Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Kian, R.
Role of components of microRNA machinery in carcinogenesis [Текст] / R. Kian, S. Moradi, S. Ghorbian // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 2-9. - Bibliogr. at the end of the art.

MeSH-главная:
МИКРО-РНК -- MICRORNAS (анализ, биосинтез, диагностическое применение)
НОВООБРАЗОВАНИЯ ПО ЛОКАЛИЗАЦИИ (ВНЕШ) -- NEOPLASMS BY SITE (NON MESH)
БЕЛКИ СЕМЕЙСТВА АРГОНАВТ -- ARGONAUTE PROTEINS (анализ, диагностическое применение)
РНК МАЛАЯ АНТИЧУВСТВИТЕЛЬНАЯ -- RNA, SMALL INTERFERING (анализ, биосинтез, диагностическое применение)
РНК НОВООБРАЗОВАНИЙ -- RNA, NEOPLASM (анализ)
Аннотация: MicroRNAs (miRNAs) are a broad class of non-coding RNAs nearly 21 nucleotides length, which play crucial functions in posttranscriptional gene regulation. These molecules are associated with many developmental and cellular processes in eukaryotic organisms. Current investigation has reported major factors contributing to miRNA biogenesis and has constituted basic principles of miRNA function. More recently, it was confirmed that various miRNAs are clearly implicated in human malignancies, such as lung, breast, ovarian, bladder, colon cancer and other kinds of carcinoma. In addition, dysregulation in the miRNA machinery elements such as Dicer, Drosha, DGCR8, Argonaut, and TRBP could be involved in the progress of many tumor types. The purpose of the current review was to compile growing information besides how miRNA biogenesis and gene silencing are modified to develop cancer
Доп.точки доступа:
Moradi, S.
Ghorbian, S.

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Clinical implications of p53 alterations in oral cancer progression: a review from India [Текст] / K. R. Patel [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 10-18. - Bibliogr. at the end of the art.

MeSH-главная:
НОВООБРАЗОВАНИЙ СУПРЕССОРНЫЙ БЕЛОК P53 -- TUMOR SUPPRESSOR PROTEIN P53 (анализ, диагностическое применение, ультраструктура)
ОДОНТОГЕННЫЕ НОВООБРАЗОВАНИЯ -- ODONTOGENIC TUMORS (диагностика, патофизиология, этиология)
ПРОТООНКОГЕНА БЕЛКИ C-MDM2 -- PROTO-ONCOGENE PROTEINS C-MDM2 (анализ, диагностическое применение, ультраструктура)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ТАБЛИЦЫ -- TABLES
Аннотация: p53 plays a central role in prevention of normal cell from the development of the malignant phenotype. Somatic alterations (mutations, loss of heterozygosity, deletions) in p53 are a hallmark of most human cancers and cause defects in normal p53 function. However, in the tumors harboring wild-type p53, there are alterations in the regulation of the p53. Thus, understanding why p53 is unable to perform its role as a tumor suppressor in these wild-type tumors is very crucial. Germ-line polymorphisms in p53 are also anticipated to cause measurable disturbance in p53 function. Over-expression as well as polymorphic variants of MDM2 might have effects on cancer development. In addition, degradation of p53 by E6 protein of high risk human papillomavirus is also suggested as one of the mechanisms which attenuate p53 responses in oral carcinogenesis. p53 has also been demonstrated to mediate cellular responses upon various DNA damaging cancer therapies, importantly, apoptosis. These responses have been implicated in an individual’s ability to respond to these cancer therapies. Thus, exploring mechanisms by which normal function of p53 is affected in the comprehensive way in oral cancer might aid in the identification of tumor characteristics, prognosis and thus in the development of a new approach to treat the oral cancer
Доп.точки доступа:
Patel, K. R.
Vajaria, B. N.
Singh, R. D.
Begum, R.
Patel, P. S.

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Characterization of the cytotoxic effects of the combination of cisplatin and flavanol (-)-epicatechin on human lung cancer cell line A549. An isobolographic approach [Текст] / O. Varela-Castillo [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 19-23. - Bibliogr. at the end of the art.

Рубрики: Эпикатехин--тер прим

MeSH-главная:
ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS (патофизиология, терапия, этиология)
ЛЕЧЕНИЯ НЕБЛАГОПРИЯТНЫЙ ИСХОД -- TREATMENT FAILURE
ПЛАТИНЫ СОЕДИНЕНИЯ -- PLATINUM COMPOUNDS (анализ, вредные воздействия, терапевтическое применение)
ФЛАВОНОИДЫ -- FLAVONOIDS (анализ, терапевтическое применение, фармакология)
КАТЕХИН -- CATECHIN (анализ, терапевтическое применение)
КЛЕТКИ ПРОЛИФЕРАЦИЯ -- CELL PROLIFERATION (действие лекарственных препаратов)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Кл.слова (ненормированные):
Коадъювант
Аннотация: Background: Among malignancies, lung cancer is a leading cause of death. Platinum-based therapeutic compounds used to treat lung cancer have not been able to increase the survival of patients and such compounds have a high incidence of adverse and toxic effects. It has been proposed that flavonoids such as catechins may significantly reduce the risk of developing cancer, alongside with other health benefits. The aim of this work was to determine the effect of (-)-epicatechin, the main flavanol found in cocoa, on the proliferation of the lung non-small cell adenocarcinoma cancer cell line A549, and to determine its effects when added simultaneously with cisplatin. Materials and Methods: Concentration-response curves for cisplatin and epicatechin were obtained, inhibitory concentrations calculated and an isobolographic analysis was then performed. Results: We found that epicatechin has a concentration-dependent inhibitory effect on proliferation of tumor cells and the isobolographic analysis reveals that the effect of its combination with cisplatin is synergistic. It was also observed that epicatechin promotes cell death by apoptosis. Conclusions: Epicatechin might be considered for future studies to explore its possible use as coadjuvant in cisplatin-based treatments
Доп.точки доступа:
Varela-Castillo, O.
Cordero, P.
Gutierrez-Iglesias, G.
Palma, I.
Rubio-Gayosso, I.
Meaney, E.
Ramirez-Sanchez, I.
Villarreal, F.
Ceballos, G.
Najera, N.

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Impact of endostatin gene therapy on myeloid-derived suppressor cells from a metastatic renal cell carcinoma [Текст] / K. C. B. Chaves [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 24-32. - Bibliogr. at the end of the art.

MeSH-главная:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
КАРЦИНОМА ПОЧЕЧНО-КЛЕТОЧНАЯ -- CARCINOMA, RENAL CELL (патофизиология, этиология)
ГЕННАЯ ТЕРАПИЯ -- GENETIC THERAPY (использование, тенденции)
ЭНДОСТАТИНЫ -- ENDOSTATINS (анализ, терапевтическое применение, фармакология)
3T3 КЛЕТКИ -- 3T3 CELLS
МИЕЛОИДНЫЕ КЛЕТКИ -- MYELOID CELLS (действие лекарственных препаратов)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: To evaluate the role of endostatin (ES) gene therapy on myeloid-derived suppressor cells (MDSC) in a metastatic model of renal cell carcinoma (RCC). Materials and Methods: Balb/C mice bearing orthotopic Renca tumors were treated with NIH/3T3LendSN or, as a control, with NIH/3T3-LXSN cells. At the end of in vivo experiment, plasma and tissue lung samples were collected. Plasma ES and granulocyte colony stimulating factor (G-CSF) levels were measured by ELISA and Milliplex, respectively. Quantification of CD11b⁺Gr⁻1⁺ cells and their subsets was performed by flow cytometry. Reactive oxygen species (ROS) production was measured in CD11b⁺Gr⁻1⁺ MDSC using the DCFDA marker by flow cytometry. Results: Metastatic RCC (mRCC) induced expansions of CD11b⁺Gr⁻1⁺ MDSC and promoted accumulation of these cells and their subtypes in lymphoid organ and metastases. ES treatment promoted low G-CSF plasmatic levels which were produced by the tumor microenvironment, reflecting the reduced metastatic accumulation of CD11b⁺Gr⁻1⁺ MDSC in the lungs. However, the therapy was selective for granulocytic cells, thus reducing the production of ROS. Conclusion: These findings confirm the expansion of MDSC during metastatic progression of RCC and indicate the important role of ES in reducing MDSC and possible use of ES therapy in combined anticancer treatment
Доп.точки доступа:
Chaves, K. C. B.
Costa, E. M.
Teixeira, L. F.
Bellini, M. H.

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Highly activated carbon enterosorbent mediates the suppression of paraneoplastic syndrome associated with lewis lung carcinoma in mice [Текст] / V. V. Sarnatskaya [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 33-41. - Bibliogr. at the end of the art.

MeSH-главная:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
КАРЦИНОМА ЛЬЮИС ЛЕГКОГО -- CARCINOMA, LEWIS LUNG (патофизиология, этиология)
ЭНТЕРОСОРБЦИЯ -- ENTEROSORPTION (использование, методы, тенденции)
МОРФОЛОГИЧЕСКИЕ И МИКРОСКОПИЧЕСКИЕ ПОКАЗАТЕЛИ -- MORPHOLOGICAL AND MICROSCOPIC FINDINGS
ЦИТОГЕНЕТИЧЕСКИЙ АНАЛИЗ -- CYTOGENETIC ANALYSIS (тенденции)
МИТОТИЧЕСКИЙ ИНДЕКС -- MITOTIC INDEX (статистика, тенденции)
НОВООБРАЗОВАНИЕ ОСТАТОЧНОЕ -- NEOPLASM, RESIDUAL (лекарственная терапия, профилактика и контроль, этиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Аннотация: To investigate the effect of enterosorption on the development of paraneoplastic syndrome in mice with Lewis lung carcinoma (LLC). Materials and Methods: The study was performed on male С57/ВL6 mice with transplanted LLC. As an enterosorbent, highly activated powder fraction of HSGD was administered per os daily at a dose of 0.625 g/kg for two weeks starting from the 7th day after tumor cell transplantation. Analysis of hemo- and myelograms, morphological alterations in vital organs, the activities of catalase and superoxide dismutase, biochemical analysis of blood and quantitative analysis of hydroperoxides, malonic dialdehyde, аdvanced oxidation protein products was carried out by standard methods after completing the course of enterosorption. Ligand loading of blood plasma proteins was estimated by the method of differential scanning microcalorimetry. Results: Administration of enterosorbent resulted in inhibition of LLC growth and in nearly 2-fold decrease of lung metastases number (p 0.05). Activation of granulocytic line in the bone marrow with nearly 3-fold enhancement of mitotic activity took place after enterosorbent administration. Red cell lineage indices and bone marrow cellularity remained unaltered. After enterosorption session, the studied biochemical indices of peripheral blood evidenced on decreasing the endogenous intoxication and oxidative stress levels, improving the functional state of kidneys, increasing the resistance of erythrocyte membranes and lowering the ligand loading of blood plasma transport proteins. Morphological structure of kidneys and liver confirmed significant positive effect of enterosorption. The data of morphologic examination of gastric fundus, small intestine, and large bowel slides after 2-week administration of enterosorbent showed its high safety and proper evacuation from intestine. Conclusion: The two-week long enterosorption session in mice with LLC caused the suppression of tumor growth and metastasis, normalization of bone marrow hemopoiesis. Enterosorption exerted a positive influence on the structural-morphologic indexes and regenerative potential of kidneys and liver, mitigated manifestations of oxidative stress, decreased the level of endogenous intoxication, promoted deliganding of albumin molecule and deloading of erythrocyte membranes
Доп.точки доступа:
Sarnatskaya, V. V.
Sakhno, L. A.
Paziuk, L. M.
Yushko, L. A.
Rodionova, N. K.
Maslenny, V. N.
Sydorenko, A. S.
Nikolaev, V. G.

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Boroday, N. V.
Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells [Текст] / N. V. Boroday, V. F. Chekhun // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 42-47. - Bibliogr. at the end of the art.

MeSH-главная:
КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER (осложнения, патофизиология, терапия, ультраструктура, этиология)
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ НОВООБРАЗОВАНИЙ -- DRUG RESISTANCE, NEOPLASM (физиология)
ТУЧНЫЕ КЛЕТКИ -- MAST CELLS (ультраструктура, физиология)
ДОКСОРУБИЦИН -- DOXORUBICIN (анализ)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Аннотация: The mechanisms of drug resistance of cancer have not been yet elucidated in details. Recently, the role of mast cells (MCs) in the development of drug resistance has been brought in the limelight. The aim of the study was to examine the morphological features of doxorubicin (DOX)-resistant Walker 256 carcinosarcoma and to assess the response of MCs and histamine content in these cells in relation to the development of resistance to DOX as well as in DOX-resistant tumors. Materials and Methods: The DOX resistance was induced by serial passages of Walker 256 carcinosarcoma in rats in the setting of DOX treatment in vivo. MCs in tumors were detected in the sections by staining with Toluidine Blue O. Histamine content in MCs stained with solution of Water Blue-Orcein was assessed by Astaldi semiquantitative method taking into account different staining intensity. Results: Formation of DOX resistance in the course of serial passages of Walker 256 carcinosarcoma was accompanied by the increase in the number of MCs in tumors and histamine content. Nevertheless, in tumors with phenotype of complete DOX resistance the number of histamine-containing MCs decreased to the same level as in tumors of the original strain that are DOX-sensitive. Conclusion: MCs are involved in formation of DOX resistance in Walker 256 carcinosarcoma
Доп.точки доступа:
Chekhun, V. F.

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Kurtenkov, O.
Signatures of anti-Thomsen — friedenreich antigen antibody diversity in colon cancer patients [Текст] / O. Kurtenkov, M. Bubina, K. Klaamas // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 48-58. - Bibliogr. at the end of the art.

MeSH-главная:
АНТИГЕНЫ ДИФФЕРЕНЦИРОВОЧНЫЕ -- ANTIGENS, DIFFERENTIATION (анализ, диагностическое применение)
ТОЩЕЙ КИШКИ НОВООБРАЗОВАНИЯ -- JEJUNAL NEOPLASMS (диагностика, патофизиология, этиология)
ИММУНОГЛОБУЛИНА G ДЕФИЦИТ -- IGG DEFICIENCY (кровь, этиология)
АНТИТЕЛА ПРОТИВООПУХОЛЕВЫЕ -- ANTIBODIES, NEOPLASM (анализ, диагностическое применение)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Кл.слова (ненормированные):
антиген Томсена–Фриденрайха
Аннотация: To determine whether the structural and functional diversities of naturally occurring antibodies to the Thomsen — Friedenreich (TF) antigen may be of diagnostic and prognostic value in colon cancer. Materials and Methods: Serum samples were taken from patients with colon cancer (n = 94) and healthy controls (n = 64). The level of TF-specific antibody isotypes and their sialylation were determined using ELISA and lectin-ELISA with synthetic TF-polyacrylamide conjugate as an antigen and a sialic acid-specific Sambucus nigra agglutinin (SNA). The avidity was determined using ammonium thiocyanate as a chaotrope. The accuracy of diagnostics was evaluated using the receiver operator characteristic curve analysis and the survival analysis employing the Kaplan — Meier method. Results: Compared to healthy controls, patients with colon cancer exhibited a lower level of anti-TF IgG antibodies, significantly lower ratios of TF-specific IgG/IgM and IgG/IgA, an increased SNA reactivity of anti-TF antibodies, mostly on account of IgG, and a lower avidity of TF-specific antibodies, especially their SNA-reactive subset. An increased SNA reactivity of anti-TF IgG was observed already at the early stages of cancer (p = 0.0004). The decrease of the ratio of IgG/IgM and IgG/IgA showed a good accuracy of diagnostics with about 60% sensitivity at 90% specificity. A similar potential was found for the SNA binding/IgG level index. The high level of TF-specific IgA antibodies was associated with a lower survival rate (hazard ratio = 0.34). Conclusion: This is the first report ever on the colon cancer-related signatures of anti-TF antibody diversity which show diagnostic potential, including in early cancer, and prognostic value. The hypersialylation of TF-specific antibodies appeared to be a common phenomenon in cancer. The signatures may be used as non-invasive antibody-based markers for colon cancer
Доп.точки доступа:
Bubina, M.
Klaamas, K.

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Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer [Текст] / O. V. Paliychuk [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 59-67. - Bibliogr. at the end of the art.

MeSH-главная:
НОВООБРАЗОВАНИЯ -- NEOPLASMS (врожденный)
РЕПРОДУКТИВНОЕ ЗДОРОВЬЕ -- REPRODUCTIVE HEALTH (тенденции)
ЖЕНЩИН ЗДОРОВЬЕ -- WOMEN'S HEALTH (тенденции)
ЛИНЧА СИНДРОМ II -- LYNCH SYNDROME II (диагностика, патофизиология, этиология)
ГЕНЫ СУПРЕССОРЫ ОПУХОЛЕВОГО РОСТА -- GENES, TUMOR SUPPRESSOR
ГЕНЫ BRCA1 -- GENES, BRCA1 (физиология)
ГЕНЫ BRCA2 -- GENES, BRCA2 (физиология)
МУТАЦИЯ -- MUTATION (физиология)
РИСКА СТЕПЕНИ ОЦЕНКА -- RISK ADJUSTMENT (использование, статистика, тенденции)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: To develop a prognostic molecular genetic model for assessing the risk of development of benign and malignant tumors of female reproductive organs (FRO) in patients from cancer-affected families. Patients and Methods: The work presents the data on a comprehensive clinical examination of 210 women (90 patients with FRO cancer with aggregation of tumor pathology in families, 65 patients with benign pathology of FRO from cancer-affected families, 55 women — control group of healthy women without family history of cancer). Clinical genealogical analysis, morphological examination of tumors and molecular genetic studies of genomic DNA from peripheral blood and tumors were carried out. Results: It was established that in the families of patients with benign and malignant pathology of FRO, malignant tumors associated with Lynch II syndrome are observed. Based on the analysis of detected ESR-1, CYP 2D6*4 and mutations in BRCA1/2 genes in cancer patients and in patients with benign pathology, molecular genetic models have been developed to assess the individual risk of development of benign and malignant tumors of FRO. It has been established that these molecular genetic models and combinations of gene mutations and gene polymorphisms (SNP) by the intergene interaction that was analyzed, were found to be reliable in assessing the risk of benign and malignant pathology of the mammary gland and ovary. Conclusions: The model, which included the polymorphic variants of the T397C(ESR1)/CYP 2D6*4 genes was of the best predictive accuracy for the evaluation of the risk of benign tumors of the FRO (71.68%) and the highest reliability (p 0.001). At the same time, all identified models of intergene interaction in the development of malignant pathology of FRO were reliable, prognostically significant with high reproduction and almost identical accuracy (65.00–68.23%). The obtained results indicate a high informativeness of such molecular genetic indices as the polymorphism of ESR1 and CYP 2D6*4 genes and mutations in BRCA1/2 genes to assess the risk of benign or malignant tumors of FRO in families of patients with family history of cancer
Доп.точки доступа:
Paliychuk, O. V.
Polishchuk, L. Z.
Rossokha, Z. I.
Chekhun, V. F.

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Buchynska, L. G.
Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients [Текст] / L. G. Buchynska, O. V. Brieieva // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 68-72. - Bibliogr. at the end of the art.

MeSH-главная:
НОВООБРАЗОВАНИЯ ГОРМОНОЗАВИСИМЫЕ -- NEOPLASMS, HORMONE-DEPENDENT (диагностика, патофизиология, этиология)
КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID (патофизиология, этиология)
ЛИМФОЦИТЫ -- LYMPHOCYTES (цитология)
ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE
РИСКА СТЕПЕНИ ОЦЕНКА -- RISK ADJUSTMENT (статистика, тенденции)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. It is assumed that the individual sensitivity to the 4OHE2 may determine the predisposition to endometrial cancer (EС). Aim: To analyze the sensitivity of peripheral blood lymphocytes (PBLs) of EC patients to the 4OHE2 and to evaluate the repair efficiency of 4OHE2-induced DNA damage. Materials and Methods: The study was performed on the PBLs of 53 EC patients and 20 healthy women. The level of DNA damage was measured using the comet assay and was expressed as % tail DNA. The DNA repair efficiency (%) was evaluated by determining the ratio between the amount of repaired DNA damage and the level of 4OHE2-induced damage that appeared after incubation of PBLs with 4OHE2. Results: In PBLs of EC patients, a higher level of 4OHE2-induced DNA damage (32.0 ± 2.2% tail DNA) and lower DNA repair efficiency (34.0 ± 4.5%) was observed compared to PBLs of healthy women (22.3 ± 2.3% tail DNA and 48.8 ± 4.5%, respectively). PBLs of EC patients with deep tumor invasion of myometrium were characterized by more prominent decrease of DNA repair than those with less invasive tumor ( ½ of myometrium) (20.9 ± 7.8 and 43.7 ± 6.7%, respectively). Furthermore, lower DNA repair efficiency was detected in the PBLs of EC patients with a family history of cancer compared to this parameter in patients with sporadic tumors (20.9±7.8 and 47.1 ± 5.5%, respectively). Conclusion: The PBLs of EC patients are characterized by increased sensitivity to the genotoxic effect of 4OHE2 and reduced repair efficiency regarding 4OHE2-induced DNA damage. A lower level of DNA repair is observed in EC patients with deep tumor myometrial invasion and a family history of cancer
Доп.точки доступа:
Brieieva, O. V.

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10.

Variant of rare hermansky — pudlak syndrome associated with granulomatous colitis: diagnostics clinical course and treatment [Текст] / L. Y. Lozynska [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 73-78. - Bibliogr. at the end of the art.

MeSH-главная:
ХЕРМАНСКОГО-ПУДЛАКА СИНДРОМ -- HERMANSKI-PUDLAK SYNDROME (генетика, диагностика, патофизиология, этиология)
ГЕНОТИП -- GENOTYPE
ФЕНОТИП -- PHENOTYPE
ГЕНЕТИЧЕСКАЯ ПРЕДРАСПОЛОЖЕННОСТЬ К БОЛЕЗНИ -- GENETIC PREDISPOSITION TO DISEASE (этиология)
ОПИСАНИЕ СЛУЧАЕВ -- CASE REPORTS
ТОЛСТАЯ КИШКА -- INTESTINE, LARGE (патофизиология)
ПРОДРОМАЛЬНЫЕ СИМПТОМЫ -- PRODROMAL SYMPTOMS
ЛЕЧЕБНО-ДИАГНОСТИЧЕСКАЯ ТАКТИКА -- CRITICAL PATHWAYS (тенденции)
Аннотация: To study the relationship between the genotype and the phenotype in the patients with Hermansky — Pudlak syndrome (HPS) associated with granulomatous colitis; to monitor clinical course of the disease for adequate treatment, cancer surveillance and genetic counseling. Materials and Methods: The diagnosis of HPS is established by physical examination, chest X-ray, computed tomography, endoscopic examination with biopsy, and laboratory tests, including histology, baseline laboratory blood, urine and feces tests, determination of ASCA-C and ANCA antibodies using an ELISA. Molecular genetic testing for HPS gene mutations, R702W, G908R, L1007fs and P268S mutations in NOD2 gene, and TaqI variant of the VDR gene were carried out. Results: We report 2 cases of HPS from unrelated families. Both were complicated by inflammatory bowel disease with pathologic features of Crohn’s disease refractory to antibiotics and corticosteroids. One patient (family 1) with Ashkenazi Jewish ancestry had pathogenic variant of the HPS-4 gene in exon 8, mutation P268S of NOD2 genes and “Tt” genotype of TaqI variant of the VDR gene. Another patient (family 2) carried two mutations P268S and G908R of NOD2 gene, and had a large paraovarian cyst diagnosed. No consistent success with the standard medical therapy, used for treating granulomatous colitis, associated with HPS, in presented cases was achieved. Patients needed surgical interventions at a young age and a long-term surveillance of the probable development of tumors and other complications. Azathioprine at 2 mg/kg/day and mesalazine 3 g/day were used with some positive effect for prevention of Crohn’s disease postoperative recurrence. Conclusion: The occurrence of perianal lesions, the histopathological findings and the results of the molecular genetic analysis confirmed the mutations P268S and G908R of NOD2 gene in these cases suggest that HPS was truly associated with Crohn’s disease variant with early onset and severe course. The search for the molecular causes of the disease in some individuals may help in the development of new therapeutic and surgical approaches, as well in the improvement of understanding of premalignant inflammatory conditions in a large bowel
Доп.точки доступа:
Lozynska, L. Y.
Plawski, A.
Lozynska, M. R.
Vytvytskyi, I.
Lozynskyi, R. Y.
Prokopchuk, N.
Tretiak, B.

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11.

Effect of cytostatic agents on expression levels of human beta-defensins-1-4 in A431 and MCF-7 cell lines [Текст] / O. S. Zubenko [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 79-81. - Bibliogr. at the end of the art.

MeSH-главная:
ДЕФЕНСИНЫ -- DEFENSINS (анализ, диагностическое применение)
БЕТА-ДЕФЕНСИНЫ -- BETA-DEFENSINS (анализ, диагностическое применение)
ЧЕЛОВЕК -- HUMANS (генетика)
ЦИТОСТАТИЧЕСКИЕ СРЕДСТВА -- CYTOSTATIC AGENTS (анализ, терапевтическое применение, фармакология)
КАРЦИНОМА ПЛОСКОКЛЕТОЧНАЯ -- CARCINOMA, SQUAMOUS CELL (патофизиология, терапия, этиология)
МЕТОТРЕКСАТ -- METHOTREXATE (анализ, терапевтическое применение, фармакология)
ДОКСОРУБИЦИН -- DOXORUBICIN (анализ, терапевтическое применение, фармакология)
ВИНКРИСТИН -- VINCRISTINE (анализ, терапевтическое применение, фармакология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: The aim of the study was to analyze an effect of cytostatic agents of different mechanism of action on expression levels of human beta-defensins-1-4 (hBD-1-4) in cultured human cancer cell lines. Materials and Methods: Expression levels of hBD-1-4 mRNA were assessed using qPCR in human epidermoid carcinoma A431 cells and human breast adenocarcinoma MCF7 cells treated with cisplatin, methotrexate, doxorubicin or vincristine at the IC20 concentrations. Results: The cytostatic agents with different mechanisms of action affected differently expression of hBDs, dependent on the cell line. Mostly, cytostatic agents suppressed significantly expression of hBDs. In contrast, vincristine caused significant up-regulation of hBD-1 (12 fold, p 0.05) and hBD-4 (2 fold, p 0.05) in MCF7, and doxorubicin significantly enhanced expression of hBD-3 (2 fold, p 0.05) and hBD-4 ( 10 fold, p 0.05) in A431 cells. Conclusion: The results of this pilot study show that expression levels of hBD-1-4 may be altered upon treatment with cytostatic agents depending on nature of cells
Доп.точки доступа:
Zubenko, O. S.
Semeniuk, D. O.
Starenka, I. O.
Pogribnyy, P. V.

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12.

Mediastinal yolk sac tumor infiltrating the heart [Текст] / R. Imaniar [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 82-84. - Bibliogr. at the end of the art.

Аннотация: As a rare tumor, yolk sac tumor is a type of neoplasm that appears like the yolk sac, extraembryonic mesenchyme, and allantois. The mediastinum is the second most frequent area after the gonadal area. Case report: We present an extremely rare case of 15 years old boy with mediastinal yolk sac tumor. The boy came with the chief complaint of swelling of the neck and face. Computed tomography scan of the chest revealed bulky mass with a cystic component that infiltrated the heart. The diagnosis of mediastinal yolk sac tumor was made after core needle biopsy. Histopathologic analysis revealed tumor mass with solid and microcystic structure and pleomorphic nucleus within the tumor cells. Laboratory finding showed elevated serum alpha-fetoprotein level reaching more than 8000 ng/ml. Echocardiography revealed a mass in the right atrium. The patient condition was rapidly deteriorated due to his vena cava superior syndrome. Unfortunately, the patient died two days after diagnosis and we did not have the chance to do the therapy. Conclusion: Mediastinal yolk sac tumor is a rare malignancy that requires comprehensive management. The diagnosis should be made based on histopathological findings with the addition of thoracic computer tomography scan to assess the degree of infiltration to surrounding organ. A life-threatening condition such as vena cava superior syndrome should be assessed promptly to allow for immediate treatment
Доп.точки доступа:
Imaniar, R.
Syahruddin, E.
Soepandi, P. Z.
Putra, A. C.
Nurwidya, F.

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13.

A long survival of a patient with brain metastasis of unknown site of the primary tumor [Текст] / Kridis W. Ben [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 85-87. - Bibliogr. at the end of the art.

Аннотация: Eighty percent of brain metastases (BM) are diagnosed in patients with known primary site of cancer. BM of unknown primary represents a difficult diagnosis. In up to 15% of patients with BM, the site of the primary tumor will not be detected despite investigations. The prognosis of this entity is very poor. We report here a case of a long survival of a patient with brain metastasis of unknown primary. The conclusion that can be drawn is that within BM of unknown primary exist patients with a very good prognosis that must be collected and published in order to base recommendations
Доп.точки доступа:
Ben, Kridis W.
Sghaier, S.
Toumi, N.
Boudawara, Z.
Khanfir, A.
Daoud, J.
Frikha, M.

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14.

Symposium and Summer School “Fundamental principles of cancer biotherapy” Kyiv Ukraine May 21-24 2018 [Текст] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 88

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