Главная Упрощенный режим Видео-инструкция Описание
Авторизация
Фамилия
Пароль
 

Базы данных


Периодические издания- результаты поиска

Вид поиска
Книги
Периодические издания
Библиотечные издания
Высшее образование
Краеведение
Редкие издания
Область поиска
в найденном
Формат представления найденных документов:
полный информационныйкраткий
Отсортировать найденные документы по:
авторузаглавиюгоду изданиятипу документа
Поисковый запрос: (<.>A=Buchynska, L. G.$<.>)
Общее количество найденных документов : 17
Показаны документы с 1 по 10
 1-10    11-17 
1.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Neslna I. P.
Заглавие : Expression ofthe cell cycle regulators p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} in human endometrial adenocarcinoma
Параллельн. заглавия :Особенности экспрессии регуляторов клеточного цикла p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} аденокарциномах эндометрия человека
Место публикации : Экспериментальная онкология. - 2006. - Т. 28, № 2. - С. 152-155 (Шифр 71097/2006/28/2)
Предметные рубрики: Эндометрия новообразования
Найти похожие
2.

Заглавие журнала :Экспериментальная онкология -2006г. т.28,N 2
Интересные статьи :
Georgolios A. The role of CD44 adhesion molecule in oral cavity cancer/ A. Georgolios [и др.] (стр.94-98)
McShane L.M. Reporting recommendations for tumor marker prognostic studies (remark)/ L. M. McShane [и др.] (стр.99-105)
Xu G. Antitumor activities of the four sesquiterpene lactones from ELEPHANTOPUS SCABER L/ G. Xu [и др.] (стр.106-109)
Kyyamova R.G. Expression of SSX2 tumor antigen in baculovirus expression system and its application for screening of blood serum of melanoma patients/ R. G. Kyyamova [и др.] (стр.110-113)
Olishevsky S. Modulation of ros/no production by murine peritoneal macrophages in responseto bacterial CPG DNA stimulation/ S. Olishevsky [и др.] (стр.114-120)
Karkabounas S. Anticarcinogenic and antiplatelet effects of carvacrol/ S. Karkabounas [и др.] (стр.121-125)
Hao S. Epigenetic transfer of metastatic activity by uptake of highly metastatic B 16 melanoma cell-released exosomes/ S. Hao [и др.] (стр.126-131)
Shlyakhovenko V. Application of dna from mushroom pleurotus ostreatus for cancer biotherapy: a pilot study/ V. Shlyakhovenko, V. Kosak, S. Olishevsky (стр.132-135)
Lu Y. Gene therapeutic treatment of pancreatic cancer based on injection of pcDNA3.1/CCK plasmid with xenogeneic homologous cholecystokinin/ Y. Lu, J. -G. Bai, H. -H. Wang (стр.136-140)
Arumugam G. Effect of gallium nitrate on tamoxifen induced hypercalcemia in rats bearing mammary tumor/ G. Arumugam, P. Shanthi, P. Sachdanandam (стр.141-145)
Isaikina Y. Growth kinetics and self-renewal of human mesenchymal stem cells derived from bone marrow of children with oncohematological diseases during expansion in vitro/ Y. Isaikina, A. Kustanovich, A. Svirnovski (стр.146-151)
Buchynska L. G. Expression of the cell cycle regulators p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} in human endometrial adenocarcinoma/ L. G. Buchynska, I. P. Neslna (стр.152-155)
Romanowicz-Makowska H. Analysis of RAD51 polymorphism and BRCA 1 mutations in polish women with breast cancer/ H. Romanowicz-Makowska [и др.] (стр.156-159)
Prylutska S.V. Effect of the visible light irradiation of fullerene-containing composites on the ros generation and the viability of tumor cells/ S. V. Prylutska [и др.] (стр.160-162)
Baran Y. Cross-resistance to cytosine arabinoside in human acute myeloid leukemia cells selected for resistance to vincristine/ Y. Baran, V. Gunduz, A. U. Ural (стр.163-165)
Glushkov A.N. Immunological images of polycyclic aromatic hydrocarbons/ A. N. Glushkov [и др.] (стр.166-168)
Bugdayci G. Matrix metalloproteinase-9 in broncho-alveolar lavage fluid of patients with non-small cell lung cancer/ G. Bugdayci [и др.] (стр.169-171)
Gluzman D.F. Structure of leukemias and lymphomas in children of Ukraine in post-chernobyl period/ D. F. Gluzman [и др.] (стр.172-174)
Интересные статьи :
Найти похожие
3.

Заглавие журнала :Экспериментальная онкология -2017г. т.39,N 4
Интересные статьи :
Liubich L. D. TGF-β1 expression by glioma C6 cells in vitro/ L. D. Liubich [та ін.] (стр.258-263)
Pyaskovskaya O. N. Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo/ O. N. Pyaskovskaya [та ін.] (стр.264-268)
Herrera-Covarrubias D. Stress during puberty facilitates precancerous prostate lesions in adult rats/ D. Herrera-Covarrubias [та ін.] (стр.269-275)
Caballero-Hernandez D. Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure/ D. Caballero-Hernandez [та ін.] (стр.276-280)
Bebeshko V. Assessment of the effect of wave device application on morphological changes in organs and cells of irradiated animals/ V. Bebeshko, I. Homolyako, V. Grynchyshyn (стр.281-285)
Matveeva A. The TGF-beta — SMAD pathway is inactivated in cronic lymphocytic leukemia cells/ A. Matveeva [та ін.] (стр.286-290)
Gordiienko I. M. CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells/ I. M. Gordiienko, L. M. Shlapatska, V. M. Kholodniuk (стр.291-298)
Buchynska L. G. DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay/ L. G. Buchynska [та ін.] (стр.299-303)
Dumanskiy Y. V. Adsorption-rheological properties of blood serum in lung cancer patients/ Y. V. Dumanskiy [та ін.] (стр.304-307)
Skrypnyk I. L-arginine is an effective medication for prevention of endothelial dysfunction a predictor of anthracycline cardiotoxicity in patients with acute leukemia/ I. Skrypnyk [та ін.] (стр.308-311)
Buchynska L. G. Phenotypic features of endometrial tumors in patients with family history of cancer/ L. G. Buchynska [та ін.] (стр.312-318)
Patial T. Consumptive hypothyroidism: an unusual paraneoplastic manifestation of a gastric gastrointestinal stromal tumor/ T. Patial [та ін.] (стр.319-321)
Volodymyr Serhiiovych Mosiienko (1934–2017) (стр.322)
Интересные статьи :
Найти похожие
4.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Brieieva O. V., Lurchenko N. P., Protsenko V. V., Nespryadko S. V.
Заглавие : DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay
Место публикации : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 299-303 (Шифр ЕУ12/2017/39/4)
Примечания : Bibliogr. at the end of the art.
Аннотация: To date, genome instability is considered to be a common feature not only of tumor cells, but also of non-malignant cells of cancer patients, including peripheral blood lymphocytes (PBLs). The issue of the association between genome instability in tumor cells and PBLs, as well as of its relationship with tumor progression remains poorly understood. Aim: To evaluate the level DNA damage in tumor cells and PBLs of endometrial cancer (EC) patients with regard to clinical and morphological characteristics of the patients. Materials and Methods: DNA damage was assessed in 106 PBLs samples and 42 samples of tumor cell suspension from EC patients by comet assay. PBLs from 30 healthy women were used as control. The level of DNA damage was expressed as the percentage of DNA in the comet tails (% tail DNA). Results: It was revealed that the amount of DNA damage in PBLs of EC patients was 2.2 times higher in comparison with that of healthy donors (8.3 ± 0.7 and 3.7 ± 0.4% tail DNA, respectively) (p 0.05). In this study, no association between the levels of DNA damage in endometrial tumor cells and PBLs was observed (r 0.05). The amounts of DNA damage both in tumor cells and PBLs were not related to the degree of tumor differentiation as well as the depth of myometrial invasion, but depended on the body mass index (BMI) of EC patients: high level of lesions was observed in patients with elevated BMI values. Furthermore, the level of DNA damage in tumor cells was associated to familial aggregation of cancer and was significantly higher in endometrial cells from patients with family history of cancer vs that from EC patients with sporadic tumors (32.3 ± 2.9 and 22.8 ± 1.8% tail DNA, respectively) (p 0.05). It was also found that for women who had high level of DNA damage in PBLs, the risk of EC was greater (odds ratio value of 3.5) compared to those with low level of such lesions. Conclusion: Genome instability that appears as an increased level of DNA damage in tumor cells and PBLs of EC patients is associated with BMI and family history of cancer and can reflect a predisposition to cancer
Найти похожие
5.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Lurchenko N. P., Glushchenko N. M., Nesina I. P.
Заглавие : Phenotypic features of endometrial tumors in patients with family history of cancer
Место публикации : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 312-318 (Шифр ЕУ12/2017/39/4)
Примечания : Bibliogr. at the end of the art.
Аннотация: To determine the peculiarities of expression of a number of proteins-regulators of the cell cycle in endometrial cancer (EC) cells in patients with a family history of oncological pathologies. Patients and Methods: 95 EC patients (stage І–ІІ) were included into the study. Clinical-genealogical analysis was performed. 54 patients (group I) had healthy relatives, and in families of 41 patients (group II) an aggregation of malignant tumors of different genesis (mainly tumors of the gastrointestinal tract and the female reproductive system) was recorded. p53, р21WAF1/CIP1, р16INK4a, and Ki-67 were assessed immunohistochemically in the surgical samples. Results: In the majority of patients, both from group I and II, moderately differentiated tumors were observed (in 38.9 and 46.3% of cases, respectively), mainly with deep myometrium invasion (64.8 and 58.5% of cases, respectively). In EC patients from group II, a significantly higher number of р16INK4a-positive cells (17.7 ± 1.7%; p = 0.001) and lower number of p53-positive (30.9 ± 3.2%; p = 0.05) and Ki-67-positive (26.9 ± 2.7%; p = 0.048) cells was observed compared to those in tumors of patients from group I (12.0 ± 1.6; 37.7 ± 2.8 and 36.7 ± 3.4%, respectively). Conclusion: Phenotypic features of the EC in the patients with family history of cancer differ from those in tumors of patients without such aggregation. The biological heterogeneity of EC seems to relate to the oncogenealogical history of patients. Also this biological heterogeneity is linked to the molecular features of EC cells, which affects cancer aggressiveness and the course of the disease
Найти похожие
6.

Заглавие журнала :Экспериментальная онкология -2018г. т.40,N 3
Интересные статьи :
Akbarzadeh A. Role of dendrimers in advanced drug delivery and biomedical applications: a review/ A. Akbarzadeh [та ін.] (стр.178-183)
Zadvornyi T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro/ T. V. Zadvornyi [та ін.] (стр.184-189)
Harper P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies/ P. Harper [та ін.] (стр.190-193)
Apykhtina О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles/ О. L. Apykhtina [та ін.] (стр.194-199)
Chekhun V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats/ V. F. Chekhun [та ін.] (стр.200-204)
Prokhorova I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6/ I. V. Prokhorova [та ін.] (стр.205-210)
Abramenko I. V. . Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients/ I. V. Abramenko [та ін.] (стр.211-217)
Nesina I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma/ I. P. Nesina, N. P. Iurchenko, L. G. Buchynska (стр.218-222)
Vernygorodskyi S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction/ S. Vernygorodskyi, T. Rekun, P. Zhuchenko (стр.223-227)
Gerashchenko T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles/ T. S. Gerashchenko [та ін.] (стр.228-234)
Agishev T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury/ T. T. Agishev [та ін.] (стр.235-238)
Dumansky Yu. V. Paraneoplastic syndrome in lung cancer/ Yu. V. Dumansky [та ін.] (стр.239-242)
Grybach S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome/ S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun (стр.243-248)
Chrysanthakopoulos N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study/ N. A. Chrysanthakopoulos, N. S. Dareioti (стр.249-250)
Tkachenko R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy/ R. Tkachenko, A. Golovko, O. Kuryk (стр.251-253)
Svitlana Pavlivna Sidorenko (1953–2018) (стр.254-255)
Yurii Yosypovych Kudryavets (1946–2018) (стр.256-257)
Интересные статьи :
Найти похожие
7.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Nesina I. P., Iurchenko N. P., Buchynska L. G.
Заглавие : Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma
Место публикации : Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 218-222 (Шифр ЕУ12/2018/40/3)
Примечания : Bibliogr. at the end of the art.
Аннотация: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p 0.001 and 54.5 ± 2.6%, respectively, p 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin
Найти похожие
8.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Brieieva O. V.
Заглавие : Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients
Место публикации : Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 68-72 (Шифр ЕУ12/2018/40/1)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: НОВООБРАЗОВАНИЯ ГОРМОНОЗАВИСИМЫЕ -- NEOPLASMS, HORMONE-DEPENDENT
КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID
ЛИМФОЦИТЫ -- LYMPHOCYTES
ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE
РИСКА СТЕПЕНИ ОЦЕНКА -- RISK ADJUSTMENT
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. It is assumed that the individual sensitivity to the 4OHE2 may determine the predisposition to endometrial cancer (EС). Aim: To analyze the sensitivity of peripheral blood lymphocytes (PBLs) of EC patients to the 4OHE2 and to evaluate the repair efficiency of 4OHE2-induced DNA damage. Materials and Methods: The study was performed on the PBLs of 53 EC patients and 20 healthy women. The level of DNA damage was measured using the comet assay and was expressed as % tail DNA. The DNA repair efficiency (%) was evaluated by determining the ratio between the amount of repaired DNA damage and the level of 4OHE2-induced damage that appeared after incubation of PBLs with 4OHE2. Results: In PBLs of EC patients, a higher level of 4OHE2-induced DNA damage (32.0 ± 2.2% tail DNA) and lower DNA repair efficiency (34.0 ± 4.5%) was observed compared to PBLs of healthy women (22.3 ± 2.3% tail DNA and 48.8 ± 4.5%, respectively). PBLs of EC patients with deep tumor invasion of myometrium were characterized by more prominent decrease of DNA repair than those with less invasive tumor ( ½ of myometrium) (20.9 ± 7.8 and 43.7 ± 6.7%, respectively). Furthermore, lower DNA repair efficiency was detected in the PBLs of EC patients with a family history of cancer compared to this parameter in patients with sporadic tumors (20.9±7.8 and 47.1 ± 5.5%, respectively). Conclusion: The PBLs of EC patients are characterized by increased sensitivity to the genotoxic effect of 4OHE2 and reduced repair efficiency regarding 4OHE2-induced DNA damage. A lower level of DNA repair is observed in EC patients with deep tumor myometrial invasion and a family history of cancer
Найти похожие
9.

Заглавие журнала :Экспериментальная онкология -2018г. т.40,N 1
Интересные статьи :
Kian R. Role of components of microRNA machinery in carcinogenesis/ R. Kian, S. Moradi, S. Ghorbian (стр.2-9)
Patel K. R. Clinical implications of p53 alterations in oral cancer progression: a review from India/ K. R. Patel [та ін.] (стр.10-18)
Varela-Castillo O. Characterization of the cytotoxic effects of the combination of cisplatin and flavanol (-)-epicatechin on human lung cancer cell line A549. An isobolographic approach/ O. Varela-Castillo [та ін.] (стр.19-23)
Chaves K. C. B. Impact of endostatin gene therapy on myeloid-derived suppressor cells from a metastatic renal cell carcinoma/ K. C. B. Chaves [та ін.] (стр.24-32)
Sarnatskaya V. V. Highly activated carbon enterosorbent mediates the suppression of paraneoplastic syndrome associated with lewis lung carcinoma in mice/ V. V. Sarnatskaya [та ін.] (стр.33-41)
Boroday N. V. Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells/ N. V. Boroday, V. F. Chekhun (стр.42-47)
Kurtenkov O. Signatures of anti-Thomsen — friedenreich antigen antibody diversity in colon cancer patients/ O. Kurtenkov, M. Bubina, K. Klaamas (стр.48-58)
Paliychuk O. V. Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer/ O. V. Paliychuk [та ін.] (стр.59-67)
Buchynska L. G. Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients/ L. G. Buchynska, O. V. Brieieva (стр.68-72)
Lozynska L. Y. Variant of rare hermansky — pudlak syndrome associated with granulomatous colitis: diagnostics clinical course and treatment/ L. Y. Lozynska [та ін.] (стр.73-78)
Zubenko O. S. Effect of cytostatic agents on expression levels of human beta-defensins-1-4 in A431 and MCF-7 cell lines/ O. S. Zubenko [та ін.] (стр.79-81)
Imaniar R. Mediastinal yolk sac tumor infiltrating the heart/ R. Imaniar [та ін.] (стр.82-84)
Ben Kridis W. A long survival of a patient with brain metastasis of unknown site of the primary tumor/ Kridis W. Ben [та ін.] (стр.85-87)
Symposium and Summer School “Fundamental principles of cancer biotherapy” Kyiv Ukraine May 21-24 2018 (стр.88)
Интересные статьи :
Найти похожие
10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Iurchenko N. P., Kashuba E. V., Brieieva O. V., Glushchenko N. M., Mints M., Lukianova N. Yu., Chekhun V. F.
Заглавие : Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas
Место публикации : Experimental Oncology. - К., 2018. - Том 40, N 4. - С. 303-308 (Шифр ЕУ12/2018/40/4)
MeSH-главная: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
ВНУТРИКЛЕТОЧНЫЕ СИГНАЛЬНЫЕ ПЕПТИДЫ И БЕЛКИ -- INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS
Аннотация: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients
Найти похожие
 1-10    11-17 
 
Стандартный
Расширенный
Профессиональный
По словарю
УДК-навигатор
Тематический навигатор
Статистика обращений
© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)