periodontitis from the position of polymorphism of nuclear transcription [Text] / N. V. Hasiuk [et al.] // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P41-46

MeSH-головна:
ПЕРИОДОНТА БОЛЕЗНИ -- PERIODONTAL DISEASES
ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙ -- POLYMORPHISM, GENETIC
Анотація: Periodontal diseases are a topical issue of contemporary dentistry because they are accompanied by severe morphological and functional disorders of maxillodental system; and are characterized by polyetiology and a number of metabolic disorders. The purpose of this study was to substantiate the pathogenic mechanisms of generalized periodontitis in relation to polymorphism of nuclear transcription factor NF- κB1. Objective. The aim of the study was to determine the genetic factors in the development of generalized periodontitis and the relationship of this parameter with immunohistochemical affiliation for cellular infiltrate of the lamina propria of gum at this nosology in young people. Hence, 2 groups were formed: І – control and II – observational. Methods. Polymorphic gene section NF-κB1 was determined using the cells of buccal epithelium of the examined people by means of polymerase chain reaction. Collection of material was performed with sterile disposable dental brush, followed by the introduction of a reagent in ependorph with DNA Express reagent (LyTeh NPF, Russia). Genome deoxyribonucleic acid was isolated by DNA Express set (LyTeh, Moscow). Results. The lack of correlation in this case indicates that no matter how parameters change, relatively major genotype (Del/Del) in this case is unchanged and the determining factor causes the development of generalized periodontitis, clinical picture of which is rapidly progressing. Conclusions. Results of correlation analysis proved that genotype (Del/Del), as polymorphic variant of gene transcription factor NF-κB1, was significantly associated with the emergence of rapidly progressive periodontitis in young people
Дод.точки доступу:
Hasiuk, N. V.
Vesnina, L. E.
Shlykova, O. A.
Izmailova, O. V.

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Kostenko, Ye. Ya.
The effectivness of chronic gingivites treatment in patients with non-removable orthodontic apparatus according to the results of periodontal tissues index assessment [Text] / Ye. Ya. Kostenko, V. S. Melnyk, L. F. Horzov // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P47-49

MeSH-головна:
ГИНГИВИТ -- GINGIVITIS
ОРТОДОНТИЧЕСКИЕ УСТРОЙСТВА -- ORTHODONTIC APPLIANCES
Анотація: The risk of chronic gingivitis is increased in patients who undergo orthodontic treatment. It is known that the gingivitis is closely correlated with the level of hygiene. Objective. The study involved 123 orthodontic patients with chronic catarrhal and hypertrophic gingivitis that developed during the first two months of active orthodontic treatment. We chose VITIS ORTНODONTIС (DENTAID INTERNATIONAL, Spain) that contains active ingredients we need to support healthy state of oral cavity. All studied patients were 12-15 years old. Methods. For dental examination we used health indices OHI-S according to Greene-Vermillion (1964). Gums bleeding was determined according to a modified SBI index by Muhlemann (1971), inflammation of the gingival margin was assessed by PMA index Parma (1960). Results. Therapeutic treatment consisted of the following: all patients underwent correction of oral hygiene, removal of dental plaque. Vitis ORTHODONTIC was prescribed due to the manufacturer's recommendations: rinse 15 ml for 30 seconds after normal procedures of oral hygiene. Eating or drinking is not recommended during the next 30 minutes after using this product. The results proved a high anti-inflammatory efficacy of the treatment schemes. Conclusions. The complex therapy of early manifestations of inflammation in periodontal had a positive effect on the subjective feelings of patients and health performance rate, gum inflammation and bleeding
Дод.точки доступу:
Melnyk, V. S.
Horzov, L. F.

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Influence of lactobacillus spp. on colonization and anti-infectious resistance of the mucous membranes of the upper respiratory tract [Text] / S. V. Kalinichenko [et al.] // International journal of medicine and medical research. - 2017. - Том Vol. 3, N 1. - P50-59

MeSH-головна:
РОТОВОЙ ПОЛОСТИ СЛИЗИСТАЯ ОБОЛОЧКА -- MOUTH MUCOSA
ЛАКТОБАЦИЛЛЫ -- LACTOBACILLUS
Анотація: Lactobacilli are very important for the formation of colonization resistance and have pronounced antagonistic effect against a wide range of microorganisms. That is why the lactobacilli have extensive use as a component of classic probiotic agents that are widely used to prevent and treat dysbiotic conditions of digestive and genital systems of people. Objective. The aim of the research was to study the effect of lactobacilli on anti-infectious resistance of mucous membranes of upper respiratory tract. Methods. The colonization degree (lg CFU / g) of nasal mucosal membranes by Lactobacillus spp. and S. aureus was determined in all carriers before the experiment. Also, the level of lysozyme and secretory immunoglobulin A (sIgA) in nasal secretions cavities was identified. Results. It was established a clear dysfunction of anti-infectious resistance in carriers of Staphylococcus aureus - a decrease of colonization resistance and local immunity of mucous membranes of upper respiratory tract. As for the anti-infectious resistance of nasal mucosal of S. aureus carriers, the level of lysozyme and secretory immunoglobulin A gradually increased after the application of probiotic strain L. rhamnosus GG, and in 21 days it reached rates of healthy individuals. Conclusions. It was found out that probiotics for nasal passages sanitation in Staphylococcus aureus carriers lead to gradual eradication of the pathogen (S. aureus) with restoration of colonization and anti-infectious resistance, mucous membranes and upper respiratory tract
Дод.точки доступу:
Kalinichenko, S. V.
Korotkykh, O. O.
Pokhil, S. I.
Bakumenko, M. G

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10.

Awareness of lyme borreliosis of the patients of ternopil regional tb dispensary [Text] / L. P. Melnyk [et al.] // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P60-63

MeSH-головна:
БОРРЕЛИОЗЫ -- BORRELIA INFECTIONS
Анотація: Lyme disease has many clinical features similar tothose in sarcoidosis and tuberculosis. Epidemiological data in the world, in particular in Ukraine, proves the increase in Lyme borreliosis incidence. Ternopil region is endemic with Lyme borreliosis. Objective. The research was aimed to investigate the prevalence of infection with Borrelia burgdorferi and epidemiology features of borreliosis among the patients of Ternopil Regional TB Dispensary. Methods. In total, 29 patients were admitted to Departments of Differential Diagnostic, TB Therapy and TB Surgery of Ternopil Regional TB Dispensary in October 2016-January 2017. All the surveyed answered the questions of an integrated international questionnaire, where they noted the area and a number of tick bites, described the removal method, noted the survey for borreliosis pathogen and complaints after tick bites. Results. It was established that 5 respondents had a history of tick bites episodes, but only in one case the patient was examined of borreliosis. Tick bites were noticed in 3 patients with sarcoidosis and 1 with tuberculosis (TB) and exudative pleurisy, respectively. Conclusions. The absence of appeals for medical care, lack of sufficient information on Lyme borreliosis and disuse of preventive measures for tick bites by the interviewed patients of Ternopil regional TB dispensary departments proves the need of improvement of health education on Lyme borreliosis (LB) among this category of population. 24 (82.7%) of 29 respondents did not remember the tick bite. The symptoms of (LB) are similar to those in sarcoidosis and tuberculosis (pleural lesions, heart, joints, nervous system, skin), and the presence of tick bites gives the reasons to examine these patients of Borrelia burgdorferi senso lato
Дод.точки доступу:
Melnyk, L. P.
Hryshchuk, L. A.
Koziol-Montewka, M.
Tabas, P. O.
Klos, R. O.

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11.

Nazarchuk, O. A.
Research in sensitivity to antibiotics, antiseptics in pseudomonas aeruginosa strains isolated from patients with infectious complications [Text] / O. A. Nazarchuk, D. V. Paliy, N. I. Osadchuk // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P64-69

MeSH-головна:
ИНФЕКЦИОННЫЕ БОЛЕЗНИ -- COMMUNICABLE DISEASES (осложнения)
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ У ГРИБКОВ -- DRUG RESISTANCE, FUNGAL
Анотація: Infections caused by Pseudomonas are one of the topical issues of medicine. Objective. The aim of the research was to study sensityvity to antibiotics, antiseptics of P. aeruginosa clinical strains that cause infectious complications in patients with burns. Methods. Microbiological study of biological material, received from 435 patients with burns of the 3rd-4th stages (2011-2015 years). In early terms of burn disease 127 clinical strains of P. aeruginosa were isolated from patients. Standard methods were used to identify clinical isolates of P. aeruginosa by their morphological, tinctirial, culture and biochemical properties. The research of antimicrobial action of antiseptics, antibiotics against Pseudomonas were carried out by means of standard methods according to the Directive of the Ministry of Health of Ukraine (No. 167 from 05.04.2007 р.) and guidelines of National Committee of Clinical and Laboratory Study (NCCLS, 2002). Results. It was established that P. aeruginosa caused infectious complications in 23.9% of patients among other pathogens. Clinical isolates of P. aeruginosa were found to be low sensitive to amoxicillin/clavulanate (30.76%), ceftazidime (25.92%), cefoperazonum/sulbactam (46.15%), aztreonam (51.85%), tobramycin (38.46%), amicacin (70.34%), doxiciclini (26.92%), fluoroquinolones (59.26%). The analitical progistic criteria of decrease of sensitivity to ceftazidime, cefepim, meropenem and gatifloxacin were found in P. aeruginosa. This pathogen was determined to be sensitive to decasan ®, antimicrobial composition of decamethoxine ®, iodine pvidone. Conclusions. Clinical strains of Pseudomonas aeruginosa, being highly resistant to antibiotics, are also very sensitive to antiseptics decasan ®, antimicrobial of decamethoxine®, povidone iodine
Дод.точки доступу:
Paliy, D. V.
Osadchuk, N. I.

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12.

Boiagina, O. D.
Morphological study of communication between the longitudinal strips and the human corpus callosum [Text] / O. D. Boiagina // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P70-74

MeSH-головна:
МОРФОЛОГИЧЕСКИЕ И МИКРОСКОПИЧЕСКИЕ ПОКАЗАТЕЛИ -- MORPHOLOGICAL AND MICROSCOPIC FINDINGS
Анотація: It is established that there is an anatomical relationship between the corpus callosum and longitudinal strips. These formations must correlate to the common commissural system of the corpus callosum conductors. At present this issue in such a formulation is not considered in literature on Neuromorphology. Objective. The study was aimed to determine the commutations between the longitudinal strips and commissural conductors of the corpus callosum. Methods. The corpus callosum of people aged from 36 to 60 was studied. Some slices of the corpus callosum stem were used for impregnation and then inserted in paraffin blocks. Another part of these slices was subjected to plastination in epoxy resin. Results. Lateral longitudinal strips contain significantly greater mass of nerve conductors. Most of them compactly pass along limbic ring, while the other part is combined to nerve fibres of the corpus callosum commissural cords. The longitudinal strips are coated with an outer limiting glial membrane (grey coating). Conclusions. By means of the corpus callosum the connections between conscious and subconscious brain areas are structurally fixed. It can be assumed that longitudinal strips have relation to hippocampal area, related to the ancient formation of the pallium. This does not exclude the fact that the nerve fibres, found within longitudinal strips may have projections on the cortical cells of vaulted gyrus, which is considered to be paleopallium sphere. So, this interaction between the ancient and the old cortex should presumably be carried out by means of lateral longitudinal strips
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13.

Ilika, V. V.
Morphological research on free-residue oxidation processes in cases of decidual cells of placenta in chorioamnionotis and basal deciduitis combined with iron-deficiency anemia in the pregnant [Text] / V. V. Ilika // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P75-78

MeSH-головна:
БЕРЕМЕННОСТЬ -- PREGNANCY
АНЕМИЯ -- ANEMIA
Анотація: The oxidative modification of proteins is lately pivotal to pathologists and it is a new way of research on different pathological conditions, as well as the diagnostics of inflammation processes in placenta. Objective. The study was aimed at the research of nitro peroxides and establishing the specific features of oxidative modification of proteins in inflammation of placenta with iron deficient anaemia in the pregnant. Methods. Сhemiluminescent and histochemical technique (with bromphenol blue on ‘acidic’ and ‘basic’ proteins according to Mikel Calvo) was applied. Results. The intensity of nitro peroxides glow in chorioamnionitis and basal deciduitis increased in comparison with the samples of physiological and iron deficient anaemia gestation. At the same time in chorioamnionitis the glow intensity is higher than in basal deciduitis. Due to the results of immune histochemical technique held while analysing the samples, together with chorioamnionitis and basal deciduitis the R/B increases and in basal deciduitis the rate, is probably, higher, than in chorioamnionitis. At the same time, the extent of oxidative modification of proteins in cases of inflammation with iron deficient anaemia in the pregnant is on the average higher than with no iron deficient anaemia in the pregnant. Conclusions. High level of nitro peroxides in placentae basal plate in secundines inflammation, the increase in R/B rate, in other words the prevalence of ‘acidic’ proteins over ‘basic’ ones, is evidenced due to the increase of the intensity of oxidative modification processes of proteins in cases of deciduitis
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14.

Khudobiak, M. M.
Morphological changes in lungs, heart and liver caused by experimental associated chest and thighs trauma [Text] / M. M. Khudobiak, M. I. Marushchak, L. M. Holovatiuk // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P79-83

MeSH-головна:
РАНЫ И ТРАВМЫ -- WOUNDS AND INJURIES
ЛЕГКИЕ -- LUNG
СЕРДЦЕ -- HEART
ПЕЧЕНЬ -- LIVER
Анотація: According to preliminary results obtained, the development of hypoxemia caused by chest trauma affected lipid peroxidation stimulation leading to disruption of cell membranes structure and consequently cell death closing the ‘vicious’ circle, which in our opinion and according to the literature cause multiple organ failure. Objective. The aim of our study was to determine the features of morphological changes in cases of heart, lungs, liver injury after associated chest and both thighs trauma in rats. Methods. For histological examination the pieces of left ventricle tissues of heart, lungs and liver were used, which were fixed in 10% neutral formalin solution, dehydrated and embedded in paraffin blocks. Results. It was established that associated trauma of chest and both thighs in 1 day after the injury is accompanied by disturbances of hemodynamics in parenchymal organs due to venous congestion that occurs during the development of cardiovascular disease caused by traumatic shock. In the most severe period of maximum likelihood of complications, within 3 days, respiratory hypoxia, cardiovascular disorders, metabolic acidosis, and induced programmed cell death may develop. Conclusions. On the background of increasing pulmonary oedema (thickening of inter air sac membranes) caused by associated trauma of chest and both thighs in rats after only one day of the experiment hemodynamic changes in heart (low-blood supply of vessels in epicardium and isolated blood vessels of venous type) and liver (mainly plethora of blood vessels) were observed, which lead to morphological changes of myocardium within 3 days
Дод.точки доступу:
Marushchak, M. I.
Holovatiuk, L. M.

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15.

Lykhatskyi, P. H.
Free radicals and inflammation in rats of different age in cases of sodium nitrites and tobacco smoke poisoning [Text] / P. H. Lykhatskyi, L. S. Fira // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P84-88

MeSH-головна:
ТАБАКА УПОТРЕБЛЕНИЕ, РАССТРОЙСТВА ЗДОРОВЬЯ -- TOBACCO USE DISORDER
СВОБОДНЫЕ РАДИКАЛЫ -- FREE RADICALS
ЖИВОТНЫЕ ЛАБОРАТОРНЫЕ -- ANIMALS, LABORATORY
Анотація: Due to the wide use of nitrate fertilizers in agriculture and their migration into groundwater and food, the spreading of nitrate poisoning has become epidemic. However, people in the process of life get into bad habits: smoking, alcohol, drugs abuse. All these factors affect health and can cause fatal outcome. In real life, people are often exposed to more toxic factors that lead to general poisoning of the body and damage of many organs. Objective. The research was aimed to study the activity of free radicals and inflammation in rats of different age in cases of sodium nitrite affection with underlying 45-day tobacco intoxication. Methods. The content of nitrite ion (NO2-) was evaluated by Gris reaction. The level of pro-inflammatory (interleukin 6 (IL-6) and anti-inflammatory (interleukin 4 (IL-4) cytokines was determined in serum by ELISA method using test kits. Results. It was proved that in rats of different age affected by sodium nitrite with underlying 45-day tobacco smoke intoxication, the content of nitrite ion in serum, liver, lungs and myocardium is increased. After poisoning the animals with the studied toxicants, inflammation was activated in the body that was evidenced by the increased pro-inflammatory cytokine IL-6 and decreased inflammatory cytokine IL-4 in serum. Conclusions. The nitrite ion content in organs was the most significant and inflammation was manifested in the immature rats. In these animals the content of anti-inflammatory cytokines was the lowest
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Fira, L. S.

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16.

Khan, I. D.
Operations throughput as a determinant of golden-hour in mass-gathering medicine [Text] / I. D. Khan, B. Asima, S. A. Khan // International journal of medicine and medical research. - 2017. - Vol. 3, N 1. - P53-59

MeSH-головна:
ХИРУРГИЧЕСКИЕ ОПЕРАЦИИ -- SURGICAL PROCEDURES, OPERATIVE
Анотація: Golden-hour, a time-tested concept for trauma-care, involves a systems approach encompassing healthcare, logistics, geographical, environmental and temporal variables. Golden-hour paradigm in massgathering-medicine such as the Hajj-pilgrimage entwines along healthcare availability, accessibility, efficiency and interoperability; expanding from the patient-centric to public-health centric approach. The realm of massgathering-medicine invokes an opportunity for incorporating operations-throughput as a determinant of golden-hour for overall capacity-building and interoperability. Methods. Golden-hour was evaluated during the Indian-Medical-Mission operations for Hajj-2016; which established, operated and coordinated a strategic network of round-the-clock medical operations. Throughput was evaluated as deliverables/time, against established Standard-Operating-Procedures for various clinical, investigation, drug-dispensing and patient-transfer algorithms. Patient encounter-time, waiting-time, turnaround-time were assessed throughout echeloned healthcare under a patient-centric healthcare-delivery model. Dynamic evaluation was carried out to cater for variation and heterogeneity. Results. Massive surge of 394 013 patients comprising 225 103 males (57.1%) and 168 910 females (42.9%) overwhelmed the throughput capacities of outpatient attendance, pharmacy, laboratory, imaging, ambulance, referrals and documentation. There was a delay in attendance, suspicion, diagnosis and isolation of patients with communicable infections. The situational-analysis of operations-throughput highlights wasted turnaround-time due to mobilization of medical-team, diverting critical healthcare resources away from emergency situations. Conclusions. Time being a crucial factor in the complexity of medical-care, operations-throughput remains an important determinant towards interoperability of bottlenecks, thereby being a determinant of golden-hour in mass-gathering-medicine. Early transportation of a patient to definitive-care reduces treatment initiation-time, notwithstanding logistics of communication, evacuation, terrain and weather being deterministic in outcome. Golden-hour needs to be emphasized under a population-based approach targeting the clientele towards administering first-aid and reaching out to hospital within the golden-hour
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Asima, B.
Khan, S. A.

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