Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Шифр: ЕУ12/2019/41/4
Журнал

Экспериментальная онкология [Текст]
2019р. Т. 41 № 4 . - 45.41, р.

Зміст:
Karaman, O. M. Macrophages - a perspective target for antineoplastic immunotherapy / O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun. - С.282-290
Orel, V. E. Nоn-linear dynamics theory and malignant melanoma / V. E. Orel [et al.]. - С.291-299
Інші автори: Korovin S. I., Molnair J., Orel V. B.
Lisyany, N. I. Cytomegaloviruses and malignant brain tumors / N. I. Lisyany [et al.]. - С.300-303
Інші автори: Klyuchnikova A. A., Belskaya L. N., Lisyany A. A., Gnedkova I. A.
Woksepp, H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392 / H. Woksepp [et al.]. - С.304-311
Інші автори: Saini R. K. R., Zakharchenko O., Gautier A., Souchelnytskyi N., Souchelnytskyi S.
Dehghan, Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression / Nayeri M. J. Dehghan [et al.]. - С.312-317
Інші автори: Mahdavi M., Fazeli H., Hosseinpour Feizi M. A.
Albuquerque, A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation / A. P. B. Albuquerque [et al.]. - С.318-322
Інші автори: Silva A. L. V., Lima C. A. D., Beltrao E. I. C.
Skuja, E. Deletions in metastatic colorectal cancer with chromothripsis / E. Skuja [et al.]. - С.323-327
Інші автори: Butane D., Nakazawa-Miklasevica M., Daneberga Z., Purkalne G., Miklasevics E.
Burlaka, A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer / A. P. Burlaka [et al.]. - С.328-334
Інші автори: Burlaka A. A., Virko S. V., Ganusevich I. I.
Buchynska, L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina. - С.335-341
Zelinskaya, A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer / A. Zelinskaya. - С.342-345
Moazeni-Roodi, A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls / A. Moazeni-Roodi, M. Taheri, M. Hashemi. - С.346-352
Skrypnyk, I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy / I. Skrypnyk [et al.]. - С.353-356
Інші автори: Maslova G., Lymanets T., Gusachenko I.
Gavars, D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia / D. Gavars [et al.]. - С.357-362
Інші автори: Perminov D., Tauckels E., Lindenberga I., Auce A., Lejniece S.
Prylutskyi, M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles / M. P. Prylutskyi, M. F. Starodub. - С.363-365
Shkatula, P. M. International scientific conference "Tumor and Host: novel aspects of old problem" / P. M. Shkatula. - С.366-367
To the 120th birthday anniversary of academician R. E. Kavetsky. - С.368-369
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Прим. 1 (вільний)

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Buchynska, L. G.
Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina // Experimental Oncology. - 2019. - Том 41, N 4. - P335-341

Анотація: The aim of the study was to evaluate the morphological features of endometrioid carcinoma of the endometrium (ECE) of low differentiation grade with different invasive potential and to characterize their molecular phenotype by the expression of a number of adhesion markers. Materials and Methods: We have studied the samples of operation material of 37 patients with ECE of low differentiation grade with deep invasion ( ½ myometrium), n = 26, and with invasion ½ myometrium, n
Дод.точки доступу:
Naleskina, L. A.
Nesina, I. P.

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Шифр: ЕУ12/2017/39/4
Журнал

Экспериментальная онкология [Текст]
2017р. Т. 39 № 4 . - 34.76, р.

Зміст:
Liubich, L. D. TGF-β1 expression by glioma C6 cells in vitro / L. D. Liubich [та ін.]. - С.258-263. - Bibliogr. at the end of the art.
Інші автори: Kovalevska L. M., Lisyany M. I., Semenova V. M., Malysheva T. A., Stayno L. P., Vaslovych V. V.
Pyaskovskaya, O. N. Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo / O. N. Pyaskovskaya [та ін.]. - С.264-268. - Bibliogr. at the end of the art.
Інші автори: Kolesnik D. L., Fedorchuk A. G., Gorbik G. V., Solyanik G. I.
Herrera-Covarrubias, D. Stress during puberty facilitates precancerous prostate lesions in adult rats / D. Herrera-Covarrubias [та ін.]. - С.269-275. - Bibliogr. at the end of the art.
Інші автори: Coria-Avila G. A., Hernandez M. E., Ismail N.
Caballero-Hernandez, D. Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure / D. Caballero-Hernandez [та ін.]. - С.276-280. - Bibliogr. at the end of the art.
Інші автори: Najera-Valderrabano D., Valadez-Lira A., Franco-Molina M., Gomez-Flores R., Tamez-Guerra P., Tamez-Guerra R., Rodriguez-Padilla C.
Bebeshko, V. Assessment of the effect of wave device application on morphological changes in organs and cells of irradiated animals / V. Bebeshko, I. Homolyako, V. Grynchyshyn. - С.281-285. - Bibliogr. at the end of the art.
Matveeva, A. The TGF-beta — SMAD pathway is inactivated in cronic lymphocytic leukemia cells / A. Matveeva [та ін.]. - С.286-290. - Bibliogr. at the end of the art.
Інші автори: Kovalevska L., Kholodnyuk I., Ivanivskaya T., Kashuba E.
Gordiienko, I. M. CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells / I. M. Gordiienko, L. M. Shlapatska, V. M. Kholodniuk. - С.291-298. - Bibliogr. at the end of the art.
Buchynska, L. G. DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay / L. G. Buchynska [та ін.]. - С.299-303. - Bibliogr. at the end of the art.
Інші автори: Brieieva O. V., Lurchenko N. P., Protsenko V. V., Nespryadko S. V.
Dumanskiy, Y. V. Adsorption-rheological properties of blood serum in lung cancer patients / Y. V. Dumanskiy [та ін.]. - С.304-307. - Bibliogr. at the end of the art.
Інші автори: Stoliarova O. Y., Syniachenko O. V., Giulmamedova M. F., Potapov Y. A.
Skrypnyk, I. L-arginine is an effective medication for prevention of endothelial dysfunction a predictor of anthracycline cardiotoxicity in patients with acute leukemia / I. Skrypnyk [та ін.]. - С.308-311. - Bibliogr. at the end of the art.
Інші автори: Maslova G., Lymanets T., Gusachenko I.
Buchynska, L. G. Phenotypic features of endometrial tumors in patients with family history of cancer / L. G. Buchynska [та ін.]. - С.312-318. - Bibliogr. at the end of the art.
Інші автори: Lurchenko N. P., Glushchenko N. M., Nesina I. P.
Patial, T. Consumptive hypothyroidism: an unusual paraneoplastic manifestation of a gastric gastrointestinal stromal tumor / T. Patial [та ін.]. - С.319-321. - Bibliogr. at the end of the art.
Інші автори: Sharma K., Thakur D., Gupta G.
Volodymyr Serhiiovych Mosiienko (1934–2017). - С.322
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Phenotypic features of endometrial tumors in patients with family history of cancer [Текст] / L. G. Buchynska [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 312-318. - Bibliogr. at the end of the art.

MeSH-головна:
ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS (патофизиология, этиология)
ГЕНЕТИЧЕСКАЯ ПРЕДРАСПОЛОЖЕННОСТЬ К БОЛЕЗНИ -- GENETIC PREDISPOSITION TO DISEASE (этиология, этнология)
ФЕНОТИП -- PHENOTYPE
ГЕННОЙ ЭКСПРЕССИИ НОВООБРАЗОВАНИЙ РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION, NEOPLASTIC
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Анотація: To determine the peculiarities of expression of a number of proteins-regulators of the cell cycle in endometrial cancer (EC) cells in patients with a family history of oncological pathologies. Patients and Methods: 95 EC patients (stage І–ІІ) were included into the study. Clinical-genealogical analysis was performed. 54 patients (group I) had healthy relatives, and in families of 41 patients (group II) an aggregation of malignant tumors of different genesis (mainly tumors of the gastrointestinal tract and the female reproductive system) was recorded. p53, р21WAF1/CIP1, р16INK4a, and Ki-67 were assessed immunohistochemically in the surgical samples. Results: In the majority of patients, both from group I and II, moderately differentiated tumors were observed (in 38.9 and 46.3% of cases, respectively), mainly with deep myometrium invasion (64.8 and 58.5% of cases, respectively). In EC patients from group II, a significantly higher number of р16INK4a-positive cells (17.7 ± 1.7%; p = 0.001) and lower number of p53-positive (30.9 ± 3.2%; p = 0.05) and Ki-67-positive (26.9 ± 2.7%; p = 0.048) cells was observed compared to those in tumors of patients from group I (12.0 ± 1.6; 37.7 ± 2.8 and 36.7 ± 3.4%, respectively). Conclusion: Phenotypic features of the EC in the patients with family history of cancer differ from those in tumors of patients without such aggregation. The biological heterogeneity of EC seems to relate to the oncogenealogical history of patients. Also this biological heterogeneity is linked to the molecular features of EC cells, which affects cancer aggressiveness and the course of the disease
Дод.точки доступу:
Buchynska, L. G.
Lurchenko, N. P.
Glushchenko, N. M.
Nesina, I. P.

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Шифр: ЕУ12/2018/40/3
Журнал

Экспериментальная онкология [Текст]
2018р. Т. 40 № 3

Зміст:
Akbarzadeh, A. Role of dendrimers in advanced drug delivery and biomedical applications: a review / A. Akbarzadeh [та ін.]. - С.178-183. - Bibliogr. at the end of the art.
Інші автори: Khalilov R., Mostafavi E., Annabi N., Abasi E., Kafshdooz T., Herizchi R., Kavetskyy T., Saghfi S., Nasibova A., Davaran S.
Zadvornyi, T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro / T. V. Zadvornyi [та ін.]. - С.184-189. - Bibliogr. at the end of the art.
Інші автори: Lukianova N. Y., Borikun T. V., Chekhun V. F.
Harper, P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies / P. Harper [та ін.]. - С.190-193. - Bibliogr. at the end of the art.
Інші автори: Hald O., Lwaleed B. A., Kyyaly A., Johnston D., Cooper A. J., Birch B.
Apykhtina, О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles / О. L. Apykhtina [та ін.]. - С.194-199. - Bibliogr. at the end of the art.
Інші автори: Dybkova S. M., Sokurenko L. M., Chaikovsky Yu. B.
Chekhun, V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats / V. F. Chekhun [та ін.]. - С.200-204. - Bibliogr. at the end of the art.
Інші автори: Storchai D. M., Todor I. N., Borikun T. V., Lukianova N. Yu.
Prokhorova, I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6 / I. V. Prokhorova [та ін.]. - С.205-210. - Bibliogr. at the end of the art.
Інші автори: Pyaskovskaya O. N., Kolesnik D. L., Solyanik G. I.
Abramenko, I. V. Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients / I. V. Abramenko [та ін.]. - С.211-217. - Bibliogr. at the end of the art.
Інші автори: Bilous N. I. , Chumak A. A., Dyagil I. S., Martina Z. V.
Nesina, I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I. P. Nesina, N. P. Iurchenko, L. G. Buchynska. - С.218-222. - Bibliogr. at the end of the art.
Vernygorodskyi, S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction / S. Vernygorodskyi, T. Rekun, P. Zhuchenko. - С.223-227. - Bibliogr. at the end of the art.
Gerashchenko, T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles / T. S. Gerashchenko [та ін.]. - С.228-234. - Bibliogr. at the end of the art.
Інші автори: Denisov E. V., Novikov N. M., Tashireva L. A., Kaigorodova E. V., Savelieva O. E., Zavyalova M. V., Cherdyntseva N. V., Perelmuter V. M.
Agishev, T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury / T. T. Agishev [та ін.]. - С.235-238. - Bibliogr. at the end of the art.
Інші автори: Topuzov E. E., Кrasnozhon D. A., Petrachkov A. O., Pavlov R. V., Doniyarov S. H.
Dumansky, Yu. V. Paraneoplastic syndrome in lung cancer / Yu. V. Dumansky [та ін.]. - С.239-242. - Bibliogr. at the end of the art.
Інші автори: Syniachenko O. V., Stepko P. A., Yehudina Ye. D., Stoliarova O. Yu.
Grybach, S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome / S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun. - С.243-248. - Bibliogr. at the end of the art.
Chrysanthakopoulos, N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study / N. A. Chrysanthakopoulos, N. S. Dareioti. - С.249-250. - Bibliogr. at the end of the art.
Tkachenko, R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy / R. Tkachenko, A. Golovko, O. Kuryk. - С.251-253
Svitlana Pavlivna Sidorenko (1953–2018). - С.254-255
Yurii Yosypovych Kudryavets (1946–2018). - С.256-257
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Nesina, I. P.
Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma [Текст] / I. P. Nesina, N. P. Iurchenko, L. G. Buchynska // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 218-222. - Bibliogr. at the end of the art.

MeSH-головна:
ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS (диагностика, патофизиология, этиология)
КЛЕТКИ ПРОЛИФЕРАЦИЯ -- CELL PROLIFERATION
КАДГЕРИНЫ -- CADHERINS (анализ, диагностическое применение)
БЕТА-КАТЕНИН -- BETA CATENIN (анализ, диагностическое применение)
ВИМЕНТИН -- VIMENTIN (анализ, диагностическое применение)
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY (использование, статистика)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Анотація: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p 0.001 and 54.5 ± 2.6%, respectively, p 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin
Дод.точки доступу:
Iurchenko, N. P.
Buchynska, L. G.

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Шифр: ЕУ12/2020/42/4
Журнал

Экспериментальная онкология [Текст]
2020р. Т. 42 № 4 . - 51.52, р.

Зміст:
Commitment to ideals of science. To the 90th birthday anniversary of academician Vadym Pinchuk. - С.250-251
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Gaptulbarova, K. A. NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer / K. A. Gaptulbarova [та ін.]. - С.263-269. - Бібліогр.: в кінці ст.
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Tykhomyrov, A. A. Plasminogen/plasmin affects expression of glycolysis regulator TIGAR and induces autophagy in lung adenocarcinoma A549 cells / A. A. Tykhomyrov [та ін.]. - С.270-276. - Бібліогр.: в кінці ст.
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Kumar, A. Microarray based gene expression profiling of advanced gall bladder cancer / A. Kumar [та ін.]. - С.277-284. - Бібліогр.: в кінці ст.
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Auziņa, D. Dickkopf-related protein 1 expression in bone marrow of multiple myeloma patients: correlation with bone disease and plasma cell malignancy type / D. Auziņa [та ін.]. - С.285-288. - Бібліогр.: в кінці ст.
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Buchynska, L. G. Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium / L. G. Buchynska [та ін.]. - С.289-294. - Бібліогр.: в кінці ст.
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Kovalevska, L. Expression pattern of MRPS18 family genes in malignantly transformed b-cells / L. Kovalevska, E. Kashuba. - С.295-299. - Бібліогр.: в кінці ст.
Buchynska, L. G. Molecular phenotype of high-grade endometrioid carcinoma of the endometrium / L. G. Buchynska [та ін.]. - С.300-305. - Бібліогр.: в кінці ст.
Інші автори: Glushchenko N. M., Nesina I. P., Brieieva O. V., Iurchenko N. P.
Shamrai, D. Granulosa and theca cell tumor in rat’s ovary after modified Biskind operation / D. Shamrai, E. Koshik, N. Melnyk. - С.306-309. - Бібліогр.: в кінці ст.
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Shcherbynina, M. Histological criteria for “intraepithelial squamous cell carcinoma” of the esophagus: continued dialogue between Ukrainian and Japanese pathologists / M. Shcherbynina, M. Itabashi, N. Soloviova. - С.314-317. - Бібліогр.: в кінці ст.
Yevstakhevych, Yu. L. Autoimmune cytopenia in chronic lymphocytic leukemia: diagnosis and treatment / Yu. L. Yevstakhevych [та ін.]. - С.318-323. - Бібліогр.: в кінці ст.
Інші автори: Vyhovska Ya. I., Yevstakhevyc I. Y., Vyhovsk O. Y., Pelenyo N. V., Semerak M. M., Novak V. L., Loginsky V. E.
Korovin, S. Burden of malignant melanoma in Ukraine in 2002–2013: incidence, mortality and survival / S. Korovin [та ін.]. - С.324-329. - Бібліогр.: в кінці ст.
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Burlaka, A. P. Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer / A. P. Burlaka [та ін.]. - С.330-332. - Бібліогр.: в кінці ст.
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Kitsera, N. Woman with Turner syndrome and her child with acute leukemia (a case report) / N. Kitsera, O. Dorosh, H. Makukh. - С.333-336. - Бібліогр.: в кінці ст.
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Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium [Текст] / L. G. Buchynska [та ін.] // Экспериментальная онкология. - 2020. - Т. 42, № 4. - С. 289-294. - Бібліогр.: в кінці ст.

Анотація: It is known that more than half of the genes encoding human proteins are regulated by various microRNAs (miRNAs, miR), the expression of which may be associated with various pathological conditions. At the same time, the question of assessing the relationship between the expression of particular miRNAs and the aggressive molecular subtype of endometrial cancer remains open. Aim of the study was to determine the relationship between the expression of miR-34a, miR-125b, miR-142 and miR-101 in endometrioid carcinomas of the endometrium (ECE) and the features of the disease course. Materials and Methods: The samples of surgical material of 51 patients with ECE (mean age 59.8 ± 7.1 years), I–III stage were investigated using morphological, immunohistochemical methods, real time polymerase chain reaction (PCR), cytofluorometry. Results: In endometrial tumors with high proliferation index ( Me), the expression of miR-34a, miR-142 and miR-125b significantly decreased (1.8, 2.7 and 1.5 times, respectively) compared with those in ECE with low proliferation index ( Me). The expression of all studied miRNAs was lower in G3 tumors and those that deeply invaded the myometrium compared to G2 carcinomas and tumors with an invasion of 1/2 myometrium and significantly decreased in tumors of patients with low stage III compared with stage I–II. The high ( Me) microvessel density in ECE was associated with a significant decrease of miR-125b and miR-101 expression, and the presence of signs of epithelial-mesenchymal transition — with a decreased expression of miR-34a and miR-101. Conclusions: The study revealed a significant heterogeneity of expression of miR-34a, miR-125b, miR-142 and miR-101 in ECE, which is associated with changes in morphofunctional characteristics of endometrial carcinoma
Дод.точки доступу:
Buchynska, L. G.
Borykun, T. V.
Iurchenko, N. P.
Nespryadko, S. V.
Nesina, I. P.

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Molecular phenotype of high-grade endometrioid carcinoma of the endometrium [Текст] / L. G. Buchynska [та ін.] // Экспериментальная онкология. - 2020. - Т. 42, № 4. - С. 300-305. - Бібліогр.: в кінці ст.

Анотація: Prognosis of the course of tumor progression is one of urgent problems of clinical oncology. A relevant specificity of endometrial cancer is its clinical polymorphism within the same histological type of the disease. The search for molecular-biological features associated with the aggressive phenotype of endometrioid carcinomas is indisputably urgent. Aim: To study molecular-biological features of endometrioid carcinoma of the endometrium (ECE) and to identify the molecular subtype of tumors with high potential of malignancy. Materials and Methods: Surgical specimens of 127 patients with EC, stages I–II, aged 36–72 (the average age — 59.3 ± 3.2) were studied using morphological and immunohistochemical methods. The multivariant analysis with the Kullback’s informative measure and PanelomiX were used to estimate the significance of the expression of specific biomarkers. Results: The expression of a complex of multifunctional markers was evaluated in ECE cells of different malignancy stage: p53, FOXP3, p21WAF1/CIP1, р16INK4a, E2F1, cyclins Е and D1, Her2/neu, с-Myc, Е-cadherin, β-catenin, vimentin, CD44, CD24. A triad of biomarkers with threshold expression levels was determined (р53 45%; FOXP3 14%; с-Myc 10%). The high expression of oncogene c-Myc and oncosuppressor p53 along with the low level of FOXP3 in tumor cells of ECE was associated with high proliferative potential, low differentiation grade, and deep invasion of a tumor into the myometrium. Conclusions: The molecular phenotype of ECE, most informative in terms of specificity and sensitivity (95%) — р53highFOXP3lowc-Mychigh, was first characterized, which would help identify a high-grade subtype of this cancer form
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Buchynska, L. G.
Glushchenko, N. M.
Nesina, I. P.
Brieieva, O. V.
Iurchenko, N. P.

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