Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Chekhun V. F., Lozovska Yu. V., Burlaka A. P., Ganusevich I. I., Shvets Yu. V., Lukyanova N. Yu., Todor I. M., Tregubova N. A., Naleskina L. A.
Заглавие : Remodulating effect of doxorubicin on the state of iron-containing proteins, and redox characteristics of tumor with allowance for its sensitivity to cytostatic agents
Параллельн. заглавия :Ремодулювальний вплив доксорубіцину на кількісні показники залізовмісних протеїнів та редоксзалежні характеристики пухлини з урахуванням її чутливості до цитостатика
Место публикации : Український біохімічний журнал. - 2016. - Т. 88, № 1. - С. 99-108 (Шифр УУ1/2016/88/1)
Примечания : Бібліогр.: в кінці ст.
MeSH-главная: БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER
ДОКСОРУБИЦИН -- DOXORUBICIN
ФЕРРИТИНЫ -- FERRITINS
ТРАНСФЕРРИНЫ -- TRANSFERRINS
КИСЛОРОДА АКТИВНЫЕ ФОРМЫ -- REACTIVE OXYGEN SPECIES
Аннотация: The study was aimed at determining the changes of metal-containing proteins in blood serum and tumor tissue of animals with parental and doxorubicin-resistant strains of Walker-256 carcinosarcoma before and after the cytostatic administration. It has been shown that upon doxorubicin action the levels of total iron and transferrin in the tissues from the both groups of animals decreased while that offerritine simultaneously increased with more pronounced pattern in the group of animals with resistant tumor strain. It has been shown that upon the action of doxorubicin in tumor tissue of animals with different sensitivity to the cytostatic there could be observed oppositely directed changes in the redox state of these cells that in turn determined the content of “free iron” complexes, ROS generation and concentration of active forms of matrix metalopro- teinase-2 and matrix metaloproteinase-9, namely, the increase of these indexes in animals with parental strain and their decrease in animals with the resistant one. So, our study has demonstrated the remodulating effect of doxorubicin on the state of metal-containing proteins and redox characteristics of tumor dependent on its sensitivity to cytostatic, at the levels of the tumor and an organism. These data may serve as a criterion for the development of programs for the correction of malfunction of iron metabolism aimed at elevating tumor sensitivity to cytostatic agents
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Заглавие журнала :Український біохімічний журнал -2016г. т.88,N 1
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Chekhun V. F. Remodulating effect of doxorubicin on the state of iron-containing proteins, and redox characteristics of tumor with allowance for its sensitivity to cytostatic agents/ V. F. Chekhun [и др.] (стр.99-108)
Sokolik V. V. Effect of β-amyloid peptide 42 on the dynamics of expression and formation of Аβ(40), IL-1β, TNFα, IL-6, IL-10 by peripheral blood mononuclear cells in vitro and its correction by curcumin / V. V. Sokolik, O. K. Koliada, S. M. Shulga (стр.109-118)
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Shvets Yu. V., Lukianova N. Yu., Chekhun V. F.
Заглавие : Human microbiota and effectiveness of cancer chemotherapy
Место публикации : Experimental Oncology. - К., 2020. - Том 42, N 2. - С. 82-93 (Шифр ЕУ12/2020/42/2)
MeSH-главная: НОВООБРАЗОВАНИЯ -- NEOPLASMS
Аннотация: This review presents up-to-date information on the effects of microbiota on the individual chemotherapy sensitivity in cancer treatment. Recent studies have shown that a fine balance between the intestinal microbiota and the immune system is crucial for maintaining an efficacy of cancer chemotherapy. A number of antitumor drugs have complex mechanisms of action involving not only direct effects but also the activity of the intestinal microbiota and the immune system. A unique combination of these factors contributes to the individual chemotherapy sensitivity
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Заглавие журнала :Экспериментальная онкология -2020г. т.42,N 2
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