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1.

Заглавие журнала :Экспериментальная онкология -2006г. т.28,N 2
Интересные статьи :
Georgolios A. The role of CD44 adhesion molecule in oral cavity cancer/ A. Georgolios [и др.] (стр.94-98)
McShane L.M. Reporting recommendations for tumor marker prognostic studies (remark)/ L. M. McShane [и др.] (стр.99-105)
Xu G. Antitumor activities of the four sesquiterpene lactones from ELEPHANTOPUS SCABER L/ G. Xu [и др.] (стр.106-109)
Kyyamova R.G. Expression of SSX2 tumor antigen in baculovirus expression system and its application for screening of blood serum of melanoma patients/ R. G. Kyyamova [и др.] (стр.110-113)
Olishevsky S. Modulation of ros/no production by murine peritoneal macrophages in responseto bacterial CPG DNA stimulation/ S. Olishevsky [и др.] (стр.114-120)
Karkabounas S. Anticarcinogenic and antiplatelet effects of carvacrol/ S. Karkabounas [и др.] (стр.121-125)
Hao S. Epigenetic transfer of metastatic activity by uptake of highly metastatic B 16 melanoma cell-released exosomes/ S. Hao [и др.] (стр.126-131)
Shlyakhovenko V. Application of dna from mushroom pleurotus ostreatus for cancer biotherapy: a pilot study/ V. Shlyakhovenko, V. Kosak, S. Olishevsky (стр.132-135)
Lu Y. Gene therapeutic treatment of pancreatic cancer based on injection of pcDNA3.1/CCK plasmid with xenogeneic homologous cholecystokinin/ Y. Lu, J. -G. Bai, H. -H. Wang (стр.136-140)
Arumugam G. Effect of gallium nitrate on tamoxifen induced hypercalcemia in rats bearing mammary tumor/ G. Arumugam, P. Shanthi, P. Sachdanandam (стр.141-145)
Isaikina Y. Growth kinetics and self-renewal of human mesenchymal stem cells derived from bone marrow of children with oncohematological diseases during expansion in vitro/ Y. Isaikina, A. Kustanovich, A. Svirnovski (стр.146-151)
Buchynska L. G. Expression of the cell cycle regulators p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} in human endometrial adenocarcinoma/ L. G. Buchynska, I. P. Neslna (стр.152-155)
Romanowicz-Makowska H. Analysis of RAD51 polymorphism and BRCA 1 mutations in polish women with breast cancer/ H. Romanowicz-Makowska [и др.] (стр.156-159)
Prylutska S.V. Effect of the visible light irradiation of fullerene-containing composites on the ros generation and the viability of tumor cells/ S. V. Prylutska [и др.] (стр.160-162)
Baran Y. Cross-resistance to cytosine arabinoside in human acute myeloid leukemia cells selected for resistance to vincristine/ Y. Baran, V. Gunduz, A. U. Ural (стр.163-165)
Glushkov A.N. Immunological images of polycyclic aromatic hydrocarbons/ A. N. Glushkov [и др.] (стр.166-168)
Bugdayci G. Matrix metalloproteinase-9 in broncho-alveolar lavage fluid of patients with non-small cell lung cancer/ G. Bugdayci [и др.] (стр.169-171)
Gluzman D.F. Structure of leukemias and lymphomas in children of Ukraine in post-chernobyl period/ D. F. Gluzman [и др.] (стр.172-174)
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2.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Neslna I. P.
Заглавие : Expression ofthe cell cycle regulators p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} in human endometrial adenocarcinoma
Параллельн. заглавия :Особенности экспрессии регуляторов клеточного цикла p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} аденокарциномах эндометрия человека
Место публикации : Экспериментальная онкология. - 2006. - Т. 28, № 2. - С. 152-155 (Шифр 71097/2006/28/2)
Предметные рубрики: Эндометрия новообразования
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3.

Заглавие журнала :Экспериментальная онкология -2019г. т.41,N 4
Интересные статьи :
Karaman O. M. Macrophages - a perspective target for antineoplastic immunotherapy/ O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun (стр.282-290)
Orel V. E. Nоn-linear dynamics theory and malignant melanoma/ V. E. Orel [et al.] (стр.291-299)
Lisyany N. I. Cytomegaloviruses and malignant brain tumors/ N. I. Lisyany [et al.] (стр.300-303)
Woksepp H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392/ H. Woksepp [et al.] (стр.304-311)
Dehghan Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression/ Nayeri M. J. Dehghan [et al.] (стр.312-317)
Albuquerque A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation/ A. P. B. Albuquerque [et al.] (стр.318-322)
Skuja E. Deletions in metastatic colorectal cancer with chromothripsis/ E. Skuja [et al.] (стр.323-327)
Burlaka A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer/ A. P. Burlaka [et al.] (стр.328-334)
Buchynska L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma/ L. G. Buchynska, L. A. Naleskina, I. P. Nesina (стр.335-341)
Zelinskaya A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer/ A. Zelinskaya (стр.342-345)
Moazeni-Roodi A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls/ A. Moazeni-Roodi, M. Taheri, M. Hashemi (стр.346-352)
Skrypnyk I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy/ I. Skrypnyk [et al.] (стр.353-356)
Gavars D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia/ D. Gavars [et al.] (стр.357-362)
Prylutskyi M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles/ M. P. Prylutskyi, M. F. Starodub (стр.363-365)
Shkatula P. M. International scientific conference "Tumor and Host: novel aspects of old problem"/ P. M. Shkatula (стр.366-367)
To the 120th birthday anniversary of academician R. E. Kavetsky (стр.368-369)
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4.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Naleskina L. A., Nesina I. P.
Заглавие : Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma
Место публикации : Experimental Oncology. - К., 2019. - Том 41, N 4. - С. 335-341 (Шифр ЕУ12/2019/41/4)
Аннотация: The aim of the study was to evaluate the morphological features of endometrioid carcinoma of the endometrium (ECE) of low differentiation grade with different invasive potential and to characterize their molecular phenotype by the expression of a number of adhesion markers. Materials and Methods: We have studied the samples of operation material of 37 patients with ECE of low differentiation grade with deep invasion ( ½ myometrium), n = 26, and with invasion ½ myometrium, n
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5.

Заглавие журнала :Экспериментальная онкология -2018г. т.40,N 4
Интересные статьи :
Chekhun V. F. Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy/ ed. V. F Chekhun (стр.258-260)
Tari K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia/ K. Tari [et al.] (стр.261-267)
Chekhun V. F. Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism/ V. F. Chekhun [et al.] (стр.268-274)
Symchych T. V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model/ T. V. Symchych [et al.] (стр.275-281)
Yakymenko I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation/ I. Yakymenko [et al.] (стр.282-287)
Smal M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer/ M. P. Smal [et al.] (стр.288-298)
Abooshahab R. Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer/ R. Abooshahab [et al.] (стр.299-302)
Buchynska L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas/ L. G. Buchynska [et al.] (стр.303-308)
Arabpour F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients/ F. Arabpour [et al.] (стр.309-314)
Gerashchenko G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer/ G. V. Gerashchenko [et al.] (стр.315-322)
Tas F. Clinical significance of serum caveolin-1 levels in gastric cancer patients/ F. Tas [et al.] (стр.323-327)
Shvachko L. P. Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells/ L. P. Shvachko [et al.] (стр.328-331)
Kuzyk P. V. Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis/ P. V. Kuzyk, M. A. Savchyna, S. G. Gychka (стр.332-335)
Zakhartseva L. M. Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart/ L. M. Zakhartseva [et al.] (стр.336-342)
Langabeer S. E. The JAK2 V617F mutation in lung cancer: caveat emptor/ S. E. Langabeer (стр.343-344)
Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary) (стр.345)
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6.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Iurchenko N. P., Kashuba E. V., Brieieva O. V., Glushchenko N. M., Mints M., Lukianova N. Yu., Chekhun V. F.
Заглавие : Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas
Место публикации : Experimental Oncology. - К., 2018. - Том 40, N 4. - С. 303-308 (Шифр ЕУ12/2018/40/4)
MeSH-главная: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS
ВНУТРИКЛЕТОЧНЫЕ СИГНАЛЬНЫЕ ПЕПТИДЫ И БЕЛКИ -- INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS
Аннотация: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients
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7.

Заглавие журнала :Экспериментальная онкология -2021г. т.43,N 2
Интересные статьи :
Vitruk Yu. V. Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302a and -377 in tumor tissue/ Yu. V. Vitruk [et al.] (стр.98-103)
Pyaskovskaya O. N. Role of tumor/endothelial cell interactions in tumor growth and metastasis/ O. N. Pyaskovskaya [et al.] (стр.104-110)
Akalovich S. 5-FU resistens colorectal cancer cells possess improved invasiveness and βIII-tubulin expression/ S. Akalovich [et al.] (стр.111-117)
Bychkov V. A. In vitro modeling of tumor interclonal interactions using breast cancer cell lines/ V. A. Bychkov [et al.] (стр.118-124)
Ayyildiz A. Co-administration of apigenin with doxorubicin enhanges anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells/ A. Ayyildiz [et al.] (стр.125-134)
Buchynska L. G. Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium/ L. G. Buchynska, O. M. Movchan, N. P. Iurchenko (стр.135-141)
Yakovlev P. G. Expression of TLR4 and major inflammatory cytokines in patients with bladder cancer of different grade and stage/ P. G. Yakovlev [et al.] (стр.142-148)
Zoubi M. S. RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population/ M. S. Zoubi [et al.] (стр.149-154)
Kornatska A. G. A variant of TP53 gene (RS 1625895, 13494GA) is associated with neoplasm localization in patients with uterine leiomyoma/ A. G. Kornatska [et al.] (стр.155-158)
Mohamed Yusoff A. A. Significance of BRAFv600E mutation in intra-axial brain tumor in Malaysian patients: case series and literature review/ A. A. Mohamed Yusoff [et al.] (стр.159-167)
Ben Kridis W. Therapeutic results of laryngeal preservation: a retrospective study/ W. Ben Kridis [et al.] (стр.168-172)
Pilinska M. A. Study of modifyng effects of astaxanthin on cytogenetic manifestations of bystander response in human peripheral blood lymphocytes in vitro/ M. A. Pilinska [et al.] (стр.173-176)
De Giorgi V. Scrotal cutaneous metastasis from rectal squamous cell carcinoma: a rare evolution into a rare tumor/ V. De Giorgi [et al.] (стр.177-179)
Liubota R. Systemic chemotherapeutic treatment of patients with breast cancer brain metastases/ R. Liubota [et al.] (стр.180-184)
Pasichnyk S. M. Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model/ S. M. Pasichnyk [et al.] (стр.185-188)
Gluzman D. F. Long-term exposure to low doses of ionizing radiation and COVID-19 pandemic: oncohematological aspects/ D. F. Gluzman [et al.] (стр.189-192)
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8.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Movchan O. M., Iurchenko N. P.
Заглавие : Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium
Место публикации : Experimental Oncology. - К., 2021. - Том 43, N 2. - С. 135-141 (Шифр ЕУ12/2021/43/2)
MeSH-главная: КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID
Аннотация: The expression of the CXCL12 chemokine and its receptor CXCR4 in the stromal component of the tumor plays an important role in tumor cell migration, proliferation, inhibition of apoptosis and determination of invasive and metastatic potential of malignant neoplasms of various genesis. The significance of CXCL12 and CXCR4 expression in endometrial tumor cells for cancer progression is not fully understood. Aim: To evaluate the content of CXCL12+-fibroblasts and expression of CXCL12 and CXCR4 in endometrial cancer cells, depending on the tumor stage. Materials and Methods: Surgical material of 45 patients with endometrioid carcinoma of the endometrium (ECE) of the stages I–II and III was studied using morphological and immunohistochemical methods. Results: In ECE of stage I–II CXCR4 expression was lower (43.3 ± 4.2%) while CXCL12 expression was higher (33.6 ± 2.4%) compared with the corresponding indices​​ in ECE of stage III (63.6 ± 3.5%, 24.5 ± 1.9%, respectively, p 0.05). In ECE of stage III, high expression of CXCR4 ( Me) and low CXCL12 ( Me) was observed in 80% of samples; these tumors invaded more than 1/2 of the myometrium. There was a positive correlation between the depth of tumor invasion in the myometrium and the presence of metastases and CXCR4 expression in tumor cells (R Me) (14.9 ± 1.3%) was detected. Conclusion: The obtained data reflect the communication of the immunosuppressive factor of the tumor microenvironment, i.e. CXCL12+-fibroblasts and CXCR4 expressing tumor cells. We suggest that the aggressiveness of ECE is determined by the combined effect of these two factors
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9.

Заглавие журнала :Экспериментальная онкология -2017г. т.39,N 4
Интересные статьи :
Liubich L. D. TGF-β1 expression by glioma C6 cells in vitro/ L. D. Liubich [та ін.] (стр.258-263)
Pyaskovskaya O. N. Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo/ O. N. Pyaskovskaya [та ін.] (стр.264-268)
Herrera-Covarrubias D. Stress during puberty facilitates precancerous prostate lesions in adult rats/ D. Herrera-Covarrubias [та ін.] (стр.269-275)
Caballero-Hernandez D. Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure/ D. Caballero-Hernandez [та ін.] (стр.276-280)
Bebeshko V. Assessment of the effect of wave device application on morphological changes in organs and cells of irradiated animals/ V. Bebeshko, I. Homolyako, V. Grynchyshyn (стр.281-285)
Matveeva A. The TGF-beta — SMAD pathway is inactivated in cronic lymphocytic leukemia cells/ A. Matveeva [та ін.] (стр.286-290)
Gordiienko I. M. CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells/ I. M. Gordiienko, L. M. Shlapatska, V. M. Kholodniuk (стр.291-298)
Buchynska L. G. DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay/ L. G. Buchynska [та ін.] (стр.299-303)
Dumanskiy Y. V. Adsorption-rheological properties of blood serum in lung cancer patients/ Y. V. Dumanskiy [та ін.] (стр.304-307)
Skrypnyk I. L-arginine is an effective medication for prevention of endothelial dysfunction a predictor of anthracycline cardiotoxicity in patients with acute leukemia/ I. Skrypnyk [та ін.] (стр.308-311)
Buchynska L. G. Phenotypic features of endometrial tumors in patients with family history of cancer/ L. G. Buchynska [та ін.] (стр.312-318)
Patial T. Consumptive hypothyroidism: an unusual paraneoplastic manifestation of a gastric gastrointestinal stromal tumor/ T. Patial [та ін.] (стр.319-321)
Volodymyr Serhiiovych Mosiienko (1934–2017) (стр.322)
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Brieieva O. V., Lurchenko N. P., Protsenko V. V., Nespryadko S. V.
Заглавие : DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay
Место публикации : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 299-303 (Шифр ЕУ12/2017/39/4)
Примечания : Bibliogr. at the end of the art.
Аннотация: To date, genome instability is considered to be a common feature not only of tumor cells, but also of non-malignant cells of cancer patients, including peripheral blood lymphocytes (PBLs). The issue of the association between genome instability in tumor cells and PBLs, as well as of its relationship with tumor progression remains poorly understood. Aim: To evaluate the level DNA damage in tumor cells and PBLs of endometrial cancer (EC) patients with regard to clinical and morphological characteristics of the patients. Materials and Methods: DNA damage was assessed in 106 PBLs samples and 42 samples of tumor cell suspension from EC patients by comet assay. PBLs from 30 healthy women were used as control. The level of DNA damage was expressed as the percentage of DNA in the comet tails (% tail DNA). Results: It was revealed that the amount of DNA damage in PBLs of EC patients was 2.2 times higher in comparison with that of healthy donors (8.3 ± 0.7 and 3.7 ± 0.4% tail DNA, respectively) (p 0.05). In this study, no association between the levels of DNA damage in endometrial tumor cells and PBLs was observed (r 0.05). The amounts of DNA damage both in tumor cells and PBLs were not related to the degree of tumor differentiation as well as the depth of myometrial invasion, but depended on the body mass index (BMI) of EC patients: high level of lesions was observed in patients with elevated BMI values. Furthermore, the level of DNA damage in tumor cells was associated to familial aggregation of cancer and was significantly higher in endometrial cells from patients with family history of cancer vs that from EC patients with sporadic tumors (32.3 ± 2.9 and 22.8 ± 1.8% tail DNA, respectively) (p 0.05). It was also found that for women who had high level of DNA damage in PBLs, the risk of EC was greater (odds ratio value of 3.5) compared to those with low level of such lesions. Conclusion: Genome instability that appears as an increased level of DNA damage in tumor cells and PBLs of EC patients is associated with BMI and family history of cancer and can reflect a predisposition to cancer
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