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1.
Шифр: ЕУ12/2021/43/3
   Журнал

Экспериментальная онкология [Текст]
2021г. Т. 43 № 3
Содержание:
To the thirties anniversary of the independence of Ukraine priorities in cancer research: retrospective and prospective aspects. - С.194-196
Chumak, A. V. Influence of bacterial lectin on key regulatory links of functional activity of macrophages in mice with Ehrlich carcinoma / A. V. Chumak [et al.]. - С.197-203
Другие авторы: Fedosova N. I., Shcherbina V. M., Cheremshenko N. L., Karaman O. M., Chekhun V. F.
Kovalevska, L. M. Expression pattern of MRPS 18 family genes in gliomas / L. M. Kovalevska [et al.]. - С.204-208
Другие авторы: Malysheva T. A., Kalman S. S., Rozumenko A. V., Verbova L. V., Rozumenko V. D., Kashuba E. V.
Roomi, M. W. A nutrient mixture reduced tumor growth of SK-UT-1 human leiomyosarcoma cells IN VIVO and IN VITRO by inhibiting MMPS and inducing apoptosis / M. W. Roomi [et al.]. - С.209-216
Другие авторы: Bhanap B., Niedzwiecki A., Rath M.
Khranovska, N. Magnetically sensitive nanocomplex enhances antitumor efficacy of dendritic cell-based immunotherapy / N. Khranovska [et al.]. - С.217-223
Другие авторы: Shachkova O., Gorbach O., Inomistova M., Orel V.
Abramenko, I. Association of lipoprotein lipase expression with TP53 gene polymorphisms in chronic lymphocytic leukemia cells / I. Abramenko [et al.]. - С.224-228
Другие авторы: Bilous N., Chumak A., Dyagil I., Martina Z.
Zotova, O. V. 11q23/MLL rearrangements in adult acute leukemia / O. V. Zotova [et al.]. - С.229-233
Другие авторы: Lukianova A. S., Valchuk M. O., Karol Yu. S., Dhalay O. O., Novak V. L., Loginsky V. E.
Horacek, J. M. Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival / J. M. Horacek [et al.]. - С.234-236
Другие авторы: Kupsa T., Vanek J., Jakl M., Stajer M., Jebavy L., Zak P.
Konovalenko, V. F. Experimental substantiation of the use of hydroxyapatite - tricalcium phosphate bioceramics for replacing bone defects after tumor removal / V. F. Konovalenko [et al.]. - С.237-241
Другие авторы: Ternovyi N. K., Tuz E. V., Protsenko V. V., Solonitsyn E. O., Udai A., Drobotun O. V., Ulianchych N. V.
Ivankova, V. S. Effects of brachytherapy on cytogenetic parameters and oxidative status in peripheral blood lymphocytes of gynecologic cancer patients / V. S. Ivankova [et al.]. - С.242-246
Другие авторы: Domina E. A., Khrulenko T. V., Makovetska L. I., Hrinchenko O. O., Baranovska L. M.
Rawoot, S. Neutrophil to lymphocyte ratio as a prognostic marker for non-metastatic renal cell carcinoma - does it add to what we already know? / S. Rawoot [et al.]. - С.247-251
Другие авторы: Punatar C., Singh V., Anand A., Shah B., Nagaonkar S., Joshi V.
Vlachou, M. S. Plasma ctDNA ras status selects patients for anti-EGER treatment rechallenge in metastatic colorectal cancer: a meta-analysis / M. S. Vlachou [et al.]. - С.252-256
Другие авторы: Mauri D., Zarkavelis G., Ntellas P., Tagkas C., Gkoura S., Pentheroudakis G.
Kukushkina, M. Safety profile and clinical outcome of adjuvant radiation therapy and intermediate-dose interferon in comparison with intermediate dose interferon alone in patients with melanoma metastases in regional lymph nodes and unfavorable prognostic factors / M. Kukushkina [et al.]. - С.252-260
Другие авторы: Korovin S., Diedkov S., Ostafiichuk V., Diedkov A.
Burlaka, A. P. Redox dependent features of tumors, adipose tissue. neutrophiles and platelets in patients with metastatic colorectal cancer / A. P. Burlaka [et al.]. - С.261-265
Другие авторы: Virko S. V., Burlaka A. A., Krupnyk K. L.
Kornatska, A. G. ESR1 gene variants affect FSHR-depended risk of fibrocystic mastopapthy in infertile women / A. G. Kornatska [et al.]. - С.266-269
Другие авторы: Rossokha Z. I., Fishchuk L. Ye., Dubenko O. D., Medvedieva N. I., Haksemberg M. A., Chubei G. V., Popova O. F., Gorovenko N. G.
Solyanik, G. I. Oxamate, an inhibitor of lactate dehydrogenase, can stimulate M2 polarization of peritoneal macrophages in mice with Lewis lung carcinoma / G. I. Solyanik [et al.]. - С.270-276
Другие авторы: Karaman O. M., Yakshibaeva Y. R., Pyaskovskaya O. N., Kolesnyk D. I.
Chekhun, V. F. Can SARS-CJV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical background) / V. F. Chekhun, E. A. Domina. - С.277-280
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2.


   
    ESR1 gene variants affect FSHR-depended risk of fibrocystic mastopathy in infertile women / A. G. Kornatska [et al.] // Experimental Oncology. - 2021. - Том 43, N 3. - P266-269


MeSH-главная:
БЕСПЛОДИЕ ЖЕНСКОЕ -- INFERTILITY, FEMALE (патофизиология)
МАСТОПАТИЯ ФИБРОЗНО-КИСТОЗНАЯ -- FIBROCYSTIC BREAST DISEASE (генетика, диагностика, этиология)
Аннотация: The infertile women have an increased risk of developing benign and malignant tumors, in particular, breast cancer. Most studies have examined the role of gene variants in the risk of developing breast cancer, but there is little evidence of genetic risk factors for benign tumors. Aim: To assess the combined genetic risk of developing mastopathy in women with FSHR (rs6165, rs6166) and ESR1 (rs9340799, rs2234693) gene variants. Materials and Methods: The study included 87 infertile women (45 with concomitant fibrocystic mastopathy and 42 without mastopathy). Results: For rs9340799 and rs2234693 variants of the ESR1 gene, we did not find any significant differences in the distribution of genotypes in infertile women with or without mastopathy. In patients with mastopathy, there was a reliable increase in the frequency of 307Ala/Ala and 680Ser/Ser genotypes of FSHR gene (χ2 = 6.39, p = 0.012, OR = 4.49 (1.48–13.65)) as compared to patients without mastopathy. In the presence of 307Thr/Thr and 680Asn/Asn genotypes of the FSHR gene, a 4.88-fold reduction of mastopathy risk (χ2 = 8.06, p = 0.005, OR = 0.21(0.07–0.59)) was observed. The frequency of the FSHR and the ESR1 genotypes combinations — 307Thr/Thr+680Asn/Asn+351AG+397TC was significantly decreased in patients with mastopathy. Conclusions: Our study did not find an association of ESR1 gene variants with the risk of developing of mastopathy in infertile women although heterozygous variants of the ESR1 gene enhanced the “protective” effect of FSHR gene variants and reduced the risk of mastopathy
Доп.точки доступа:
Kornatska, A. G.
Rossokha, Z. I.
Fishchuk, L. Ye.
Dubenko, O. D.
Medvedieva, N. I.
Haksemberg, M. A.
Chubei, G. V.
Popova, O. F.
Gorovenko, N. G.

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