Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Brieieva O., Nesina I., Buchynska L.
Заглавие : Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients
Место публикации : Experimental Oncology. - К., 2017. - Том 39, N 1. - С. 93 (Шифр ЕУ12/2017/39/1)
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
ГИДРОКСИЭСТРОНЫ -- HYDROXYESTRONES
ЛИМФОЦИТЫ -- LYMPHOCYTES
Аннотация: The endometrial cancer (EC) pathogenesis to a large extent may be determined by genotoxic effects of estrogen metabolites, among which the 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. Genomic instability and sensitivity to genotoxic estrogen metabolites in cells of EC patients depend on the DNA repair efficiency. The aim of the study was to analyze the level of DNA damage in peripheral blood lymphocytes (PBL) of EC patients after treatment with the 4OHE2 and to evaluate the repair efficiency of induced DNA damag
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Neslna I. P.
Заглавие : Expression ofthe cell cycle regulators p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} in human endometrial adenocarcinoma
Параллельн. заглавия :Особенности экспрессии регуляторов клеточного цикла p53, p21{\up WAF1/CIP1} and p-16 {\up INK4A} аденокарциномах эндометрия человека
Место публикации : Экспериментальная онкология. - 2006. - Т. 28, № 2. - С. 152-155 (Шифр 71097/2006/28/2)
Предметные рубрики: Эндометрия новообразования
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Brieieva O. V., Lurchenko N. P., Protsenko V. V., Nespryadko S. V.
Заглавие : DNA damage in tumor cells and peripheral blood lymphocytes of endometrial cancer patients assessed by the comet assay
Место публикации : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 299-303 (Шифр ЕУ12/2017/39/4)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
ГЕНЫ СУПРЕССОРЫ ОПУХОЛЕВОГО РОСТА -- GENES, TUMOR SUPPRESSOR
ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE
ЛИМФОЦИТЫ, ИНФИЛЬТРИРУЮЩИЕ ОПУХОЛЕВЫЕ КЛЕТКИ -- LYMPHOCYTES, TUMOR-INFILTRATING
ПЕНЕТРАНТНОСТЬ -- PENETRANCE
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: To date, genome instability is considered to be a common feature not only of tumor cells, but also of non-malignant cells of cancer patients, including peripheral blood lymphocytes (PBLs). The issue of the association between genome instability in tumor cells and PBLs, as well as of its relationship with tumor progression remains poorly understood. Aim: To evaluate the level DNA damage in tumor cells and PBLs of endometrial cancer (EC) patients with regard to clinical and morphological characteristics of the patients. Materials and Methods: DNA damage was assessed in 106 PBLs samples and 42 samples of tumor cell suspension from EC patients by comet assay. PBLs from 30 healthy women were used as control. The level of DNA damage was expressed as the percentage of DNA in the comet tails (% tail DNA). Results: It was revealed that the amount of DNA damage in PBLs of EC patients was 2.2 times higher in comparison with that of healthy donors (8.3 ± 0.7 and 3.7 ± 0.4% tail DNA, respectively) (p 0.05). In this study, no association between the levels of DNA damage in endometrial tumor cells and PBLs was observed (r 0.05). The amounts of DNA damage both in tumor cells and PBLs were not related to the degree of tumor differentiation as well as the depth of myometrial invasion, but depended on the body mass index (BMI) of EC patients: high level of lesions was observed in patients with elevated BMI values. Furthermore, the level of DNA damage in tumor cells was associated to familial aggregation of cancer and was significantly higher in endometrial cells from patients with family history of cancer vs that from EC patients with sporadic tumors (32.3 ± 2.9 and 22.8 ± 1.8% tail DNA, respectively) (p 0.05). It was also found that for women who had high level of DNA damage in PBLs, the risk of EC was greater (odds ratio value of 3.5) compared to those with low level of such lesions. Conclusion: Genome instability that appears as an increased level of DNA damage in tumor cells and PBLs of EC patients is associated with BMI and family history of cancer and can reflect a predisposition to cancer
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Movchan O. M., Svintsitskiy V. S., Tsip N. P., Nespryadko S. V., Bubliieva O. I., Iurchenko N. P.
Заглавие : Features of recurrence of endometrioid type endometrial cancer of I stage
Место публикации : Experimental Oncology. - К., 2021. - Том 43, N 4. - С. 365-369 (Шифр ЕУ12/2021/43/4)
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
НЕОПЛАСТИЧЕСКИЕ ПРОЦЕССЫ -- NEOPLASTIC PROCESSES
Аннотация: The aim of this study was to determine the rates of recurrences of stage I endometrial cancer (EC) and features of their localization depending on the clinical and pathological characteristics of the tumor and methods of patients’ treatment. Patients and Methods: The study included 968 patients with stage I endometrioid EC, who underwent surgical treatment in the Department of Oncogynecology of the National Cancer Institute in 2015–2019. Surveillance of patients lasted from January 2015 to December 2020, with a minimum follow-up period of 1 year from the date of surgery. Adjuvant radiation or chemotherapy was performed depending on the clinical and pathological characteristics of the EC case. Results: During the follow-up period, recurrences were observed in 7.0% of cases and were most often found in stage IC of low differentiation grade. It was found that during surgical treatment without adjuvant therapy relapses occurred in 12–36 months after the start of treatment, with adjuvant radiation therapy — in 6–18 months, and with adjuvant chemotherapy — in 32–60 months. Recurrences most often occurred in patients with EC who underwent surgical treatment in combination with chemotherapy (p 0.05). The lowest number of recurrences was recorded among patients who underwent surgery as an only treatment. The best 5-year survival rate was observed in the group of patients with surgical treatment (93%), and the worst — in the patients treated with combination of surgery and chemotherapy (57%). In patients without recurrences, the survival rate after treatment was 97%, while in patients diagnosed with relapses, the survival rate was 65%. Conclusion: Despite the predominantly favorable course of EC stage I, some patients develop relapses. The rate and localization of recurrences depend on the histological structure of the tumor and treatment regimens of the EC patients
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Benyuk V. O., Kalenskaya O. V., Goncharenko V. M., Strokan A. M., Bubnov R. V.
Заглавие : Immunohistological chemichal research of the apoptosis and endometrium APUD-system state interreaction in normal and pathological conditions
Параллельн. заглавия :Иммуногистохимическое исследование взаимоотношений процессов апоптоза и состояния APUD-системы эндометрия в норме и при патологии/ В.А. Бенюк, О.В. Каленская, В.Н. Гончаренко, А.Н. Строкань, Р.В. Бубнов
Место публикации : Здоровье женщины. - Киев, 2016. - № 1. - С. 63-66 (Шифр ЗУ3/2016/1)
MeSH-главная: ЭНДОМЕТРИЯ ГИПЕРПЛАЗИЯ -- ENDOMETRIAL HYPERPLASIA
ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY
АПОПТОЗ -- APOPTOSIS
BCL-АССОЦИИРОВАННЫЙ С АПОПТОЗОМ БЕЛОК -- BCL-ASSOCIATED DEATH PROTEIN
АПУД-КЛЕТКИ -- APUD CELLS
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Nesina I. P., Iurchenko N. P., Buchynska L. G.
Заглавие : Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma
Место публикации : Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 218-222 (Шифр ЕУ12/2018/40/3)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
КЛЕТКИ ПРОЛИФЕРАЦИЯ -- CELL PROLIFERATION
КАДГЕРИНЫ -- CADHERINS
БЕТА-КАТЕНИН -- BETA CATENIN
ВИМЕНТИН -- VIMENTIN
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Аннотация: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p 0.001 and 54.5 ± 2.6%, respectively, p 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Buchynska L. G., Lurchenko N. P., Glushchenko N. M., Nesina I. P.
Заглавие : Phenotypic features of endometrial tumors in patients with family history of cancer
Место публикации : Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 312-318 (Шифр ЕУ12/2017/39/4)
Примечания : Bibliogr. at the end of the art.
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
ГЕНЕТИЧЕСКАЯ ПРЕДРАСПОЛОЖЕННОСТЬ К БОЛЕЗНИ -- GENETIC PREDISPOSITION TO DISEASE
ФЕНОТИП -- PHENOTYPE
ГЕННОЙ ЭКСПРЕССИИ НОВООБРАЗОВАНИЙ РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION, NEOPLASTIC
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Аннотация: To determine the peculiarities of expression of a number of proteins-regulators of the cell cycle in endometrial cancer (EC) cells in patients with a family history of oncological pathologies. Patients and Methods: 95 EC patients (stage І–ІІ) were included into the study. Clinical-genealogical analysis was performed. 54 patients (group I) had healthy relatives, and in families of 41 patients (group II) an aggregation of malignant tumors of different genesis (mainly tumors of the gastrointestinal tract and the female reproductive system) was recorded. p53, р21WAF1/CIP1, р16INK4a, and Ki-67 were assessed immunohistochemically in the surgical samples. Results: In the majority of patients, both from group I and II, moderately differentiated tumors were observed (in 38.9 and 46.3% of cases, respectively), mainly with deep myometrium invasion (64.8 and 58.5% of cases, respectively). In EC patients from group II, a significantly higher number of р16INK4a-positive cells (17.7 ± 1.7%; p = 0.001) and lower number of p53-positive (30.9 ± 3.2%; p = 0.05) and Ki-67-positive (26.9 ± 2.7%; p = 0.048) cells was observed compared to those in tumors of patients from group I (12.0 ± 1.6; 37.7 ± 2.8 and 36.7 ± 3.4%, respectively). Conclusion: Phenotypic features of the EC in the patients with family history of cancer differ from those in tumors of patients without such aggregation. The biological heterogeneity of EC seems to relate to the oncogenealogical history of patients. Also this biological heterogeneity is linked to the molecular features of EC cells, which affects cancer aggressiveness and the course of the disease
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Romaniuk A. M., Gyryavenko N. I., Lуndіn M. S., Sikora V. V., Piddubnyi A. M.
Заглавие : The case of synchronous fallopian tube and endometrium cancer. Clinical observation
Место публикации : Патологія. - Запоріжжя, 2018. - Т. 15, N 1. - С. 109-113 (Шифр ПУ40/2018/15/1)
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
MeSH-неглавная: МАТОЧНЫХ ТРУБ НОВООБРАЗОВАНИЯ -- FALLOPIAN TUBE NEOPLASMS
АДЕНОКАРЦИНОМА -- ADENOCARCINOMA
Аннотация: Background. The problems of pre-operative cancer diagnosis of the fallopian tube are associated with a rare occurrence of this disease. More rarely, there is a combination of the fallopian tube cancer and other gynecological tumors. Clinical observation of the fallopian tube cancer and endometrial cancer in postmenopausal woman is presented, which demonstrates the difficulty of the pre-operative diagnostics of these pathologies combination. Case presentation. We described a case of uterine tube cancer in Ukrainian woman (77 years), which had been combined with adenocarcinoma of an endometrium. Conclusion. Primary fallopian tubes carcinoma is a rare disease with an insufficiently studied etiology. The clinical manifestations are not always present in full. Diagnosis in pre-operative period is very hard to establish. Only the qualitative morphological investigation allows establishing the primary lesion of the fallopian tube. Introducing immunohistochemical investigations in practice serves as additional methods for correct diseases diagnostic, which allow more fully characterizing the prognosis and suggesting appropriate treatment of the patients.
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Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Mints M., Mushtag M., Iurchenko N., Kovalevska L., Buchynska L., Kashuba E.
Заглавие : The MRPS 18-2 protein as a putative marker of carcinogenesis
Место публикации : Experimental Oncology. - К., 2017. - Том 39, N 1. - С. 92 (Шифр ЕУ12/2017/39/1)
MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL
БЕЛКИ НОВООБРАЗОВАНИЙ -- NEOPLASM PROTEINS
Аннотация: Endometrial cancer (EC) is one of the most frequent causes of cancer death among women in developed countries. Histopathological diagnosis and imaging techniques for EC are limited, thus new prognostic markers are needed to offer patients the best treatment and follow-up
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10.

Вид документа : Статья из журнала
Шифр издания :
Автор(ы) : Адамян Р. Т.
Заглавие : Гормонотерапия атипической гиперплазии и аденокарциномы эндометрия комбинацией прогестинов и антикоагулянтов
Место публикации : Вопросы онкологии. - 2001. - Т. 47, № 3. - С. 359-362 (Шифр ВР55/2001/47/3). - СПб.; Т. 47
MeSH-главная: ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА ГОРМОНАЛЬНЫЕ -- ANTINEOPLASTIC AGENTS, HORMONAL
ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS
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