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1.

Заглавие журнала :Экспериментальная онкология -2017г. т.39,N 1
Интересные статьи :
Circulating tumor cells in breast cancer (стр.2-11)
Kashuba E. Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?/ E. Kashuba, M. Mushtag (стр.12-16)
Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro (стр.17-24)
Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics (стр.25-29)
Parthenolide reduces gene transcription of prosurvival mediators in U937 cells (стр.30-35)
Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells (стр.36-41)
Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma (стр.42-48)
EPR spectroscopy studies of changes in erythrocyte membranes in patients with laryngeal cancer (стр.49-52)
Auzina D. Prognostic value of the bone turnover markers in multiple myeloma/ D. Auzina, R. Erts, S. Lejniece (стр.53-56)
Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population (стр.57-64)
Chekhun V.F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes/ V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova (стр.65-68)
Satinder K. Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women/ K. Satinder, R. C. Sobti, K. Pushpinder (стр.69-74)
The impact of coloregional treatment on survival of patients with primary metastatic breast cancer (стр.75-77)
Diagnostic challenges with intraoral myeloid sarcoma (стр.78-85)
Trichilemmal cystis in metastatic melanoma (стр.86-87)
Materials of international vactrain/ 3-rd Swedish-Ukrainian conference on cancer diseases, January 16-17, 2017, Stockholm, Sweden (стр.88-93)
Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells (стр.88-89)
The adaptor protein Ruk/CIN85 paradoxically enhances EMT of triple negative mouse breast adenocarcinoma 4T1 cells (стр.89)
Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines (стр.89-90)
Alternative direction of inhibition of malignant properties in tumor cells in vitro and in vivo by gene therapy with INF-beta gene in recombinant baculovirus vector (стр.90)
CD150/SLAMF1 as a new potential target for anti-tumor therapy (стр.90-91)
CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia (стр.91-92)
Borikun T. Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer/ T. Borikun, N. Lukianova, V. Chekhun (стр.92)
The MRPS 18-2 protein as a putative marker of carcinogenesis (стр.92)
High expression levels of MRPS 18-2 and presence of the RB protein are required for the maintenance of stem cell phenotype (стр.92-93)
Mankovska O. Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors/ O. Mankovska, V. Kashuba (стр.93)
Brieieva O. Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients/ O. Brieieva, I. Nesina, L. Buchynska (стр.93)
Kyiv, May 11-12, 2017 Workshop with international participation. New trends in cancer research and innovative tumor vaccines (стр.94)
International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine (стр.95)
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2.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Brieieva O., Nesina I., Buchynska L.
Заглавие : Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients
Место публикации : Experimental Oncology. - К., 2017. - Том 39, N 1. - С. 93 (Шифр ЕУ12/2017/39/1)
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
ГИДРОКСИЭСТРОНЫ -- HYDROXYESTRONES
ЛИМФОЦИТЫ -- LYMPHOCYTES
Аннотация: The endometrial cancer (EC) pathogenesis to a large extent may be determined by genotoxic effects of estrogen metabolites, among which the 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. Genomic instability and sensitivity to genotoxic estrogen metabolites in cells of EC patients depend on the DNA repair efficiency. The aim of the study was to analyze the level of DNA damage in peripheral blood lymphocytes (PBL) of EC patients after treatment with the 4OHE2 and to evaluate the repair efficiency of induced DNA damag
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3.

Заглавие журнала :Экспериментальная онкология -2019г. т.41,N 4
Интересные статьи :
Karaman O. M. Macrophages - a perspective target for antineoplastic immunotherapy/ O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun (стр.282-290)
Orel V. E. Nоn-linear dynamics theory and malignant melanoma/ V. E. Orel [et al.] (стр.291-299)
Lisyany N. I. Cytomegaloviruses and malignant brain tumors/ N. I. Lisyany [et al.] (стр.300-303)
Woksepp H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392/ H. Woksepp [et al.] (стр.304-311)
Dehghan Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression/ Nayeri M. J. Dehghan [et al.] (стр.312-317)
Albuquerque A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation/ A. P. B. Albuquerque [et al.] (стр.318-322)
Skuja E. Deletions in metastatic colorectal cancer with chromothripsis/ E. Skuja [et al.] (стр.323-327)
Burlaka A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer/ A. P. Burlaka [et al.] (стр.328-334)
Buchynska L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma/ L. G. Buchynska, L. A. Naleskina, I. P. Nesina (стр.335-341)
Zelinskaya A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer/ A. Zelinskaya (стр.342-345)
Moazeni-Roodi A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls/ A. Moazeni-Roodi, M. Taheri, M. Hashemi (стр.346-352)
Skrypnyk I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy/ I. Skrypnyk [et al.] (стр.353-356)
Gavars D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia/ D. Gavars [et al.] (стр.357-362)
Prylutskyi M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles/ M. P. Prylutskyi, M. F. Starodub (стр.363-365)
Shkatula P. M. International scientific conference "Tumor and Host: novel aspects of old problem"/ P. M. Shkatula (стр.366-367)
To the 120th birthday anniversary of academician R. E. Kavetsky (стр.368-369)
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4.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Naleskina L. A., Nesina I. P.
Заглавие : Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma
Место публикации : Experimental Oncology. - К., 2019. - Том 41, N 4. - С. 335-341 (Шифр ЕУ12/2019/41/4)
Аннотация: The aim of the study was to evaluate the morphological features of endometrioid carcinoma of the endometrium (ECE) of low differentiation grade with different invasive potential and to characterize their molecular phenotype by the expression of a number of adhesion markers. Materials and Methods: We have studied the samples of operation material of 37 patients with ECE of low differentiation grade with deep invasion ( ½ myometrium), n = 26, and with invasion ½ myometrium, n
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5.

Заглавие журнала :Экспериментальная онкология -2021г. т.43,N 4
Интересные статьи :
Nesina I. Peculiari of epithelial-mesenchymal transition in endometrial carcinomas/ I. Nesina (стр.282-289)
Yildirim-Kahriman S. Non-intrinsic cancer risk factors/ S. Yildirim-Kahriman (стр.290-297)
Kovalevska L. Differential expression patterns of AIP, UCKL1, and PKN1 genes in breast cancer of different molecular subtypes/ L. Kovalevska [et al.] (стр.298-305)
Svyrydova K. Comparative characteristics of DNA loop domaing rearrangement in glioblastoma multiforme T98G and glioblastoma astrocytoma U373 cell lines under different culture conditions/ K. Svyrydova [et al.] (стр.306-311)
Gordiienko I. M. SLAMF1/CD150 expression and topology in prostate and breast cancer cell lines/ I. M. Gordiienko [et al.] (стр.312-316)
Herrera-Covarrubias D. Effects of obesity in rats on prostate histology and expression of leptin receptor, prolactin receptor, IL-6, and NF-кB/ D. Herrera-Covarrubias [et al.] (стр.317-321)
Studennikov A. E. Detection of antibodies against benzo[A]pyrene in blood sera of lung cancer patients by ELISA using human recombinant idiotypic and anti-idiotypic antibodies/ A. E. Studennikov, A. N. Glushkov, V. A. Ustinov (стр.323-327)
Ata Abbasi. High grade breast ductal carcinomas have high density of tumor-associated macrophages/ Abbasi Ata [et al.] (стр.328-330)
Zakhartseva L. Tumor-infiltrating lymphocytes as easily accessible prognostic tool in adenocarcinoma of the colon/ L. Zakhartseva, B. Shkurupii (стр.331-335)
Kostiukova N. I. CYP2C19*2 gene variant (G681A, RS4244285) as a prognostic marketr for the clinical course of multiple myeloma/ N. I. Kostiukova [et al.] (стр.336-340)
Lukavenko I. M. Positive association between SRA1 RS801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females/ I. M. Lukavenko [et al.] (стр.341-345)
Kriachok I. Ukrainian prospective study in patients with T-cell non-hodgkin lymphomas/ I. Kriachok [et al.] (стр.346-350)
Golovko T. S. Comparison of ultrasound and MRI informativeness for detection and treatment monitoring of cervical cancer metastases in the vagina/ T. S. Golovko [et al.] (стр.351-358)
Sakhno L. A. Efficacy of dispersed fibrous carbon sorbent in treatment of malignant fungating wounds/ L. A. Sakhno [et al.] (стр.359-364)
Movchan O. M. Features of recurrence of endometrioid type endometrial cancer of I stage/ O. M. Movchan [et al.] (стр.365-369)
Kernychnyi V. V. Distal sacrectomy for recurrent rectal cancer/ V. V. Kernychnyi, B. E. Li (стр.370-372)
Zaichuk V. V. The giant phyllodes tumor of the breast - a case report/ V. V. Zaichuk [et al.] (стр.373-375)
Janowska A. An unusual presentation of primary cutaneous follicle center lymphoma/ A. Janowska [et al.] (стр.376-378)
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6.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Nesina I.
Заглавие : Peculiari of epithelial-mesenchymal transition in endometrial carcinomas
Место публикации : Experimental Oncology. - К., 2021. - Том 43, N 4. - С. 282-289 (Шифр ЕУ12/2021/43/4)
MeSH-главная: КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID
ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМНЫЙ ПЕРЕХОД -- EPITHELIAL-MESENCHYMAL TRANSITION
Аннотация: Epithelial-mesenchymal transition is an important component of tumor progression, due to which the cells of malignant neoplasms acquire invasive and migratory properties. Analysis of the literature and our own data show that the activation of proteins involved in epithelial-mesenchymal transition crucially affects the progression of endometrioid carcinoma of the endometrium and the significant variability of their expression could determine the clinical and morphological heterogeneity of this cancer. The most aggressive endometrioid carcinomas of the endometrium are characterized by a hybrid epithelial-mesenchymal phenotype, which is often associated with a collective type of invasion of endometrial tumor cells into the myometrium
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7.

Заглавие журнала :Экспериментальная онкология -2017г. т.39,N 4
Интересные статьи :
Liubich L. D. TGF-β1 expression by glioma C6 cells in vitro/ L. D. Liubich [та ін.] (стр.258-263)
Pyaskovskaya O. N. Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo/ O. N. Pyaskovskaya [та ін.] (стр.264-268)
Herrera-Covarrubias D. Stress during puberty facilitates precancerous prostate lesions in adult rats/ D. Herrera-Covarrubias [та ін.] (стр.269-275)
Caballero-Hernandez D. Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure/ D. Caballero-Hernandez [та ін.] (стр.276-280)
Bebeshko V. Assessment of the effect of wave device application on morphological changes in organs and cells of irradiated animals/ V. Bebeshko, I. Homolyako, V. Grynchyshyn (стр.281-285)
Matveeva A. The TGF-beta — SMAD pathway is inactivated in cronic lymphocytic leukemia cells/ A. Matveeva [та ін.] (стр.286-290)
Gordiienko I. M. CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells/ I. M. Gordiienko, L. M. Shlapatska, V. M. Kholodniuk (стр.291-298)
Buchynska L. G. DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay/ L. G. Buchynska [та ін.] (стр.299-303)
Dumanskiy Y. V. Adsorption-rheological properties of blood serum in lung cancer patients/ Y. V. Dumanskiy [та ін.] (стр.304-307)
Skrypnyk I. L-arginine is an effective medication for prevention of endothelial dysfunction a predictor of anthracycline cardiotoxicity in patients with acute leukemia/ I. Skrypnyk [та ін.] (стр.308-311)
Buchynska L. G. Phenotypic features of endometrial tumors in patients with family history of cancer/ L. G. Buchynska [та ін.] (стр.312-318)
Patial T. Consumptive hypothyroidism: an unusual paraneoplastic manifestation of a gastric gastrointestinal stromal tumor/ T. Patial [та ін.] (стр.319-321)
Volodymyr Serhiiovych Mosiienko (1934–2017) (стр.322)
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8.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Lurchenko N. P., Glushchenko N. M., Nesina I. P.
Заглавие : Phenotypic features of endometrial tumors in patients with family history of cancer
Место публикации : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 312-318 (Шифр ЕУ12/2017/39/4)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
ГЕНЕТИЧЕСКАЯ ПРЕДРАСПОЛОЖЕННОСТЬ К БОЛЕЗНИ -- GENETIC PREDISPOSITION TO DISEASE
ФЕНОТИП -- PHENOTYPE
ГЕННОЙ ЭКСПРЕССИИ НОВООБРАЗОВАНИЙ РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION, NEOPLASTIC
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Аннотация: To determine the peculiarities of expression of a number of proteins-regulators of the cell cycle in endometrial cancer (EC) cells in patients with a family history of oncological pathologies. Patients and Methods: 95 EC patients (stage І–ІІ) were included into the study. Clinical-genealogical analysis was performed. 54 patients (group I) had healthy relatives, and in families of 41 patients (group II) an aggregation of malignant tumors of different genesis (mainly tumors of the gastrointestinal tract and the female reproductive system) was recorded. p53, р21WAF1/CIP1, р16INK4a, and Ki-67 were assessed immunohistochemically in the surgical samples. Results: In the majority of patients, both from group I and II, moderately differentiated tumors were observed (in 38.9 and 46.3% of cases, respectively), mainly with deep myometrium invasion (64.8 and 58.5% of cases, respectively). In EC patients from group II, a significantly higher number of р16INK4a-positive cells (17.7 ± 1.7%; p = 0.001) and lower number of p53-positive (30.9 ± 3.2%; p = 0.05) and Ki-67-positive (26.9 ± 2.7%; p = 0.048) cells was observed compared to those in tumors of patients from group I (12.0 ± 1.6; 37.7 ± 2.8 and 36.7 ± 3.4%, respectively). Conclusion: Phenotypic features of the EC in the patients with family history of cancer differ from those in tumors of patients without such aggregation. The biological heterogeneity of EC seems to relate to the oncogenealogical history of patients. Also this biological heterogeneity is linked to the molecular features of EC cells, which affects cancer aggressiveness and the course of the disease
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9.

Заглавие журнала :Экспериментальная онкология -2018г. т.40,N 3
Интересные статьи :
Akbarzadeh A. Role of dendrimers in advanced drug delivery and biomedical applications: a review/ A. Akbarzadeh [та ін.] (стр.178-183)
Zadvornyi T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro/ T. V. Zadvornyi [та ін.] (стр.184-189)
Harper P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies/ P. Harper [та ін.] (стр.190-193)
Apykhtina О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles/ О. L. Apykhtina [та ін.] (стр.194-199)
Chekhun V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats/ V. F. Chekhun [та ін.] (стр.200-204)
Prokhorova I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6/ I. V. Prokhorova [та ін.] (стр.205-210)
Abramenko I. V. . Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients/ I. V. Abramenko [та ін.] (стр.211-217)
Nesina I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma/ I. P. Nesina, N. P. Iurchenko, L. G. Buchynska (стр.218-222)
Vernygorodskyi S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction/ S. Vernygorodskyi, T. Rekun, P. Zhuchenko (стр.223-227)
Gerashchenko T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles/ T. S. Gerashchenko [та ін.] (стр.228-234)
Agishev T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury/ T. T. Agishev [та ін.] (стр.235-238)
Dumansky Yu. V. Paraneoplastic syndrome in lung cancer/ Yu. V. Dumansky [та ін.] (стр.239-242)
Grybach S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome/ S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun (стр.243-248)
Chrysanthakopoulos N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study/ N. A. Chrysanthakopoulos, N. S. Dareioti (стр.249-250)
Tkachenko R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy/ R. Tkachenko, A. Golovko, O. Kuryk (стр.251-253)
Svitlana Pavlivna Sidorenko (1953–2018) (стр.254-255)
Yurii Yosypovych Kudryavets (1946–2018) (стр.256-257)
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Nesina I. P., Iurchenko N. P., Buchynska L. G.
Заглавие : Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma
Место публикации : Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 218-222 (Шифр ЕУ12/2018/40/3)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
КЛЕТКИ ПРОЛИФЕРАЦИЯ -- CELL PROLIFERATION
КАДГЕРИНЫ -- CADHERINS
БЕТА-КАТЕНИН -- BETA CATENIN
ВИМЕНТИН -- VIMENTIN
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Аннотация: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p 0.001 and 54.5 ± 2.6%, respectively, p 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin
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11.

Заглавие журнала :Экспериментальная онкология -2020г. т.42,N 4
Интересные статьи :
Commitment to ideals of science. To the 90th birthday anniversary of academician Vadym Pinchuk (стр.250-251)
Naleskina L. A. Modern views on the role of main components of stroma and tumor microinvironment in invasion, migration and metastasis/ L. A. Naleskina, L. M. Kunska, V. F. Chekhun (стр.252-262)
Gaptulbarova K. A. NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer/ K. A. Gaptulbarova [та ін.] (стр.263-269)
Tykhomyrov A. A. Plasminogen/plasmin affects expression of glycolysis regulator TIGAR and induces autophagy in lung adenocarcinoma A549 cells/ A. A. Tykhomyrov [та ін.] (стр.270-276)
Kumar A. Microarray based gene expression profiling of advanced gall bladder cancer/ A. Kumar [та ін.] (стр.277-284)
Auziņa D. Dickkopf-related protein 1 expression in bone marrow of multiple myeloma patients: correlation with bone disease and plasma cell malignancy type/ D. Auziņa [та ін.] (стр.285-288)
Buchynska L. G. Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium/ L. G. Buchynska [та ін.] (стр.289-294)
Kovalevska L. Expression pattern of MRPS18 family genes in malignantly transformed b-cells/ L. Kovalevska, E. Kashuba (стр.295-299)
Buchynska L. G. Molecular phenotype of high-grade endometrioid carcinoma of the endometrium/ L. G. Buchynska [та ін.] (стр.300-305)
Shamrai D. Granulosa and theca cell tumor in rat’s ovary after modified Biskind operation/ D. Shamrai, E. Koshik, N. Melnyk (стр.306-309)
Bolgova L. S. Histogenesis of central lung cancer: cytological investigation/ L. S. Bolgova [та ін.] (стр.310-313)
Shcherbynina M. Histological criteria for “intraepithelial squamous cell carcinoma” of the esophagus: continued dialogue between Ukrainian and Japanese pathologists/ M. Shcherbynina, M. Itabashi, N. Soloviova (стр.314-317)
Yevstakhevych Yu. L. Autoimmune cytopenia in chronic lymphocytic leukemia: diagnosis and treatment/ Yu. L. Yevstakhevych [та ін.] (стр.318-323)
Korovin S. Burden of malignant melanoma in Ukraine in 2002–2013: incidence, mortality and survival/ S. Korovin [та ін.] (стр.324-329)
Burlaka A. P. Cytochrome P450 content in primary tumors and liver metastases of patients with metastatic colorectal cancer/ A. P. Burlaka [та ін.] (стр.330-332)
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12.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Borykun T. V., Iurchenko N. P., Nespryadko S. V., Nesina I. P.
Заглавие : Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium
Место публикации : Экспериментальная онкология. - 2020. - Т. 42, № 4. - С. 289-294 (Шифр ЕУ12/2020/42/4)
Примечания : Бібліогр.: в кінці ст.
MeSH-главная: КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID
ГЕННОЙ ЭКСПРЕССИИ НОВООБРАЗОВАНИЙ РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION, NEOPLASTIC
МОРФОЛОГИЧЕСКИЕ И МИКРОСКОПИЧЕСКИЕ ПОКАЗАТЕЛИ -- MORPHOLOGICAL AND MICROSCOPIC FINDINGS
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY
ПОЛИМЕРАЗНАЯ ЦЕПНАЯ РЕАКЦИЯ -- POLYMERASE CHAIN REACTION
ЦИТОФЛЮОРОМЕТРИЯ -- FLOW CYTOMETRY
ГЕНЕТИЧЕСКАЯ ГЕТЕРОГЕННОСТЬ -- GENETIC HETEROGENEITY
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Ключевые слова (''Своб.индексиров.''): экспрессии мир-34а, мир-125b, мир-142 и мир-101
Аннотация: It is known that more than half of the genes encoding human proteins are regulated by various microRNAs (miRNAs, miR), the expression of which may be associated with various pathological conditions. At the same time, the question of assessing the relationship between the expression of particular miRNAs and the aggressive molecular subtype of endometrial cancer remains open. Aim of the study was to determine the relationship between the expression of miR-34a, miR-125b, miR-142 and miR-101 in endometrioid carcinomas of the endometrium (ECE) and the features of the disease course. Materials and Methods: The samples of surgical material of 51 patients with ECE (mean age 59.8 ± 7.1 years), I–III stage were investigated using morphological, immunohistochemical methods, real time polymerase chain reaction (PCR), cytofluorometry. Results: In endometrial tumors with high proliferation index ( Me), the expression of miR-34a, miR-142 and miR-125b significantly decreased (1.8, 2.7 and 1.5 times, respectively) compared with those in ECE with low proliferation index ( Me). The expression of all studied miRNAs was lower in G3 tumors and those that deeply invaded the myometrium compared to G2 carcinomas and tumors with an invasion of 1/2 myometrium and significantly decreased in tumors of patients with low stage III compared with stage I–II. The high ( Me) microvessel density in ECE was associated with a significant decrease of miR-125b and miR-101 expression, and the presence of signs of epithelial-mesenchymal transition — with a decreased expression of miR-34a and miR-101. Conclusions: The study revealed a significant heterogeneity of expression of miR-34a, miR-125b, miR-142 and miR-101 in ECE, which is associated with changes in morphofunctional characteristics of endometrial carcinoma
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13.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Glushchenko N. M., Nesina I. P., Brieieva O. V., Iurchenko N. P.
Заглавие : Molecular phenotype of high-grade endometrioid carcinoma of the endometrium
Место публикации : Экспериментальная онкология. - 2020. - Т. 42, № 4. - С. 300-305 (Шифр ЕУ12/2020/42/4)
Примечания : Бібліогр.: в кінці ст.
MeSH-главная: КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID
МОЛЕКУЛЯРНАЯ БИОЛОГИЯ -- MOLECULAR BIOLOGY
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL
ГЕНЫ MYC -- GENES, MYC
НОВООБРАЗОВАНИЙ СУПРЕССОРНЫЕ БЕЛКИ -- TUMOR SUPPRESSOR PROTEINS
ДИАГНОСТИКИ МОЛЕКУЛЯРНОЙ МЕТОДЫ -- MOLECULAR DIAGNOSTIC TECHNIQUES
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Ключевые слова (''Своб.индексиров.''): р53highfoxp3lowc-mychigh
Аннотация: Prognosis of the course of tumor progression is one of urgent problems of clinical oncology. A relevant specificity of endometrial cancer is its clinical polymorphism within the same histological type of the disease. The search for molecular-biological features associated with the aggressive phenotype of endometrioid carcinomas is indisputably urgent. Aim: To study molecular-biological features of endometrioid carcinoma of the endometrium (ECE) and to identify the molecular subtype of tumors with high potential of malignancy. Materials and Methods: Surgical specimens of 127 patients with EC, stages I–II, aged 36–72 (the average age — 59.3 ± 3.2) were studied using morphological and immunohistochemical methods. The multivariant analysis with the Kullback’s informative measure and PanelomiX were used to estimate the significance of the expression of specific biomarkers. Results: The expression of a complex of multifunctional markers was evaluated in ECE cells of different malignancy stage: p53, FOXP3, p21WAF1/CIP1, р16INK4a, E2F1, cyclins Е and D1, Her2/neu, с-Myc, Е-cadherin, β-catenin, vimentin, CD44, CD24. A triad of biomarkers with threshold expression levels was determined (р53 45%; FOXP3 14%; с-Myc 10%). The high expression of oncogene c-Myc and oncosuppressor p53 along with the low level of FOXP3 in tumor cells of ECE was associated with high proliferative potential, low differentiation grade, and deep invasion of a tumor into the myometrium. Conclusions: The molecular phenotype of ECE, most informative in terms of specificity and sensitivity (95%) — р53highFOXP3lowc-Mychigh, was first characterized, which would help identify a high-grade subtype of this cancer form
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