Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302a and -377 in tumor tissue [Text] / Yu. V. Vitruk [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P98-103

MeSH-главная:
КАРЦИНОМА ПОЧЕЧНО-КЛЕТОЧНАЯ -- CARCINOMA, RENAL CELL (генетика, патофизиология, терапия)
РЕЦЕПТОРНЫЕ ПРОТЕИН-ТИРОЗИН-КИНАЗЫ (стандарты)
РНК -- RNA (генетика)
Аннотация: Renal cell carcinoma (RCC) is one of the most common solid tumors in adults highly resistant to conventional therapies. The expression profile of a number of miRNAs correlates with RCC response to chemotherapeutic agents. Aim: To identify the association of tumor miRNAs expression with neoadjuvant treatment response in patients with RCC. Materials and Methods: We analyzed the expression levels of tumor miR-99b, -144, -155, -210, -222, -302а, -377 in 93 RCC patients who received pazopanib or sunitinib in neoadjuvant regimen using RT-PCR. RNU48 was used as a reference miRNA. Results: The levels of expression of miR-99b and -377 are associated with the RCC response to pazopanib, and microRNA-210 and -377 to sunitinib. The characteristic expression profile of miR-99b, -144, -222, -377, and miR-302a determined in 90% of cases was delineated in pazopanib responders as opposed to nonresponders. Similarly, the characteristic expression profile of miR-210, -222, -302a and -377 was suggested for sunitinib responders. Conclusions: Levels of miR-99b, -210 and -377 expression in RCC tumor tissue might be used as a basis for future predictive panel intended for the assessment of the sensitivity to the regimens of neoadjuvant RCC treatment
Доп.точки доступа:
Vitruk, Yu. V.
Semko, S. L.
Voylenko, O. A.
Pikul, M. V.
Borikun, T. V.
Zadvornyi, T. V.
Yalovenko, T. M.
Stakhovsky, E. O.
Rossylna, O. V.

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Role of tumor/endothelial cell interactions in tumor growth and metastasis [Text] / O. N. Pyaskovskaya [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P104-110

MeSH-главная:
КЛЕТОК ТРАНСФОРМАЦИЯ НЕОПЛАСТИЧЕСКАЯ -- CELL TRANSFORMATION, NEOPLASTIC (метаболизм, патология)
ЭНДОТЕЛИАЛЬНЫЕ КЛЕТКИ -- ENDOTHELIAL CELLS (патология)
НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS (патофизиология)
Аннотация: It is known that interactions between tumor and endothelial cells have a significant influence on the growth and metastasis of malignant tumors. Aim: To study the reciprocal effect of Lewis lung carcinoma (LLC) and endothelial cells on the growth rate of each other upon their co-cultivation in vitro and to assess the contribution of such tumor/endothelial cell crosstalk to in vivo LLC growth and metastasis. Materials and Methods: Two variants of Lewis lung carcinoma cells, high-metastatic (LLC) and low-metastatic (LLC/R9), and murine aorta endothelial cell line (MAEC) were used. Kinetics of tumor cell growth in vitro and in vivo, electrokinetic properties of tumor cells and their adhesion to endothelial monolayer, and the number of tumor and endothelial viable cells after 1-day contact or non-contact co-cultivation were estimated. Results: LLC/R9 had significantly higher growth rate in vivo (as opposed to in vitro) than LLC. However, the number and volume of lung metastatic lesions in LLC/R9-bearing mice were 4.5-fold (p 0.05) and 3.6-fold lower (p 0.05), respectively, compared to those in LLC-bearing mice. Non-contact co-cultivation of LLC/R9 + MAEC caused more than a 34% (p 0.05) LLC/R9-induced increase in the number of MAEC and a 60% (p 0.05) MAEC-induced increase in the number of LLC/R9 cells as compared to those of corresponding controls (cells cultured alone). In contrast, in the case of LLC + MAEC, both the number of LLC and MAEC cells after their non-contact co-cultivation and cultivation alone did not differ significantly. Contact co-cultivation LLC+MAEC (in contrast to LLC/R9+MAEC) caused more than a 50% (p 0.01) LLC-induced decrease in the number of MAEC and a 50% decrease (p 0.05) MAEC-induced in the number of LLC cells as compared to the corresponding controls. Both tumor cell variants showed a bimodal distribution of cells by ζ-potential, but in the case of LLC there was observed a shift towards high values due to 52% of cells with a surface charge density 10 C/m2, while in the case of LLC/R9 such a subpopulation was absent and 19% of cells had a surface charge 5 C/m2. The number of LLC cells that adhered to the monolayer of endothelial cells was by 65% (p 0.05) higher than that of LLC/R9 cells. Conclusion. Obtained data demonstrated that the tumor/endothelial cell relationships might reflect the features of tumor growth and metastasis of a malignant tumor
Доп.точки доступа:
Pyaskovskaya, O. N.
Kolesnik, D. L.
Garmanchouk, L. V.
Yanish, Yu. V.
Solyanik, G. I.

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5-FU resistens colorectal cancer cells possess improved invasiveness and ?III-tubulin expression [Text] / S. Akalovich [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P111-117

MeSH-главная:
КОЛОРЕКТАЛЬНЫЕ НОВООБРАЗОВАНИЯ -- COLORECTAL NEOPLASMS (терапия)
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ НОВООБРАЗОВАНИЙ -- DRUG RESISTANCE, NEOPLASM (действие лекарственных препаратов)
ФТОРУРАЦИЛ -- FLUOROURACIL (терапевтическое применение)
Аннотация: Elevated βIII-tubulin levels are associated with resistance to a broad spectrum of drugs in different carcinomas and with poor prognosis of various epithelial cancers. 5-Fluorouracil (5-FU) is a widely used standard drug in chemotherapeutic regimens for colorectal cancer treatment, although the resistance to 5-FU is a major obstacle to successful therapy. Aim: The aim of the study was to compare the invasive and adhesion properties and the expression levels of βIII-tubulin in a 5-fluorouracil (5-FU)-resistant colorectal cancer (CRC) cell line HCT116 and parental cells. Materials and Methods: The 5-FU-resistant cell line was established by continuous stepwise selection with increasing concentrations of 5-FU. Cell viability and properties were evaluated using MTT, adhesion and Transwell invasion assays, respectively. The expression of βIII-tubulin was revealed by immunoblot and immunofluorescence. Results: The derivative line is 25-fold more resistant to 5-FU and characterized by altered cell morphology. Twice as many cells of the 5-FU-resistant line fail to adhere as compared to the parental cell line. 5-FU-resistant cells are characterized by enhanced invasiveness, accompanied with the increased βIII-tubulin expression. In addition, we found that loss of βIII-tubulin expression was correlated with loss of 5-FU resistance. Conclusion: Our results indicate that even though 5-FU does not target microtubules, there appears to be a correlation between βIII-tubulin expression and resistance to 5-FU that is particularly important with regard to invasiveness. These findings indicate a possible contribution of βIII-tubulin to 5-FU resistance in vivo
Доп.точки доступа:
Akalovich, S.
Portyanko, A.
Pundik, A.
Mezheyeuski, A.
Doroshenko, T.

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In vitro modeling of tumor interclonal interactions using breast cancer cell lines [Text] / V. A. Bychkov [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P118-124

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (метаболизм, патофизиология)
Аннотация: To study the peculiarities of ecological relationships of breast cancer (BC) cell lines MCF-7, BT-474 and MDA-MD-231 under co-culturing conditions. Materials and Methods: Three BC cell lines: luminal A — MCF-7, luminal B — BT-474 and triple-negative — MDA-MD-231 were co-cultured pairwise. Immunocytochemistry was used to differentiate the cell lines in the wells. The effect of the cell-free culture medium on the growth rate of the alternate cell line in the pair was also evaluated. Results: It was shown that when BT-474 cells were co-cultured with MCF-7 and BT-474 cells were co-cultured with MDA-MD-231, two types of ecological interactions could be observed: commensalism and amensalism, respectively. While the cells do not interact with each other in contact, the supernatants of single cultures of MCF-7 and MDA-MD-231 exert the same effect on BT-474 as co-cultivation of BT-474 with these cells. Conclusions: The paracrine mechanism of intercellular interaction between different human BC cell lines has been demonstrated. The models used in population ecology can be applicable to identify the types of interaction between cell lines
Доп.точки доступа:
Bychkov, V. A.
Pevzner, A. M.
Nebova, J. A.
Ermakova, N. N.
Ibragimova, M. K.
Tsyganov, M. M.
Lyapunova, L. S.
Litviakov, N. V.

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Co-administration of apigenin with doxorubicin enhanges anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells [Text] / A. Ayyildiz [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P125-134

MeSH-главная:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (лекарственная терапия)
ДОКСОРУБИЦИН -- DOXORUBICIN (терапевтическое применение)
АПИГЕНИН (терапевтическое применение)
Аннотация: Prostate cancer is one of the leading cancers in men, and new approaches are needed for its treatment. The aim of this study was to investigate the effect of co-administration of naturally occurring flavone apigenin and doxorubicin to androgen-insensitive prostate cancer cells. Methods: The effect of the treatment on survival and migration of human PC3 cells was evaluated by MTT and scratch assay, respectively. Apoptosis and cell cycle distribution were detected by image-based cytometry. mRNA and protein expression were determined by real-time quantitative polymerase chain reaction and Western blot, respectively. Results: Apigenin and doxorubicin dose-dependently inhibited cell survival, and co-administration of both agents significantly induced cell death via upregulating the mRNA expression of caspases, Bax and cytochrome c, and downregulating Bcl-XL. Combination therapy caused cell cycle arrest by upregulating the expression of p21 and p27. The treatment modality inhibited cell migration via downregulating Snail, Twist and MMPs in which doxorubicin was ineffective. Apigenin dephosphorylated Akt strongly, significantly suppressed ERK phosphorylation, and increased PTEN expression 4.5-fold. The combination of apigenin and doxorubicin inhibited PI3K and AKT phosphorylation more strongly than a single administration. Conclusions: Our data indicate that a combination of the natural flavone apigenin with doxorubicin might have a potential in treatment of castration-resistant prostate cancer
Доп.точки доступа:
Ayyildiz, A.
Koc, H.
Turkekul, K.
Erdogan, S.

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Buchynska, L. G.
Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium [Text] / L. G. Buchynska, O. M. Movchan, N. P. Iurchenko // Experimental Oncology. - 2021. - Том 43, N 2. - P135-141

MeSH-главная:
КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID (лекарственная терапия, метаболизм, патофизиология)
Аннотация: The expression of the CXCL12 chemokine and its receptor CXCR4 in the stromal component of the tumor plays an important role in tumor cell migration, proliferation, inhibition of apoptosis and determination of invasive and metastatic potential of malignant neoplasms of various genesis. The significance of CXCL12 and CXCR4 expression in endometrial tumor cells for cancer progression is not fully understood. Aim: To evaluate the content of CXCL12+-fibroblasts and expression of CXCL12 and CXCR4 in endometrial cancer cells, depending on the tumor stage. Materials and Methods: Surgical material of 45 patients with endometrioid carcinoma of the endometrium (ECE) of the stages I–II and III was studied using morphological and immunohistochemical methods. Results: In ECE of stage I–II CXCR4 expression was lower (43.3 ± 4.2%) while CXCL12 expression was higher (33.6 ± 2.4%) compared with the corresponding indices in ECE of stage III (63.6 ± 3.5%, 24.5 ± 1.9%, respectively, p 0.05). In ECE of stage III, high expression of CXCR4 ( Me) and low CXCL12 ( Me) was observed in 80% of samples; these tumors invaded more than 1/2 of the myometrium. There was a positive correlation between the depth of tumor invasion in the myometrium and the presence of metastases and CXCR4 expression in tumor cells (R Me) (14.9 ± 1.3%) was detected. Conclusion: The obtained data reflect the communication of the immunosuppressive factor of the tumor microenvironment, i.e. CXCL12+-fibroblasts and CXCR4 expressing tumor cells. We suggest that the aggressiveness of ECE is determined by the combined effect of these two factors
Доп.точки доступа:
Movchan, O. M.
Iurchenko, N. P.

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Expression of TLR4 and major inflammatory cytokines in patients with bladder cancer of different grade and stage [Text] / P. G. Yakovlev [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P142-148

MeSH-главная:
МОЧЕВОГО ПУЗЫРЯ НОВООБРАЗОВАНИЯ -- URINARY BLADDER NEOPLASMS (иммунология, патофизиология)
Аннотация: The bladder cancer is immunogenic, and neoantigens generated by tumor cells trigger a notable immune response in the host. On the other hand, multiple immune escape mechanisms allow for avoiding the recognition by the host immune system. Toll-like receptor type 4 and inflammatory cytokines play major role in the immune response to bladder cancer. Aim: To assess the expression of TLR4 and the genes of major inflammatory cytokines in tumor cells and in unaffected tissue of the bladder. Materials and Methods: The pairs of samples from the urinary bladder tumor and unaffected adjacent tissue were obtained from 50 surgically treated patients with bladder cancer. The level of expression of TLR4, TGF-β1, INF-γ, TNF-α genes was evaluated by real-time polymerase chain reaction. Results: Bladder cancer cells are characterized by lower expression levels of TLR4, TGF-β1, INF-γ, TNF-α as compared to unaffected tissue. In patients with recurrent cancer, expression of TLR-4 and cytokines does not change both in tumor and in unaffected tissue of the bladder. Expression of TLR4 is identically low both in low- and high-grade cancer. Expression levels of the INF-γ and TNF-α are remarkably low in muscle-invasive cancer compared to the unaffected bladder tissue. The level of TGF-β1 in bladder cancer is comparable to the unaffected tissue of the bladder, while in the intact and metastatic lymph nodes it is significantly upregulated. Conclusion: Bladder cancer tissue differs from the unaffected part of the bladder wall in the level of TLR4, TGF-β1, INF-γ, TNF-α expression
Доп.точки доступа:
Yakovlev, P. G.
Gorbach, O. I.
Ostapchenko, L. I.
Garmanchuk, L. V.
Skachkova, O. V.
Khranovska, N. M.
Senchylo, N. V.

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RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population [Text] / M. S. Zoubi [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P149-154

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (генетика, патофизиология)
ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙ -- POLYMORPHISM, GENETIC (физиология)
ЖЕНЩИНЫ -- WOMEN
ИОРДАНИЯ -- JORDAN (эпидемиология)
Аннотация: Genetic predisposition to breast cancer (BC) has been extensively explored to achieve an enhanced understanding of the biology of BC. Targeting candidate genes to screen different genetic variants such as RAD51 gene that plays a critical role in DNA repair pathways including the double-strand break repair system is an important task. Aim: To study several single nucleotide polymorphisms (SNPs) within RAD51-UTR gene and to find their relationship with BC risk and prognosis among Jordanian females. Materials and Methods: In this case-control study, DNA sequencing technique was used to screen SNPs within the untranslated region (UTR) of RAD51 in 206 cases and 185 controls and the resulting data were statistically analyzed using different types of genetic analyses. Patients’ clinical and pathological features were obtained from their medical records to perform genotype-phenotype association analysis. Results: Our findings show a significant association between both SNPs rs528590644, rs1801320 and BC risk (p = 0.016). We estimated the correlation between many of BC prognostic factors and BC risk, and we found an association between rs1801321 and age at first menstruation (p = 0.032) in addition to a strong correlation between age at BC diagnosis and rs1801320 (p = 0.008). Conclusion: RAD51-UTR polymorphisms may be involved in BC development and progression
Доп.точки доступа:
Zoubi, M. S.
Al-Eitan, L. N.
Rababa, D. M.
Al-Batayneh, K.
Farzand, R.
Quinn, G. A.
Tambuwala, M. M.
Bakshi, H. A.

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A variant of TP53 gene (RS 1625895, 13494GA) is associated with neoplasm localization in patients with uterine leiomyoma [Text] / A. G. Kornatska [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P155-158

MeSH-главная:
ЛЕЙОМИОМА -- LEIOMYOMA (генетика)
МАТКИ НОВООБРАЗОВАНИЯ -- UTERINE NEOPLASMS (генетика, патофизиология)
Аннотация: Uterine leiomyoma (UL) is the most common benign neoplasm of the uterus. It is still unknown surely what exactly initiates transformation of the uterine myometrial cells into UL. Aim: To study the effect of the TP53 gene variants on the risk of development and clinical features of UL. Materials and Methods: Case-control study was performed using molecular genetic analyses of variants rs1042522 (119 GC) and rs1625895 (13494GA) of TP53 gene in patients with UL and comparison group of healthy women. Results: Investigated TP53 gene variants were not associated with the risk of UL development. The patients with the 13494GG genotype (rs1625895) had significantly more often subserous UL (р 0.05). In patients with heterozygous variant of TP53 — 13494GA genotype (rs1625895) intramural UL was observed (р 0.05). Conclusions: The rs1625895 (13494GA) variant of TP53 gene was associated with UL localization. The identified dependence of the UL localization on the TP53 gene variant could be useful for personalized approach to treatment
Доп.точки доступа:
Kornatska, A. G.
Flaksemberg, M. A.
Chubei, G. V.
Trokhymovych, O. V.
Rossokha, Z. I.
Fishchuk, L. Ye.
Medvedieva, N. L.
Vershyhora, V. O.
Gorovenko, N. G.

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10.

Significance of BRAFv600E mutation in intra-axial brain tumor in Malaysian patients: case series and literature review [Text] / A. A. Mohamed Yusoff [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P159-167

MeSH-главная:
МОЗГА ГОЛОВНОГО НОВООБРАЗОВАНИЯ -- BRAIN NEOPLASMS (генетика)
ГЕНЕТИЧЕСКАЯ ИЗМЕНЧИВОСТЬ -- GENETIC VARIATION (генетика)
ОПИСАНИЕ СЛУЧАЕВ -- CASE REPORTS
ОБЗОР -- REVIEW
Аннотация: To date, BRAF mutations in brain tumor patients have not been characterized in the Malaysian population. Based on the numerous reported studies, there are main mutations that exist in BRAF gene in various types of cancers. A missense mutation in codon 600 of the BRAF nuclear oncogene (BRAFV600E) is the most prevalent hotspot point mutation that has been identified in multiple human malignancies. Aim: We here aimed to find out the frequency of BRAFV600E mutation in a series of Malaysian patients with brain tumors and if any association exists between BRAFV600E mutation and clinicopathological features of patients. Material and Methods: Fresh frozen tumor tissue samples from 50 Malaysian brain tumor patients were analyzed for BRAFV600E mutational status, and its correlation with clinicopathological features (including age, gender, and tumor localization such as intra-axial: within the brain substance or extra-axial: outside the brain substance) was examined. Results: The overall BRAFV600E mutation frequency was determined to be 22% (in 11 of 50 patients). BRAFV600E was significantly correlated with the tumor location group, which shows BRAFV600E was more frequent in the intra-axial tumor than the extra-axial tumor group. In this study, we also observed that male patients were slightly more susceptible to BRAFV600E mutation, and this mutation was predominant in patients of the age group 40 years. However, these parameters did not translate to statistical significance. Conclusion: The data demonstrate that BRAFV600E mutation is observed significantly more often in intra-axial brain tumor patients, which can serve as baseline information for further research on genetic alteration that occurs during brain tumor progression in the Malaysian population
Доп.точки доступа:
Mohamed Yusoff, A. A.
Abd Radzak, S. M.
Mohd Khair, S. Z. N.
Abdullah, J. M.

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11.

Therapeutic results of laryngeal preservation: a retrospective study [Text] / W. Ben Kridis [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P168-172

MeSH-главная:
ГОРТАНИ НОВООБРАЗОВАНИЯ -- LARYNGEAL NEOPLASMS (хирургия)
ОРГАНОСОХРАНЯЮЩЕЕ ЛЕЧЕНИЕ -- ORGAN SPARING TREATMENTS (использование, стандарты, тенденции)
Аннотация: The objective of this study is to report the therapeutic results of the preservation strategy in locally advanced laryngeal cancers. Patients and Methods: Between January 2008 and December 2015, 24 patients with locoregional advanced non-metastatic laryngeal cancer (T2–4/N0–2) were collected retrospectively. Different therapeutic sequences were used: either induction chemotherapy followed by concurrent chemoradiotherapy or induction chemotherapy followed by radiotherapy or concurrent chemoradiotherapy or radiotherapy alone. Results: The objective response rate was 85.7%. Overall survival rates at 1 year, 3 years and 5 years were 91.3%, 80.2% and 53.5%, respectively. Administration of induction chemotherapy did not improve overall survival. The 1-year overall survival was 83.3% in the induction chemotherapy group vs 94.1% for those who did not received induction chemotherapy (p = 0.7). Conclusion: Our study showed the feasibility of this preservation strategy in clinical practice, with acceptable term toxicity
Доп.точки доступа:
Ben Kridis, W.
Werda, I.
Mnejja, W.
Toumi, N.
Charfeddine, I.
Daoud, J.
Khanfir, A.

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12.

Study of modifyng effects of astaxanthin on cytogenetic manifestations of bystander response in human peripheral blood lymphocytes in vitro [Text] / M. A. Pilinska [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P173-176

MeSH-главная:
ЛЕЙКОЗ-ЛИМФОМА ПРЕ-КЛЕТОЧНЫЙ ЛИМФОБЛАСТНЫЙ -- PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA (генетика, кровь, патофизиология)
ЛИМФОЦИТЫ -- LYMPHOCYTES (патология)
Аннотация: To study the possible impact of astaxanthin on the cytogenetic manifestations of the simultaneous development of radiation-induced (RIBE) and tumor-induced bystander effect (TIBE) in human peripheral blood lymphocytes. Materials and Methods: Peripheral blood lymphocytes from healthy persons and patients with chronic lymphocytic leukemia were cultured separately or cocultured with or without previous irradiation in vitro by 137Cs at a dose of 0.5 Gy. The cells were cultured with and without 20 μg/ml astaxanthin. Results: In the presence of astaxanthin, the decrease of chromosomal instability both in the variant with separate TIBE and with simultaneous development of TIBE and RIBE was observed as the reduction in the frequency of simple chromosome-type aberrations, namely, double fragments. The average level of chromatid-type aberrations did not change under the action of astaxanthin. Although the total chromosome instability in bystander cells diminished, this did not lead to the elimination of the RIBE and TIBE development in the presence of astaxanthin. Conclusion: In the setting of experiment, astaxanthin did not reduce the frequency of chromatid-type aberrations in bystander cells due to RIBE and TIBE but reduced the frequency of simple aberrations of chromosomal type, not associated with the development of bystander response phenomenon
Доп.точки доступа:
Pilinska, M. A.
Shemetun, O. V.
Talan, O. O.
Dibska, O. B.
Talko, V. V.

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13.

Scrotal cutaneous metastasis from rectal squamous cell carcinoma: a rare evolution into a rare tumor [Text] / V. De Giorgi [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P177-179

MeSH-главная:
КАРЦИНОМА ПЛОСКОКЛЕТОЧНАЯ -- CARCINOMA, SQUAMOUS CELL (метаболизм, патофизиология)
ПРЯМОЙ КИШКИ НОВООБРАЗОВАНИЯ -- RECTAL NEOPLASMS (осложнения)
НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS (патофизиология, терапия)
МОШОНКА -- SCROTUM (патология, патофизиология)
Аннотация: The scrotum is a rare site for metastases and represents less than 1% of the body’s total surface area. Clinically, metastatic deposits in the scrotum can present in a variety of ways. They may appear as solitary cutaneous nodules, papules, plaques, or generalized induration or edema. Indeed, scrotum metastasis may be mistaken for other skin lesions since several dermatologic conditions can present with inflammation or dermatitis of the scrotum. Properly diagnosing cutaneous metastasis requires histopathological examination since the clinical appearances are, as described, highly variable and non-specific. We present a 63-year-old man with painless nodules on the scrotal skin. Excisional biopsy of the nodules revealed a metastasis from rectal squamous cell carcinoma. The incidence of this kind of tumors is estimated around 0.1–0.25 per 1000 colorectal neoplasms
Доп.точки доступа:
De Giorgi, V.
Venturi, F.
Portelli, F.
Maida, P.
Scarfi, F.
Trane, L.
Gori, A.
Silvestri, F.
Massi, D.

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14.

Systemic chemotherapeutic treatment of patients with breast cancer brain metastases [Text] / R. Liubota [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P180-184

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (осложнения)
НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS (патофизиология, терапия)
МОЗГА ГОЛОВНОГО НОВООБРАЗОВАНИЯ -- BRAIN NEOPLASMS (лекарственная терапия)
Аннотация: Brain metastases of solid tumors are the most common intracranial neoplasms in adults. We provide a short overview of the role of the blood-brain barrier in the pathogenesis of breast cancer brain metastases, and the effectiveness of systemic anticancer therapy in the treatment of such patients
Доп.точки доступа:
Liubota, R.
Vereshchako, R.
Anikusko, M.
Liubota, I.
Vakulenko, G.

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15.

Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model [Text] / S. M. Pasichnyk [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P185-188

MeSH-главная:
ПОЧЕК НОВООБРАЗОВАНИЯ -- KIDNEY NEOPLASMS (метаболизм, патофизиология)
ПОЧЕЧНЫХ КЛУБОЧКОВ ФИЛЬТРАЦИИ СКОРОСТЬ -- GLOMERULAR FILTRATION RATE (физиология)
Аннотация: Chronic renal failure is one of the most challenging complications after the completed surgical treatment for renal cell cancer. In 2016, a grading system of tumorous renal involvement was developed, referred to as NCIU nephrometry. However, the systematic parameter to reflect the functional status of the functional renal parenchyma is defined by tumor volume only, with no regard for spatial disposition of the segment(s) where the tumor is located. Our research team decided to improve the NCIU nephrometry system by developing and testing a modified formula for calculation of creatinine clearance, which makes allowance for spatial disposition of tumor within the kidney. We performed numerical computations and analysis of changes in functional status of renal parenchyma depending on coordinate-based spatial location of the tumor in order to augment the existing NCIU nephrometry scale; Matlab, a specialized software package was used as a principal instrument to calculate the number of nephrons and functional renal parenchyma depending on the coordinate-based position of the mass center of the tumor and tumor volume. This model was shown to create a feasible opportunity to increase the percentage of organ-sparing procedures for renal cell cancer and to reduce the incidence/progression of chronic renal failure in these patients
Доп.точки доступа:
Pasichnyk, S. M.
Pasichnyk, M. S.
Lychkovsky, A. E.
Stakhovsky, E. O.
Gozhenko, A. I.
Shatnyi, S. V.
Pasichnyk, M. A.

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16.

Long-term exposure to low doses of ionizing radiation and COVID-19 pandemic: oncohematological aspects [Text] / D. F. Gluzman [et al.] // Experimental Oncology. - 2021. - Том 43, N 2. - P189-192

MeSH-главная:
КРОВЕТВОРНАЯ СИСТЕМА -- HEMATOPOIETIC SYSTEM (воздействие облучения)
ЛИМФОИДНАЯ ТКАНЬ -- LYMPHOID TISSUE (воздействие облучения)
НОВООБРАЗОВАНИЯ, СОСТОЯЩИЕ ИЗ ЛИМФОИДНОЙ ТКАНИ -- LYMPHATIC VESSEL TUMORS (этиология)
ГЕМАТОЛОГИЧЕСКИЕ НОВООБРАЗОВАНИЯ -- HEMATOLOGIC NEOPLASMS (этиология)
Аннотация: For more than 35 years after Chornobyl catastrophe, about 5 million people in Ukraine, Republic of Belarus and Russian Federation inhabit the territories that are residually contaminated with long-lived radionuclides such as 137Cs, 90Sr. The previous studies of the Reference Laboratory operating at RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology allowed specifying the effects of the protracted low dose irradiation on the state of the hematopoietic and lymphoid tissues resulting in the increased proportion of the B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma and acute myeloid leukemia among the patients referred from the contaminated areas of Ukraine. Since the beginning of 2020, these effects of radiation were superimposed by the factors associated with COVID-19 pandemic. SARS-CoV-2 infection is associated with the significant impact on hematopoiesis and immune system. Particular attention should be given to the role of such combined burden in the development of the immunodeficiency-associated lymphoid neoplasms. The extensive studies of the combined effects of low dose irradiation and COVID-19 within the large affected populations could be made a priority in future endeavors of epidemiologists and oncohematologists
Доп.точки доступа:
Gluzman, D. F.
Zavelevich, M. P.
Philchenkov, A. A.
Koval, S. V.
Guslitser, L. N.
Zinchenko, V. N.
Bezhenar, T. O.

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