Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vari S. G.
Заглавие : The Sisyphus Effect
Параллельн. заглавия :Ефект Сізіфа
Место публикации : The Ukrainian Biochemical Journal. - 2019. - Т. 91, № 2. - С. 5 (Шифр УУ60/2019/91/2)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: ФИЗИОЛОГИЧЕСКИЕ ПРОЦЕССЫ -- PHYSIOLOGICAL PROCESSES
ГОМЕОСТАЗ -- HOMEOSTASIS
АКТИВАЦИЯ МЕТАБОЛИЧЕСКАЯ -- ACTIVATION, METABOLIC
БИОМЕДИЦИНСКИЕ ИССЛЕДОВАНИЯ -- BIOMEDICAL RESEARCH
Аннотация: Scientific work for researchers, women and men equally, is an endless challenge. Determining new markers for early diagnosis of diseases, investigating the maintenance of cell and tissue homeostasis, studying metabolic regulation and dysregulation as well as intra-organ and interorgan crosstalk can be tiresome work and can sometimes seem like the punishment Zeus gave to Sisyphus. Sisyphus, the Greek mythological figure, was condemned to roll a boulder up a mountain but near the top of the mountain the boulder roll down; for eternity Sisyphus was forced to repeat this task over and over. Although scientific research can sometimes seem like this, the cleverness of scientists helps to overcome the “Sisyphus Effect”. “I leave Sisyphus at the foot of the mountain. One always finds one’s burden again. But Sisyphus teaches the higher fidelity that negates the gods and raises rocks”. Sisyphus is a symbol of self-overcoming. Sisyphus was also infamous for his deception though, which had led Zeus to punish him to roll the boulder up a hill that rolled down repeatedly, and Sisyphus had to keep trying again and again for eternity. While the vast majority of scientists are honest and work hard to achieve their research goals, some scientists are egotistical and may resort to trickery and doing things unethically. In Science the role of Sisyphus is played by the community of researchers, and to ensure that the boulder does not roll down the hill again. We researchers have to share our research results as well as repeat the published methods and research protocols again and again and these tasks can seem like “Sisyphean” work. Furthermore, in Science, the research community also plays the role of Zeus and will punish dishonesty so therefore we researchers must roll a boulder up a hill again and again and after we have proved that the published scientific work is sound, the “boulder” and the scientist will stay on top of the hill. In the Association for Regional Cooperation in the Fields of Health, Science and Technology (RECOOP HST Association) scientists equally share the burden of Zeus and Sisyphus independently of the status of their X and Y chromosomes, and I know from Albert Camus’ essay that Sisyphus is Happy. Each atom of that stone, each mineral flake of that night-filled mountain, in itself, forms a world. The struggle itself toward the heights is enough to fill a man’s heart. One must imagine Sisyphus happy
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vari S. G.
Заглавие : Inflammation is the common mechanism of diseases (CMD) in COVID-19 disease during pregnancy and in gestational diabetes mellitus
Место публикации : The Ukrainian biochemical journal. - Київ, 2021. - Vol. 93, № 2. - С. 5 (Шифр УУ60/2021/93/2)
MeSH-главная: БЕРЕМЕННОСТИ ОСЛОЖНЕНИЯ -- PREGNANCY COMPLICATIONS
ДИАБЕТ ГЕСТАЦИОННЫЙ -- DIABETES, GESTATIONAL
КОРОНАВИРУСНЫЕ ИНФЕКЦИИ -- CORONAVIRUS INFECTIONS
КОМОРБИДНОСТЬ -- COMORBIDITY
Аннотация: The Regional Cooperation for Health, Science and Technology (RECOOP HST) Consortium, led by Cedars-Sinai Medical Center was formed in 2006, was transformed into an Association in 2012 and includes 17 universities and academic organizations from eight countries: seven in Central and Eastern Europe (Croatia, Czech Republic, Hungary, Poland, Romania, Slovakia, Ukraine) and the United States. RECOOP builds multinational, multidisciplinary collaborations, and assists as well as coordinates the research activities of the sixteen research groups that are the Cedars-Sinai Medical Center – RECOOP Research Centers (CRRCs). https://www.cedars-sinai.org/research/administration/recoop.html.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vari S. G.
Заглавие : Homo scientist can lead HOMO SAPIENS to the next evolutionary stage, to HOMO ingenious
Место публикации : The Ukrainian biochemical journal. - Київ, 2020. - Vol. 92, № 2. - С. 5-6 (Шифр УУ60/2020/92/2)
MeSH-главная: ЧЕЛОВЕКА РАЗВИТИЕ -- HUMAN DEVELOPMENT
Аннотация: The worldwide COVID-19 (novel coronavirus) pandemic has created an unpredicted and unexperienced chain reaction for our human species Homo sapiens due to “social distancing” and community lockdowns. The situation is far beyond our “business as usual” mode and has become our “everyday functioning”. The pandemic is putting extreme pressure on healthcare systems and is significantly changing the economy, due to the lockdown of the workforce, therefore reducing the supply (output of industry), consumer demand for supplies, as well as consumer earnings and buying power. Therefore, the resulting reduced gross domestic product (GDP) will change the lives of individuals and communities, both small and large, not only for the next couple of months but for years
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Vari S. G.
Заглавие : COVID-19 infection: disease mechanism, vascular dysfunction, immune responses, markers, multiorgan failure, treatments, and vaccination
Место публикации : The Ukrainian biochemical journal. - Київ, 2020. - Vol. 92, № 3: 21 (Шифр УУ60/2020/92/3)
MeSH-главная: КОРОНАВИРУСНЫЕ ИНФЕКЦИИ -- CORONAVIRUS INFECTIONS
Аннотация: The new SARS-CoV-2 virus is a great danger for the worldwide population since there is no known pre-immunity, no specific treatment, and no vaccine. Still, the testing and tracing are the best tools to isolate the infected and prevent the spread of COVID-19. The major goals are to save lives, reduce the mortality rate, increase the survival rate of those are in severe or critical conditions, reduce the hospital stay and accelerate the recovery. This review summarizes the findings on the novel coronavirus that causes COVID-19 and outlines information about symptoms, testing, disease mechanism, vascular dysfunction, immune responses, treatments, and vaccination. At this time no vaccine is available to prevent COVID-19. A literature review reveals that more research is necessary to investigate the interactions between respiratory viruses, human coronaviruses, and the new SARS-CoV-2 virus in the infected population to guide the design of COVID-19 specific therapeutics and vaccines. Almost every government on earth has realized that daily life cannot return to normal until citizens have built up antibodies to safeguard them from the virus. Scientists and manufacturers worldwide are accelerating COVID-19 vaccine research, and pharmaceutical companies are already investing in the large-scale production of vaccines. A synopsis of the most recent sources presented in this review was the starting point for several COVID-19 research projects in the Regional Cooperation for Health, Science and Technology (RECOOP HST) Association managed by Cedars – Sinai Medical Center to gain a better understanding of the COVID-19 disease
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Заглавие журнала :The Ukrainian biochemical journal -2021г. т.93,N 2
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Vari S. G. Inflammation is the common mechanism of diseases (CMD) in COVID-19 disease during pregnancy and in gestational diabetes mellitus/ S. G. Vari (стр.5)
Kobylinska L. In silico identification and biochemical validation of plausible molecular targets of 4-thiazolidinone derivative les-3833 as a potential anticancer agent/ L. Kobylinska [et al.] (стр.7-23)
Shevchuk O. O. Locally delivered lovastatin-containing chitosan nanoparticles promote bone regeneration in rats/ O. O. Shevchuk, Ya. V. Panasiuk, M. M. Korda (стр.24-38)
Finiuk N. S. Effect of a novel thiazole derivative and its complex with a polymeric carrier on stability of DNA in human breast cancer cells/ N. S. Finiuk [et al.] (стр.39-52)
Poshyvak O. B. Oxidative stress suppression contributes to antiseizure action of axitinib and rapamycin in pentylenetetrazol-induced kindling/ O. B. Poshyvak, O. R. Pinyazhko, L. S. Godlevsky (стр.53-60)
Korolova D. S. Thromboelastographic study of fibrin clot and molecular basis of maximum clot firmness/ D. S. Korolova [et al.] (стр.62-70)
Pavlyshyn H. A. The association between vitamin D status and cardiometabolic disorders in overweight and obese adolescents/ H. A. Pavlyshyn, A.-M. A. Shulha (стр.72-81)
Pavlyshyn H. A. Investigating the connections between night eating syndrome and metabolic syndrome in children/ H. A. Pavlyshyn, K. V. Kozak, K. T. Hlushko (стр.83-94)
Hlushko K. T. Clinical and immunological peculiarities of parasitic infections in children with digestive system disorders in Western Ukraine/ K. T. Hlushko, H. A. Pavlyshyn, K. V. Kozak (стр.96-105)
Kucher S. V. Inclusion of enterosorbents in anti-inflammatory therapy improve treatment effectiveness in COPD patients during exacerbations/ S. V. Kucher, O. V. Lototska (стр.107-114)
Danylova T. V. Double Nobel prize winner: Frederick Sanger - the father of genomics/ T. V. Danylova, S. V. Komisarenko (стр.116-122)
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Заглавие журнала :The Ukrainian biochemical journal -2020г. т.92,N 3
Интересные статьи :
Chernyshenko V. Presenting thematic ’Molecular and clinical studies of hemostasis’ issue/ V. Chernyshenko, S. Komisarenko (стр.5)
Vari S. G. COVID-19 infection: disease mechanism, vascular dysfunction, immune responses, markers, multiorgan failure, treatments, and vaccination/ S. G. Vari
Medved L. Structure and function of fibrinogen BβN-Domains/ L. Medved, S. Yakovlev (стр.22-32)
Lugovskoi E. The fibrin Bβ125-135 site is involved in the lateral association of protofibrils/ E. Lugovskoi [et al.] (стр.33-45)
Kapustianenko L. G. Identification of the binding site for plasminogen kringle 5 in the α-chain of fibrin(ogen) D-fragment/ L. G. Kapustianenko [et al.] (стр.46-57)
Lugovska N. E. Novel monoclonal antibody to fibrin(ogen) αC-region for detection of the earliest forms of soluble fibrin/ N. E. Lugovska [et al.] (стр.58-70)
Mykhaloiko I. S. D-dimer as a potential predictor of thromboembolic and cardiovascular complications in patients with chronic kidney disease/ I. S. Mykhaloiko [et al.] (стр.71-76)
Panibratiuk O. A. Warfarin therapy in patients with coronary heart disease and atrial fibrillation: drug interactions and genetic sensitivity to warfarin/ O. A. Panibratiuk, O. A. Yakovleva (стр.77-85)
Chernyshenko V. O. Men of the molecules/ V. O. Chernyshenko (стр.86-90)
Григор’єва М. В. 20 років тому завершилися "перегони" секвенування геному людини/ М. В. Григор’єва ; М. В. Григор’єва, С. В. Комісаренко (стр.91-92)
Danylova T. V. Nobel prize winner erwin schrodinger: the physicist, philosopher, and godfather of molecular biology and genetics/ T. V. Danylova, S. V. Komisarenko (стр.93-100)
До 70-річчя від дня народження члена-кореспондента НАН України, професора Ростислава Стефановича Стойки (стр.101-102)
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Заглавие журнала :The Ukrainian biochemical journal -2020г. т.92,N 2
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Vari S. G. Homo scientist can lead HOMO SAPIENS to the next evolutionary stage, to HOMO ingenious/ S. G. Vari (стр.5-6)
Korolyuk O. Ya. Hypertriclyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients/ O. Ya. Korolyuk, O. M. Radchenko (стр.8-19)
Bozhenko M. Freezing influences, the exposure of IgG glycans in sera from multiple sclerosis patients/ M. Bozhenko [et al.] (стр.21-31)
Nasadyuk C. M. Lectinocytochemical study of rat stomach mucosa under the conditions of cyclooxygenase-1/-2 blockage and pretreatment with H-GLU-ASP-GLY-OH/ C. M. Nasadyuk [et al.] (стр.33-43)
Onopchenko O. V. The effect of N-stearoylethanolamine on the lipid composition of the rat testes and testosterone level during the early stages of streptozotocin-induced diabetes/ O. V. Onopchenko [et al.] (стр.45-59)
Tkachenko O. S. Protective action of N-stearoylethanolamine on blood coagulation and arterial changes in spontaneously hypertensive rats fed cholesterol-rich diet/ O. S. Tkachenko [et al.] (стр.60-71)
Stohnii Y. M. Aggregation of platelets, proliferation of endothelial cells and motility of cancer cells are mediated by the Bβ1(15)-42 residue of fibrin(ogen)/ Y. M. Stohnii [et al.] (стр.72-85)
Revenko O. Exogenous hydrogen sulfide for the treatment of mesenteric damage associated with fructose-induced malfunctions via inhibition of oxidative stress/ O. Revenko [et al.] (стр.86-98)
Bila G. Novel approach for discrimination of eosinophilic granulocytes and evaluation of their surface receptors in a multicolor fluorescent histological assessment/ G. Bila [et al.] (стр.99-107)
Kryshchyshyn A. Synthesis and anti-leukemic activity of pyrrolidinedione-thiazolidinone hybrids/ A. Kryshchyshyn [et al.] (стр.108-120)
Hreniukh V. P. Effects of thiazole derivatives on intracellular structure and functions in murine lymphoma cells/ V. P. Hreniukh [et al.] (стр.121-131)
Chaban T. I. Development of effective anti-inflammatory drug candidates among novel thiazolopyridines/ T. I. Chaban [et al.] (стр.132-139)
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Заглавие журнала :The Ukrainian biochemical journal -2019г. т.91,N 2
Интересные статьи :
Vari S. G. The Sisyphus Effect/ S. G. Vari (стр.5)
Kobylinska L. Targeting of the pro-oxidant-antioxidant balance in vitro and in vivo by 4-thiazolidinone-based chemotherapeutics with anticancer potential/ L. Kobylinska [та ін.] (стр.7-18)
Chernyshenko V. Preparation of highly-concentrated autologous platelet-rich plasma for biomedical use/ V. Chernyshenko [та ін.] (стр.19-28)
Finiuk N. S. Apoptosis induction in human leukemia cells by novel 2-amino-5-benzylthiazole derivatives/ N. S. Finiuk [та ін.] (стр.29-40)
Paryzhak S. Ya. Interaction of 4 allotropic modifications of carbon nanoparticles with living tissues/ S. Ya. Paryzhak [та ін.] (стр.41-51)
Chernyshenko V. Blood coagulation parameters in rats with acute radiation syndrome receiving activated carbon as a preventive remedy/ V. Chernyshenko [та ін.] (стр.52-64)
Young scientists conference Modern Aspects of Biochemistry and Biotechnology – 2019 (стр.65-93)
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