Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Шифр: УУ60/2020/92/5
Журнал

The Ukrainian biochemical journal [Текст]. - Выходит раз в два месяца
2020г. Т. 92 № 5

Содержание:
Akopova, O. V. ATP-sensitive potassium transport in rat brain mitochondria is highly sensitive to mK ATP channels openers: a light scattering study / O. V. Akopova [et at.]. - P.5-14
Другие авторы: Kolchinskaya L. I., Nosar V. I., Smirnov A. N., Bratus L. V.
Bobrovnik, S. A. Kinetics of interaction between polyreactive immunoglobulins and antigen / S. A. Bobrovnik [et al.]. - P.15-22
Другие авторы: Ogloblya O. V., Demchenko M. O., Komisarenko S. V.
Pokhodylo, N. Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents / N. Pokhodylo [et al.]. - P.23-32
Другие авторы: Shyyka O., Finiuk N., Stoika R.
Shahouzehi, B. L-carnitine administration effects on AMPK, APPL1 and PPARγ genes expression in the liver and serum adiponectin levels and HOMA-IR in type 2 diabetes rat model induced by STZ and nicotinamide / B. Shahouzehi, H. Fallah, Y. Masoumi-Ardakani. - P.33-40
Gulevskyy, A. K. Cryoprotective agents affect amino acids incorporation into total proteins in cells of lymphoid organs and liver of experimental animals / A. K. Gulevskyy, Yu. S. Akhatova, A. Yu. Nikolchenko. - P.41-49
Minchenko, O. H. ERN1 dependent regulation of TMED10, MYL9, SPOCK1, CUL4A and CUL4B genes expression at glucose and glutamine deprivations in U87 glioma cells / O. H. Minchenko [et al.]. - P.50-61
Другие авторы: Hnatiuk O. S., Tsymbal D. O., Viletska Y. M., Danilovskyi S. V., Halkin O. V., Kryvdiuk I. V., Rudnytska O. V.
Afanasieva, K. DNA loop domain rearrangements in blast transformed human lymphocytes and lymphoid leukaemic Jurkat T cells / K. Afanasieva [et al.]. - P.62-69
Другие авторы: Olefirenko V., Martyniak A., Lukash L., Sivolob A.
Vasylchenko, V. S. The oxidative status in patients with chronic kidney disease / V. S. Vasylchenko [et al.]. - P.70-77
Другие авторы: Korol L. V., Kuchmenko O. B., Stepanova N. M.
Kotyk, B. I. Effects of ethylthiosulfanylate and chromium (VI) on the state of pro/antioxidant system in rat liver / B. I. Kotyk [et al.]. - P.78-86
Другие авторы: Iskra R. Ya., Slivinska O. M., Liubas N. M., Pylypets A. Z., Lubenets V. I., Pryimych V. I.
Khoma, V. V. Metallothioneins contribution to the response of Bivalve mollusk to xenobiotics / V. V. Khoma [et al.]. - P.87-96
Другие авторы: Gnatyshyna L. L., Martyniuk V. V., Mackiv T. R., Mishchuk N. Y., Stoliar O. B.
Strilbytska, O. Dietary sucrose defines lifespan and metabolism in Drosophila / O. Strilbytska [et al.]. - P.97-105
Другие авторы: Strutynska T., Semaniuk U., Burdyliyk N., Lushchak O.
Oliynyk, O. Effect of sucralose on the blood content of thyroid hormones / O. Oliynyk [et al.]. - P.106-110
Другие авторы: Slifirczyk A., Oliynyk Y., Pereviznyk B.
Rezaeinasab, H. Changes in gene expression of lactate carriers (MCT1 and CD147) in cardiac muscle of diabetic male rats: the effect of dichloroacetate and endurance training / H. Rezaeinasab [et al.]. - P.111-119
Другие авторы: Habibi A., Nikbakht M., Rashno M., Shakerian S.
Hrushanyk, N. V. Oxidative stress regulation in the yeast Ogataea polymorpha producer of human α-synuclein / N. V. Hrushanyk, O. V. Stasyk, O. G. Stasyk. - P.120-133
Виноградова, Р. П. Дослідження структури, механізму та регуляції активності ензимів у роботах Нобелівських лауреатів. К. Анфінсен, С. Мур, В. Стайн, С. Прузинер, Є. Скоу, Д. Бойєр, Д. Вокер / Р. П. Виноградова, B. М. Данилова, С. В. Комісаренко. - P.134-154
Григор’єва, М. В. Новий погляд на РНК: відкриття Сідні Олтмена і Томаса Чека 1989 року / М. В. Григор’єва, B. М. Данилова, С. В. Комісаренко. - P.155-160
Ebrahimi, M. A glance on the role of Hsien Wu in immunology development / M. Ebrahimi. - P.161-165
The Nobel Prize in Physiology or Medicine 2020. - P.166-167
The Nobel Prize in Chemistry 2020. - P.168
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(21.04.2021г. Экз. 1 - Б.ц.) (свободен)

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Шифр: УУ60/2019/91/6
Журнал

The Ukrainian biochemical journal [Текст]. - Выходит раз в два месяца
2019г. Т. 91 № 6 . - 138.92, р.

Содержание:
Mazur, H. M. Dependence of the mitochondrial adaptive capacity of hepatocytes on the oxidative substrates availability / H. M. Mazur [та ін.]. - P.5-14. - Bibliogr. at the end of the art.
Другие авторы: Merlavsky V. M., Manko B. O., Manko V. V.
Mankovska, O. Analysis of Aurora kinases genes expression points on their distinct roles in prostate cancer development / O. Mankovska [та ін.]. - P.15-26. - Bibliogr. at the end of the art.
Другие авторы: Gerashchenko G., Rozenberg E., Stakhovsky E., Kononenko O., Bondarenko Yu., Kashuba V.
Pyrogova, L. V. Comparative analysis of the influence of chlorine and fluorine anions on the fibrin polymerization / L. V. Pyrogova [та ін.]. - P.27-37. - Bibliogr. at the end of the art.
Другие авторы: Bereznitsky G. K., Gogolinskaya G. K., Platonova T. M., Kolesnikova I. M., Masenko O. O., Marunich R. Yu., Tsap P. Yu., Ushenin Yu. V., Makogonenko Y. M., Lugovskoi E. V.
Grinenko, T. Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface / T. Grinenko [та ін.]. - P.38-48. - Bibliogr. at the end of the art.
Другие авторы: Yusova O., Revka O., Patalakh I., Yatsenko T.
Korotkyi, O. Effect of probiotic composition on oxidative/antioxidant balance in blood of rats under experimental osteoarthritis / O. Korotkyi [та ін.]. - P.49-58. - Bibliogr. at the end of the art.
Другие авторы: Dvorshchenko K., Vovk A., Dranitsina A., Tymoshenko M., Kot L., Ostapchenko L.
Masoumi-Ardakani, Y. Carnitine effects on serum and pancreas inflammatory response in diabetic rats / Y. Masoumi-Ardakani, H. Fallah, B. Shahouzehi. - P.59-66. - Bibliogr. at the end of the art.
Falfushynska, H. I. Oxidative stress and thiols depletion impair tibia fracture healing in young men with type 2 diabetes / H. I. Falfushynska [та ін.]. - P.67-78. - Bibliogr. at the end of the art.
Другие авторы: Horyn O. I., Poznansky D. V., Osadchuk D. V., Savchyn T. О., Krytskyi T. І., Merva L. S., Hrabra S. Z.
Hrabovska, O. I. The concentration of ceruloplasmin in blood of tumor-bearing rats after administration of a dirhenium(III) compound and cisplatin / O. I. Hrabovska [та ін.]. - P.79-85. - Bibliogr. at the end of the art.
Другие авторы: Shamelashvili K. L., Shtemenko O. V., Shtemenko N. I.
Shafaee, M. M.A. Effect of selenium and nano-selenium on cisplatin-induced nephrotoxicity in albino rats / M. M.A. Shafaee [та ін.]. - P.86-95. - Bibliogr. at the end of the art.
Другие авторы: Mohamed H. S., Ahmed S. A., Kandeil M. A.
Gudzenko, T. V. Fatty acids composition of Bacillus subtilis ONU551 lipids / T. V. Gudzenko [та ін.]. - P.96-102. - Bibliogr. at the end of the art.
Другие авторы: Voliuvach O. V., Gorshkova O. G., Ostapchuk А. М., Ivanytsia V. O.
Kolupaev, Yu. E. Hydrogen peroxide as a signal mediator at inducing heat resistance in wheat seedlings by putrescine / Yu. E. Kolupaev [та ін.]. - P.103-111. - Bibliogr. at the end of the art.
Другие авторы: Kokorev A. I., Yastreb T. O., Horielova E. I.
Vovkun, T. V. Corvitin modulates the content of lipids in rat liver bile / T. V. Vovkun [та ін.]. - P.112-121. - Bibliogr. at the end of the art.
Другие авторы: Yanchuk P. I., Shtanova L. Ya., Veselsky S. P., Filimonova N. B., Komarov I. V.
Andrushchenko, T. A. Allelic polymorphisms of DNA repairing genes as markers of resistance to asbestos-containing aerosols / T. A. Andrushchenko [та ін.]. - P.122-128. - Bibliogr. at the end of the art.
Другие авторы: Goncharov S. V., Dosenko V. E., Stroy D. O., Ishchejkin K. E.
Matyshevska, O. P. The contribution of the Nobel laureates to the study of lipid metabolism and its regulation. F. Lynen, K. Bloch, S. Bergström, B. Samuelsson, J. Vane, M. Brown, J. Goldstein / O. P. Matyshevska, V. M. Danilova, S. V. Komisarenko. - P.129-143. - Bibliogr. at the end of the art.
Kosterin, S. O. XIІ Ukrainian Biochemical Congress (30 September – 4 October 2019, Ternopil / S. O. Kosterin [та ін.]. - P.144-149. - Bibliogr. at the end of the art.
Другие авторы: Matyshevska O. P., Danilova V. M., Grigorieva M. V.
The Nobel Prize in Physiology or Medicine 2019. - P.150
The Nobel Prize in Chemistry 2019. - P.151
In memory of O. S. Mikosha. - P.152
Имеются экземпляры в отделах: всего 1
Свободны: 1

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Шифр: УУ60/2018/90/6
Журнал

The Ukrainian biochemical journal [Текст]. - Выходит раз в два месяца
2018г. Т. 90 № 6

Содержание:
Asmaa, Missoum. The role of gene GJB2 and connexin 26 in hearing impairment / Missoum Asmaa. - P.5-11
Kolupaev, Yu. E. Phenylalanine ammonia-lyase activity and content of flavonoid compounds in wheat seedlings at the action of hypothermia and hydrogen sulfide donor / Yu. E. Kolupaev [et al.]. - P.12-20
Другие авторы: Horielova E. I., Yastreb T. O., Popov Yu. V., Ryabchun N. I.
Chernyshenko, V. O. Haemostasis modulation by calix[4]arene methylenebisphosphonic acid C-145 and its sulfur-containing analogue / V. O. Chernyshenko [et al.]. - P.21-30
Другие авторы: Savchuk O. V., Cherenok S. O., Silenko O. M., Negelia A. O., Kasatkina L. O., Pirogova L. V., Didkivskyi V. A., Yusova O. I., Kalchenko V. I., Garmanchuk L. V., Grinenko T. V., Lugovskoy E. V., Komisarenko S. V.
Tykhomyrov, A. A. Plasminogen modulates formation of reactive oxygen species in human platelets / A. A. Tykhomyrov [et al.]. - P.31-40
Другие авторы: Zhernosekov D. D., Guzyk M. M., Korsa V. V., Grinenko T. V.
Siromolot, A. A. Specificity and sensitivity of the new test for serological evaluation of tuberculosis using MPT83-MPT63 fusion antigen / A. A. Siromolot [et al.]. - P.41-48
Другие авторы: Chudina T. O., Danilova I. S., Rekalova O. M., Kolybo D. V., Komisarenko S. V.
Lylyk, M. P. Effects of alpha-ketoglutarate on lifespan and functional aging. Of Drosophila melanogaster flies / M. P. Lylyk [et al.]. - P.49-61
Другие авторы: Bayliak M. M., Shmihel H. V., Storey J. M., Storey K. B., Lushchak V. I.
Purkan, P. Immunogenicity assay of KatG protein from Mycobacterium tuberculosis in mice: preliminary screening of TB vaccine / P. Purkan [et al.]. - P.62-69
Другие авторы: Budiyanto R., Akbar R., Wahyuningsih S. P., Retnowati W.
Zavodovskyi, D. O. Influence of C60 fullerene on the ischemia-reperfusion injury in the skeletal muscle of rat limb: mechanokinetic and biochemical analysis / D. O. Zavodovskyi [et al.]. - P.70-81
Другие авторы: Zay S. Yu., Matvienko T. Yu., Prylutskyy Yu. I., Nurishchenko N. Y., Paradizova S. S., Bezuh L. L., Ritter U., Scharff P.
Nakonechna, O. A. Disturbance of the transmembrane phosphatidylserine asymmetry in hepatocytes as an apoptosis marker under the action of xenobiotics on rats / O. A. Nakonechna, L. A. Babijchuk, A. I. Bezrodna. - P.82-88
Aminizadeh, S. The effects of PDK4 inhibition on AMPK protein levels and PGC-1α gene expression following endurance training in skeletal muscle of Wistar rats / S. Aminizadeh, Y. Masoumi-Ardakani, B. Shahouzehi. - P.89-96
Horid’ko, T. M. Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment / T. M. Horid’ko [et al.]. - P.97-109
Другие авторы: Kosiakova H. V., Berdyshev A. G., Meged O. F., Onopchenko O. V., Klimashevsky V. M., Tkachenko O. S., Bazylianska V. R., Kholin V. O., Peschana K. O., Mykhalskiy S. A., Hula N. M.
Hurmach, Y. The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma / Y. Hurmach [et al.]. - P.110-119
Другие авторы: Rudyk M., Svyatetska V., Senchylo N., Skachkova O., Pjanova D., Vaivode K., Skivka L.
Marounek, M. Long-term hypocholesterolemic effect of amidated alginate in rats / M. Marounek [et al.]. - P.120-125
Другие авторы: Volek Z., Taubner T., Duskova D., Kalachniuk L.
Данилова, В. М. Внесок Нобелівських лауреатів початку ХХ ст. в розвиток молекулярної імунології: Е. Берінг, І. І. Мечников, П. Ерліх, Ш. Ріше, Ж. Борде, К. Ландштейнер / В. М. Данилова, Р. П. Виноградова, С. В. Комісаренко. - P.126-142
Дмитро Олексійович Мельничук. До 75-річчя з дня народження. - P.143-144
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Шифр: УУ60/2018/90/1
Журнал

The Ukrainian biochemical journal [Текст]. - Выходит раз в два месяца
2018г. Т. 90 № 1

Содержание:
Danylovych, G. V. The biosynthesis of nitric oxide from L-arginine. Nitric oxide formation features and its functional role in mitochondria / G. V. Danylovych, T. V. Bohach, Yu. V. Danylovych. - P.3-24
Danylovych, G. V. Calix[4]arene C-956 is effective inhibitor of H+-Ca2+-exchanger in smooth muscle mitochondria / G. V. Danylovych [et al.]. - P.25-33
Другие авторы: Kolomiets O. V., Danylovych Yu. V., Rodik R. V., Kalchenko V. I., Kosterin S. O.
Shahouzehi, B. Effects of Pistacia atlantica resin oil on the level of VEGF, hydroxyproline, antioxidant and wound healing activity in STZ-induced diabetic rats / B. Shahouzehi [et al.]. - P.34-41
Другие авторы: Shabani M., Shahrokhi N., Sadeghiyan S., Masoumi-Ardakani Y.
Voloshchuk, O. M. Activity of the mitochondrial isoenzymes of endogenous aldehydes catabolism under the conditions of acetaminophen-induced hepatitis / O. M. Voloshchuk, G. P. Kopylchuk, Y. I. Mishyna. - P.42-47
Fafula, R. V. Responsiveness to progesterone and potassium channel blockers 4-aminopyridine, tetraethylammonium and free Ca2+ contentration in spermatozoa of patients with oligozoospermia/leucocytospermia / R. V. Fafula [et al.]. - P.48-57
Другие авторы: Danylovych G. V., Besedina A. S., Melnyk O. V., Vorobets Z. D.
Yusova, O. I. Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension / O. I. Yusova [et al.]. - P.58-67
Другие авторы: Savchuk O. V., Grinenko T. V., Kuchmenko O. B., Mhitaryan L. S., Kupchins’ka O. H., Yevstratova I. N., Matova O. O., Vasilinchuk N. M., Drobot’ko T. F.
Salmanian, Tabasi N. Designing, docking and heterologous expression of an anti-her2 affibody molecule / N. Salmanian Tabasi, A. Gholizadeh, B. Baghban Kohnehrouz. - P.68-76
Луговська, Г. Г. Інноваційна діяльність інституту біохімії ім. О. В. Палладіна НАН України: проблеми і перспективи / Г. Г. Луговська, В. М. Данилова, С. В. Комісаренко. - P.77-99
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Шифр: УУ60/2017/89/6
Журнал

The Ukrainian biochemical journal [Текст]. - Выходит раз в два месяца
2017г. Т. 89 № 6

Содержание:
Osadchuk, T. V. Synthesis and investigation of the derivatives of amidinohydrazonelated aromatic compounds as furin inhibitors / T. V. Osadchuk [et al.]. - P.3-12
Другие авторы: Semyroz A. V., Shybyryn O. V., Kibirev V. K.
Kolas, I. K. Copurification of chicken liver soluble htiamine monophosphatase and low molecular weight acid phosphatase / I. K. Kolas, A. F. Makarchikov. - P.13-21
Kuznetsova, T. Y. Antioxidant activity of melatonin and glutathione interacting with hydroxyl and superoxide anion radicals / T. Y. Kuznetsova [et al.]. - P.22-30
Другие авторы: Solovyova N. V., Solovyov V. V., Kostenko V. O.
Chudina, T. O. Changes in proHB-EGF expression after functional activation of the immune system cells / T. O. Chudina [et al.]. - P.31-38
Другие авторы: Labintsev A. J., Romaniuk S. I., Kolybo D. V., Komisarenko S. V.
Gonchar, O. A. Time-dependent effect of severe hypoxia/reoxygenation on oxidative stress level, antioxidant capacity and p53 accumulation in mitochondria of rat heart / O. A. Gonchar, I. N. Mankovska. - P.39-47
Shahouzehi, B. Effect of L-carnitine administration on serum insulin and adiponectin levels, and AMPK, APPL1 and PPAR? gene expression in STZ-induced diabetic rat liver / B. Shahouzehi [et al.]. - P.48-55
Другие авторы: Barkhordari K., Aminizadeh S., Masoumi-Ardakani Y.
Pylypets, A. Z. Effects of thiosulfonates on the lipid composition of rat tissues / A. Z. Pylypets et al.]. - P.56-62
Другие авторы: Iskra R. Ya., Havryliak V. V., Nakonechna A. V., Novikov V. P., Lubenets V. I.
Комісаренко, С. В. Для чого потрібні циркадні ритми, або як змінити хід "біологічного годинника" / С. В. Комісаренко, С. І. Романюк. - P.63-73
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Shahouzehi, B.
L-carnitine administration effects on AMPK, APPL1 and PPARγ genes expression in the liver and serum adiponectin levels and HOMA-IR in type 2 diabetes rat model induced by STZ and nicotinamide / B. Shahouzehi, H. Fallah, Y. Masoumi-Ardakani // The Ukrainian biochemical journal. - 2020. - Vol. 92, № 5. - P33-40

MeSH-главная:
ПЕЧЕНЬ -- LIVER (действие лекарственных препаратов, патофизиология, повреждения)
КАРНИТИН -- CARNITINE (генетика, фармакокинетика)
ГЕННАЯ ЭКСПРЕССИЯ -- GENE EXPRESSION (действие лекарственных препаратов)
АДИПОНЕКТИН -- ADIPONECTIN (фармакокинетика)
КРОВИ СЫВОРОТКА -- SERUM (действие лекарственных препаратов, метаболизм)
СТРЕПТОЗОТОЦИН -- STREPTOZOCIN (вредные воздействия)
НИКОТИНАМИД -- NIACINAMIDE (вредные воздействия)
ДИАБЕТ САХАРНЫЙ -- DIABETES MELLITUS (генетика, метаболизм, патофизиология)
ЭУКАРИОТЫ -- EUKARYOTA
Аннотация: Diabetes is a chronic disease and a public health problem globally. L-Carnitine is synthesized in the liver, promotes fatty acids oxidation and currently is used as a supplement against weight gain. Carnitine level is found to be reduced in diabetic patients and to be beneficial as a supplement at diabetes, but the mechanisms of this effect is not fully understood. Therefore, we evaluated the oral L-carnitine supplementation on expression of AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma (PPARγ), adaptor protein APPL1 genes in the liver and insulin and adiponectin levels in the serum of diabetic rats. Rats were randomly divided into three groups (n = 8) as follow: group 1 – control without any treatment, group 2 – diabetic control rats which received STZ (45 mg/kg) and nicotinamide (200 mg/kg) by i.p. injection, group 3 – diabetic rats which received 600 mg/kg/day carnitine orally for 35 days. It was found that L-carnitine supplementation reduced the level of fasting glucose compared to that in control and diabetic groups (P = 0.001, P = 0.0001 respectively) and increased adiponectin level compared to diabetic nontreated rats (P = 0.0001). Homeostasis model assessment of insulin resistance (HOMA-IR) was significantly increased in the diabetic group and reduced in the group that received L-carnitine. These promising beneficial effect of L-carnitine on the type 2 diabetes in rats’ model was shown to be conducted through the up-regulation of AMPK, PPARγ and APPL1 genes expression in the liver and elevation of serum adiponectin level
Доп.точки доступа:
Fallah, H.
Masoumi-Ardakani, Y.

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Masoumi-Ardakani, Y.
Carnitine effects on serum and pancreas inflammatory response in diabetic rats [Текст] = Вплив карнітину на запальну реакцію в сироватці крові і підшлунковій залозі діабетичних щурів / Y. Masoumi-Ardakani, H. Fallah, B. Shahouzehi // The Ukrainian Biochemical Journal. - 2019. - Т. 91, № 6. - С. 59-66. - Bibliogr. at the end of the art.

MeSH-главная:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
ДИАБЕТ САХАРНЫЙ ЭКСПЕРИМЕНТАЛЬНЫЙ -- DIABETES MELLITUS, EXPERIMENTAL (патофизиология, терапия, этиология)
КАРНИТИН -- CARNITINE (анализ, метаболизм, терапевтическое применение, фармакология)
ПОДЖЕЛУДОЧНАЯ ЖЕЛЕЗА -- PANCREAS (действие лекарственных препаратов, метаболизм, патофизиология)
КРОВИ СЫВОРОТКА -- SERUM (действие лекарственных препаратов, метаболизм)
ДИАГРАММЫ -- CHARTS
Аннотация: Diabetes is a group of disorders characterized by elevated blood glucose and insulin secretion defect. Previous studies have reported L-carnitine beneficial and hypoglycemic effects in diabetic models. L carnitine anti-inflammatory properties in diabetes were not assessed perfectly, and there is a lack of information about this matter. Therefore, we designed this study and evaluated L-carnitine different doses supplementation on pro-inflammatory cytokines in STZ-induced diabetic rats’ pancreas and serum. We selected 48 male rats (200 ± 10 g) and randomly divided them into six groups (n = 8). Group 1, control; group 2, Diabetic control (DC); groups 3-6, STZ-induced diabetic rats which received L-carnitine different doses as follow; 300, 200, 100 and 50 mg/kg/day by intraperitoneal injection for 5 weeks. When the study ended, serum and pancreas samples were collected and cytokines levels were measured by specific ELISA kits. Our results showed that in diabetic rats, pro-inflammatory cytokines levels were elevated. Two L-carnitine doses 300 and 200 mg/kg/day showed beneficial effects and 300 mg/kg/day showed more effective and significant effects than other doses. The 300 mg/kg significantly reduced IL-1β and IL-6 levels in pancreas and serum. Our data proved the protective effects of intraperitoneal L-carnitine administration against diabetes and inflammation in diabetic rats. Indeed, L-carnitine long term supplementation through the intraperitoneal injection can be considered as a good and safe therapeutic strategy in diabetes
Діабет належить до захворювань, які характеризуються підвищеним рівнем глюкози в крові і порушенням секреції інсуліну. У попередніх дослідженнях на діабетичних моделях було виявлено, що L-карнітин виявляє гіпоглікемічний ефект. Однак, протизапальні властивості L-карнітину за діабету вивчені недостатньо. Метою дослідження було оцінити ефект різних доз L-карнітину на прозапальні цитокіни в підшлунковій залозі і сироватці крові в щурів зі стрептозоциніндукованим діабетом. Було відібрано 48 щурів-самців (200 ± 10 г) і розділено випадковим чином на шість груп (n = 8). Група 1 – контрольна група; 2 – діабетичний контроль (ДК); групи 3-6 – щури зі стрептозоциніндукованим діабетом, яким вводили L-карнітин в різних дозах: 300, 200, 100 і 50 мг/кг на добу шляхом інтраперитонеальних ін’єкцій протягом 5 тижнів. Після цього збирали зразки сироватки крові і підшлункової залози і визначали рівень цитокінів за допомогою наборів ELISA. Виявлено, що у діабетичних щурів рівень прозапальних цитокінів був підвищений. Дві дози L-карнітину 300 і 200 мг/кг на добу показали позитивні ефекти, при цьому ефект від введення L-карнітину в дозі 300 мг/кг на добу був значнішим. L-карнітин у дозі 300 мг/кг на добу істотно знижував вміст IL-1β і IL-6 у підшлунковій залозі і сироватці крові. Одержані результати підтвердили захисний ефект інтраперитонеально введеного L-карнітину у разі запалення в діабетичних щурів. Отже, введення L-карнітину протягом тривалого часу можна розглядати як ефективну і безпечну терапевтичну стратегію за діабету
Доп.точки доступа:
Fallah, H.
Shahouzehi, B.

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Effects of Pistacia atlantica resin oil on the level of VEGF, hydroxyproline, antioxidant and wound healing activity in STZ-induced diabetic rats / B. Shahouzehi [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 1. - P34-41

MeSH-главная:
СМОЛЫ РАСТИТЕЛЬНЫЕ -- RESINS, PLANT (фармакология)
МАСЛА -- OILS (фармакология)
ДИАБЕТИЧЕСКАЯ СТОПА -- DIABETIC FOOT (лекарственная терапия)
РАНЫ ЗАЖИВЛЕНИЕ -- WOUND HEALING (действие лекарственных препаратов)
ЭУКАРИОТЫ -- EUKARYOTA
Аннотация: Diabetes mellitus is a chronic metabolic disorder which is followed by many complications. One of these problems following diabetes is diabetic ulcers and 2.5% of diabetic patients develop foot ulcer annually. Natural resources are useful stock for finding traditional treatment. Studies which examined Pistacia atlantica properties showed that it has some beneficial effects including: antimicrobial, antifungal, antioxidant and wound healing. Yet, Pistacia atlantica resin oil effects on diabetic wound have not been examined. Therefore, we evaluate Pistacia atlantica resin oil antioxidant and wound healing activity. Sprague-Dawley male rats were entered to the study and randomly grouped (n = 10) as follows: group 1 – control group – burnt rats which received neither STZ nor Pistacia atlantica resin oil; group 2 – diabetic burnt rats; group 3 – diabetic burnt rats which received 250 µl/day Pistacia atlantica resin oil topically as an ointment for two weeks. At the end of the study antioxidant status, Vascular Endothelial Growth Factor (VEGF) and hydroxyproline contents were examined in the wound area. Our results showed that Pistacia atlantica resin oil has remarkable antioxidant activity in STZ-induced diabetic rats. Also, it promoted VEGF and hydroxyproline contents in the wound area which showed that it increases angiogenesis and collagen turnover in the diabetic wound. We concluded that Pistacia atlantica resin oil can be considered as a new therapeutic agent in diabetic wound healing, and also it is safe, available and cheap treatment of other wounds and skin injuries
Доп.точки доступа:
Shahouzehi, B.
Shabani, M.
Shahrokhi, N.
Sadeghiyan, S.
Masoumi-Ardakani, Y.

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Effect of L-carnitine administration on serum insulin and adiponectin levels, and AMPK, APPL1 and PPAR? gene expression in STZ-induced diabetic rat liver / B. Shahouzehi [et al.] // The Ukrainian Biochemical Journal. - 2017. - Том 89, N 6. - P48-55

MeSH-главная:
ДИАБЕТ САХАРНЫЙ ЭКСПЕРИМЕНТАЛЬНЫЙ -- DIABETES MELLITUS, EXPERIMENTAL (метаболизм)
КРОВЬ -- BLOOD (действие лекарственных препаратов)
ПЕЧЕНЬ -- LIVER (действие лекарственных препаратов)
КАРНИТИН -- CARNITINE (фармакокинетика)
Аннотация: Diabetes is considered as a metabolic disease in which insulin secretion and functions are disturbed and characterized by hyperglycemia. L-carnitine is synthesized in most mammals and plays critical role in fatty acid oxidation and energy production. Data about the L-carnitine hypoglycemic effects are controversial. We evaluated long-term oral L-carnitine administration effects on blood glucose, insulin and adiponectin levels, as well as expression of AMPK, APPL1 and PPARγ genes in liver of STZ-induced diabetic rats. Group 1 (control), did not receive any treatment, group 2 received 50 mg/kg STZ by i.p injection, group 3 received single dose of 50 mg/kg STZ by i.p injection and also 600 mg/kg/day L-carnitine orally for 5 weeks. Our results showed that L-carnitine long-term oral supplementation significantly reduced blood glucose and normalized insulin levels in diabetic rats. Also, we found that L-carnitine significantly increased AMPK and APPL1 expression, and showed a mild elevation of PPARγ expression. In sum, we suggest that long-term L-carnitine supplementation has beneficial effects on diabetic rats which showed hypoglycemic effects. Probably the beneficial effects of L-carnitine are contributed to the upregulation of insulin sensitizers such as AMPK and adiponectin
Доп.точки доступа:
Shahouzehi, B.
Barkhordari, K.
Aminizadeh, S.
Masoumi-Ardakani, Y.

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10.

Aminizadeh, S.
The effects of PDK4 inhibition on AMPK protein levels and PGC-1α gene expression following endurance training in skeletal muscle of Wistar rats [Text] / S. Aminizadeh, Y. Masoumi-Ardakani, B. Shahouzehi // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 6. - P89-96

MeSH-главная:
ФИЗИЧЕСКАЯ НАГРУЗКА У ЖИВОТНЫХ -- PHYSICAL CONDITIONING, ANIMAL
МЫШЦА СКЕЛЕТНАЯ -- MUSCLE, SKELETAL
КЛЕТОК КОНТАКТНОЕ ИНГИБИРОВАНИЕ -- CONTACT INHIBITION
Аннотация: There are regulatory networks in cells which surveil the physiological and environmental states. These cellular regulations are conducted through gene expression modulation. Skeletal muscle is able to adapt shortly and produce ATP at different conditions. AMPK (AMP-activated protein kinase) and PGC-1α (peroxisome proliferator-activated receptor-gamma coactivator-1alpha) are important regulators of cellular energy homeostasis. We designed this study to examine the effects of interactions between endurance training and PDK4 (pyruvate dehydrogenase kinase 4) inhibition on AMPK and PGC-1α expression in rat skeletal muscle. Thirty-two male Wistar rats were randomly selected and divided into 4 groups (n = 8); Group 1 control which did not receive any treatment, Group 2 received dichloroacetic acid (DCA) (150 mg/kg/day), Group 3 (endurance training group), Group 4 which received DCA and performed endurance training. AMPK protein expression, PDK4 and PGC-1α gene expression were measured by western blotting and real-time PCR, respectively. Our data showed that PDK4 inhibition caused AMPK protein elevation. Endurance training (group 2) and PDK4 inhibition (group 4) induce significant enhancement of PGC-1α gene expression compared to control group. The group which received DCA showed significant elevation of PDK4 gene expression compared to control group (P = 0.001), also other two groups (groups 2 & 3) showed significant elevation of PDK4 gene expression compared to control (P = 0.006). It seems that the combination of endurance training and PDK4 inhibition by up-regulation of PGC-1α expression, effectively improves energy state and performance in skeletal muscle
Доп.точки доступа:
Masoumi-Ardakani, Y.
Shahouzehi, B.

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