Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Altukhov, O. O.
Synthesis and properties of N-[2-(benzoylamino) (2-oxoindolin-3-ylidene)acetyl]amino acids ethyl esters [Текст] = Синтез і властивості етилових естерів N[2-(бензоїламіно)(2-оксоіндолін-3-іліден)ацетил]амінокислот / O. O. Altukhov // Вісник фармації. - 2014. - № 2. - С. 38-42

MeSH-главная:
ЭФИР ЭТИЛОВЫЙ -- ETHER (фармакология, химический синтез)
АМИНОКИСЛОТЫ -- AMINO ACIDS
ХИМИЯ ФАРМАЦЕВТИЧЕСКАЯ -- CHEMISTRY, PHARMACEUTICAL (методы)
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Gulevskyy, A. K.
Cryoprotective agents affect amino acids incorporation into total proteins in cells of lymphoid organs and liver of experimental animals / A. K. Gulevskyy, Yu. S. Akhatova, A. Yu. Nikolchenko // The Ukrainian biochemical journal. - 2020. - Vol. 92, № 5. - P41-49

MeSH-главная:
ПЕЧЕНЬ -- LIVER (действие лекарственных препаратов)
ЛИМФОИДНАЯ ТКАНЬ -- LYMPHOID TISSUE (действие лекарственных препаратов)
КРИОПРОТЕКТОРЫ -- CRYOPROTECTIVE AGENTS (фармакокинетика)
АМИНОКИСЛОТЫ -- AMINO ACIDS (фармакокинетика)
ЭУКАРИОТЫ -- EUKARYOTA
Аннотация: The effect of penetrating (glycerol, DMSO) and poorly penetrating (PEG-400) cryoprotective agents on labeled amino acids incorporation into de novo synthesized proteins in the cells of mice thymus, lymph nodes, spleen and cell-free rat liver extract was studied. Cryoprotective agents within the range of concentrations which provide a cryoprotective effect were found to inhibit significantly protein synthesis in cell-free systems under investigation. The most effective inhibition was exerted by polymeric cryoprotective agent PEG-400. Cryoprotective agents more efficiently inhibited protein synthesis at a cell level as compared with that in cell-free system that was likely associated with their effect on amino acids transport system. An inhibitory effect of cryoprotective agents on the protein synthesizing apparatus of cells was determined to be Mg2+-dependent and reversible
Доп.точки доступа:
Akhatova, Yu. S.
Nikolchenko, A. Yu.

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Kolychev, I. O.
The study of the amino acid composition of the alcoholic extract from bilberry leaves [Text] / I. O. Kolychev, T. O. Krasnikova, O. M. Koshovyi // Вісн. фармації. - 2016. - № 2. - P12-14

MeSH-главная:
ЧЕРНИКА -- HUCKLEBERRY PLANT
АМИНОКИСЛОТЫ -- AMINO ACIDS
РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS
РАСТЕНИЙ ЛИСТЬЯ -- PLANT LEAVES
Доп.точки доступа:
Krasnikova, T. O.
Koshovyi, O. M.

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Lenchyk, L. V.
The study of the amino acid composition of the extracts obtained from cherry leaves and shoots, leaves of apricot and peach [Text] / L. V. Lenchyk // Вісн. фармації. - 2016. - № 2. - P9-11

MeSH-главная:
РАСТЕНИЙ ПОБЕГИ -- PLANT SHOOTS
АМИНОКИСЛОТЫ -- AMINO ACIDS
Кл.слова (ненормированные):
ВИШНЯ -- ПЕРСИК -- АБРИКОС
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Molecular parameters and the antimicrobial activity of some N-substituted amino acids [Text] / М. Yu. Golik [et al.] // Вісн. фармації. - 2017. - № 3. - P10-15

MeSH-главная:
АМИНОКИСЛОТЫ -- AMINO ACIDS (фармакология)
БИОДОСТУПНОСТЬ -- BIOLOGICAL AVAILABILITY
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS
Аннотация: The concept of “drug likeness” is used when developing drugs for a potential biologically active substance, which must meet some specific criteria, in particular it should be bioavailable. The traditional method of “drug likeness” assessment is verification of compliance with Lipinski’s rule. Aim. To determine the compliance of the “drug likeness” concept for some N-substituted amino acids and identify the quantitative “structure – microbiological activity” relationships. Materials and methods. Using ChemOffice 2016 software the physicochemical parameters determining the bioavailability of some N-substituted amino acids were calculated. Determination of the possible correlations and quantitative ratios of the biological activity data experimentally obtained with the molar refraction (MR) values calculated was conducted using STATISTIKA 8 program. Results and discussion. All compounds studied in their physicochemical properties meet the requirements for new BAS at the stage of testing their biological activity (correspond to Lipinski’s rule). The dependence of the microbiological action of some N-substituted amino acids on MR is maximal for compounds, which MR value is in the range of 2.13-4.53. The growth of all microorganisms was observed for unsubstituted amino acids (MR 2.8). The maximum activity of all compounds studied was observed against gram-positive (B. subtilis and S. aureus), and the less activity was against gram-negative microorganisms (E. coli, P. vulgaris, P. aeruginosa) and fungi (C. albicans). It may be associated with the structural peculiarities of the cellular wall. The MR values calculated correlate satisfactorily with the experimental data of the antimicrobial activity of compounds. Conclusions. Statistically significant values of MR correlation with the values of the antimicrobial activity of some N-substituted amino acids against the microorganisms studied have been determined. It quantitatively confirms the presence of the “structure – activity” relationship in this series of compounds
Доп.точки доступа:
Golik, М. Yu.
Kryskiv, О. S.
Komissarenko, A. M.
Kolisnyk, O. V.

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Ohiri, R. C.
Nutriceutical potential of Pleurotus tuber-regium sclerotium / R. C. Ohiri // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 3. - P84-93

MeSH-главная:
PLEUROTUS -- PLEUROTUS
МИКРОЭЛЕМЕНТЫ -- TRACE ELEMENTS
АМИНОКИСЛОТЫ -- AMINO ACIDS
ЛЕТУЧИЕ ОРГАНИЧЕСКИЕ СОЕДИНЕНИЯ -- VOLATILE ORGANIC COMPOUNDS
ФАРМАКОГНОЗИЯ -- PHARMACOGNOSY
Аннотация: The aim of the study was to determine the composition of the sclerotium of Pleurotus tuber-regium and to analyze its nutritional potential. Major minerals and micronutrients content of the P. tuber-regium sclerotium were determined. The study has shown fairly high concentrations of potassium and magnesium as major minerals with values of 60.66 ± 4.13 and 41.79 ± 3.14 mg/kg, while manganese and zinc were micronutrients with the highest values of 1.20 ± 0.10 and 0.95 ± 0.07 mg/kg. Glutamic acid and aspartic acid were also observed in high concentrations with values of 11.51 ± 1.01 and 5.52 ± 0.86 mg/kg. The mushroom powder of P. tuber-regium was a source for production of oil, which was analyzed by GC-MS method. Benzenedicarboxylic acid mono-(2-ethylhexyl) ester and benzenedicarboxylic acid butyl-cyclohexyl ester were volatile constituents predominating with percentage total of 78.7 and 5.2, respectively. It is concluded that the presence of mineral elements, amino acids and volatile components observed in this fungus indicated the presence of the nutritional potential in the sclerotia of P. tuber-regium
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Shevchenko, O. S.
Dynamics of life quality in patients with pulmonary tuberculosis against the background of the appointment of an essential amino acids complex [Текст] = Динаміка показників якості життя хворих на туберкульоз легень на тлі призначення комплексу незамінних амінокислот / O. S. Shevchenko, O. O. Pohorielova // Туберкульоз, Легеневі хвороби, ВІЛ-інфекція : український науково-практичний журнал. - 2021. - N 1. - С. 15-24. - Bibliogr. at the end of the art.

MeSH-главная:
ТУБЕРКУЛЕЗ ЛЕГКИХ -- TUBERCULOSIS, PULMONARY (патофизиология, профилактика и контроль, терапия, этиология)
АМИНОКИСЛОТЫ -- AMINO ACIDS (анализ, прием и дозировка, терапевтическое применение, фармакология)
КАЧЕСТВО ЖИЗНИ -- QUALITY OF LIFE (психология)
ТАБЛИЦЫ -- TABLES
Аннотация: Objective — to investigate the dynamics of life quality in patients with pulmonary tuberculosis against the background of the appointment of an essential amino acids complex
The appointment of a complex of amino acids as an additional pathogenetic therapy in patients with pulmonary tuberculosis improves the quality of life, and the appointment of an injectable form of amino acids accelerates patients’ adaptation and increases adherence to treatment, which is one of the key factors in the effectiveness of therapy
Мета роботи — дослідити динаміку показників якості життя хворих на туберкульоз легень на тлі призначення комплексу незамінних амінокислот
Призначення комплексу амінокислот як додаткової патогенетичної терапії у хворих на туберкульоз легень дає змогу підвищити якість життя пацієнтів, а призначення ін’єкційної форми амінокислот прискорює їхню адаптацію і підвищує прихильність до лікування, що є одним з ключових чинників ефективності терапії
Доп.точки доступа:
Pohorielova, O. O.

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The quantitative “structure–antibacterial activity” relationships in a series of N-substituted amino acids [Text] / M. Yu. Golik [et al.] // Вісн. фармації. - 2017. - № 1. - P14-20

MeSH-главная:
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА -- ANTI-BACTERIAL AGENTS (химический синтез)
АМИНОКИСЛОТЫ -- AMINO ACIDS (химический синтез)
Аннотация: The presence of the antibacterial and antifungal activity in derivatives of amino acids is determined by different mechanisms; therefore, a promising field of research is to obtain new N-substituted amino acids and study their antibacterial action. Aim. To determine the quantitative “structure – antibacterial action” relationships in a series of N-substituted amino acid
Доп.точки доступа:
Golik, M. Yu.
Kryskiv, O. S.
Komissarenko, A. M.
Kolisnyk, O. V.
Dudka, K. I.

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The reactivity of propyl esters of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl]amino acids [Текст] / O. M. Svechnikova [et al.] // Вісн. фармації. - 2017. - № 2. - С. 3-6

MeSH-главная:
СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP
ПРОПАНОЛЫ -- PROPANOLS (химия)
ИНДОЛЫ -- INDOLES (химия)
АМИНОКИСЛОТЫ -- AMINO ACIDS (химия)
Аннотация: The study of the reactivity of substances allows optimizing the conditions of their synthesis and creating mathematical models of the “structure-biological activity” relationship that enable to carry out the targeted search of compounds with a specified high level of the biological action. Aim. To study the reactivity of propyl esters of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl]amino acids. Materials and methods. The reactivity of propyl esters of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl]amino acids was studied in reversible conditions on the model of acid-base equilibria by the method of potentiometric titration. Results and discussion. The ionization constants of 9 propyl esters of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl]amino acids indicate that these compounds are weak acids. Elongation of the methylene fragments in the amino acid groups of molecules decreases their acidity. In contrast to the length of the methylene fragments their branching and the presence of the substituents do not affect acidity of the esters studied. In the framework of the principle of linearity of free energies the effect of the length of the methylene chain in the amino acid fragment of the molecules of propyl esters of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl]amino acids was quantitatively assessed by Hammett equation. Conclusions. It has been found that propyl esters of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl]amino acids have the functions of weak monobasic acids. Elongation of the polymethylene chain weakens ionization. The low sensitivity of the reaction center to elongation of the methylene chain has been identified
Доп.точки доступа:
Svechnikova, O. M.
Kolisnyk, S. V.
Vinnyk, O. F.
Kolisnyk, O. V.

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10.

Vovk, G. V.
The amino acid and monosaccharide composition of a dry extract from Salvia officinalis leaves obtained by complex processing [Text] / G. V. Vovk, O. M. Koshovyi, A. M. Komissarenko // Вісн. фармації. - 2016. - № 1. - P33-35

MeSH-главная:
(химия)
АМИНОКИСЛОТЫ -- AMINO ACIDS (анализ, выделение и очистка)
МОНОСАХАРИДЫ -- MONOSACCHARIDES (анализ, выделение и очистка)
Кл.слова (ненормированные):
РАСТЕНИЙ ЭКСТРАКТЫ СУХИЕ
Доп.точки доступа:
Koshovyi, O. M.
Komissarenko, A. M.

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