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1.
Шифр: ЕУ12/2021/43/2
   Журнал

Экспериментальная онкология [Текст]
2021г. Т. 43 № 2
Содержание:
Vitruk, Yu. V. Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302a and -377 in tumor tissue / Yu. V. Vitruk [et al.]. - С.98-103
Другие авторы: Semko S. L., Voylenko O. A., Pikul M. V., Borikun T. V., Zadvornyi T. V., Yalovenko T. M., Stakhovsky E. O., Rossylna O. V.
Pyaskovskaya, O. N. Role of tumor/endothelial cell interactions in tumor growth and metastasis / O. N. Pyaskovskaya [et al.]. - С.104-110
Другие авторы: Kolesnik D. L., Garmanchouk L. V., Yanish Yu. V., Solyanik G. I.
Akalovich, S. 5-FU resistens colorectal cancer cells possess improved invasiveness and βIII-tubulin expression / S. Akalovich [et al.]. - С.111-117
Другие авторы: Portyanko A., Pundik A., Mezheyeuski A., Doroshenko T.
Bychkov, V. A. In vitro modeling of tumor interclonal interactions using breast cancer cell lines / V. A. Bychkov [et al.]. - С.118-124
Другие авторы: Pevzner A. M., Nebova J. A., Ermakova N. N., Ibragimova M. K., Tsyganov M. M., Lyapunova L. S., Litviakov N. V.
Ayyildiz, A. Co-administration of apigenin with doxorubicin enhanges anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells / A. Ayyildiz [et al.]. - С.125-134
Другие авторы: Koc H., Turkekul K., Erdogan S.
Buchynska, L. G. Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium / L. G. Buchynska, O. M. Movchan, N. P. Iurchenko. - С.135-141
Yakovlev, P. G. Expression of TLR4 and major inflammatory cytokines in patients with bladder cancer of different grade and stage / P. G. Yakovlev [et al.]. - С.142-148
Другие авторы: Gorbach O. I., Ostapchenko L. I., Garmanchuk L. V., Skachkova O. V., Khranovska N. M., Senchylo N. V.
Zoubi, M. S. RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population / M. S. Zoubi [et al.]. - С.149-154
Другие авторы: Al-Eitan L. N., Rababa D. M., Al-Batayneh K., Farzand R., Quinn G. A., Tambuwala M. M., Bakshi H. A.
Kornatska, A. G. A variant of TP53 gene (RS 1625895, 13494G>A) is associated with neoplasm localization in patients with uterine leiomyoma / A. G. Kornatska [et al.]. - С.155-158
Другие авторы: Flaksemberg M. A., Chubei G. V., Trokhymovych O. V., Rossokha Z. I., Fishchuk L. Ye., Medvedieva N. L., Vershyhora V. O., Gorovenko N. G.
Mohamed, Yusoff A. A. Significance of BRAFv600E mutation in intra-axial brain tumor in Malaysian patients: case series and literature review / A. A. Mohamed Yusoff [et al.]. - С.159-167
Другие авторы: Abd Radzak S. M., Mohd Khair S. Z. N., Abdullah J. M.
Ben, Kridis W. Therapeutic results of laryngeal preservation: a retrospective study / W. Ben Kridis [et al.]. - С.168-172
Другие авторы: Werda I., Mnejja W., Toumi N., Charfeddine I., Daoud J., Khanfir A.
Pilinska, M. A. Study of modifyng effects of astaxanthin on cytogenetic manifestations of bystander response in human peripheral blood lymphocytes in vitro / M. A. Pilinska [et al.]. - С.173-176
Другие авторы: Shemetun O. V., Talan O. O., Dibska O. B., Talko V. V.
De, Giorgi V. Scrotal cutaneous metastasis from rectal squamous cell carcinoma: a rare evolution into a rare tumor / V. De Giorgi [et al.]. - С.177-179
Другие авторы: Venturi F., Portelli F., Maida P., Scarfi F., Trane L., Gori A., Silvestri F., Massi D.
Liubota, R. Systemic chemotherapeutic treatment of patients with breast cancer brain metastases / R. Liubota [et al.]. - С.180-184
Другие авторы: Vereshchako R., Anikusko M., Liubota I., Vakulenko G.
Pasichnyk, S. M. Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model / S. M. Pasichnyk [et al.]. - С.185-188
Другие авторы: Pasichnyk M. S., Lychkovsky A. E., Stakhovsky E. O., Gozhenko A. I., Shatnyi S. V., Pasichnyk M. A.
Gluzman, D. F. Long-term exposure to low doses of ionizing radiation and COVID-19 pandemic: oncohematological aspects / D. F. Gluzman [et al.]. - С.189-192
Другие авторы: Zavelevich M. P., Philchenkov A. A., Koval S. V., Guslitser L. N., Zinchenko V. N., Bezhenar T. O.
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(23.05.2022г. Экз. 1 - Б.ц.) (свободен)

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2.


    Buchynska, L. G.
    Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium [Text] / L. G. Buchynska, O. M. Movchan, N. P. Iurchenko // Experimental Oncology. - 2021. - Том 43, N 2. - P135-141


MeSH-главная:
КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID (лекарственная терапия, метаболизм, патофизиология)
Аннотация: The expression of the CXCL12 chemokine and its receptor CXCR4 in the stromal component of the tumor plays an important role in tumor cell migration, proliferation, inhibition of apoptosis and determination of invasive and metastatic potential of malignant neoplasms of various genesis. The significance of CXCL12 and CXCR4 expression in endometrial tumor cells for cancer progression is not fully understood. Aim: To evaluate the content of CXCL12+-fibroblasts and expression of CXCL12 and CXCR4 in endometrial cancer cells, depending on the tumor stage. Materials and Methods: Surgical material of 45 patients with endometrioid carcinoma of the endometrium (ECE) of the stages I–II and III was studied using morphological and immunohistochemical methods. Results: In ECE of stage I–II CXCR4 expression was lower (43.3 ± 4.2%) while CXCL12 expression was higher (33.6 ± 2.4%) compared with the corresponding indices​​ in ECE of stage III (63.6 ± 3.5%, 24.5 ± 1.9%, respectively, p 0.05). In ECE of stage III, high expression of CXCR4 ( Me) and low CXCL12 ( Me) was observed in 80% of samples; these tumors invaded more than 1/2 of the myometrium. There was a positive correlation between the depth of tumor invasion in the myometrium and the presence of metastases and CXCR4 expression in tumor cells (R Me) (14.9 ± 1.3%) was detected. Conclusion: The obtained data reflect the communication of the immunosuppressive factor of the tumor microenvironment, i.e. CXCL12+-fibroblasts and CXCR4 expressing tumor cells. We suggest that the aggressiveness of ECE is determined by the combined effect of these two factors
Доп.точки доступа:
Movchan, O. M.
Iurchenko, N. P.

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3.


   
    Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium [Текст] / L. G. Buchynska [та ін.] // Экспериментальная онкология. - 2020. - Т. 42, № 4. - С. 289-294. - Бібліогр.: в кінці ст.

Аннотация: It is known that more than half of the genes encoding human proteins are regulated by various microRNAs (miRNAs, miR), the expression of which may be associated with various pathological conditions. At the same time, the question of assessing the relationship between the expression of particular miRNAs and the aggressive molecular subtype of endometrial cancer remains open. Aim of the study was to determine the relationship between the expression of miR-34a, miR-125b, miR-142 and miR-101 in endometrioid carcinomas of the endometrium (ECE) and the features of the disease course. Materials and Methods: The samples of surgical material of 51 patients with ECE (mean age 59.8 ± 7.1 years), I–III stage were investigated using morphological, immunohistochemical methods, real time polymerase chain reaction (PCR), cytofluorometry. Results: In endometrial tumors with high proliferation index ( Me), the expression of miR-34a, miR-142 and miR-125b significantly decreased (1.8, 2.7 and 1.5 times, respectively) compared with those in ECE with low proliferation index ( Me). The expression of all studied miRNAs was lower in G3 tumors and those that deeply invaded the myometrium compared to G2 carcinomas and tumors with an invasion of 1/2 myometrium and significantly decreased in tumors of patients with low stage III compared with stage I–II. The high ( Me) microvessel density in ECE was associated with a significant decrease of miR-125b and miR-101 expression, and the presence of signs of epithelial-mesenchymal transition — with a decreased expression of miR-34a and miR-101. Conclusions: The study revealed a significant heterogeneity of expression of miR-34a, miR-125b, miR-142 and miR-101 in ECE, which is associated with changes in morphofunctional characteristics of endometrial carcinoma
Доп.точки доступа:
Buchynska, L. G.
Borykun, T. V.
Iurchenko, N. P.
Nespryadko, S. V.
Nesina, I. P.

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4.


   
    Molecular phenotype of high-grade endometrioid carcinoma of the endometrium [Текст] / L. G. Buchynska [та ін.] // Экспериментальная онкология. - 2020. - Т. 42, № 4. - С. 300-305. - Бібліогр.: в кінці ст.

Аннотация: Prognosis of the course of tumor progression is one of urgent problems of clinical oncology. A relevant specificity of endometrial cancer is its clinical polymorphism within the same histological type of the disease. The search for molecular-biological features associated with the aggressive phenotype of endometrioid carcinomas is indisputably urgent. Aim: To study molecular-biological features of endometrioid carcinoma of the endometrium (ECE) and to identify the molecular subtype of tumors with high potential of malignancy. Materials and Methods: Surgical specimens of 127 patients with EC, stages I–II, aged 36–72 (the average age — 59.3 ± 3.2) were studied using morphological and immunohistochemical methods. The multivariant analysis with the Kullback’s informative measure and PanelomiX were used to estimate the significance of the expression of specific biomarkers. Results: The expression of a complex of multifunctional markers was evaluated in ECE cells of different malignancy stage: p53, FOXP3, p21WAF1/CIP1, р16INK4a, E2F1, cyclins Е and D1, Her2/neu, с-Myc, Е-cadherin, β-catenin, vimentin, CD44, CD24. A triad of biomarkers with threshold expression levels was determined (р53 45%; FOXP3 14%; с-Myc 10%). The high expression of oncogene c-Myc and oncosuppressor p53 along with the low level of FOXP3 in tumor cells of ECE was associated with high proliferative potential, low differentiation grade, and deep invasion of a tumor into the myometrium. Conclusions: The molecular phenotype of ECE, most informative in terms of specificity and sensitivity (95%) — р53highFOXP3lowc-Mychigh, was first characterized, which would help identify a high-grade subtype of this cancer form
Доп.точки доступа:
Buchynska, L. G.
Glushchenko, N. M.
Nesina, I. P.
Brieieva, O. V.
Iurchenko, N. P.

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5.
Шифр: ЕУ12/2020/42/4
   Журнал

Экспериментальная онкология [Текст]
2020г. Т. 42 № 4 . - 51.52, р.
Содержание:
Commitment to ideals of science. To the 90th birthday anniversary of academician Vadym Pinchuk. - С.250-251
Naleskina, L. A. Modern views on the role of main components of stroma and tumor microinvironment in invasion, migration and metastasis / L. A. Naleskina, L. M. Kunska, V. F. Chekhun. - С.252-262. - Бібліогр.: в кінці ст.
Gaptulbarova, K. A. NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer / K. A. Gaptulbarova [та ін.]. - С.263-269. - Бібліогр.: в кінці ст.
Другие авторы: Tsyganov M. M., Pevzner A. M., Ibragimova M. K., Litviakov N. V.
Tykhomyrov, A. A. Plasminogen/plasmin affects expression of glycolysis regulator TIGAR and induces autophagy in lung adenocarcinoma A549 cells / A. A. Tykhomyrov [та ін.]. - С.270-276. - Бібліогр.: в кінці ст.
Другие авторы: Nedzvetsky V. S., Aĝca C. A., Guzyk M. M., Korsa V. V., Grinenko T. V.
Kumar, A. Microarray based gene expression profiling of advanced gall bladder cancer / A. Kumar [та ін.]. - С.277-284. - Бібліогр.: в кінці ст.
Другие авторы: Gupta R., Mathur N., Iyer V. K., Thulkar S., Prasad C. P., Das P., Rani L., Maqbool M., Shukla N. K., Pal S., Sundar D., Sharma A.
Auziņa, D. Dickkopf-related protein 1 expression in bone marrow of multiple myeloma patients: correlation with bone disease and plasma cell malignancy type / D. Auziņa [та ін.]. - С.285-288. - Бібліогр.: в кінці ст.
Другие авторы: Beinaroviča I., Janicka-Kupra B., Lejniece S., Lejnieks A., Groma V.
Buchynska, L. G. Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium / L. G. Buchynska [та ін.]. - С.289-294. - Бібліогр.: в кінці ст.
Другие авторы: Borykun T. V., Iurchenko N. P., Nespryadko S. V., Nesina I. P.
Kovalevska, L. Expression pattern of MRPS18 family genes in malignantly transformed b-cells / L. Kovalevska, E. Kashuba. - С.295-299. - Бібліогр.: в кінці ст.
Buchynska, L. G. Molecular phenotype of high-grade endometrioid carcinoma of the endometrium / L. G. Buchynska [та ін.]. - С.300-305. - Бібліогр.: в кінці ст.
Другие авторы: Glushchenko N. M., Nesina I. P., Brieieva O. V., Iurchenko N. P.
Shamrai, D. Granulosa and theca cell tumor in rat’s ovary after modified Biskind operation / D. Shamrai, E. Koshik, N. Melnyk. - С.306-309. - Бібліогр.: в кінці ст.
Bolgova, L. S. Histogenesis of central lung cancer: cytological investigation / L. S. Bolgova [та ін.]. - С.310-313. - Бібліогр.: в кінці ст.
Другие авторы: Tuganova T. N., Alekseenko O. I., Litvinets O. M., Suprun G. A., Ponomarenko A. A.
Shcherbynina, M. Histological criteria for “intraepithelial squamous cell carcinoma” of the esophagus: continued dialogue between Ukrainian and Japanese pathologists / M. Shcherbynina, M. Itabashi, N. Soloviova. - С.314-317. - Бібліогр.: в кінці ст.
Yevstakhevych, Yu. L. Autoimmune cytopenia in chronic lymphocytic leukemia: diagnosis and treatment / Yu. L. Yevstakhevych [та ін.]. - С.318-323. - Бібліогр.: в кінці ст.
Другие авторы: Vyhovska Ya. I., Yevstakhevyc I. Y., Vyhovsk O. Y., Pelenyo N. V., Semerak M. M., Novak V. L., Loginsky V. E.
Korovin, S. Burden of malignant melanoma in Ukraine in 2002–2013: incidence, mortality and survival / S. Korovin [та ін.]. - С.324-329. - Бібліогр.: в кінці ст.
Другие авторы: Fedorenko Z., Michailovich Yu., Kukushkina M., Sekerija M., Ryzhov A.
Burlaka, A. P. Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer / A. P. Burlaka [та ін.]. - С.330-332. - Бібліогр.: в кінці ст.
Другие авторы: Virko S. V., Burlaka A. A., Chernobai V. А., Yatsyna O. I., Ganusevich I. I.
Kitsera, N. Woman with Turner syndrome and her child with acute leukemia (a case report) / N. Kitsera, O. Dorosh, H. Makukh. - С.333-336. - Бібліогр.: в кінці ст.
Buchatskyi, L. P. Hypoxia induces melanotic pseudotumors in the larvae of mosquitoes of Culicidae family / L. P. Buchatskyi. - С.337. - Бібліогр.: в кінці ст.
Mykola Oleksandrovych Druzhyna (1940–2020). - С.338
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6.
Шифр: ЕУ12/2019/41/4
   Журнал

Экспериментальная онкология [Текст]
2019г. Т. 41 № 4 . - 45.41, р.
Содержание:
Karaman, O. M. Macrophages - a perspective target for antineoplastic immunotherapy / O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun. - С.282-290
Orel, V. E. Nоn-linear dynamics theory and malignant melanoma / V. E. Orel [et al.]. - С.291-299
Другие авторы: Korovin S. I., Molnair J., Orel V. B.
Lisyany, N. I. Cytomegaloviruses and malignant brain tumors / N. I. Lisyany [et al.]. - С.300-303
Другие авторы: Klyuchnikova A. A., Belskaya L. N., Lisyany A. A., Gnedkova I. A.
Woksepp, H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392 / H. Woksepp [et al.]. - С.304-311
Другие авторы: Saini R. K. R., Zakharchenko O., Gautier A., Souchelnytskyi N., Souchelnytskyi S.
Dehghan, Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression / Nayeri M. J. Dehghan [et al.]. - С.312-317
Другие авторы: Mahdavi M., Fazeli H., Hosseinpour Feizi M. A.
Albuquerque, A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation / A. P. B. Albuquerque [et al.]. - С.318-322
Другие авторы: Silva A. L. V., Lima C. A. D., Beltrao E. I. C.
Skuja, E. Deletions in metastatic colorectal cancer with chromothripsis / E. Skuja [et al.]. - С.323-327
Другие авторы: Butane D., Nakazawa-Miklasevica M., Daneberga Z., Purkalne G., Miklasevics E.
Burlaka, A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer / A. P. Burlaka [et al.]. - С.328-334
Другие авторы: Burlaka A. A., Virko S. V., Ganusevich I. I.
Buchynska, L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina. - С.335-341
Zelinskaya, A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer / A. Zelinskaya. - С.342-345
Moazeni-Roodi, A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls / A. Moazeni-Roodi, M. Taheri, M. Hashemi. - С.346-352
Skrypnyk, I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy / I. Skrypnyk [et al.]. - С.353-356
Другие авторы: Maslova G., Lymanets T., Gusachenko I.
Gavars, D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia / D. Gavars [et al.]. - С.357-362
Другие авторы: Perminov D., Tauckels E., Lindenberga I., Auce A., Lejniece S.
Prylutskyi, M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles / M. P. Prylutskyi, M. F. Starodub. - С.363-365
Shkatula, P. M. International scientific conference "Tumor and Host: novel aspects of old problem" / P. M. Shkatula. - С.366-367
To the 120th birthday anniversary of academician R. E. Kavetsky. - С.368-369
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7.


    Buchynska, L. G.
    Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas [Текст] / L. G. Buchynska, O. V. Brieiev, N. P. Iurchenko // Экспериментальная онкология. - 2019. - Т. 41, № 2. - С. 138-143. - Bibliogr. at the end of the art.

Аннотация: To analyze copy number variations of HER-2/neu, c-MYC and CCNE1 oncogenes and their protein expression in endometrioid endometrial carcinomas in relation to the degree of tumor progression and presence of a family history of cancer in cancer patients. Materials and Methods: The study was conducted on endometrial cancer (EC) samples from 68 patients with I–II FIGO stages of disease. Copy number analysis of HER-2/neu, c-MYC and CCNE1 genes was performed by quantitative PCR. Protein expression was analyzed using immunohistochemistry. Results: Assessment of copy number variations of HER-2/neu, c-MYC and CCNE1 genes revealed their amplification in the tumors of 18.8, 25.0 and 14.3% of EC patients, respectively. High expression of corresponding proteins was detected in 14.6, 23.5 and 65.6% of patients, respectively. It was established that HER-2/neu gene amplification is more common in the group of tumors of low differentiation grade than in moderate grade EC (35.7 and 5.5% of cases, respectively, p 0.05). Also, high expression of c-Myc protein was more frequently observed in low differentiated tumors compared to the moderately differentiated EC (36.6 and 13.2% of cases, respectively, p 0.05). Expression of HER-2/neu and cyclin E proteins was found to be dependent on the depth of tumor invasion into the myometrium. High expression of HER-2/neu protein was observed in 25.0 and 4.1% of EC patients with tumor invasion ½ and ½ of the myometrium, respectively, and cyclin E — in 86.7 and 46.6% of cases, respectively, p 0.05. It was shown that among patients with a family history of cancer, a larger proportion of cases with high expression of c-Myc protein was observed compared to the group of patients with sporadic tumors (43.8 and 17.3%, respectively; p 0.05). Conclusions: Amplification of HER-2/neu gene, along with high expression of c-Myc, HER-2/neu and cyclin E proteins, are associated with such indices of tumor progression as a low differentiation grade and deep myometrial invasion, suggesting the potential possibility of including these markers in the panel for determining the molecular EC subtype associated with an aggressive course of the disease. In a certain category of EC patients, there is a relationship between a family history of cancer and high expression of c-Myc protein
Доп.точки доступа:
Brieiev, O. V.
Iurchenko, N. P.

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8.
Шифр: ЕУ12/2019/41/2
   Журнал

Экспериментальная онкология [Текст]
2019г. Т. 41 № 2 . - 45.41, р.
Содержание:
Verma, S. Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies / S. Verma [та ін.]. - С.90-94. - Bibliogr. at the end of the art.
Другие авторы: Khambhala P., Joshi S., Kothari V., Patel T., Seshadri S.
Syvyk, A. E. Inducible dominant negative ErbB2 rat spermatogonial line for generation of transgenic rat model and dissecting ERBB2 tyrosine kinase mediated pathways / A. E. Syvyk, T. L. Syvyk. - С.95-105. - Bibliogr. at the end of the art.
Prylutska, S. V. Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma / S. V. Prylutska [та ін.]. - С.106-111. - Bibliogr. at the end of the art.
Другие авторы: Lynchak O. V., Kostjukov V. V., Evstigneev M. P., Remeniak O. V., Rybalchenko V. K., Prylutskyy Yu. I., Ritter U., Scharff P.
Petrellis, M. C. Proinflammatory effects of photoactivated methylene blue on rat model of Walker 256 carcinosarcoma / M. C. Petrellis [та ін.]. - С.112-122. - Bibliogr. at the end of the art.
Другие авторы: Frigo L., Ribeiro W., Leal-Junior E. C. P., Oliveira F. R., Maria D. A., Lopes-Martins R. Á. B.
Kolesnik, D. L. Metformin enhances antitumor action of sodium dichloroacetate against glioma C6 / D. L. Kolesnik [та ін.]. - С.123-129. - Bibliogr. at the end of the art.
Другие авторы: Pyaskovskaya O. N., Yurchenko O. V., Solyanik G. I.
Herrera-Covarrubias, D. Prepuberal stress and obesity: effects on serum corticosterone, prolactin, testosterone and precancerous prostate lesions in adult rats / D. Herrera-Covarrubias [та ін.]. - С.130-137. - Bibliogr. at the end of the art.
Другие авторы: Coria-Avila G. A., Aranda-Abreu G. E., Manzo J., Hernández M. E.
Buchynska, L. G. Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas / L. G. Buchynska, O. V. Brieiev, N. P. Iurchenko. - С.138-143. - Bibliogr. at the end of the art.
Kravets, O. V. Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma / O. V. Kravets [та ін.]. - С.144-147. - Bibliogr. at the end of the art.
Другие авторы: Protsyk V. S., Burtyn O. V., Hlynin O. V., Hurianov V. H.
Burlaka, A. P. Tumor-associated redox state in metastatic colorectal cancer / A. P. Burlaka [та ін.]. - С.148-152. - Bibliogr. at the end of the art.
Другие авторы: Ganusevich I. I., Burlaka A. A., Virko S. V., Kolesnik О. О.
Tajaldeen, A. Investigation of dosimetric impact of organ motion in static and dynamic conditions for three stereotactic ablative body radiotherapy techniques: 3D conformal radiotherapy, intensity modulated radiation therapy, and volumetric modulated arc therapy by usi / A. Tajaldeen, S. Alghamdi. - С.153-159. - Bibliogr. at the end of the art.
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Dumanskiy, Y. V. The Kі-67 marker for assessing the effectiveness of systemic or regional neoadjuvant polychemotherapy in patients with locally advanced breast cancer / Y. V. Dumanskiy, O. V. Bondar, E. A. Stoliarchuk. - С.176-178. - Bibliogr. at the end of the art.
Starchenko, I. I. The observation of congenital retroperitoneal large size neuroblastoma / I. I. Starchenko [та ін.]. - С.179-181. - Bibliogr. at the end of the art.
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Ben, Kridis W. Buschke — Lowenstein anal tumor: an ambiguous entity / Kridis W. Ben [та ін.]. - С.182-184. - Bibliogr. at the end of the art.
Другие авторы: Werda I., Charfi S., Toumi N., Boudawara T., Mzali R., Daoud J., Khanfir A.
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9.


    Buchynska, L. G.
    Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina // Experimental Oncology. - 2019. - Том 41, N 4. - P335-341

Аннотация: The aim of the study was to evaluate the morphological features of endometrioid carcinoma of the endometrium (ECE) of low differentiation grade with different invasive potential and to characterize their molecular phenotype by the expression of a number of adhesion markers. Materials and Methods: We have studied the samples of operation material of 37 patients with ECE of low differentiation grade with deep invasion ( ½ myometrium), n = 26, and with invasion ½ myometrium, n
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Naleskina, L. A.
Nesina, I. P.

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10.


    Buchynska, L. G.
    Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients [Текст] / L. G. Buchynska, O. V. Brieieva // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 68-72. - Bibliogr. at the end of the art.


MeSH-главная:
НОВООБРАЗОВАНИЯ ГОРМОНОЗАВИСИМЫЕ -- NEOPLASMS, HORMONE-DEPENDENT (диагностика, патофизиология, этиология)
КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID (патофизиология, этиология)
ЛИМФОЦИТЫ -- LYMPHOCYTES (цитология)
ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE
РИСКА СТЕПЕНИ ОЦЕНКА -- RISK ADJUSTMENT (статистика, тенденции)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. It is assumed that the individual sensitivity to the 4OHE2 may determine the predisposition to endometrial cancer (EС). Aim: To analyze the sensitivity of peripheral blood lymphocytes (PBLs) of EC patients to the 4OHE2 and to evaluate the repair efficiency of 4OHE2-induced DNA damage. Materials and Methods: The study was performed on the PBLs of 53 EC patients and 20 healthy women. The level of DNA damage was measured using the comet assay and was expressed as % tail DNA. The DNA repair efficiency (%) was evaluated by determining the ratio between the amount of repaired DNA damage and the level of 4OHE2-induced damage that appeared after incubation of PBLs with 4OHE2. Results: In PBLs of EC patients, a higher level of 4OHE2-induced DNA damage (32.0 ± 2.2% tail DNA) and lower DNA repair efficiency (34.0 ± 4.5%) was observed compared to PBLs of healthy women (22.3 ± 2.3% tail DNA and 48.8 ± 4.5%, respectively). PBLs of EC patients with deep tumor invasion of myometrium were characterized by more prominent decrease of DNA repair than those with less invasive tumor ( ½ of myometrium) (20.9 ± 7.8 and 43.7 ± 6.7%, respectively). Furthermore, lower DNA repair efficiency was detected in the PBLs of EC patients with a family history of cancer compared to this parameter in patients with sporadic tumors (20.9±7.8 and 47.1 ± 5.5%, respectively). Conclusion: The PBLs of EC patients are characterized by increased sensitivity to the genotoxic effect of 4OHE2 and reduced repair efficiency regarding 4OHE2-induced DNA damage. A lower level of DNA repair is observed in EC patients with deep tumor myometrial invasion and a family history of cancer
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Brieieva, O. V.

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