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1.

Заглавие журнала :Экспериментальная онкология -2017г. т.39,N 4
Интересные статьи :
Liubich L. D. TGF-β1 expression by glioma C6 cells in vitro/ L. D. Liubich [та ін.] (стр.258-263)
Pyaskovskaya O. N. Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo/ O. N. Pyaskovskaya [та ін.] (стр.264-268)
Herrera-Covarrubias D. Stress during puberty facilitates precancerous prostate lesions in adult rats/ D. Herrera-Covarrubias [та ін.] (стр.269-275)
Caballero-Hernandez D. Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure/ D. Caballero-Hernandez [та ін.] (стр.276-280)
Bebeshko V. Assessment of the effect of wave device application on morphological changes in organs and cells of irradiated animals/ V. Bebeshko, I. Homolyako, V. Grynchyshyn (стр.281-285)
Matveeva A. The TGF-beta — SMAD pathway is inactivated in cronic lymphocytic leukemia cells/ A. Matveeva [та ін.] (стр.286-290)
Gordiienko I. M. CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells/ I. M. Gordiienko, L. M. Shlapatska, V. M. Kholodniuk (стр.291-298)
Buchynska L. G. DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay/ L. G. Buchynska [та ін.] (стр.299-303)
Dumanskiy Y. V. Adsorption-rheological properties of blood serum in lung cancer patients/ Y. V. Dumanskiy [та ін.] (стр.304-307)
Skrypnyk I. L-arginine is an effective medication for prevention of endothelial dysfunction a predictor of anthracycline cardiotoxicity in patients with acute leukemia/ I. Skrypnyk [та ін.] (стр.308-311)
Buchynska L. G. Phenotypic features of endometrial tumors in patients with family history of cancer/ L. G. Buchynska [та ін.] (стр.312-318)
Patial T. Consumptive hypothyroidism: an unusual paraneoplastic manifestation of a gastric gastrointestinal stromal tumor/ T. Patial [та ін.] (стр.319-321)
Volodymyr Serhiiovych Mosiienko (1934–2017) (стр.322)
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2.

Заглавие журнала :Экспериментальная онкология -2021г. т.43,N 2
Интересные статьи :
Vitruk Yu. V. Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302a and -377 in tumor tissue/ Yu. V. Vitruk [et al.] (стр.98-103)
Pyaskovskaya O. N. Role of tumor/endothelial cell interactions in tumor growth and metastasis/ O. N. Pyaskovskaya [et al.] (стр.104-110)
Akalovich S. 5-FU resistens colorectal cancer cells possess improved invasiveness and βIII-tubulin expression/ S. Akalovich [et al.] (стр.111-117)
Bychkov V. A. In vitro modeling of tumor interclonal interactions using breast cancer cell lines/ V. A. Bychkov [et al.] (стр.118-124)
Ayyildiz A. Co-administration of apigenin with doxorubicin enhanges anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells/ A. Ayyildiz [et al.] (стр.125-134)
Buchynska L. G. Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium/ L. G. Buchynska, O. M. Movchan, N. P. Iurchenko (стр.135-141)
Yakovlev P. G. Expression of TLR4 and major inflammatory cytokines in patients with bladder cancer of different grade and stage/ P. G. Yakovlev [et al.] (стр.142-148)
Zoubi M. S. RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population/ M. S. Zoubi [et al.] (стр.149-154)
Kornatska A. G. A variant of TP53 gene (RS 1625895, 13494GA) is associated with neoplasm localization in patients with uterine leiomyoma/ A. G. Kornatska [et al.] (стр.155-158)
Mohamed Yusoff A. A. Significance of BRAFv600E mutation in intra-axial brain tumor in Malaysian patients: case series and literature review/ A. A. Mohamed Yusoff [et al.] (стр.159-167)
Ben Kridis W. Therapeutic results of laryngeal preservation: a retrospective study/ W. Ben Kridis [et al.] (стр.168-172)
Pilinska M. A. Study of modifyng effects of astaxanthin on cytogenetic manifestations of bystander response in human peripheral blood lymphocytes in vitro/ M. A. Pilinska [et al.] (стр.173-176)
De Giorgi V. Scrotal cutaneous metastasis from rectal squamous cell carcinoma: a rare evolution into a rare tumor/ V. De Giorgi [et al.] (стр.177-179)
Liubota R. Systemic chemotherapeutic treatment of patients with breast cancer brain metastases/ R. Liubota [et al.] (стр.180-184)
Pasichnyk S. M. Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model/ S. M. Pasichnyk [et al.] (стр.185-188)
Gluzman D. F. Long-term exposure to low doses of ionizing radiation and COVID-19 pandemic: oncohematological aspects/ D. F. Gluzman [et al.] (стр.189-192)
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3.

Заглавие журнала :Экспериментальная онкология -2018г. т.40,N 1
Интересные статьи :
Kian R. Role of components of microRNA machinery in carcinogenesis/ R. Kian, S. Moradi, S. Ghorbian (стр.2-9)
Patel K. R. Clinical implications of p53 alterations in oral cancer progression: a review from India/ K. R. Patel [та ін.] (стр.10-18)
Varela-Castillo O. Characterization of the cytotoxic effects of the combination of cisplatin and flavanol (-)-epicatechin on human lung cancer cell line A549. An isobolographic approach/ O. Varela-Castillo [та ін.] (стр.19-23)
Chaves K. C. B. Impact of endostatin gene therapy on myeloid-derived suppressor cells from a metastatic renal cell carcinoma/ K. C. B. Chaves [та ін.] (стр.24-32)
Sarnatskaya V. V. Highly activated carbon enterosorbent mediates the suppression of paraneoplastic syndrome associated with lewis lung carcinoma in mice/ V. V. Sarnatskaya [та ін.] (стр.33-41)
Boroday N. V. Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells/ N. V. Boroday, V. F. Chekhun (стр.42-47)
Kurtenkov O. Signatures of anti-Thomsen — friedenreich antigen antibody diversity in colon cancer patients/ O. Kurtenkov, M. Bubina, K. Klaamas (стр.48-58)
Paliychuk O. V. Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer/ O. V. Paliychuk [та ін.] (стр.59-67)
Buchynska L. G. Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients/ L. G. Buchynska, O. V. Brieieva (стр.68-72)
Lozynska L. Y. Variant of rare hermansky — pudlak syndrome associated with granulomatous colitis: diagnostics clinical course and treatment/ L. Y. Lozynska [та ін.] (стр.73-78)
Zubenko O. S. Effect of cytostatic agents on expression levels of human beta-defensins-1-4 in A431 and MCF-7 cell lines/ O. S. Zubenko [та ін.] (стр.79-81)
Imaniar R. Mediastinal yolk sac tumor infiltrating the heart/ R. Imaniar [та ін.] (стр.82-84)
Ben Kridis W. A long survival of a patient with brain metastasis of unknown site of the primary tumor/ Kridis W. Ben [та ін.] (стр.85-87)
Symposium and Summer School “Fundamental principles of cancer biotherapy” Kyiv Ukraine May 21-24 2018 (стр.88)
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4.

Заглавие журнала :Экспериментальная онкология -2019г. т.41,N 2
Интересные статьи :
Verma S. Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies/ S. Verma [та ін.] (стр.90-94)
Syvyk A. E. Inducible dominant negative ErbB2 rat spermatogonial line for generation of transgenic rat model and dissecting ERBB2 tyrosine kinase mediated pathways/ A. E. Syvyk, T. L. Syvyk (стр.95-105)
Prylutska S. V. Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma/ S. V. Prylutska [та ін.] (стр.106-111)
Petrellis M. C. Proinflammatory effects of photoactivated methylene blue on rat model of Walker 256 carcinosarcoma/ M. C. Petrellis [та ін.] (стр.112-122)
Kolesnik D. L. Metformin enhances antitumor action of sodium dichloroacetate against glioma C6/ D. L. Kolesnik [та ін.] (стр.123-129)
Herrera-Covarrubias D. Prepuberal stress and obesity: effects on serum corticosterone, prolactin, testosterone and precancerous prostate lesions in adult rats/ D. Herrera-Covarrubias [та ін.] (стр.130-137)
Buchynska L. G. Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas/ L. G. Buchynska, O. V. Brieiev, N. P. Iurchenko (стр.138-143)
Kravets O. V. Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma/ O. V. Kravets [та ін.] (стр.144-147)
Burlaka A. P. Tumor-associated redox state in metastatic colorectal cancer/ A. P. Burlaka [та ін.] (стр.148-152)
Tajaldeen A. Investigation of dosimetric impact of organ motion in static and dynamic conditions for three stereotactic ablative body radiotherapy techniques: 3D conformal radiotherapy, intensity modulated radiation therapy, and volumetric modulated arc therapy by usi/ A. Tajaldeen, S. Alghamdi (стр.153-159)
Yakovlev P.G. Bladder sparing surgery in high-grade bladder cancer/ P. G. Yakovlev, D. A. Klyushin, R. I. Vereshchako (стр.160-165)
Cešeiko R. The impact of maximal strength training on quality of life among women with breast cancer undergoing treatment/ R. Cešeiko [та ін.] (стр.166-172)
Ben Kridis W. Prognostic factors in metastatic gastric carcinoma/ Kridis W. Ben [та ін.] (стр.173-175)
Dumanskiy Y. V. The Kі-67 marker for assessing the effectiveness of systemic or regional neoadjuvant polychemotherapy in patients with locally advanced breast cancer/ Y. V. Dumanskiy, O. V. Bondar, E. A. Stoliarchuk (стр.176-178)
Starchenko I. I. The observation of congenital retroperitoneal large size neuroblastoma / I. I. Starchenko [та ін.] (стр.179-181)
Ben Kridis W. Buschke — Lowenstein anal tumor: an ambiguous entity/ Kridis W. Ben [та ін.] (стр.182-184)
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5.

Заглавие журнала :Экспериментальная онкология -2018г. т.40,N 3
Интересные статьи :
Akbarzadeh A. Role of dendrimers in advanced drug delivery and biomedical applications: a review/ A. Akbarzadeh [та ін.] (стр.178-183)
Zadvornyi T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro/ T. V. Zadvornyi [та ін.] (стр.184-189)
Harper P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies/ P. Harper [та ін.] (стр.190-193)
Apykhtina О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles/ О. L. Apykhtina [та ін.] (стр.194-199)
Chekhun V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats/ V. F. Chekhun [та ін.] (стр.200-204)
Prokhorova I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6/ I. V. Prokhorova [та ін.] (стр.205-210)
Abramenko I. V. . Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients/ I. V. Abramenko [та ін.] (стр.211-217)
Nesina I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma/ I. P. Nesina, N. P. Iurchenko, L. G. Buchynska (стр.218-222)
Vernygorodskyi S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction/ S. Vernygorodskyi, T. Rekun, P. Zhuchenko (стр.223-227)
Gerashchenko T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles/ T. S. Gerashchenko [та ін.] (стр.228-234)
Agishev T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury/ T. T. Agishev [та ін.] (стр.235-238)
Dumansky Yu. V. Paraneoplastic syndrome in lung cancer/ Yu. V. Dumansky [та ін.] (стр.239-242)
Grybach S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome/ S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun (стр.243-248)
Chrysanthakopoulos N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study/ N. A. Chrysanthakopoulos, N. S. Dareioti (стр.249-250)
Tkachenko R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy/ R. Tkachenko, A. Golovko, O. Kuryk (стр.251-253)
Svitlana Pavlivna Sidorenko (1953–2018) (стр.254-255)
Yurii Yosypovych Kudryavets (1946–2018) (стр.256-257)
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6.

Заглавие журнала :Экспериментальная онкология -2006г. т.28,N 2
Интересные статьи :
Georgolios A. The role of CD44 adhesion molecule in oral cavity cancer/ A. Georgolios [и др.] (стр.94-98)
McShane L.M. Reporting recommendations for tumor marker prognostic studies (remark)/ L. M. McShane [и др.] (стр.99-105)
Xu G. Antitumor activities of the four sesquiterpene lactones from ELEPHANTOPUS SCABER L/ G. Xu [и др.] (стр.106-109)
Kyyamova R.G. Expression of SSX2 tumor antigen in baculovirus expression system and its application for screening of blood serum of melanoma patients/ R. G. Kyyamova [и др.] (стр.110-113)
Olishevsky S. Modulation of ros/no production by murine peritoneal macrophages in responseto bacterial CPG DNA stimulation/ S. Olishevsky [и др.] (стр.114-120)
Karkabounas S. Anticarcinogenic and antiplatelet effects of carvacrol/ S. Karkabounas [и др.] (стр.121-125)
Hao S. Epigenetic transfer of metastatic activity by uptake of highly metastatic B 16 melanoma cell-released exosomes/ S. Hao [и др.] (стр.126-131)
Shlyakhovenko V. Application of dna from mushroom pleurotus ostreatus for cancer biotherapy: a pilot study/ V. Shlyakhovenko, V. Kosak, S. Olishevsky (стр.132-135)
Lu Y. Gene therapeutic treatment of pancreatic cancer based on injection of pcDNA3.1/CCK plasmid with xenogeneic homologous cholecystokinin/ Y. Lu, J. -G. Bai, H. -H. Wang (стр.136-140)
Arumugam G. Effect of gallium nitrate on tamoxifen induced hypercalcemia in rats bearing mammary tumor/ G. Arumugam, P. Shanthi, P. Sachdanandam (стр.141-145)
Isaikina Y. Growth kinetics and self-renewal of human mesenchymal stem cells derived from bone marrow of children with oncohematological diseases during expansion in vitro/ Y. Isaikina, A. Kustanovich, A. Svirnovski (стр.146-151)
Buchynska L. G. Expression of the cell cycle regulators p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} in human endometrial adenocarcinoma/ L. G. Buchynska, I. P. Neslna (стр.152-155)
Romanowicz-Makowska H. Analysis of RAD51 polymorphism and BRCA 1 mutations in polish women with breast cancer/ H. Romanowicz-Makowska [и др.] (стр.156-159)
Prylutska S.V. Effect of the visible light irradiation of fullerene-containing composites on the ros generation and the viability of tumor cells/ S. V. Prylutska [и др.] (стр.160-162)
Baran Y. Cross-resistance to cytosine arabinoside in human acute myeloid leukemia cells selected for resistance to vincristine/ Y. Baran, V. Gunduz, A. U. Ural (стр.163-165)
Glushkov A.N. Immunological images of polycyclic aromatic hydrocarbons/ A. N. Glushkov [и др.] (стр.166-168)
Bugdayci G. Matrix metalloproteinase-9 in broncho-alveolar lavage fluid of patients with non-small cell lung cancer/ G. Bugdayci [и др.] (стр.169-171)
Gluzman D.F. Structure of leukemias and lymphomas in children of Ukraine in post-chernobyl period/ D. F. Gluzman [и др.] (стр.172-174)
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7.

Заглавие журнала :Экспериментальная онкология -2018г. т.40,N 4
Интересные статьи :
Chekhun V. F. Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy/ ed. V. F Chekhun (стр.258-260)
Tari K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia/ K. Tari [et al.] (стр.261-267)
Chekhun V. F. Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism/ V. F. Chekhun [et al.] (стр.268-274)
Symchych T. V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model/ T. V. Symchych [et al.] (стр.275-281)
Yakymenko I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation/ I. Yakymenko [et al.] (стр.282-287)
Smal M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer/ M. P. Smal [et al.] (стр.288-298)
Abooshahab R. Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer/ R. Abooshahab [et al.] (стр.299-302)
Buchynska L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas/ L. G. Buchynska [et al.] (стр.303-308)
Arabpour F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients/ F. Arabpour [et al.] (стр.309-314)
Gerashchenko G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer/ G. V. Gerashchenko [et al.] (стр.315-322)
Tas F. Clinical significance of serum caveolin-1 levels in gastric cancer patients/ F. Tas [et al.] (стр.323-327)
Shvachko L. P. Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells/ L. P. Shvachko [et al.] (стр.328-331)
Kuzyk P. V. Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis/ P. V. Kuzyk, M. A. Savchyna, S. G. Gychka (стр.332-335)
Zakhartseva L. M. Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart/ L. M. Zakhartseva [et al.] (стр.336-342)
Langabeer S. E. The JAK2 V617F mutation in lung cancer: caveat emptor/ S. E. Langabeer (стр.343-344)
Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary) (стр.345)
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8.

Заглавие журнала :Экспериментальная онкология -2019г. т.41,N 4
Интересные статьи :
Karaman O. M. Macrophages - a perspective target for antineoplastic immunotherapy/ O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun (стр.282-290)
Orel V. E. Nоn-linear dynamics theory and malignant melanoma/ V. E. Orel [et al.] (стр.291-299)
Lisyany N. I. Cytomegaloviruses and malignant brain tumors/ N. I. Lisyany [et al.] (стр.300-303)
Woksepp H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392/ H. Woksepp [et al.] (стр.304-311)
Dehghan Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression/ Nayeri M. J. Dehghan [et al.] (стр.312-317)
Albuquerque A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation/ A. P. B. Albuquerque [et al.] (стр.318-322)
Skuja E. Deletions in metastatic colorectal cancer with chromothripsis/ E. Skuja [et al.] (стр.323-327)
Burlaka A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer/ A. P. Burlaka [et al.] (стр.328-334)
Buchynska L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma/ L. G. Buchynska, L. A. Naleskina, I. P. Nesina (стр.335-341)
Zelinskaya A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer/ A. Zelinskaya (стр.342-345)
Moazeni-Roodi A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls/ A. Moazeni-Roodi, M. Taheri, M. Hashemi (стр.346-352)
Skrypnyk I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy/ I. Skrypnyk [et al.] (стр.353-356)
Gavars D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia/ D. Gavars [et al.] (стр.357-362)
Prylutskyi M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles/ M. P. Prylutskyi, M. F. Starodub (стр.363-365)
Shkatula P. M. International scientific conference "Tumor and Host: novel aspects of old problem"/ P. M. Shkatula (стр.366-367)
To the 120th birthday anniversary of academician R. E. Kavetsky (стр.368-369)
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9.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Brieieva O. V.
Заглавие : Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients
Место публикации : Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 68-72 (Шифр ЕУ12/2018/40/1)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: НОВООБРАЗОВАНИЯ ГОРМОНОЗАВИСИМЫЕ -- NEOPLASMS, HORMONE-DEPENDENT
КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID
ЛИМФОЦИТЫ -- LYMPHOCYTES
ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE
РИСКА СТЕПЕНИ ОЦЕНКА -- RISK ADJUSTMENT
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. It is assumed that the individual sensitivity to the 4OHE2 may determine the predisposition to endometrial cancer (EС). Aim: To analyze the sensitivity of peripheral blood lymphocytes (PBLs) of EC patients to the 4OHE2 and to evaluate the repair efficiency of 4OHE2-induced DNA damage. Materials and Methods: The study was performed on the PBLs of 53 EC patients and 20 healthy women. The level of DNA damage was measured using the comet assay and was expressed as % tail DNA. The DNA repair efficiency (%) was evaluated by determining the ratio between the amount of repaired DNA damage and the level of 4OHE2-induced damage that appeared after incubation of PBLs with 4OHE2. Results: In PBLs of EC patients, a higher level of 4OHE2-induced DNA damage (32.0 ± 2.2% tail DNA) and lower DNA repair efficiency (34.0 ± 4.5%) was observed compared to PBLs of healthy women (22.3 ± 2.3% tail DNA and 48.8 ± 4.5%, respectively). PBLs of EC patients with deep tumor invasion of myometrium were characterized by more prominent decrease of DNA repair than those with less invasive tumor ( ½ of myometrium) (20.9 ± 7.8 and 43.7 ± 6.7%, respectively). Furthermore, lower DNA repair efficiency was detected in the PBLs of EC patients with a family history of cancer compared to this parameter in patients with sporadic tumors (20.9±7.8 and 47.1 ± 5.5%, respectively). Conclusion: The PBLs of EC patients are characterized by increased sensitivity to the genotoxic effect of 4OHE2 and reduced repair efficiency regarding 4OHE2-induced DNA damage. A lower level of DNA repair is observed in EC patients with deep tumor myometrial invasion and a family history of cancer
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Neslna I. P.
Заглавие : Expression ofthe cell cycle regulators p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} in human endometrial adenocarcinoma
Параллельн. заглавия :Особенности экспрессии регуляторов клеточного цикла p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} аденокарциномах эндометрия человека
Место публикации : Экспериментальная онкология. - 2006. - Т. 28, № 2. - С. 152-155 (Шифр 71097/2006/28/2)
Предметные рубрики: Эндометрия новообразования
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