Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Kopchak, N. H.
Age-specific features of fatty acid composition of lipid serum in rats with obesity under the influence of iodine [Текст] = Вікові особливості жирнокислотного складу ліпідів сироватки крові щурів з ожирінням при впливі йоду / N. H. Kopchak, O. S. Pokotylo // Медична та клінічна хімія. - 2018. - Том 20, N 3. - С. 63-69

MeSH-главная:
КРОВИ СЫВОРОТКА -- SERUM
КРЫСЫ -- RATS
ЖИРНЫЕ КИСЛОТЫ -- FATTY ACIDS
ОЖИРЕНИЕ -- OBESITY
ИОД -- IODINE
Аннотация: The article presents new data on the age-specific features of the fatty acid composition of the total serum lipids of white male rats with experimental alimentary obesity in the comparative effect of intragastric administration of biologically active iodine in the composition of Jodis-concentrate and inorganic iodine as a part of the Iodomarin
У статті наведено нові дані про вікові особливості складу жирних кислот загального вмісту ліпідів сироватки крові білих щурів-самців з експериментальним аліментарним ожирінням у порівняльному ефекті внутрішньошлункового введення біологічно активного йоду в складі йодіс-концентрату і неорганічного йоду в складі йодомарину
Доп.точки доступа:
Pokotylo, O. S.

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Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells / Yu. Kit [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P36-41 : il. - 34 ref.

MeSH-главная:
ЛЕЙКОЗ T-КЛЕТОЧНЫЙ -- LEUKEMIA, T-CELL
ВОЛЧАНКА КРАСНАЯ СИСТЕМНАЯ -- LUPUS ERYTHEMATOSUS, SYSTEMIC
КРОВИ СЫВОРОТКА -- SERUM
КЛЕТКИ ПРОЛИФЕРАЦИЯ -- CELL PROLIFERATION
ПЕРЕКРЕСТНЫЕ РЕАКЦИИ -- CROSS REACTIONS
АУТОАНТИТЕЛА -- AUTOANTIBODIES
Аннотация: The aim of this study was to characterize the proliferative activity of the anti-histone H1 IgGs towards human T-leukaemia CEM cells. Materials and Methods: Anti-histone H1 IgGs were purified from blood serum of systemic lupus erythematosus patients by precipitation of serum proteins with 50% ammonium sulfate followed by a sequential affinity chromatography on Protein GSepharose and histone H1-Sepharose columns. To avoid contamination with other proteins, anti-histone H1 IgGs were subjected to strongly acidic pH 2.0 during gel filtration through HPLC column. The effects of the anti-histone H1 IgGs on cell viability and cell cycle were tested by MTS-assay and flow cytometry, correspondingly. The cross-reactivity of the anti-histone H1 antibodies towards heterogenetic and cellular antigens was evaluated by Western-blot analysis. Results: It was found that incubation of CEM cells with the HPLC-purified anti-histone H1 IgGs resulted in significant stimulation of cell growth by 46% after 48 h of incubation. These IgGs possess an antigenic poly-specificity to positively charged heterogenetic antigens and different cellular antigens. FITC-labeled and biotinylated anti-histone H1 IgGs are internalized by CEM cells and preferentially accumulated in the cytoplasm. Conclusion: The anti-histone H1 IgGs are shown to internalize human T-leukemia CEM and stimulate their proliferation. These IgGs are polyspecific toward cellular antigens
Доп.точки доступа:
Kit, Yu.
Magorivska, I.
Bilyi, R.
Myronovskij, S.
Stoika, R.

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Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier [Text] = Біохімічні показники нефротоксичності у сироватці крові щурів за дії нових похідних 4-тіазолідинонів та їхніх комплексів із поліетиленглікольвмісним полімерним нанорозмірним носієм / L. I. Kоbylinska [et al.] // Український біохімічний журнал. - 2016. - Т. 88, № 1. - P51-60. - Бібліогр.: в кінці ст.

MeSH-главная:
МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL
КРОВИ СЫВОРОТКА -- SERUM (метаболизм, химия)
ПОЧЕЧНАЯ ЭЛИМИНАЦИЯ -- RENAL ELIMINATION (физиология)
ТИАЗОЛИДИНЫ -- THIAZOLIDINES (анализ, метаболизм, химический синтез)
ДОКСОРУБИЦИН -- DOXORUBICIN (анализ, кровь, метаболизм)
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (методы, статистика, тенденции)
ПОЛИЭТИЛЕНГЛИКОЛИ -- POLYETHYLENE GLYCOLS (анализ, химический синтез)
НАНОТЕХНОЛОГИЯ -- NANOTECHNOLOGY (методы, тенденции)
Доп.точки доступа:
Kоbylinska, L. I.
Havrylyuk, D. Ya.
Mitina, N. E.
Zаichenko, A. S.
Lesyk, R. B.
Zіmenkovsky, B. S.
Stoika, R. S.

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Masoumi-Ardakani, Y.
Carnitine effects on serum and pancreas inflammatory response in diabetic rats [Текст] = Вплив карнітину на запальну реакцію в сироватці крові і підшлунковій залозі діабетичних щурів / Y. Masoumi-Ardakani, H. Fallah, B. Shahouzehi // The Ukrainian Biochemical Journal. - 2019. - Т. 91, № 6. - С. 59-66. - Bibliogr. at the end of the art.

MeSH-главная:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
ДИАБЕТ САХАРНЫЙ ЭКСПЕРИМЕНТАЛЬНЫЙ -- DIABETES MELLITUS, EXPERIMENTAL (патофизиология, терапия, этиология)
КАРНИТИН -- CARNITINE (анализ, метаболизм, терапевтическое применение, фармакология)
ПОДЖЕЛУДОЧНАЯ ЖЕЛЕЗА -- PANCREAS (действие лекарственных препаратов, метаболизм, патофизиология)
КРОВИ СЫВОРОТКА -- SERUM (действие лекарственных препаратов, метаболизм)
ДИАГРАММЫ -- CHARTS
Аннотация: Diabetes is a group of disorders characterized by elevated blood glucose and insulin secretion defect. Previous studies have reported L-carnitine beneficial and hypoglycemic effects in diabetic models. L carnitine anti-inflammatory properties in diabetes were not assessed perfectly, and there is a lack of information about this matter. Therefore, we designed this study and evaluated L-carnitine different doses supplementation on pro-inflammatory cytokines in STZ-induced diabetic rats’ pancreas and serum. We selected 48 male rats (200 ± 10 g) and randomly divided them into six groups (n = 8). Group 1, control; group 2, Diabetic control (DC); groups 3-6, STZ-induced diabetic rats which received L-carnitine different doses as follow; 300, 200, 100 and 50 mg/kg/day by intraperitoneal injection for 5 weeks. When the study ended, serum and pancreas samples were collected and cytokines levels were measured by specific ELISA kits. Our results showed that in diabetic rats, pro-inflammatory cytokines levels were elevated. Two L-carnitine doses 300 and 200 mg/kg/day showed beneficial effects and 300 mg/kg/day showed more effective and significant effects than other doses. The 300 mg/kg significantly reduced IL-1β and IL-6 levels in pancreas and serum. Our data proved the protective effects of intraperitoneal L-carnitine administration against diabetes and inflammation in diabetic rats. Indeed, L-carnitine long term supplementation through the intraperitoneal injection can be considered as a good and safe therapeutic strategy in diabetes
Діабет належить до захворювань, які характеризуються підвищеним рівнем глюкози в крові і порушенням секреції інсуліну. У попередніх дослідженнях на діабетичних моделях було виявлено, що L-карнітин виявляє гіпоглікемічний ефект. Однак, протизапальні властивості L-карнітину за діабету вивчені недостатньо. Метою дослідження було оцінити ефект різних доз L-карнітину на прозапальні цитокіни в підшлунковій залозі і сироватці крові в щурів зі стрептозоциніндукованим діабетом. Було відібрано 48 щурів-самців (200 ± 10 г) і розділено випадковим чином на шість груп (n = 8). Група 1 – контрольна група; 2 – діабетичний контроль (ДК); групи 3-6 – щури зі стрептозоциніндукованим діабетом, яким вводили L-карнітин в різних дозах: 300, 200, 100 і 50 мг/кг на добу шляхом інтраперитонеальних ін’єкцій протягом 5 тижнів. Після цього збирали зразки сироватки крові і підшлункової залози і визначали рівень цитокінів за допомогою наборів ELISA. Виявлено, що у діабетичних щурів рівень прозапальних цитокінів був підвищений. Дві дози L-карнітину 300 і 200 мг/кг на добу показали позитивні ефекти, при цьому ефект від введення L-карнітину в дозі 300 мг/кг на добу був значнішим. L-карнітин у дозі 300 мг/кг на добу істотно знижував вміст IL-1β і IL-6 у підшлунковій залозі і сироватці крові. Одержані результати підтвердили захисний ефект інтраперитонеально введеного L-карнітину у разі запалення в діабетичних щурів. Отже, введення L-карнітину протягом тривалого часу можна розглядати як ефективну і безпечну терапевтичну стратегію за діабету
Доп.точки доступа:
Fallah, H.
Shahouzehi, B.

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Kozak, D. V.
Dynamic content pro- and anti-inflammatory cytokines in serum blood in response to polytrauma in the experiment [] / D. V. Kozak // Вісник морфології. - 2015. - Т. 21, № 2. - С. 433-436

MeSH-главная:
ЦИТОКИНЫ -- CYTOKINES (кровь)
КРОВИ СЫВОРОТКА -- SERUM (химия)
ТРАВМА МНОЖЕСТВЕННАЯ -- MULTIPLE TRAUMA (кровь)
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Evaluation of the effect of excess and deficiency of serum hydrogen sulfide on the condition of the vaginal wall of intact rats [Текст] / D. I. Grebeniuk [та ін.] // Biomedical and Biosocial Anthropology. - 2020. - № 41. - С. 24-29. - Bibliogr. at the end of the art.

MeSH-главная:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
ВЛАГАЛИЩЕ -- VAGINA (ультраструктура)
СЕРОВОДОРОД -- HYDROGEN SULFIDE (анализ, диагностическое применение)
МОРФОЛОГИЧЕСКИЕ И МИКРОСКОПИЧЕСКИЕ ПОКАЗАТЕЛИ -- MORPHOLOGICAL AND MICROSCOPIC FINDINGS
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
ТАБЛИЦЫ -- TABLES
КРОВИ СЫВОРОТКА -- SERUM (химия)
Аннотация: Various pathological conditions can be characterized not only by a decrease or increase in basal levels of hydrogen sulfide in the serum, but also the levels of hydrogen sulfide can modulate the course of the pathological process. The impact of serum hydrogen sulfide on the condition of the intact vaginal wall of rats was evaluated in this study. The aim of the study was to evaluate the effect of excess and deficiency of serum hydrogen sulfide on the condition of the vaginal wall of intact rats. The study was performed on 75 female Wistar rats under 1 year of age and weighing 160.0 to 200.0 grams. All animals were divided into 6 groups: control (intact rats); experimental 1 (H2S excess); experimental 2 (H2S deficiency); experimental 3 (intravaginal administration of suppositories with clindamycin); experimental 4 (H2S excess + suppositories with clindamycin); experimental 5 (H2S deficiency + suppositories with clindamycin). The levels of serum hydrogen sulfide were studied, as well as microscopic examination of the structure of the vaginal wall and determination of the levels of TNF-α and IL-1β in tissue homogenate were performed. In experimental groups 3, 4 and 5 all studies were performed in dynamics – 10 minutes, 4, 8 and 24 hours after a single intravaginal administration of clindamycin phosphate. The data were processed using the statistical software package SPSS 20.0 for Windows. Under conditions of both hydrogen sulfide deficiency and excess, no statistically significant changes in TNF-α and IL-1β levels in the vaginal wall of intact rats were observed. Also, no changes in the histological structure of the wall were found. Similar data were demonstrated in experimental groups 3, 4 and 5. This picture is explained by the fact that hydrogen sulfide affects various parts of the inflammatory process, while reducing the production of inflammatory mediators. In intact tissues, in the absence of an inflammatory process, there is no point of application of hydrogen sulfide, and therefore no significant changes are observed. Thus, both excess and deficiency of serum hydrogen sulfide do not affect the condition of the vaginal wall of intact rats
Доп.точки доступа:
Grebeniuk, D. I.
Voloshchuk, N. I.
Taran, I. V.
Gormash, P. P.
Nazarchuk, O. A.

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Zakharov, S. V.
Features of biochemical indices and content of enzymes in the serum of syphilis patients with viral hepatites B and C in the course of treatment [Text] / S. V. Zakharov, V. K. Zakharov, V. V. Gorbuntsov // Медичні перспективи. - 2021. - Т. 26, № 3WМУ10/2021/26/3. - P107-113. - Bibliogr. at the end of the art.

MeSH-главная:
СИФИЛИС -- SYPHILIS (диагностика, кровь, лекарственная терапия)
ГЕПАТИТ B -- HEPATITIS B (диагностика, кровь, лекарственная терапия)
ГЕПАТИТ C -- HEPATITIS C (диагностика, кровь, лекарственная терапия)
КОИНФЕКЦИЯ -- COINFECTION (диагностика, кровь, лекарственная терапия)
КРОВИ СЫВОРОТКА -- SERUM (микробиология, химия, цитология)
ФЕРМЕНТЫ -- ENZYMES (диагностическое применение, кровь, химия)
БИОХИМИЯ -- BIOCHEMISTRY
Аннотация: Objective – before and after the treatment to determine the functional state of the liver, serum levels of enzymes and biochemical indices in syphilis patients with viral hepatites B and C. The results of the study are based on the data from a comprehensive examination of 35 patients with syphilis alone and 127 patients with syphilis co-infected with viral hepatites B and C before and after treatment. Test methods: hepatology, rheogeopathography, enzyme content and biochemical parameters determined in the serum. According to the results of radionuclide hepatology it has been established that disorders of the functional capacity of the liver already occur in the early stages of the disease. The most significant disorders have been in the patients with the prescription of infection for more than 12 months and in the patients co-infected with viral hepatites B and C. A disorder of pigment metabolism and increased activity of transaminases have been revealed in early latent syphilis. In co-infection with viral hepatites B and C an increase in total bilirubin, Lactate dehydrogenase, Alanine transaminase, Aspartate aminotransferase and albumin has been revealed. Dysproteinemia has been revealed in patients with early latent syphilis co-infected with hepatitis C. Patients with early latent syphilis treated with immunomodulators tend to normalize these indices. In patients with syphilis a disorder of the functional state of the liver have been revealed already at an early stage of the disease. The most pronounced disorder of biochemical parameters and activity of liver enzymes are observed in syphilis patients with viral hepatites B and C, as well as in patients with early latent syphilis only with the prescription of the infection for more than 12 months; in such a case it is advisable to use drugs affecting the immune system
Доп.точки доступа:
Zakharov, V. K.
Gorbuntsov, V. V.

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Shahouzehi, B.
L-carnitine administration effects on AMPK, APPL1 and PPARγ genes expression in the liver and serum adiponectin levels and HOMA-IR in type 2 diabetes rat model induced by STZ and nicotinamide / B. Shahouzehi, H. Fallah, Y. Masoumi-Ardakani // The Ukrainian biochemical journal. - 2020. - Vol. 92, № 5. - P33-40

MeSH-главная:
ПЕЧЕНЬ -- LIVER (действие лекарственных препаратов, патофизиология, повреждения)
КАРНИТИН -- CARNITINE (генетика, фармакокинетика)
ГЕННАЯ ЭКСПРЕССИЯ -- GENE EXPRESSION (действие лекарственных препаратов)
АДИПОНЕКТИН -- ADIPONECTIN (фармакокинетика)
КРОВИ СЫВОРОТКА -- SERUM (действие лекарственных препаратов, метаболизм)
СТРЕПТОЗОТОЦИН -- STREPTOZOCIN (вредные воздействия)
НИКОТИНАМИД -- NIACINAMIDE (вредные воздействия)
ДИАБЕТ САХАРНЫЙ -- DIABETES MELLITUS (генетика, метаболизм, патофизиология)
ЭУКАРИОТЫ -- EUKARYOTA
Аннотация: Diabetes is a chronic disease and a public health problem globally. L-Carnitine is synthesized in the liver, promotes fatty acids oxidation and currently is used as a supplement against weight gain. Carnitine level is found to be reduced in diabetic patients and to be beneficial as a supplement at diabetes, but the mechanisms of this effect is not fully understood. Therefore, we evaluated the oral L-carnitine supplementation on expression of AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma (PPARγ), adaptor protein APPL1 genes in the liver and insulin and adiponectin levels in the serum of diabetic rats. Rats were randomly divided into three groups (n = 8) as follow: group 1 – control without any treatment, group 2 – diabetic control rats which received STZ (45 mg/kg) and nicotinamide (200 mg/kg) by i.p. injection, group 3 – diabetic rats which received 600 mg/kg/day carnitine orally for 35 days. It was found that L-carnitine supplementation reduced the level of fasting glucose compared to that in control and diabetic groups (P = 0.001, P = 0.0001 respectively) and increased adiponectin level compared to diabetic nontreated rats (P = 0.0001). Homeostasis model assessment of insulin resistance (HOMA-IR) was significantly increased in the diabetic group and reduced in the group that received L-carnitine. These promising beneficial effect of L-carnitine on the type 2 diabetes in rats’ model was shown to be conducted through the up-regulation of AMPK, PPARγ and APPL1 genes expression in the liver and elevation of serum adiponectin level
Доп.точки доступа:
Fallah, H.
Masoumi-Ardakani, Y.

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Long-term hypocholesterolemic effect of amidated alginate in rats [Text] / M. Marounek [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 6. - P120-125

MeSH-главная:
ПЕЧЕНЬ -- LIVER (действие лекарственных препаратов)
КРОВИ СЫВОРОТКА -- SERUM (действие лекарственных препаратов)
АЛЬГИНАТЫ -- ALGINATES
ХОЛЕСТЕРИН -- CHOLESTEROL
ЖЕЛЧНЫЕ КИСЛОТЫ И СОЛИ -- BILE ACIDS AND SALTS
ЭУКАРИОТЫ -- EUKARYOTA
Аннотация: The effect of octadecylamide of alginic acid on blood serum and hepatic cholesterol, and the faecal output of fat and sterols was examined in female rats fed diets containing cholesterol and palm fat at 10 and 50 g/kg, respectively for 10 weeks. Amidated alginate, supplied at 10 and 20 g/kg, significantly decreased serum cholesterol from 5.25 to 2.99 and 2.39 µmol/ml, respectively, and decreased hepatic cholesterol from 30.7 to 12.3 and 9.4 µmol/g, respectively. Amidated alginate increased the faecal output of fat and at higher dosing significantly decreased faecal output of bile acids. Faecal output of bile acids and hepatic cholesterol significantly correlated (r = 0.791; P 0.001). The results of the present experiment showed that hypocholesterolemic effect of amidated alginate persisted within 10 weeks of feeding
Доп.точки доступа:
Marounek, M.
Volek, Z.
Taubner, T.
Duskova, D.
Kalachniuk, L.

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10.

Zakharov, S. V.
Nonspecific protective factors in patients with early latent syphilis (report 1) [Text] / S. V. Zakharov, V. K. Zakharov // Медичні перспективи. - 2021. - Т. 26, № 4. - P138-143. - Bibliogr. at the end of the art.

MeSH-главная:
СИФИЛИС -- SYPHILIS (диагностика, кровь, метаболизм)
ДИАГНОСТИКА РАННЯЯ -- EARLY DIAGNOSIS
ИНТЕРЛЕЙКИНЫ -- INTERLEUKINS (диагностическое применение, кровь, метаболизм)
КРОВИ СЫВОРОТКА -- SERUM (метаболизм, химия, цитология)
Аннотация: The objective of this work is to study nonspecific protective factors in patients with latent early syphilis. The results of the study are based on the data of a comprehensive examination before treatment of 142 patients with early latent syphilis and 20 patients of the comparison group. Methods of investigation: serological methods for the diagnosis of syphilis complex of serological reactions, enzyme-linked immunosorbent assay (IgM, IgG), Indirect immunofluorescence reaction (RIF) RIF-200, RIF-abs; determination of cytokines IL-2, IL-6, IL-10, TNFα and INFγ in blood serum by enzyme-linked immunosorbent assay; determination of the phenotype of lymphocytes (CD-receptors), the concentration of circulating immune complexes, phagocytic number, phagocytic index, Nitroblue tetrazolium test. In the blood serum of patients the concentration of IL-2, IL-6, IL-10 and TNFα, INFγ was significantly increased. The concentration of IL-10 and IL-6 was also significantly increased in patients with more than 1 year of infection. The most significant disorders of the parameters of the metabolic activity of neutrophils were found in patients with an infection of more than 1 year; an imbalance in the circulating immune complexes concentration was also established. Under the increasing duration of the infection, the concentration of CD16+ in the blood serum progressively decreases. The content of pro-inflammatory and anti-inflammatory cytokines in the blood serum of patients with early latent syphilis was significantly increased and depended on the timing of infection. This relationship was most pronounced for IL-6 and IL-10. In patients with early latent syphilis there is also an imbalance between CD25+ and late activation factor HLA-DR against the background of a progressive decrease in the number of CD16+ lymphocytes. A direct relationship was established between the time of infection and the number of NK-cells. The revealed disorders may be the consequence of significant disorders on the part of neutrophils and may be one of the factors of the latent course of syphilitic infection
Доп.точки доступа:
Zakharov, V. K.

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