Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Батыралиев Т. А., Фетцер Д. В., Сидоренко Б. А., Озгуль С. , Першуков И. В. , Серчелик Α. , Сариев Э. , Беленков Ю. Н.
Заглавие : Двухлетний клинический опыт применения пенетрационного катетера Tornus при чрескожных коронарных вмешательствах на хронических тотальных окклюзиях коронарных артерий
Место публикации : Кардиология. - 2012. - Т. 52, № 1. - С. 52-57 (Шифр КР9/2012/52/1)
Предметные рубрики: Катетерное иссечение-- методы
Коронарной артерии шунтирование-- методы
Пенетрантность
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Микалюк Л. В., Колоскова О. К.
Заглавие : Патогенетичні взаємозв’язки екогенетичних чинників у формуванні бронхіальної астми в дітей
Место публикации : Клінічна та експериментальна патологія. - 2013. - Т. 12, № 1. - С. 190-193 (Шифр КУ27/2013/12/1)
MeSH-главная: АСТМА БРОНХИАЛЬНАЯ -- ASTHMA
ДЕТИ -- CHILD
ПЕНЕТРАНТНОСТЬ -- PENETRANCE
ОКРУЖАЮЩЕЙ СРЕДЫ ВОЗДЕЙСТВИЕ, БОЛЕЗНИ -- ENVIRONMENTAL ILLNESS
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Brieieva O. V., Lurchenko N. P., Protsenko V. V., Nespryadko S. V.
Заглавие : DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay
Место публикации : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 299-303 (Шифр ЕУ12/2017/39/4)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
ГЕНЫ СУПРЕССОРЫ ОПУХОЛЕВОГО РОСТА -- GENES, TUMOR SUPPRESSOR
ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE
ЛИМФОЦИТЫ, ИНФИЛЬТРИРУЮЩИЕ ОПУХОЛЕВЫЕ КЛЕТКИ -- LYMPHOCYTES, TUMOR-INFILTRATING
ПЕНЕТРАНТНОСТЬ -- PENETRANCE
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: To date, genome instability is considered to be a common feature not only of tumor cells, but also of non-malignant cells of cancer patients, including peripheral blood lymphocytes (PBLs). The issue of the association between genome instability in tumor cells and PBLs, as well as of its relationship with tumor progression remains poorly understood. Aim: To evaluate the level DNA damage in tumor cells and PBLs of endometrial cancer (EC) patients with regard to clinical and morphological characteristics of the patients. Materials and Methods: DNA damage was assessed in 106 PBLs samples and 42 samples of tumor cell suspension from EC patients by comet assay. PBLs from 30 healthy women were used as control. The level of DNA damage was expressed as the percentage of DNA in the comet tails (% tail DNA). Results: It was revealed that the amount of DNA damage in PBLs of EC patients was 2.2 times higher in comparison with that of healthy donors (8.3 ± 0.7 and 3.7 ± 0.4% tail DNA, respectively) (p 0.05). In this study, no association between the levels of DNA damage in endometrial tumor cells and PBLs was observed (r 0.05). The amounts of DNA damage both in tumor cells and PBLs were not related to the degree of tumor differentiation as well as the depth of myometrial invasion, but depended on the body mass index (BMI) of EC patients: high level of lesions was observed in patients with elevated BMI values. Furthermore, the level of DNA damage in tumor cells was associated to familial aggregation of cancer and was significantly higher in endometrial cells from patients with family history of cancer vs that from EC patients with sporadic tumors (32.3 ± 2.9 and 22.8 ± 1.8% tail DNA, respectively) (p 0.05). It was also found that for women who had high level of DNA damage in PBLs, the risk of EC was greater (odds ratio value of 3.5) compared to those with low level of such lesions. Conclusion: Genome instability that appears as an increased level of DNA damage in tumor cells and PBLs of EC patients is associated with BMI and family history of cancer and can reflect a predisposition to cancer
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Brieiev O. V., Iurchenko N. P.
Заглавие : Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas
Место публикации : Экспериментальная онкология. - 2019. - Т. 41, № 2. - С. 138-143 (Шифр ЕУ12/2019/41/2)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL
РЕЦЕПТОР ERBB-2 -- RECEPTOR, ERBB-2
ПРОТООНКОГЕНА БЕЛКИ C-MYC -- PROTO-ONCOGENE PROTEINS C-MYC
ПЕНЕТРАНТНОСТЬ -- PENETRANCE
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: To analyze copy number variations of HER-2/neu, c-MYC and CCNE1 oncogenes and their protein expression in endometrioid endometrial carcinomas in relation to the degree of tumor progression and presence of a family history of cancer in cancer patients. Materials and Methods: The study was conducted on endometrial cancer (EC) samples from 68 patients with I–II FIGO stages of disease. Copy number analysis of HER-2/neu, c-MYC and CCNE1 genes was performed by quantitative PCR. Protein expression was analyzed using immunohistochemistry. Results: Assessment of copy number variations of HER-2/neu, c-MYC and CCNE1 genes revealed their amplification in the tumors of 18.8, 25.0 and 14.3% of EC patients, respectively. High expression of corresponding proteins was detected in 14.6, 23.5 and 65.6% of patients, respectively. It was established that HER-2/neu gene amplification is more common in the group of tumors of low differentiation grade than in moderate grade EC (35.7 and 5.5% of cases, respectively, p 0.05). Also, high expression of c-Myc protein was more frequently observed in low differentiated tumors compared to the moderately differentiated EC (36.6 and 13.2% of cases, respectively, p 0.05). Expression of HER-2/neu and cyclin E proteins was found to be dependent on the depth of tumor invasion into the myometrium. High expression of HER-2/neu protein was observed in 25.0 and 4.1% of EC patients with tumor invasion ½ and ½ of the myometrium, respectively, and cyclin E — in 86.7 and 46.6% of cases, respectively, p 0.05. It was shown that among patients with a family history of cancer, a larger proportion of cases with high expression of c-Myc protein was observed compared to the group of patients with sporadic tumors (43.8 and 17.3%, respectively; p 0.05). Conclusions: Amplification of HER-2/neu gene, along with high expression of c-Myc, HER-2/neu and cyclin E proteins, are associated with such indices of tumor progression as a low differentiation grade and deep myometrial invasion, suggesting the potential possibility of including these markers in the panel for determining the molecular EC subtype associated with an aggressive course of the disease. In a certain category of EC patients, there is a relationship between a family history of cancer and high expression of c-Myc protein
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