Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Adsorption-rheological properties of blood serum in lung cancer patients [Текст] / Y. V. Dumanskiy [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 304-307. - Bibliogr. at the end of the art.

MeSH-главная:
ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS (кровь, патофизиология, этиология)
КРОВИ ВЯЗКОСТЬ -- BLOOD VISCOSITY (физиология)
ГЕМОРЕОЛОГИЯ -- HEMORHEOLOGY (физиология)
АДСОРБЦИЯ -- ADSORPTION (физиология)
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (анализ)
ЦИРРОЗЫ ПЕЧЕНИ -- LIVER CIRRHOSIS (кровь, патофизиология, этиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. Patients and Methods: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women. The parameters of surface (interfacial) viscosity, elasticity, viscoelasticity module, tension and relaxation of blood serum were studied by the oscillating drop method using a computer tensiometer “PAT2-Sinterface”, and its volumetric viscosity was investigated using a Low-Shear-30 rotational viscometer. ARPB parameters were also studied in a control group composed from 50 healthy donors. Results: Increased levels of volumetrical viscosity, surface tension, surface elasticity and the relaxation time of the blood are typical for patients with LC and depended on the localization of the tumor, its histological variant, differentiation grade, severity of the course of the disease, the number of metastases in the lymph nodes, distant organs and skeleton, involvement of the pleura and ribs, the development of compression pulmonary syndrome, metastasis into the spine, adrenals, brain, and pancreas. The surface-active, viscoelastic and relaxation properties of the blood correlated with the levels of tumor markers (TGFβ1, VEGF, C-reactive protein, α2-macroglobulin). Conclusions: Integral changes of ARPB observed in every fifth patient with LC are involved in the pathogenesis of the disease, have predictive value in relation to the clinical course of disease (volumetric viscosity) and the development of complications from radiochemotherapy (surface viscosity)
Доп.точки доступа:
Dumanskiy, Y. V.
Stoliarova, O. Y.
Syniachenko, O. V.
Giulmamedova, M. F.
Potapov, Y. A.

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Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas [Текст] / Y. V. Dumanskiy [та ін.] // Экспериментальная онкология. - 2020. - Т. 42, № 3. - С. 220-223. - Бібліогр.: в кінці ст.

MeSH-главная:
ЖЕЛУДКА НОВООБРАЗОВАНИЯ -- STOMACH NEOPLASMS (метаболизм, патофизиология, этиология)
КАРЦИНОМА ПЛОСКОКЛЕТОЧНАЯ -- CARCINOMA, SQUAMOUS CELL (метаболизм, патофизиология, этиология)
ОСНОВНОЙ ОБМЕН ВЕЩЕСТВ -- BASAL METABOLISM (физиология)
ПУРИНЫ -- PURINES (анализ, вредные воздействия, диагностическое применение, метаболизм)
МУЖЧИНЫ -- MEN
НЕОПЛАСТИЧЕСКИЕ ПРОЦЕССЫ -- NEOPLASTIC PROCESSES
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: To study the state of purine metabolism in gastric (GAC) and pulmonary (PAC) adenocarcinomas and to assess its clinical and pathogenetic significance. Patients and Methods: One hundred and six male patients were examined, among whom were 63 subjects aged 34 to 79 suffering from GAC, and 43 subjects aged 24 to 76 suffering from PAC. In GAC, the ratio of the pyloric, corporeal and antral localization of the tumor and variant of overall gastric lesion accounted to 24:5:1:1; and that of the central and peripheral PAC was 2:1. Serum levels of purine metabolism products (uric acid, oxypurinol, adenine, guanine, xanthine, hypoxanthine) were measured and activities of xanthine oxidase, xanthine deaminase, adenosine deaminase and 5-nucleotidase were analyzed. Results: Purine metabolism disorders are observed in all GAC and 91% of PAC patients; among other things, hyperuricemia is observed in ¾ and ½ of cases, respectively; moreover, the nature of changes is more pronounced in gastric cancer and, in both groups of patients, these indices reflect the disease course severity, are associated with the neoplastic process localization, have a predictive value, trigger the development of metastases. Conclusion: Сhanges in purine metabolism are involved in the pathogenetic patterns of GAC and PAC, reflect the course of the tumor process, are associated with tumor localization and have prognostic significance
Доп.точки доступа:
Dumanskiy, Y. V.
Stoliarova, O. Y.
Syniachenko, O. V.
Aliev, R. F.
Iermolaeva, М. V.
Sokrut, О. P.

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Dumanskiy, Y. V.
The Kі-67 marker for assessing the effectiveness of systemic or regional neoadjuvant polychemotherapy in patients with locally advanced breast cancer [Текст] / Y. V. Dumanskiy, O. V. Bondar, E. A. Stoliarchuk // Экспериментальная онкология. - 2019. - Т. 41, № 2. - С. 176-178. - Bibliogr. at the end of the art.

Аннотация: Over the past decades, breast cancer (BC) is the most common cancer and one of the key causes of mortality and disability among women in developed countries. Aim: Determination of the role of Ki-67 index in assessing the quality of neoadjuvant polychemotherapy treatment using regional or systemic delivery routes of pharmacological agents in patients with locally advanced breast cancer (LABC). Materials and Methods: The retrospective analysis of 30 clinical trials of LABC treatment based on selective intra-arterial therapy in patients with BC (T4A-DN0-3M0) was used. Results: The decrease in Ki-67 level in LABC after selective intra-arterial polychemotherapy was more pronounced than after systemic polychemotherapy. No correlation of the tumor metastatic potential with a Ki-67 level was detected. Conclusion: Assessment of Ki-67 expression allows to evaluate effectively the biological properties of the tumor, predict the course of the disease and choose the optimal tactics of neoadjuvant polychemotherapy (regional or systemic variant) as part of integrated antitumor treatment
Доп.точки доступа:
Bondar, O. V.
Stoliarchuk, E. A.

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Шифр: ЕУ12/2020/42/3
Журнал

Экспериментальная онкология [Текст]
2020г. Т. 42 № 3 . - 51.52, р.

Содержание:
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Ghosh, S. K. Antiproliferative and apoptotic effect of ethanolic extract of Calocybe indica on PANC-1 and MIAPaCa2 cell lines of pancreatic cancer / S. K. Ghosh, T. Sanyal. - С.178-182. - Бібліогр.: в кінці ст.
Sanaei, M. Effect of valproic acid and zebularine on SOCS-1 and SOCS-3 gene expression in colon carcinoma SW48 cell line / M. Sanaei, F. Kavoosi, H. Behjoo. - С.183-187. - Бібліогр.: в кінці ст.
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Шифр: ЕУ12/2017/39/4
Журнал

Экспериментальная онкология [Текст]
2017г. Т. 39 № 4 . - 34.76, р.

Содержание:
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Шифр: ЕУ12/2019/41/2
Журнал

Экспериментальная онкология [Текст]
2019г. Т. 41 № 2 . - 45.41, р.

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