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1.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Tomarovska L. Yu., Baiurka S. V., Karpushyna S. A.
Заглавие : Development of the UV-spectrophotometric and extraction-spectrophotometric methods of the atomoxetine quantitative determination suitable for the chemical and toxicological analysis
Место публикации : Вісн. фармації. - Х., 2017. - № 4. - С. 15-19 (Шифр ВУ18/2017/4)
Предметные рубрики: Атомоксетин
MeSH-главная: АНТИДЕПРЕССАНТЫ -- ANTIDEPRESSIVE AGENTS
СУДЕБНАЯ ТОКСИКОЛОГИЯ -- FORENSIC TOXICOLOGY
СПЕКТРОФОТОМЕТРИЯ УЛЬТРАФИОЛЕТОВАЯ -- SPECTROPHOTOMETRY, ULTRAVIOLET
Аннотация: The acute and lethal antidepressant poisonings have the tendency to grow, therefore, development of the methods for its chemical and toxicological analysis is a topical issueКількість гострих та летальних отруєнь лікарськими препаратами антидепресивної дії має тенденцію до зростання, що робить актуальним розробку методів їх хіміко-токсикологічного аналізу
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2.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Tomarovska L. Yu., Baiurka S. V., Karpushyna S. A.
Заглавие : Development of the methods for atomoxetine identification suitable for the chemical and toxicological analysis
Место публикации : Вісн. фармації. - Х., 2017. - № 2. - С. 13-20 (Шифр ВУ18/2017/2)
Предметные рубрики: Атомоксетин
MeSH-главная: АНТИДЕПРЕССАНТЫ -- ANTIDEPRESSIVE AGENTS
ТОКСИКОЛОГИЯ -- TOXICOLOGY
Аннотация: The cases of acute and lethal poisonings by atomoxetine, an antidepressant, have been registered. Therefore, development of the available and reliable methods for its chemical and toxicological analysis is the topical issue. Aim. To develop the conditions for atomoxetine detection in the presence of a number of its pharmacological and structural analogs when performing the general TLC-screening and identification of the antidepressant by UV spectrophotometry. Materials and methods. Chromatographic mobility of antidepressants in thin sorbent layers was studied in 11 mobile phases, including those recommended by TIAFT, using five types of chromatographic plates. A number of chromogenic reagents was used for visualization. The UV-spectrum of atomoxetine was studied in 0.1 Mol • L-1 solution of hydrochloric acid. Results and discussion. Chromatographic systems with the low correlation of Rf values for atomoxetine that make them suitable for the general TLC-screening have been found. The UV spectrum of atomoxetine in the acid solution had light absorption maxima at wavelengths of 270 (ε = 1300; A11 = 45) and 277 nm. Conclusions. A combined use of three mobile phases: methanol – 25 % ammonia solution (100 : 1.5), cyclohexane – toluene – diethylamine (75 : 15 : 10), and toluene – acetone – 25 % ammonia solution (45 : 45 : 7.5 : 2.5) provides a reliable atomoxetine detection in the presence of a number of its pharmacological and structural analogs when performing the general TLC-screening. The presence of specific light absorption in the UV region of the spectrum for atomoxetine makes the UV spectrophotometry method suitable for identification of the antidepressant in toxicological studies metry method suitable for identification of the antidepressant in toxicological studies
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3.

Заглавие журнала :Вісник фармації -2017г.,N 2
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The reactivity of propyl esters of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl]amino acids , O. M. Svechnikova, S. V. Kolisnyk (стр.3-6)
Determination of related impurities in glimepiride tablets by the HPLC method , N. O. Savina, N. M. Ocherethyana (стр.7-12)
Tomarovska L. Yu. Development of the methods for atomoxetine identification suitable for the chemical and toxicological analysis/ L. Yu. Tomarovska, S. V. Baiurka, S. A. Karpushyna (стр.13-20)
Comparison of chromatographic methods of analysis in a thin layer of the sorbent for identification of famotidine in tablets , A. V. Myhal, M. Marksa (стр.21-24)
The synthesis of the substituted 4-alkyl/arylsulfonyl-5-amino-3-alkylthiopyrazoles as promising pharmaceutical agents with the antifungal action , P. V. Tkachenko, O. V. Tkachenko (стр.25-30)
Slipchenko G. D. Development of the methods for spectrophotometric determination of the flavonoid concentration in solution to study bioavailability of the amount of bioactive substances in capsules containing the powder of Scutellaria baikalensis roots and rhizomes/ G. D. Slipchenko, V. O. Hrudko, O. A. Ruban (стр.31-36)
The study of the chemical composition and the immunomodulatory activity of polysaccharide complexes from Veronica teucrium L. , A. P. Osmachko, A. M. Kovaleva (стр.37-42)
Zujkina S. S. The pharmacotechnological studies of the phytospecies composition for the complex therapy of mastopathy/ S. S. Zujkina, L. I. Vishnevska (стр.43-47)
Garkusha M. I. Analysis of the Ukrainian employer current requirements to the pharmaceutical personnel/ M. I. Garkusha, R. V. Sahaidak-Nikitiuk, G. A. Gretska (стр.48-53)
Tovchiga O. V. The effects of goutweed (Aegopodium podagraria L.) preparations on glycemia in intact rats and against the background of metformin/ O. V. Tovchiga (стр.54-62)
Tryschuk N. M. The effect of benzilic acid derivatives on the pain threshold using the “hot plate” test/ N. M. Tryschuk [та ін.] (стр.63-66 )
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4.

Заглавие журнала :Вісник фармації -2017г.,N 4
Интересные статьи :
The use of the HPLC method for the quantitative determination of cetylpyridinium hexafluorosilicate in a dental gel , V. Yu. Anisimov, V. O. Gelmboldt (стр.3-9)
Serdiukova Yu. Yu. Development of a novel kinetic spectrophotometric method for the quantitative determination of Cefuroxime using Caro’s acid/ Yu. Yu. Serdiukova, S. G. Leonova, Yu. S. Kolisnyk (стр.10-14)
Tomarovska L. Yu. Development of the UV-spectrophotometric and extraction-spectrophotometric methods of the atomoxetine quantitative determination suitable for the chemical and toxicological analysis/ L. Yu. Tomarovska, S. V. Baiurka, S. A. Karpushyna (стр.15-19)
The synthesis of 3,5-dibromo-2-chlorobenzoic acid hydrazides as potential antituberculous drugs , D. O. Alferova, I. S. Gritsenko (стр.20-24)
The phytochemical profile and antibacterial activity of fluid extracts of Galium verum L. herb , I. L. Shynkovenko, T. V. Ilyina (стр.25-28)
Lyapunova A. M. The study of o/w emulsions using the rotating viscometer method and the method of spin probes/ A. M. Lyapunova, O. P. Bezugla, O. M. Lyapunov (стр.29-34)
Development of the composition and technology of a soap with sapropel , O. Y. Strus, N. P. Polovko (стр.35-40)
The general methodological approach to development of modern foam washing , I. I. Baranova, L. S. Petrovska (стр.41-44)
Stadnichenko O. V. The study of liophilization parameters in the liposomal irinotecan development/ O. V. Stadnichenko, Yu. M. Krasnopolsky, T. G. Yarnykh (стр.45-49)
Savchenkova L. V. The DDD-monitoring of consumption of fluoroquinolones when treating community-acquired pneumonia in a multi-specialty hospital in the Republic of Tajikistan/ L. V. Savchenkova, M. N. Saidova, N. S. Sanginova (стр.50-55)
The study of hypolipidemic properties of Ginger extract on the model of type 2 diabetes induced by dexamethasone , N. M. Kononenko, V. V. Chikitkina (стр.56-61)
The effect of the new combined cream on the protein synthetic activity of cells on the model of the thermal skin damage in rats , N. M. Kononenko, A. M. Sheikhali (стр.62-66)
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