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1.

Заглавие журнала :Экспериментальная онкология -2017г. т.39,N 4
Интересные статьи :
Liubich L. D. TGF-β1 expression by glioma C6 cells in vitro/ L. D. Liubich [та ін.] (стр.258-263)
Pyaskovskaya O. N. Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo/ O. N. Pyaskovskaya [та ін.] (стр.264-268)
Herrera-Covarrubias D. Stress during puberty facilitates precancerous prostate lesions in adult rats/ D. Herrera-Covarrubias [та ін.] (стр.269-275)
Caballero-Hernandez D. Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure/ D. Caballero-Hernandez [та ін.] (стр.276-280)
Bebeshko V. Assessment of the effect of wave device application on morphological changes in organs and cells of irradiated animals/ V. Bebeshko, I. Homolyako, V. Grynchyshyn (стр.281-285)
Matveeva A. The TGF-beta — SMAD pathway is inactivated in cronic lymphocytic leukemia cells/ A. Matveeva [та ін.] (стр.286-290)
Gordiienko I. M. CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells/ I. M. Gordiienko, L. M. Shlapatska, V. M. Kholodniuk (стр.291-298)
Buchynska L. G. DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay/ L. G. Buchynska [та ін.] (стр.299-303)
Dumanskiy Y. V. Adsorption-rheological properties of blood serum in lung cancer patients/ Y. V. Dumanskiy [та ін.] (стр.304-307)
Skrypnyk I. L-arginine is an effective medication for prevention of endothelial dysfunction a predictor of anthracycline cardiotoxicity in patients with acute leukemia/ I. Skrypnyk [та ін.] (стр.308-311)
Buchynska L. G. Phenotypic features of endometrial tumors in patients with family history of cancer/ L. G. Buchynska [та ін.] (стр.312-318)
Patial T. Consumptive hypothyroidism: an unusual paraneoplastic manifestation of a gastric gastrointestinal stromal tumor/ T. Patial [та ін.] (стр.319-321)
Volodymyr Serhiiovych Mosiienko (1934–2017) (стр.322)
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2.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Dumanskiy Y. V., Stoliarova O. Y., Syniachenko O. V., Giulmamedova M. F., Potapov Y. A.
Заглавие : Adsorption-rheological properties of blood serum in lung cancer patients
Место публикации : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 304-307 (Шифр ЕУ12/2017/39/4)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS
КРОВИ ВЯЗКОСТЬ -- BLOOD VISCOSITY
ГЕМОРЕОЛОГИЯ -- HEMORHEOLOGY
АДСОРБЦИЯ -- ADSORPTION
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL
ЦИРРОЗЫ ПЕЧЕНИ -- LIVER CIRRHOSIS
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. Patients and Methods: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women. The parameters of surface (interfacial) viscosity, elasticity, viscoelasticity module, tension and relaxation of blood serum were studied by the oscillating drop method using a computer tensiometer “PAT2-Sinterface”, and its volumetric viscosity was investigated using a Low-Shear-30 rotational viscometer. ARPB parameters were also studied in a control group composed from 50 healthy donors. Results: Increased levels of volumetrical viscosity, surface tension, surface elasticity and the relaxation time of the blood are typical for patients with LC and depended on the localization of the tumor, its histological variant, differentiation grade, severity of the course of the disease, the number of metastases in the lymph nodes, distant organs and skeleton, involvement of the pleura and ribs, the development of compression pulmonary syndrome, metastasis into the spine, adrenals, brain, and pancreas. The surface-active, viscoelastic and relaxation properties of the blood correlated with the levels of tumor markers (TGFβ1, VEGF, C-reactive protein, α2-macroglobulin). Conclusions: Integral changes of ARPB observed in every fifth patient with LC are involved in the pathogenesis of the disease, have predictive value in relation to the clinical course of disease (volumetric viscosity) and the development of complications from radiochemotherapy (surface viscosity)
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3.

Заглавие журнала :Экспериментальная онкология -2019г. т.41,N 2
Интересные статьи :
Verma S. Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies/ S. Verma [та ін.] (стр.90-94)
Syvyk A. E. Inducible dominant negative ErbB2 rat spermatogonial line for generation of transgenic rat model and dissecting ERBB2 tyrosine kinase mediated pathways/ A. E. Syvyk, T. L. Syvyk (стр.95-105)
Prylutska S. V. Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma/ S. V. Prylutska [та ін.] (стр.106-111)
Petrellis M. C. Proinflammatory effects of photoactivated methylene blue on rat model of Walker 256 carcinosarcoma/ M. C. Petrellis [та ін.] (стр.112-122)
Kolesnik D. L. Metformin enhances antitumor action of sodium dichloroacetate against glioma C6/ D. L. Kolesnik [та ін.] (стр.123-129)
Herrera-Covarrubias D. Prepuberal stress and obesity: effects on serum corticosterone, prolactin, testosterone and precancerous prostate lesions in adult rats/ D. Herrera-Covarrubias [та ін.] (стр.130-137)
Buchynska L. G. Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas/ L. G. Buchynska, O. V. Brieiev, N. P. Iurchenko (стр.138-143)
Kravets O. V. Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma/ O. V. Kravets [та ін.] (стр.144-147)
Burlaka A. P. Tumor-associated redox state in metastatic colorectal cancer/ A. P. Burlaka [та ін.] (стр.148-152)
Tajaldeen A. Investigation of dosimetric impact of organ motion in static and dynamic conditions for three stereotactic ablative body radiotherapy techniques: 3D conformal radiotherapy, intensity modulated radiation therapy, and volumetric modulated arc therapy by usi/ A. Tajaldeen, S. Alghamdi (стр.153-159)
Yakovlev P.G. Bladder sparing surgery in high-grade bladder cancer/ P. G. Yakovlev, D. A. Klyushin, R. I. Vereshchako (стр.160-165)
Cešeiko R. The impact of maximal strength training on quality of life among women with breast cancer undergoing treatment/ R. Cešeiko [та ін.] (стр.166-172)
Ben Kridis W. Prognostic factors in metastatic gastric carcinoma/ Kridis W. Ben [та ін.] (стр.173-175)
Dumanskiy Y. V. The Kі-67 marker for assessing the effectiveness of systemic or regional neoadjuvant polychemotherapy in patients with locally advanced breast cancer/ Y. V. Dumanskiy, O. V. Bondar, E. A. Stoliarchuk (стр.176-178)
Starchenko I. I. The observation of congenital retroperitoneal large size neuroblastoma / I. I. Starchenko [та ін.] (стр.179-181)
Ben Kridis W. Buschke — Lowenstein anal tumor: an ambiguous entity/ Kridis W. Ben [та ін.] (стр.182-184)
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4.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Dumanskiy Y. V., Bondar O. V., Stoliarchuk E. A.
Заглавие : The Kі-67 marker for assessing the effectiveness of systemic or regional neoadjuvant polychemotherapy in patients with locally advanced breast cancer
Место публикации : Экспериментальная онкология. - 2019. - Т. 41, № 2. - С. 176-178 (Шифр ЕУ12/2019/41/2)
Примечания : Bibliogr. at the end of the art.
Аннотация: Over the past decades, breast cancer (BC) is the most common cancer and one of the key causes of mortality and disability among women in developed countries. Aim: Determination of the role of Ki-67 index in assessing the quality of neoadjuvant polychemotherapy treatment using regional or systemic delivery routes of pharmacological agents in patients with locally advanced breast cancer (LABC). Materials and Methods: The retrospective analysis of 30 clinical trials of LABC treatment based on selective intra-arterial therapy in patients with BC (T4A-DN0-3M0) was used. Results: The decrease in Ki-67 level in LABC after selective intra-arterial polychemotherapy was more pronounced than after systemic polychemotherapy. No correlation of the tumor metastatic potential with a Ki-67 level was detected. Conclusion: Assessment of Ki-67 expression allows to evaluate effectively the biological properties of the tumor, predict the course of the disease and choose the optimal tactics of neoadjuvant polychemotherapy (regional or systemic variant) as part of integrated antitumor treatment
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5.

Заглавие журнала :Экспериментальная онкология -2020г. т.42,N 3
Интересные статьи :
Chekhun V. F. Association of circulating miR-21, -205, and -182 with response of luminal breast cancers to neoadjuvant FAC and AC treatment/ V. F. Chekhun [та ін.] (стр.162-166)
Kirkilevsky S. I. Prognostic significance of microRNA-200b and ERCC1 expression in tumor cells of patients with esophageal cancer/ S. I. Kirkilevsky [та ін.] (стр.167-171)
Abramenko I. V. Analysis of immunoglobulin heavy variable chain rearrangement in chronic lymphocytic leukemia patients among Chornobyl clean-up workers/ I. V. Abramenko [та ін.] (стр.172-177)
Ghosh S. K. Antiproliferative and apoptotic effect of ethanolic extract of Calocybe indica on PANC-1 and MIAPaCa2 cell lines of pancreatic cancer/ S. K. Ghosh, T. Sanyal (стр.178-182)
Sanaei M. Effect of valproic acid and zebularine on SOCS-1 and SOCS-3 gene expression in colon carcinoma SW48 cell line/ M. Sanaei, F. Kavoosi, H. Behjoo (стр.183-187)
Mehri S. Osteopontin siRNA does not confer resistance to toxic effects of parthenolide in Jurkat cells/ S. Mehri [та ін.] (стр.188-191)
Pyaskovskaya O. N. Tumor microenvironment changes tumor cell sensitivity to action of energy metabolism modifiers/ O. N. Pyaskovskaya [та ін.] (стр.192-196)
Symchych T. V. Functions of tumor-associated macrophages and macrophages residing in remote anatomical niches in Ehrlich carcinoma bearing mice/ T. V. Symchych [та ін.] (стр.197-203)
Todor I. N. Biomagnetism of tumor in rats with Guerin’s carcinoma after injection of ferromagnetic nanocomposite (Ferroplat): contactless measurement/ I. N. Todor [та ін.] (стр.204-207)
Çavuş B. Assessment of prognostic and diagnostic value of some biomarkers in hepatocellular carcinoma/ B. Çavuş [та ін.] (стр.208-214)
Babkina T. M. Detection of breast cancer presenting as a mass in women with dense breasts — digital breast tomosynthesis versus full-field digital mammography/ T. M. Babkina [та ін.] (стр.215-219)
Dumanskiy Y. V. Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas/ Y. V. Dumanskiy [та ін.] (стр.220-223)
Stakhovskyi O. E. Quality of life in patients after radical cystectomy with modified ureterocutaneostomy and Bricker urinary diversion/ O. E. Stakhovskyi [та ін.] (стр.224-227)
Kravets O. V. Comparative analysis of the efficacy of definitive chemoradiation therapy and surgery followed by adjuvant radiation therapy in advanced-stage oral tongue cancer/ O. V. Kravets [та ін.] (стр.228-232)
Baranovska V. V. Histological differential diagnostics of renal oncocytoma/ V. V. Baranovska, A. M. Romanenko, L. M. Zakhartseva (стр.233-237)
Trociukas I. Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma/ I. Trociukas [та ін.] (стр.238-241)
Golovko A. Thyroid metastasis of vaginal leiomyosarcoma: a case report and review of the literature/ A. Golovko [та ін.] (стр.242-244)
Filenko B. M. Clinicomorphological observation of refractory hepatoblastoma: a case report/ B. M. Filenko [та ін.] (стр.245-247)
Zinovkin D. A. Water clear cell adenoma of parathyroid gland: a rare lesion/ D. A. Zinovkin, M. Yu. Zhandarov, M. Z .I. Pranjol (стр.248)
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6.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Dumanskiy Y. V., Stoliarova O. Y., Syniachenko O. V., Aliev R. F., Iermolaeva М. V., Sokrut О. P.
Заглавие : Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas
Место публикации : Экспериментальная онкология. - 2020. - Т. 42, № 3. - С. 220-223 (Шифр ЕУ12/2020/42/3)
Примечания : Бібліогр.: в кінці ст.
MeSH-главная: ЖЕЛУДКА НОВООБРАЗОВАНИЯ -- STOMACH NEOPLASMS
КАРЦИНОМА ПЛОСКОКЛЕТОЧНАЯ -- CARCINOMA, SQUAMOUS CELL
ОСНОВНОЙ ОБМЕН ВЕЩЕСТВ -- BASAL METABOLISM
ПУРИНЫ -- PURINES
МУЖЧИНЫ -- MEN
НЕОПЛАСТИЧЕСКИЕ ПРОЦЕССЫ -- NEOPLASTIC PROCESSES
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: To study the state of purine metabolism in gastric (GAC) and pulmonary (PAC) adenocarcinomas and to assess its clinical and pathogenetic significance. Patients and Methods: One hundred and six male patients were examined, among whom were 63 subjects aged 34 to 79 suffering from GAC, and 43 subjects aged 24 to 76 suffering from PAC. In GAC, the ratio of the pyloric, corporeal and antral localization of the tumor and variant of overall gastric lesion accounted to 24:5:1:1; and that of the central and peripheral PAC was 2:1. Serum levels of purine metabolism products (uric acid, oxypurinol, adenine, guanine, xanthine, hypoxanthine) were measured and activities of xanthine oxidase, xanthine deaminase, adenosine deaminase and 5-nucleotidase were analyzed. Results: Purine metabolism disorders are observed in all GAC and 91% of PAC patients; among other things, hyperuricemia is observed in ¾ and ½ of cases, respectively; moreover, the nature of changes is more pronounced in gastric cancer and, in both groups of patients, these indices reflect the disease course severity, are associated with the neoplastic process localization, have a predictive value, trigger the development of metastases. Conclusion: Сhanges in purine metabolism are involved in the pathogenetic patterns of GAC and PAC, reflect the course of the tumor process, are associated with tumor localization and have prognostic significance
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