Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine: 25 years with the OECI [Текст] // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 187

MeSH-главная:
ОНКОЛОГИЯ МЕДИЦИНСКАЯ -- MEDICAL ONCOLOGY (организация и управление, тенденции)
МЕЖДУНАРОДНОЕ СОТРУДНИЧЕСТВО -- INTERNATIONAL COOPERATION (история)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Кл.слова (ненормированные):
Европейские институты рака
Аннотация: It was in 1994 when R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine (IEPOR) became a member of the Organisation of European Cancer Institutes (OECI) — a non-governmental, non-profit legal entity established in 1979 to promote greater cooperation among European Cancer Centres and Institutes. The basic aim of the Organisation is “promoting efficient partnership across Europe, notwithstanding its linguistic barriers and traditional care and research heterogeneity”
All these 25 years, IEPOR takes an active part in different OECI activities, including translational research in oncology, molecular pathology, education and training, etc. Annually the OECI holds General Assemblies along with relevant scientific conferences during OECI Oncology Days. IEPOR actively participates in these events either making presentations or taking part in Round Tables and Panel discussions. The participation of IEPOR Director in these events provides real opportunities for “synchronizing watches” in issues of modern European trends in scientific research in the field of oncology. The Institute’s active position in the OECI activities contributes to the increase of the scientific research level and comprehensive inclusion in the European oncology scientific space
Nowadays, the OECI is a network of 93 members who are collaborating to reduce fragmentation and to give to all European cancer patients the possibility of receiving the best available care. The detailed information on the OECI is available on the official website: www.oeci.eu. After more than 40 years of its activity, the OECI still provides the best forum for the directors of member institutes to meet regularly, to exchange views, and to formulate plans for future, inter-institutional collaborative ventures. It provides the right setting and the appropriate note of informality to overcome the political or cultural barriers, which sometimes risk frustrating the true and universal working relationship amongst the main players of the European cancer community
In the OECI Statute (Article 4 “Object”) the following is postulated: “The ultimate objective is the development of oncology in Europe for reducing mortality and morbidity due to cancer and increasing survival and quality of life of the patients. Therefore, the model of oncology must be based on a global vision of the cancer problem emphasizing the integration of research and education with diagnosis, prevention and care to promote the development of comprehensive and multidisciplinary organization within the European Cancer Institutes. With a view to simplifying and developing the scientiﬁc, educational and economic activities of its Members, to improving the conditions and increasing the outcomes, the object of the Grouping is mainly: the information, the formation, the research, the treatment, the care, the rehabilitation, the drafting of guidelines, the storage and evaluation of data, the costs beneﬁt, the clinical and preclinical research, the telemedicine and telematics, the education, the communication, the accreditation, the “labelisation” (marking), the translational research, the epidemiology and the ethical and social aspects in the cancer area”
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Chekhun, V. F.
MicroRNAs are a key factor in the globalization of tumor-host relationships [Текст] / V. F. Chekhun // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 188-194. - Bibliogr. at the end of the art.

MeSH-главная:
ОБЗОР -- REVIEW
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (патофизиология, этиология)
ЭПИГЕНЕЗ ГЕНЕТИЧЕСКИЙ -- EPIGENESIS, GENETIC
МИКРО-РНК -- MICRORNAS (анализ, диагностическое применение)
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (анализ)
ДИАГНОСТИКА ДИФФЕРЕНЦИАЛЬНАЯ -- DIAGNOSIS, DIFFERENTIAL
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: A new round of molecular oncology development in the post-genomic era significantly changes the conventional understanding of the nature and origin of the malignant process. Increasingly, fundamental phenomena are emerging that change the “canonical” views of the dominant role of gene mutations that contribute to the uncontrolled proliferation and emergence of heterogeneous malignant cells. Recent numerous studies have shown that significant variability in the initiation, proliferation and control of the apoptotic program of tumor cells is due to numerous epigenetic processes, including the level of expression of microRNAs (miRNAs). This paper reviews the literature data and presents the results of own research in which miRNAs have been found to form a molecular phenotype for malignancy. Their role as a “conductor” of the functioning of a genetic-epigenetic orchestra that coordinates various aspects of malignancy has been suggested. MiRNAs have been shown to be an active participant in balancing mechanisms in the development of controversial processes in breast cancer cell lines of varying degrees of malignancy. The analysis of the literature data and the own studies of the expression profile of only a few miRNAs suggests that scientists and clinicians have received a new marker and a target that simultaneously plays the role of an active insider in both the oncogene-oncosuppressor relationship and in the globalization of this process at the tumor-host level. Further investigation of the “alarm” marker in this network will allow to reconsider the molecular genetic classification of neoplastic disease, which will provide the development of a new strategy for cancer therapy
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Shlyakhovenko, V. O.
The dual role of ribonucleases in tumor-host relationship [Текст] / V. O. Shlyakhovenko, O. A. Samoylenko // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 195-199. - Bibliogr. at the end of the art.

MeSH-главная:
РИБОНУКЛЕАЗЫ -- RIBONUCLEASES (анализ, антагонисты и ингибиторы, действие лекарственных препаратов, терапевтическое применение)
БИОХИМИЧЕСКИЕ ФЕНОМЕНЫ -- BIOCHEMICAL PHENOMENA
АНТИГЕНЫ ОПУХОЛЕВЫЕ -- ANTIGENS, NEOPLASM (анализ, диагностическое применение)
ПОСТЕРЫ -- POSTERS
ЭПИГЕНОМИКА -- EPIGENOMICS (тенденции)
Аннотация: Ribonucleases are enzymes that destroy RNA, play an important role in protein synthesis, epigenetic regulation of genetic activity, cell proliferation and apoptosis. Ribonucleases are important antimicrobial, antiviral and immune defense factors. Despite the same biochemical properties, they exhibit unequal, sometimes opposite biological effects. While mostly ribonucleases inhibit cell proliferation, induce apoptosis and inhibit the growth of tumors, some ribonucleases stimulate vascular growth, proliferation and tumor development. RNase inhibitors have an opposite effect. The correct use of these features of RNases can provide additional opportunities for the development of a strategy of targeted influence on tumor growth
Доп.точки доступа:
Samoylenko, O. A.

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Shuba, Ya. M.
Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? [Текст] / Ya. M. Shuba // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 200-206. - Bibliogr. at the end of the art.

MeSH-главная:
ОБЗОР -- REVIEW
МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL
НЕОПЛАСТИЧЕСКИЕ ПРОЦЕССЫ -- NEOPLASTIC PROCESSES
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (анализ)
ПОСТЕРЫ -- POSTERS
Кл.слова (ненормированные):
ORAI белок
Аннотация: The ORAI family of ion channel-forming proteins in mammals includes three members, ORAI1, ORAI2 and ORAI3, encoded by homologous genes. Of these proteins the ORAI1 one received major attention as plasma membrane constituent of store-operated calcium entry (SOCE) in non-excitable cells. The functional significance of two other proteins, ORAI2 and ORAI3, is much less defined, although both of them participate to various extends in cell-specific modulation of SOCE as well as in supporting some of the store-independent calcium entry mechanisms. Calcium signaling becomes remodeled in cancer to promote cancer hallmarks — enhanced proliferation, resistance to apoptosis, motility and metastasizing. Although such remodeling commonly involves rearrangements of the whole molecular Ca2+-handling toolkit of the cell (Ca2+ pumps and transporters, Ca2+-binding and storage proteins, Ca2+ entry and release channels, Ca2+-dependent effectors), Ca2+ entry through Orai-based channels is especially important, as its dysregulation may contribute to several cancer hallmarks. The latter depend on the type of Ca2+-permeable channel formed by ORAI-proteins, spatiotemporal characteristics of Ca2+ signal that this channel contributes to, and the type Ca2+-dependent effector(s) targeted by this signal, all of which may be cancer-specific. By participating in global Ca2+ entry, ORAI-based SOCE may also contribute to cytosolic Ca2+ overload of cancer cells thereby playing pro-apoptotic, antineoplastic roles which can potentially be exploited for cancer treatment. This mini review examines various aspects of ORAI proteins in malignant transformation
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Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia [Текст] / T. S. Ivanivska [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 207-209. - Bibliogr. at the end of the art.

MeSH-главная:
ЛЕЙКОЗ МИЕЛОИДНЫЙ ОСТРЫЙ -- LEUKEMIA, MYELOID, ACUTE (патофизиология, этиология)
НОВООБРАЗОВАНИЙ СТВОЛОВЫЕ КЛЕТКИ -- NEOPLASTIC STEM CELLS (ультраструктура, физиология)
КЛЕТОК КУЛЬТУРЫ МЕТОДЫ ИССЛЕДОВАНИЯ -- CELL CULTURE TECHNIQUES (тенденции)
МОРФОГЕНЕЗ -- MORPHOGENESIS
ЦИТОЛОГИЧЕСКИЕ МЕТОДЫ -- CYTOLOGICAL TECHNIQUES (использование, статистика, тенденции)
Аннотация: According to the modern concept, leukemic stem cells (LSC) in acute myeloid leukemia (AML) are distinct from the bulk of leukemic cells in bone marrow and peripheral blood of AML patients. Nevertheless, LSC are responsible for managing all the hierarchy of the bulk of leukemic blast populations. This mini-review provides brief information on the distinctive features of LSC and blast cells in cytologically recognized types of AML. The study of different phenotypes of LSC and blast cells in AML with the aid of up-to-date flow cytometric techniques is important both for the deep insight into the mechanisms of leukemogenesis and development of novel strategies of target therapy. The urgent need for extending the diagnostic panel of monoclonal antibodies used for diagnosing AML is beyond doubt
Доп.точки доступа:
Ivanivska, T. S.
Sklyarenko, L. M.
Zavelevich, M. P.
Philchenkov, A. A.
Koval, S. V.
Polishchuk, A. S.
Gluzman, D. F.

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Role of nitric oxide in pathogenesis of tumor growth and its possible application in cancer treatment [Текст] / V. V. Holotiuk [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 210-215. - Bibliogr. at the end of the art.

MeSH-главная:
ОБЗОР -- REVIEW
АЗОТА ОКСИДЫ -- NITROGEN OXIDES (анализ, диагностическое применение)
КЛЕТКИ СМЕРТЬ -- CELL DEATH (физиология)
КЛЕТКИ ВЫЖИВАНИЕ -- CELL SURVIVAL (физиология)
НОВООБРАЗОВАНИЯ -- NEOPLASMS (патофизиология, этиология)
КЛИНИЧЕСКОЕ ИССЛЕДОВАНИЕ -- CLINICAL TRIAL
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS (фармакология)
Аннотация: In this review, the role of nitric oxide (NO) in the pathogenesis of the tumor growth and possibilities of its application in the treatment of cancer patients are analyzed. NO is one of the most important mediators of physiological processes being involved in the regulation of practically all body functions in health and disease. The role of NO in the development of many pathological conditions has been extensively studied and debated in recent years. Today it is clear that NO in relation to malignant tumors may exhibit a dual activity — can stimulate tumor growth and cause an opposite antitumor effect. Effects of NO are mostly dependent on its concentration. At low concentrations, NO could inhibit apoptosis and cause mutations that potentially lead to the formation of malignant growth loci. However, a high concentration of NO appears to be detrimental to malignant cells, in particular under conditions of simultaneous exposure to ionizing radiation. In humans, the inducible NO synthase (iNOS, type II) is the most powerful form of NO synthases (NOS) and has the ability to synthesize large amounts of NO for a long time and exert a protective function. iNOS is expressed in macrophages, monocytes, neutrophils, fibroblasts, hepatocytes, and other cell types. In tissue of malignant tumors, the macrophagal iNOS is the main form. Experimental data provide an evidence that activated macrophages and leukocytes, which are the part of peritumorous inflammatory infiltrate, can provide radiosensitization of tumors by direct synthesis of NO and indirectly — through the secretion of cytokines stimulating iNOS activity in cancer cells. Such approach could be useful for the development of new schemes and methods of anticancer therapy based on the activation of endogenous NO biosynthesis pathways
Доп.точки доступа:
Holotiuk, V. V.
Kryzhanivska, A. Y.
Churpiy, I. K.
Tataryn, B. B.
Ivasiutyn, D. Ya.

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Oshyvalova, O.
Modern view on epidermal dysplasia carcinogenesis [Текст] / O. Oshyvalova, Z. Rossokha // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 216-223. - Bibliogr. at the end of the art.

MeSH-главная:
КОЖИ НОВООБРАЗОВАНИЯ -- SKIN NEOPLASMS (патофизиология, этиология)
КАРЦИНОМА ПЛОСКОКЛЕТОЧНАЯ -- CARCINOMA, SQUAMOUS CELL (патофизиология, этиология)
ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙ -- POLYMORPHISM, GENETIC (физиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Кл.слова (ненормированные):
TP53 (G13494A), L-myc (T3109G), TNF-α (G308A)
Аннотация: Squamous cell carcinoma of the skin develops from the spectrum of facultative precancerous conditions, which in the course of malignant transformation through cancer stage in situ without early treatment fully transform into invasive squamous cell carcinoma. According to classical model of carcinogenesis, the transformation of actinic keratosis into squamous cell carcinoma of the skin occurs due to a mutation in one gene, more often a tumor suppressor, and undergoes a stage of development with lack of control of cell cycle. The aim of the research is to supplement current knowledge of genetic determination of pathogenetic mechanisms of epidermal dysplasia of the skin by studying the genetic determinant in the skin lesion of varying degrees of malignancy. Materials and Methods: We analyzed 85 skin bioptates of patients with epidermal dysplasia of the skin (Gr 1 — 43 patients with actinic keratosis; Gr 2 — 21 patients with non-invasive squamous cell carcinoma of the skin; Gr 3 — 21 patients with invasive squamous cell carcinoma of the skin) by molecular genetic testing of gene polymorphisms: TP53 (G13494A), L-myc (T3109G), TNF-α (G308A) in tumor tissue. The histological examination revealed the levels of dysplasia of the epidermis. Results: In case of the same disease duration in patients of Gr1/Gr3, L-myc (3109TT) is a genetic component of malignant transformation of epithelial skin cells (p = 0.004) and the development of invasive squamous cell carcinoma. Other variants of 3109TG and 3109GG genes do not have such prognostic value for the risk of skin cancer compared to 3109TT. Significant differences were found in the distribution of (13494GA) when comparing Gr 1 with Gr 3 (p = 0.014) and Gr 2 with Gr 3 (p = 0.038). A significant increase in the distribution of 13494GA genotype was revealed in patients with invasive form of keratinocyte intraepidermal neoplasia. 13494A allele was more likely to be detected in patients of Gr 3 compared to Gr 2 (p = 0.030) that proves the association of this allele with the development of invasive malignancies of the skin. The association of 308GG genotype and TNF-α (308G) allele with the development of malignant skin lesions was found. Comparing the distribution of 308G allele in patients of Gr 1 and Gr 2, we found its significant increase in patients of Gr 1. Comparative analysis of gene polymorphism with tumor invasion level showed a significant difference only in 308GG genotype between patients with grade III of KIN (keratinocyte intraepidermal neoplasia) in Gr 2 and patients with KIN III of Gr 1 (p = 0.007), and 308GA between patients with KIN III of Gr 2 and KIN III of Gr 1 (p = 0.027). Conclusions. Our work has supplemented modern vision of genetic component in pathogenetic mechanism of the development of epidermal dysplasia of the skin. Thus, the association of L-myc (3109TT) with the development of malignant skin lesions of different invasiveness and the modifying effect of TNF-α (G308A) and TP53 (G13494A) gene variants on pathological transformation in the focus of EDS depending on the level of epithelial dysplasia was revealed
Доп.точки доступа:
Rossokha, Z.

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Bazalytska, S. V.
Моlecular mechanisms of initiation of carcinogenesis in the testis [Текст] / S. V. Bazalytska, Y. Persidsky, A. M. Romanenko // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 224-234. - Bibliogr. at the end of the art.

MeSH-главная:
ОБЗОР -- REVIEW
ПРЕДРАКОВЫЕ СОСТОЯНИЯ -- PRECANCEROUS CONDITIONS (патофизиология, этиология)
ЯИЧКА НОВООБРАЗОВАНИЯ -- TESTICULAR NEOPLASMS (патофизиология, этиология)
ДИАГНОСТИКА РАННЯЯ -- EARLY DIAGNOSIS
ОКРУЖАЮЩЕЙ СРЕДЫ ВОЗДЕЙСТВИЕ, БОЛЕЗНИ -- ENVIRONMENTAL ILLNESS (профилактика и контроль, этиология)
ПОСТЕРЫ -- POSTERS
Аннотация: In this review, literature data on the study of precancerous changes in testicular tissue and molecular changes, as well as the influence of environmental factors that can initiate carcinogenesis, were analyzed and summarized for the future determination of early diagnosis of germ cell tumors of the testis and the development of preventive measures. The review also discusses the significant new changes presented in the Fourth Edition of the World Health Organization Classification of Urogenital Tumors, published in 2016, and modern concepts of the etiology and pathogenesis of these diseases. Among the environmental factors that can initiate carcinogenesis, the most noteworthy are the biological effects of low doses of ionizing radiation, such as the effect of radiation-induced genome instability, which increases the risk of carcinogenesis, the “bystander effect”, and chronic oxidative stress. Disruption of ubiquitin-proteasomal proteolysis, impaired molecular-level components of the blood-testis barrier, and impaired regulatory action of TGF-β on the cell cycle can play a crucial role in the pathogenesis of male infertility and the initiation of carcinogenesis in the testis. The effect of low doses of ionizing radiation as an additional etiological factor leads to changes in the structural, as well as molecular, components of the testis, including epigenetic changes, which can be characterized as environmental pathomorphosis, which leads to impaired spermatogenesis and increased risk of malignancy. Summarizing the literature review data, we can state that patients with blocked spermatogenesis, in which atypical germ cell neoplasia in situ cells are detected in testicular tissue, constitute a group at increased risk of testicular carcinogenesis. The presence of additional etiological factors, such as chronic low doses of ionizing radiation, can initiate the progression of carcinogenesis in the testicle
Доп.точки доступа:
Persidsky, Y.
Romanenko, A. M.

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Histopathological characteristics and post-operative follow-up of patients with potentially radiogenic papillary thyroid carcinoma depending on oncocytic changes availability in the tumor cells [Текст] / T. Bogdanova [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 235-241. - Bibliogr. at the end of the art.

MeSH-главная:
ЩИТОВИДНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- THYROID NEOPLASMS (патофизиология, этиология)
ЗДОРОВЬЯ ИЗМЕНЕНИЯ ПРИ ВОЗДЕЙСТВИИ ИЗЛУЧЕНИЙ -- RADIOLOGIC HEALTH (статистика, тенденции)
КАРЦИНОМА ПАПИЛЛЯРНАЯ -- CARCINOMA, PAPILLARY (патофизиология, профилактика и контроль, терапия, этиология)
ВОЗРАСТНЫЕ ФАКТОРЫ -- AGE FACTORS
ЧЕРНОБЫЛЬ -- CHERNOBYL
МОРФОЛОГИЧЕСКИЕ И МИКРОСКОПИЧЕСКИЕ ПОКАЗАТЕЛИ -- MORPHOLOGICAL AND MICROSCOPIC FINDINGS
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: Aim: To compare the frequency of main histopathological characteristics, 131І thyroid radiation doses, invasive properties and post-operative follow-up of patients of different age groups with potentially radiogenic papillary thyroid carcinoma (PTC) with the presence and absence of oncocytic changes in tumor cells. Materials and Methods: PTC removed in 483 patients from high risk age-group for radiogenic thyroid cancer development (children and adolescents at the time of Chornobyl accident who lived in the northern regions of Ukraine: Kyiv, Zhytomyr, and Chernihiv regions) have been studied microscopically. Results: The frequency of PTC with the presence of oncocytic changes (OCh) in tumor cells increased significantly with increasing of patients’ age at the time of surgery: from 8.3% in children 4–14 years old to 54.3% in adults 39–48 years old (ptrend 0.0001). The presence of such changes is associated with papillary and solid-trabecular dominant tumor growth pattern in more than 90% of cases in each age group. The mean 131І thyroid dose in the whole series of PTC patients with OCh was significantly lower compared to the same index in PTC patients without OCh (493.7 mGy and 765.8 mGy, respectively, p 0.0001). In addition, regional metastases recurrences were revealed more frequently in patients with OCh in primary PTC compared with patients without OCh in primary tumor (7.2% vs 1.5%, p
Доп.точки доступа:
Bogdanova, T.
Zurnadzhy, L.
Masiuk, S.
Burko, S.
Degtyaryova, T.
Kovalenko, A.
Bolgov, M.
Chernyshov, S.
Gulevatyi, S.
Thomas, G.
Tronko, M.

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10.

Lukianova, N. Yu.
Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer [Текст] / N. Yu. Lukianova, T. V. Borikun, V. F. Chekhun // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 242-247. - Bibliogr. at the end of the art.

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (генетика, патофизиология, этиология)
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY (статистика, тенденции)
МИКРО-РНК -- MICRORNAS (анализ, диагностическое применение)
ГЕННАЯ ЭКСПРЕССИЯ -- GENE EXPRESSION (физиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) were analyzed in tissue of BC using immunohistochemical method. Relative expression levels of the miR-155, -320a, and -205 were examined in tissue and sera from BC patients using quantitative reverse transcription polymerase chain reaction. Results: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. Nevertheless, we established the relation of circulating and tissue miR-155, -320a, and -205 to lymph node metastases and basal breast cancer subtype. Conclusions: Changes of miR-155, -320a, and -205 expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC
Доп.точки доступа:
Borikun, T.V.
Chekhun, V. F.

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11.

Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes [Текст] / M. Patysheva [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 248-253. - Bibliogr. at the end of the art.

MeSH-главная:
ОБЗОР -- REVIEW
НОВООБРАЗОВАНИЙ МИКРООКРУЖЕНИЕ -- TUMOR MICROENVIRONMENT (действие лекарственных препаратов)
ХЕМОТАКСИЧЕСКИЕ ФАКТОРЫ -- CHEMOTACTIC FACTORS (анализ, диагностическое применение)
МАКРОФАГИ -- MACROPHAGES (физиология)
ЦИТОСТАТИЧЕСКИЕ СРЕДСТВА -- CYTOSTATIC AGENTS (анализ, терапевтическое применение, фармакология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Аннотация: Macrophages are important effectors of innate immunity and the key component of the tumor microenvironment strongly influencing cancer disease outcome and efficiency of cancer therapy. Moreover, recent data have shown that monocytes as macrophage precursors can impact on tumor ability to progression. It’s well known that although tumor-associated macrophages consist of diverse populations, in general, they have tumor-supporting activity. To change tumor-supporting state of tumor-associated macrophages toward tumor-inhibiting mode is one of prospective aims of modern cancer immunotherapy. Cytostatics seems to be possible tools to achieve this aim, because recently it has been shown that chemo- and radiotherapy possess immunomodulatory effects. Most of the findings are related to lymphocytes — T-lymphocytes and NK-cells, but not to monocyte/macrophage lineage. In the review, we have analyzed how cytostatic drugs influence the properties of monocyte/macrophage lineage cells to prospect using of chemotherapy to enhance their antitumor activity
Доп.точки доступа:
Patysheva, M.
Stakheyeva, M.
Larionova, I.
Fedorov, A.
Kzhyshkowska, J.
Cherdyntseva, N.

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12.

Adsorptive therapy as a modificator for tumor-host interaction [Текст] / L. A. Sakhno [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 254-257. - Bibliogr. at the end of the art.

MeSH-главная:
МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL
КАРЦИНОМА ЛЬЮИС ЛЕГКОГО -- CARCINOMA, LEWIS LUNG (патофизиология, этиология)
ЭНТЕРОСОРБЦИЯ -- ENTEROSORPTION (использование, методы, тенденции)
ДРЕВЕСНЫЙ УГОЛЬ -- CHARCOAL (анализ, терапевтическое применение, фармакология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Аннотация: The potential of one of the adsorption methods, enterosorption (ES), using the new generation of carbon adsorbents to correct the negative manifestations of tumor-host interaction in the framework of paraneoplastic syndrome (PNS) as well as systemic toxicity of chemo- and radiation therapy, is discussed. The ES influence on the development of PNS was demonstrated in C57/BL6 mice with transplanted Lewis lung carcinoma. Two-week administration of carbon enterosorbents resulted in a significant suppression of metastasis and correction of tumor-related anemia, activation of granulocytic line in the bone marrow with nearly 3-fold enhancement of its mitotic activity. ES exerted a positive influence on the structural-morphologic indexes and regenerative potential of kidneys and liver, mitigated manifestations of oxidative stress, decreased the level of endogenous intoxication, increased resistance of erythrocyte membranes and decreased ligand loading of blood plasma transport proteins. The effect of ES on anticancer activity and toxic reactions of cisplatin (CP) was evaluated in Guerin carcinoma-bearing rats. ES reduced significantly creatinine and other kidney biochemical indexes elevated in the blood plasma of rats after CP treatment. ES attenuated dystrophic changes in the histological structure of internal organs (kidney, liver, spleen), caused by tumor growth and significantly aggravated under the influence of CP. Such changes were specially traced in the kidneys and well reflect the nephroprotective potential of ES. In rats irradiated with X-ray in sublethal dose, highly activated granulated carbonic enterosorbents facilitated the restoration of white blood cells and lymphocyte count. The results obtained confirm the insights of academician R.E. Kavetsky predicting the future of adsorptive detoxification with activated carbons in the treatment of cancer patients
Доп.точки доступа:
Sakhno, L. A.
Sarnatskaya, V. V.
Yushko, L. A.
Snezhkova, E. A.
Bardakhivskaya, K. I.
Shevchuk, O. O.
Sidorenko, A. S.
Nikolaev, V. G.

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13.

Materials of the II International Conference “Tumor and Host: Novel Aspects of Old Problem” (November 21–22, 2019, Kyiv, Ukraine) [Текст] // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 258-280

MeSH-главная:
ЛЕЙКОЗ МИЕЛОГЕННЫЙ ХРОНИЧЕСКИЙ, BCR-ABL ПОЛОЖИТЕЛЬНЫЙ -- LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE (патофизиология, этиология)
УБИКВИТИН-СПЕЦИФИЧЕСКИЕ ПРОТЕАЗЫ -- UBIQUITIN-SPECIFIC PROTEASES (анализ, диагностическое применение)
БЕЛКИ СЛИТЫЕ, BCR-ABL -- FUSION PROTEINS, BCR-ABL (анализ, диагностическое применение)
КРАТКИЙ ОБЗОР -- OUTLINES
КЛИНИЧЕСКАЯ КОНФЕРЕНЦИЯ -- CLINICAL CONFERENCE
Кл.слова (ненормированные):
взаимодействие между белком USP1 и доменом Ph онкопротеина Bcr-Abl
Аннотация: Chronic myelogenous leukemia (CML) is characterized by the appearance of the cytogenetic marker of the Philadelphia chromosome (Ph), which is the result of translocation between 9 and 22 chromosomes. The product of this aberration is the hybrid oncoprotein Bcr-Abl.According to the preliminary results of the mass spectrometric analysis, 23 proteins were identified as potential candidates for interaction with the Ph domain of Bcr-Abl oncoprotein. The main function of ubiquitin specific protease 1 (USP1) protein is deubiquitination of cell proteins. As a result of deubiquitination, USP1 protein can prevent proteasomal degradation of Bcr-Abl oncoprotein in a cell and, consequently, contribute to its accumulation and progression of the disease
Aim. To create the pCMVHA-USP1 genetic construct for eukaryotic protein expression and to determine the interaction of USP1 protein with the Рh domain of the Bcr-Abl oncoprotein. Materials and Methods. The amplification of the coding sequence of USP1 gene was performed using primers USP1 fwd AATTGCCTGGTGTCATACCTAGTG and USP1 rev GAGAGACCAATAATATCCAGTAGC, pCMV-XL5-USP1 was used from the plasmid bank of the Department of Molecular Genetics of the IMBG NASU as a template. The resulting sequence of USP1 gene was ligated to pUC18 vector at Sma1 site. USP1 was subcloned to pCMVHA vector using Kpn1 and SalI restriction endonucleases. Co-transfection of pCMVHA-USP1 and pmCitrineC1-PH plasmids into HEK 293T cells was performed using 3:1 ratio of μl PEI : μg DNA. Transfection mixture was added to HEK293T cells and grown for 24 hours at a temperature of +37 °C and 5% CO2. Co-immunoprecipitation of HEK293T cells was done using Sepharose G and anti-His antibodies (Sigma, USA). The results were visualized by Western blot analysis using anti-USP1 antibodies (Thermo Fisher Scientific, USA), anti-His (Sigma, USA). Results and Discussion. Coding sequence of USP1 gene was amplified by PCR and ligated to the pUC18 vector. Genetic construct pCMVHA-USP1 for eukaryotic protein expression was created by sub-cloning the sequence of USP1 gene. Co-transfection of pCMVHA-USP1 and pmCitrineC1-PH vectors in HEK293T cells and co-immunoprecipitation assay revealed the interaction between USP1 protein and Ph domain of the Bcr-Abl oncoprotein. Conclusions. Genetic constructs pUC18-USP1 and pCMVHA-USP1 have been created. For the first time, the interaction between USP1 protein and РН domain of the Bcr-Abl oncoprotein was shown. The results obtained are important for the understanding of signaling in this pathology and may be the basis for the development of new alternative methods of CML treatment
Доп.точки доступа:
«Опухоль и хозяин: новые аспекты старой проблемы»

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