Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F. Chekhun // Experimental Oncology. - 2018. - Том 40, N 4. - P258-260

MeSH-главная:
ОНКОЛОГИЯ МЕДИЦИНСКАЯ -- MEDICAL ONCOLOGY (организация и управление, тенденции)
АКАДЕМИИ И ИНСТИТУТЫ -- ACADEMIES AND INSTITUTES (история, организация и управление, тенденции)
УКРАИНА -- UKRAINE
Аннотация: Fluctuation of time is determined by the order and sequence of historical events of global and/or local scale, the harmonization of which reflects the dynamics of the development of society. The top of universal values of this process was and remains the academic science, which is based on the principles of an inextricable triad: education, science and culture. The intellectual and creative “explosion” of the 20th and the beginning of the 21st century has fundamentally changed human consciousness and priority values. Along with the knowledge of physical, natural phenomena and the search for energy sources, man has become not only a subject, but also an object of research. The pace of development of the life sciences reached the apogee. The struggle for higher expectancy and quality of life is a priority of modern science. The key problem of biomedical research has been and remains malignant neoplasms, which dynamics becomes a threat of civilizational scale
Доп.точки доступа:
Chekhun, V. F. \ed.\

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The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia / K. Tari [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P261-267

MeSH-главная:
ЛЕЙКОЗ ЛИМФОИДНЫЙ -- LEUKEMIA, LYMPHOID (генетика, патофизиология)
Аннотация: Chronic lymphocytic leukemia (CLL) is increased proliferation of B-cells with peripheral blood and bone marrow involvement, which is usually observed in older people. Genetic mutations, epigenetic changes and miRs play a role in CLL pathogenesis. Del 11q, del l17q, del 6q, trisomy 12, p53 and IgVH mutations are the most important genetic changes in CLL. Deletion of miR-15a and miR-16a can increase bcl2 gene expression, miR-29 and miR-181 deletions decrease the expression of TCL1, and miR-146a deletion prevents tumor metastasis. Epigenetic changes such as hypo- and hypermethylation, ubiquitination, hypo- and hyperacetylation of gene promoters involved in CLL pathogenesis can also play a role in CLL. Expression of CD38 and ZAP70, presence or absence of mutation in IgVH and P53 mutation are among the factors involved in CLL prognosis. Use of monoclonal antibodies against surface markers of B-cells like anti-CD20 as well as tyrosine kinase inhibitors are the most important therapeutic approaches for CLL
Доп.точки доступа:
Tari, K.
Shamsi, Z.
Ghafari, H. R.
Atashi, A.
Shahjahani, M.
Abroun, S.

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Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P268-274

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (метаболизм, патофизиология)
Аннотация: To study the effect of Ferroplat (FrP) on the indexes of pro/antioxidant balance and energy metabolism in breast cancer cells of different malignancy degree and different sensitivity to drug therapy. Materials and Methods: The study was carried out on breast cancer cells of low (T47D, MCF-7) and high malignancy degree (MCF-7/DDP (cisplatin-resistant), MDA-MB-231, MDA-MB-468) using cell culture techniques, immunocytochemical, biochemical, biophysical methods, flow cytometry and polarography. Results: We established that the addition of FrP to the culture medium reduces the activity of glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD) and the level of non-protein thiols by 32–41% (p 0.05). At the same time, there was an increase of the total level of ROS and the rate of NO generation by inducible NO synthase by 1.7–2.5 times (p 0.05). This testifies that FrP disturbs the antioxidant balance in cells, resulting in their death. Also, the use of FrP led to a decrease in the rate of oxygen absorption in MCF-7 and T47D cells by 26% and 25%, respectively (p 0.05). In cells of high malignancy degree this index decreased by 38–40% under the influence of FrP. Incubation of MCF-7 and T47D cells with the indicated agent also reduced the content of phospholipid cardiolipin by 15–16% (p 0.05), and in MDA-MB-231, MCF-7/DDP, MDA-MB-468 cells — by 29%, 30% and 32%, respectively. In addition, the effect of FrP caused a decrease in the levels of Mg2+ and lactate in MCF-7 and T47D cells by 21–29% and 14–24%, respectively, whereas in MDA-MB-231, MDA-MB-468, MCF-7/DDP cells — by 34–38% and 32–35%, respectively. In this case, the agent raised the level of glucose in the cells of low malignancy degree by 20–23% (p 0.05), and in the cells of high malignancy degree and with the phenotype of drug resistance — by 31–36%. However, the nanocomposite did not affect the activity of lactate dehydrogenase in all studied breast cancer cells. Conclusion: The study has shown that FrP has an effect on the pro/antioxidant balance and energy metabolism of cancer cells. In addition, the denoted effect of FrP was more pronounced in the breast cancer cells with a high malignancy degree and the phenotype of drug resistance
Доп.точки доступа:
Chekhun, V. F.
Todor, I. N.
Lukianova, N. Yu.
Horbyk, D. M.
Lozovskaya, Yu. V.
Burlaka, A. P.
Borikun, T. V.

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The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model / T. V. Symchych [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P275-281

MeSH-главная:
КАРЦИНОМА ЛЬЮИС ЛЕГКОГО -- CARCINOMA, LEWIS LUNG (профилактика и контроль)
Аннотация: To investigate the effect of chicken embryo proteins (CEP) as a prototype of xenogeneic vaccine on immune reactions in mice immunized after Lewis lung carcinoma (LLC) surgical removal. Materials and Methods: C57Bl male mice were immunized on days 1, 8, and 15 after surgical removal of LLC. The immune response was assessed on days 7, 14, 21 and 28 after tumor resection. Cytotoxic activity of natural killer cells (NK) and cytotoxic T-lymphocytes as well as antibody dependent cellular cytotoxicity was estimated in MTT-assay; specific antibodies were detected in ELISA; lymphocyte proliferation was tested in reaction of in vitro blast transformation. Results: None of the immunized mice developed LLC metastases. Immunization with CEP seems to prevent the potential decrease in NK cell cytotoxic activity and spontaneous blast transformation activity of lymphocytes following the surgically induced stress. Further research on improving immunization schedule and elucidating the mechanisms of NK modulation with CEP is needed
Доп.точки доступа:
Symchych, T. V.
Fedosova, N. I.
Karaman, O. M.
Voyeykova, I. M.
Didenko, G. V.

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Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation / I. Yakymenko [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P282-287

MeSH-главная:
МИКРОВОЛНЫ -- MICROWAVES (вредные воздействия)
ЗДОРОВЬЯ ИЗМЕНЕНИЯ ПРИ ВОЗДЕЙСТВИИ ИЗЛУЧЕНИЙ -- RADIOLOGIC HEALTH (тенденции)
Аннотация: Despite a significant number of epidemiological studies on potential carcinogenicity of microwave radiation (MWR) from wireless devices and a bulk of experimental studies on oxidative and mutagenic effects of low intensity MWR, the discussion on potential carcinogenicity of low intensity MWR is going on. This study aims to assess oxidative and mutagenic effects of low intensity MWR from a typical commercial model of a modern smartphone. Materials and Methods: The model of developing quail embryos has been used for the assessment of oxidative and mutagenic effects of Global System for Mobile communication (GSM) 1800 MHz MWR from a commercial model of smartphone. The embryos were exposed in ovo to 0.32 µW/cm2, discontinuously — 48 s — On, 12 s — Off, during 5 days before and 14 days through the incubation period. Results: The exposure of quail embryos before and during the incubation period to low intensity GSM 1800 MHz has resulted in expressive statistically significant oxidative effects in embryonic cells, including a 2-fold increase in superoxide generation rate and 85% increase in nitrogen oxide generation rate, damages of DNA integrity and oxidative damages of DNA (up to twice increased levels of 8-oxo-dG in cells of 1-day old chicks from the exposed embryos). Finally, the exposure resulted in a significant, almost twice, increase of embryo mortality. Conclusion: The exposure of model biological system to low intensity GSM 1800 MHz MWR resulted in significant oxidative and mutagenic effects in exposed cells, and thus should be recognized as a significant risk factor for living cells
Доп.точки доступа:
Yakymenko, I.
Burlaka, A.
Tsybulin, O.
Brieieva, O.
Buchynska, L.
Tsehmistrenko, S.
Chekhun, V.

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Ber gene polymorphisms associated with key molecular events in bladder cancer / M. P. Smal [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P288-298

MeSH-главная:
МОЧЕВОГО ПУЗЫРЯ НОВООБРАЗОВАНИЯ -- URINARY BLADDER NEOPLASMS (генетика, патофизиология)
ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙ -- POLYMORPHISM, GENETIC (физиология)
Аннотация: Base excision repair (BER) gene polymorphisms are known to play an independent role in predisposition to developing different cancers as well as to be associated with clinicopathological traits of the disease modifying its clinical outcomes. One of the underlying mechanisms is presumed to include interplay between BER gene polymorphisms and key mutational, epigenetic and chromosomal events in tumor tissues. The present study was aimed at elucidating potential gene-gene interaction and assessing their mutual effects in bladder cancer (BC). Materials and Methods: The earlier obtained data on genotyping patients with verified diagnosis of BC for OGG1 rs1052133 (Ser326Cys) and XRCC1 rs25487 (Arg399Gln) polymorphisms were used for this study. The tumor tissue samples from the same patients were analyzed for mutations, epigenetic variations and losses of heterozygosity in some key genes involved in divergent pathogenic pathways of BC. Results: It was shown that the OGG1 (326 codon) heterozygous genotype as well as the minor 326Cys allele can intensify a mutational response of the RAS locus in urothelial carcinomas in the total cohort of patients simultaneously decreasing the mutation rates in the PIK3CA locus in smokers. The XRCC1 (399 codon) heterozygous genotype as well as the minor 399Gln allele reduced the frequency of LOH in the PTEN and TNKS genes, but did not affect the mutational variability in any locus tested. Both polymorphisms influenced the methylation status, carriers of OGG1 326Ser/Cys or Ser/Cys+Cys/Cys genotypes demonstrating increased frequency of methylated RUNX3 and ISL1 genes whereas the similar effect of XRCC1 polymorphism concerning methylation of p16 and TIMP3 genes. When dividing the total cohort into groups based on the extent of tumor spread, the observed associations were characteristic of non-muscle invasive BC. Conclusion: The BER gene polymorphisms contributed to modification of key molecular events in urothelial carcinomas. Their mutual effects mainly manifested in non-muscle invasive BC. The underlying mechanisms as well as possible clinical outcomes need to be further explored to propose novel prognostic biomarkers for BC
Доп.точки доступа:
Smal, M. P.
Kuzhir, T. D.
Savina, N. V.
Nikitchenko, N. V.
Rolevich, A. I.
Krasny, S. A.
Goncharova, R. I.

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Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer / R. Abooshahab [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P299-302

MeSH-главная:
ЩИТОВИДНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- THYROID NEOPLASMS (диагностика, метаболизм, патофизиология)
Аннотация: Adipokines are the proteins secreted from adipose tissue and play an important role in the control of metabolism. Dipeptidyl peptidase-4 (DPP4) is a novel adipokine with different biological role. As indicated by various studies, serum levels of DPP4 had been associated with body mass index (BMI), insulin resistance, metabolic syndrome and malignancy. The aim of this study was to assess the serum levels of DPP4 in patients with medullary thyroid cancer (MTC) in comparison with these in the control group. Materials and Methods: This study was performed on 45 MTC patients (24 females and 21 males) and 45 healthy controls (21 females and 24 males). DPP4 and insulin serum levels were measured by ELISA, fasting glucose serum levels by enzyme-calorimetric method and insulin resistance index (HOMA-IR) by calculation using relevant equation. BMI (kg/m2) was also calculated. Results: Our data did not demonstrate a significant difference between serum DPP4 levels in MTC and healthy group (41.06 ± 22.08 ng/ml vs 39.94 ± 20.77 ng/ml, p 0.05). Additionally, no significant difference was found in serum insulin and HOMA-IR concentrations between MTC patients and the controls (p 0.05). Conclusions: This study suggests that the fluctuation in the levels of DPP4 does not play an important role in prognosis, early detection and diagnosis of MTC. Furthermore, higher levels of DPP4 cannot be considered as a risk factor for MTC
Доп.точки доступа:
Abooshahab, R.
Niyazi, E.
Yaghmaie, P.
Chadaksaz, H. G.
Hedayati, M.

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Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P303-308

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика, метаболизм, патофизиология)
ВНУТРИКЛЕТОЧНЫЕ СИГНАЛЬНЫЕ ПЕПТИДЫ И БЕЛКИ -- INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS (метаболизм)
Аннотация: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients
Доп.точки доступа:
Buchynska, L. G.
Iurchenko, N. P.
Kashuba, E. V.
Brieieva, O. V.
Glushchenko, N. M.
Mints, M.
Lukianova, N. Yu.
Chekhun, V. F.

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FoxP3 gene polymorphism is associated with breast cancer in iranian patients / F. Arabpour [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P309-314

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (генетика)
ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙ -- POLYMORPHISM, GENETIC
Аннотация: Breast cancer (BC) is one of the leading causes of cancer death among women. Recent studies have characterized FoxP3 as a marker of regulatory T cells and an X-linked tumor suppressor gene, which is involved in the pathogenesis of BC. Therefore, we investigated the potential influence of three single-nucleotide polymorphisms (SNPs) of FoxP3 gene on the development of BC in Iranian women. Materials and Methods: The association between FoxP3 rs2232365, rs3761548 and rs4824747 polymorphisms and BC risk was assessed in 124 BC patients and 198 healthy controls using sequence-specific primers. Results: We identified significant difference of rs3761548 in both allele and genotype frequencies between cases and control groups. Our results showed that individuals carrying FoxP3 rs3761548 AA genotype had about 4.3-fold increased risk of BC compared with CC carriers. No significant association was found between rs3761548CA polymorphism and clinical outcome parameters (age of onset, tumor size, lymph nodes metastasis, tumor stage, progesterone receptor status, estrogen receptor status, Ki-67 status, HER-2 status and duration of disease). Conclusion: This study has provided the first genetic data on the FoxP3 gene polymorphism in south of Iran and proposes the rs3761548 polymorphism of FoxP3 gene as a risk factor, but not a prognostic marker in the development of BC in Iranian population
Доп.точки доступа:
Arabpour, F.
Shafizad, A.
Rahimzadeh, M.
Norouzian, M.
Naderi, N.

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10.

Expression pattern of genes associated with tumor microenvironment in prostate cancer / G. V. Gerashchenko [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P315-322

MeSH-главная:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (генетика)
Аннотация: To assess relative expression (RE) levels of CAF-, TAM-specific, immune defense-associated genes in prostate tumors and to show correlation of RE with clinical, pathological and molecular characteristics, with the aim to define clinically significant specific alterations in a gene expression pattern. Methods: RE of 23 genes was analyzed by a quantitative polymerase chain reaction in 37 freshly frozen samples of prostate cancer tissues of a different Gleason score (GS) and at various tumor stages, compared with RE in 37 paired conventionally normal prostate tissue (CNT) samples and 20 samples of prostate adenomas. Results: Differences in RE were shown for 11 genes out of 23 studied, when tumor samples were compared with corresponding CNTs. 7 genes, namely ACTA2, CXCL14, CTGF, THY1, FAP, CD163, CCL17 were upregulated in tumors. 4 genes, namely CCR4, NOS2A, MSMB, IL1R1 were downregulated in tumors. 14 genes demonstrated different RE in TNA at different stages: CXCL12, CXCL14, CTGF, FAP, HIF1A, THY1, CCL17, CCL22, CCR4, CD68, CD163, NOS2A, CTLA4, IL1R1. RE changes of 9 genes — CXCL12, CXCL14, HIF1A, CCR4, CCL17, NOS2A, CTLA4, IL1R1, IL2RA — were found in tumors with different GS. Moreover, 9 genes showed differences in RE in TNA, dependently on the presence or absence of the TMPRSS2/ERG fusion and 7 genes showed differences in RE of groups with differential PTEN expression. Significant correlations were calculated between RE of 9 genes in adenocarcinomas and the stage, and GS; also, between RE of 2 genes and the fusion presence; and between RE of 4 genes and PTEN expression. Conclusions: Several gene expression patterns were identified that correlated with the GS, stage and molecular characteristics of tumors, i.e. presence of the TMPRSS2/ERG fusion and alterations in PTEN expression. These expression patterns can be used for molecular profiling of prostate tumors, with the aim to develop personalized medicine approaches. However, the proposed profiling requires a more detailed analysis and a larger cohort of patients with prostate tumor
Доп.точки доступа:
Gerashchenko, G. V.
Grygoruk, O. V.
Kononenko, O. A.
Gryzodub, O. P.
Stakhovsky, E. O.
Kashuba, V. I.

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11.

Clinical significance of serum caveolin-1 levels in gastric cancer patients / F. Tas [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P323-327

MeSH-главная:
ЖЕЛУДКА НОВООБРАЗОВАНИЯ -- STOMACH NEOPLASMS (диагностика, метаболизм, патофизиология)
Аннотация: Caveolin-1 plays a significant role in the pathogenesis of various carcinomas and its expression affects the survival of cancer patients. However, the molecular function of caveolin-1 and its possible clinical importance has remained uncertain in gastric cancer. No clinical trial has examined serum caveolin-1 levels in gastric cancer patients so far, instead all available results were provided from studies conducted on tissue samples. In the current study, we analyzed the soluble serum caveolin-1 levels in gastric cancer patients, and specified its associations with the clinical factors and prognosis. Material and Methods: Sixty-three patients with pathologically confirmed gastric cancer were enrolled into the trial. Serum caveolin-1 concentrations were detected by ELISA method. Thirty healthy subjects were also included in the study. Results: The median age of patients was 62 years, ranging from 28 to 82 years. The serum caveolin-1 levels in gastric cancer patients were significantly higher than those in control group (p 0.001). The common clinical parameters including patient age, sex, lesion localization, histopathology, histological grade, disease stage, and various serum tumor markers (e.g. LDH, CEA, and CA 19.9) were not found to be associated with serum caveolin-1 levels (p 0.05). Similarly, no correlation existed between serum caveolin-1 concentration and chemotherapy responsiveness (p = 0.93). Furthermore, serum caveolin-1 level was not found to have a prognostic role (p = 0.16). Conclusion: Even though it is neither predictive nor prognostic, serum caveolin-1 level may be a valuable diagnostic indicator in patients with gastric cancer
Доп.точки доступа:
Tas, F.
Karabulut, S.
Erturk, K.
Duranyildiz, D.

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12.

Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells / L. P. Shvachko [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P328-331

MeSH-главная:
ЛЕЙКОЗЫ -- LEUKEMIA (метаболизм, патофизиология)
ВИТАМИН E -- VITAMIN E (метаболизм)
Аннотация: Background: Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder associated with the activity of BCR-ABL fusion oncogene. Tyrosine kinase inhibitors are the current treatment of CML, but secondary mutations finally contribute to therapy resistance and blast crisis of the disease. The search for the novel compounds for the effective control of CML is now in the spotlight. The progression of CML to blast crisis is correlated with down-modulation of C/EBP alpha. Therefore, C/EBP alpha may be considered as a putative target in differentiation therapies in myeloid leukemias. The aim of the study was to assess the potential of vitamin E as the possible inducer of C/EBP alpha expression in BCR-ABL-positive CML K562 cells. Materials and Methods: RNA extracted from K562 cells cultured with valproic acid or vitamin E was converted to cDNA, RT-PCR reactions were carried out using HotStarTaq DNA polymerase with primers for C/EBP alpha and granulocyte colony-stimulating factor receptor (G-CSFR). Results: We have not found detectable expression of C/EBP alpha in K562 cells. Upon 48-h culture with vitamin E at a dose of 100 µM, K562 cells expressed both C/EBP alpha and G-CSFR. Conclusion: Vitamin E restored the expression of C/EBP alpha mRNA in chronic myelogenous leukemia K562 cells. In this setting, G-CSFR expression in vitamin E treated K562 cells seems to suggest the activation to granulocytic differentiation. It should be further elucidated whether such effects of vitamin E on C/EBP alpha transcription factor are direct or mediated indirectly due to antioxidant properties of vitamin E
Доп.точки доступа:
Shvachko, L. P.
Zavelevich, M. P.
Gluzman, D. F.
Kravchuk, I. V.
Telegeev, G. D.

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13.

Kuzyk, P. V.
Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis / P. V. Kuzyk, M. A. Savchyna, S. G. Gychka // Experimental Oncology. - 2018. - Том 40, N 4. - P332-335

MeSH-главная:
ТУБЕРКУЛЕЗ ЛЕГКИХ -- TUBERCULOSIS, PULMONARY (патофизиология)
ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS (метаболизм, патофизиология)
Аннотация: To describe the case of rare benign lymphoproliferative disorder — pulmonary nodular lymphoid hyperplasia in the patient with previous pulmonary tuberculosis. Materials and Methods: In the case of pulmonary nodular lymphoid hyperplasia clinical, laboratory, instrumental and morphological examination was performed. Results: 44-year-old woman in 7 years after successfully treated infiltrative drug-susceptible tuberculosis of the right lung, was hospitalized with a suspected tumor of the left lung root. The patient underwent left-sided pneumonectomy with lymph nodes dissection. The results of histopathological and immunohistochemical studies evidenced on nodular lymphoid hyperplasia of the left lung. Conclusion: Pulmonary nodular lymphoid hyperplasia is a rare lymphoproliferative disorder of the lung with favorable prognosis. For the purpose of differential diagnosis, it is necessary to apply immunohistochemistry
Доп.точки доступа:
Savchyna, M. A.
Gychka, S. G.

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14.

Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart / L. M. Zakhartseva [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P336-342

Аннотация: Tumors of the heart are uncommon and usually benign (in 93% cases myxomas are observed). More often secondary, metastatic tumors are detected in the heart, as a rule, at pronounced progression of the malignant neoplasm with multiple lesions of other internal organs (lung, pleura, liver, etc.). Literature review on cardiac metastases of different tumors is given. Case Report: Own observation of a young man with rare single metastasis of malignant testicular germ cell tumor with predominance of embryonic carcinoma in the right ventricle of the heart is presented; the primary tumor was detected after metastasis revealing. The diagnostic algorithm using routine histological study supplemented with immunohistochemistry, including detection of cytokeratin pan, cytokeratin 5/6, cytokeratin 7, CD30, OCT4, TTF-1, hCG, and AFP markers expression, is described
Доп.точки доступа:
Zakhartseva, L. M.
Zakharova, L. P.
Shatrova, K. M.
Chitaeva, G. E.
Vitovsky, R. M.

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15.

Langabeer, S. E.
The JAK2 V617F mutation in lung cancer: caveat emptor / S. E. Langabeer // Experimental Oncology. - 2018. - Том 40, N 4. - P343-344

MeSH-главная:
ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS (генетика, патофизиология)
Аннотация: As acquisition of the JAK2 V617F is considered to be restricted to myeloid malignancies, the recurrent identification of this mutation in non-small cell lung cancer (NSCLC) merits discussion, particularly in the light of accumulating evidence which suggests that the JAK2 V617F may not be a true driver mutation of NSCLC. Targeted exon sequencing (TES) of solid tumors by a variety of next-generation sequencing approaches has become incorporated into routine laboratory practice with the ability to identify clinically actionable targets with increasing precision and sensitivity. Previous TES studies of NSCLC specimens have repeatedly identified the JAK2 V617F and proposed that lung tumors harboring this mutation would be amenable to therapy with JAK inhibitors [1, 2]. While the percentage of samples appears small, these findings are not trivial when considering the global incidence of NSCLC
The JAK2 V617F mutation is the most common, somatic driver mutation in the Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), present in nearly all polycythemia vera (PV) patients and in more than half of patients with essential thrombocythemia and primary myelofibrosis. Acquisition of this mutation results in constitutive activation of the JAK-STAT pathway, critical for hematopoietic growth factor signalling, and a consequent expansion of mature myeloid cell types. Present in three distinct diseases, supplementary genetic, epigenetic and host factors are all likely to interact and play a role in determining the phenotype. The discovery of the JAK2 V617F mutation in 2005 has led to the breakthrough of a plethora of JAK1/2 inhibitors for MPN patients currently in routine use, in clinical trials, or in drug development pipelines [3]. While found predominantly in MPN, the JAK2 V617F is also present at lower frequencies in other myeloid malignancies such as myelodysplastic/myeloproliferative syndromes and acute myeloid leukemia. Intriguingly, founder clones driven by the JAK2 V617F and mutations in other myeloid malignancy-associated, epigenetic modifier genes such as DNMT3A and TET2 have been detected in the blood of hematologically normal individuals with this clonal hematopoiesis of indeterminate potential (CHIP) cumulatively accruing with advancing age
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16.

Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary) // Experimental Oncology. - 2018. - Том 40, N 4. - P345

MeSH-главная:
ОНКОЛОГИЯ МЕДИЦИНСКАЯ -- MEDICAL ONCOLOGY (история, кадры)
Аннотация: Volodymyr Shlyakhovenko has been working at the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine since 1965 after his postgraduate fellowship. In 1967, he got his PhD degree. In 1985, Dr. Shlyakhovenko defended his doctorate thesis “Molecular heterogeneity and complex-forming properties of ribonucleases in leukemia” and got his doctorate degree. Since 1971, Dr. Shlyakhovenko was senior research fellow. In 1979–1984, Dr. Shlyakhovenko was a Deputy Director of the Institute
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Shlyakhovenko, Volodymyr Oleksiiovych (1938) \о нем\

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