Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Nesina, I.
Peculiari of epithelial-mesenchymal transition in endometrial carcinomas [Text] / I. Nesina // Experimental Oncology. - 2021. - Том 43, N 4. - P282-289

MeSH-главная:
КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID (диагностика, патофизиология)
ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМНЫЙ ПЕРЕХОД -- EPITHELIAL-MESENCHYMAL TRANSITION
Аннотация: Epithelial-mesenchymal transition is an important component of tumor progression, due to which the cells of malignant neoplasms acquire invasive and migratory properties. Analysis of the literature and our own data show that the activation of proteins involved in epithelial-mesenchymal transition crucially affects the progression of endometrioid carcinoma of the endometrium and the significant variability of their expression could determine the clinical and morphological heterogeneity of this cancer. The most aggressive endometrioid carcinomas of the endometrium are characterized by a hybrid epithelial-mesenchymal phenotype, which is often associated with a collective type of invasion of endometrial tumor cells into the myometrium
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Yildirim-Kahriman, S.
Non-intrinsic cancer risk factors [Text] / S. Yildirim-Kahriman // Experimental Oncology. - 2021. - Том 43, N 4. - P290-297

MeSH-главная:
НОВООБРАЗОВАНИЯ -- NEOPLASMS (этиология)
ФАКТОРЫ РИСКА -- RISK FACTORS
Аннотация: Our knowledge about the etiology of cancer is increasing. Many studies show that non-intrinsic factors such as environment or lifestyle are the main risk factors for the occurrence of cancer. On the other hand, there are studies showing that the main risk factors in the occurrence of cancer are caused by DNA replication errors (known as the intrinsic factors). This view limits highly the possibility of protection from cancer. However, the findings obtained from the literature show that non-intrinsic factors contribute substantially to cancer risk and that cancer should be considered as a preventable disease. This review is aimed to examine the factors known as non-intrinsic cancer risk factors in the light of recent research.Key Words: cancer, non-intrinsic risk factors, cancer prevention
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Differential expression patterns of AIP, UCKL1, and PKN1 genes in breast cancer of different molecular subtypes [Text] / L. Kovalevska [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P298-305

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (генетика, диагностика, классификация)
Аннотация: Classification of breast cancer (BC) in the molecular subtypes had the enormous impact on the development of the individualized therapy. Nevertheless, there is a need for additional biomarkers that would help to refine molecular subtypes of BC and propose the therapeutic approach for each patient. Aim: To study differential expression patterns of AIP, UCKL1, and PKN1 genes in blood sera and tumor tissue of patients with BC of different molecular subtypes. Materials and Methods: The total extracellular RNA was isolated from serum of 26 BC patients. cDNAs was synthesized and quantitative polymerase chain reaction was performed. Also, immunohistochemical studies of UCKL, AIP and PKN1 were performed on deparaffined tissue sections. The study was supplemented by a bioinformatic analysis of the publicly available databases. Results: AIP and UCKL-1 extracellular mRNA levels were 100–1000-fold increased in blood sera of all BC patients, compared to the healthy donors. The highest levels were detected in the luminal A and HER2 (ERRB2) BC subtypes. The highest levels of PKN1 were detected blood sera of the patients with luminal B and basal subtypes; its expression levels were just 10–100-fold higher in BC samples compared to healthy donors. Conclusions: The UCKL1, AIP, PKN1 genes are overexpressed at the mRNA level in blood sera of BC patients compared to the sera of healthy individuals. Among three genes under study, only for the AIP gene, the pattern of extracellular mRNA expression in sera paralleled to protein expression in BC tissues of each specified molecular subtype
Доп.точки доступа:
Kovalevska, L.
Kashuba, E.
Zadvornyi, T.
Astrid, K.
Lukianova, N.
Chekhun, V.

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Comparative characteristics of DNA loop domaing rearrangement in glioblastoma multiforme T98G and glioblastoma astrocytoma U373 cell lines under different culture conditions [Text] / K. Svyrydova [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P306-311

MeSH-главная:
ГЛИОБЛАСТОМА -- GLIOBLASTOMA (диагностика, кровь)
Аннотация: The loop domain organization of chromatin, which plays an important role in transcription regulation, may depend on the cell functional state. The aim of this work was to investigate DNA loop reorganization upon functional transitions in two cell lines ‒ glioblastoma multiforme T98G and glioblastoma astrocytoma U373. Materials and Methods: Single cell gel electrophoresis (the comet assay) was used to analyze the kinetics of the DNA loop migration from the nucleoids obtained from the lysed cells. Results: The DNA fraction in the surface loops and the size of these loops were found to be similar in two glioblastoma cell lines. When synthetic processes were inhibited, the migration of a small portion of inner loops was observed in T98G but not U373 cells. In T98G cells, stimulation of cell proliferation and transcription was accompanied by an increase in DNA fraction in the inner loops and an essential increase in the size of these loops. The effect of stimulation was practically absent in U373 cells. However, the linear density of the loops resolved by the comet assay was found to decrease upon stimulation of proliferation in both cell lines. Conclusion: A decrease in the loop density appears to be associated with an intensification of the synthetic processes in cells upon their stimulation
Доп.точки доступа:
Svyrydova, K.
Vasylieva, V.
Kropyvko, S.
Afanasieva, K.
Sivolob, A.

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SLAMF1/CD150 expression and topology in prostate and breast cancer cell lines [Text] / I. M. Gordiienko [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P312-316

MeSH-главная:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (генетика, диагностика)
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (генетика, диагностика)
Аннотация: SLAMF1/CD150 receptor is aberrantly expressed in malignant hematopoietic cells compared to ubiquitous expression in their normal analogues. However, the data about CD150 expression and function outside the hematopoietic system are limited. The aim of this pilot study was to examine the profile of mRNA expression of CD150 isoforms and the protein topology in highly and low malignant breast (BC) and prostate cancer (PC) cell lines. Materials and Methods: The study was performed on BC T47D, MDA-MB-231, ВСС/Р and BC/ML cell lines and PC LNCap, Du-145 and PC-3 cell lines. The quantitative polymerase chain reaction was applied for study of CD150 isoforms mRNA expression and flow cytometry was used for determination of protein localization. Results: Analyzed BC cell lines did not express CD150 on the cell surface membrane (csCD150-), but more than 45% of cells were positive for CD150 cytoplasmic reaction (cyCD150+). The cyCD150 expression level in T47D cells of luminal BC subtype was higher than in basal BC cell lines MDA-MB-231, ВСС/Р and BC/ML. The PC cell lines expressed CD150 both on the cell surface and in cytoplasm. The highest number of csCD150+ and cyCD150+ cells was revealed in less aggressive androgen responsive, non-metastatic LNCap cell line. All studied BC and PC cell lines expressed mRNA of canonical transmembrane mCD150 and novel nCD150 isoforms but with different pattern of prevalence. Soluble CD150 isoform was revealed at the low level only in BCC/P BC cell line and LNCap, PC-3 PC cell lines. Conclusions: We have shown that BC and PC cell lines differentially expressed multifunctional receptor CD150 at the mRNA and protein levels that may indicate its association with the degree of their malignancy
Доп.точки доступа:
Gordiienko, I. M.
Lykhova, O. O.
Shcherbina, V. M.
Shlapatska, L. M.

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Effects of obesity in rats on prostate histology and expression of leptin receptor, prolactin receptor, IL-6, and NF-кB [Text] / D. Herrera-Covarrubias [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P317-321

MeSH-главная:
ОЖИРЕНИЕ -- OBESITY (генетика, диагностика, метаболизм)
ПРЕДСТАТЕЛЬНАЯ ЖЕЛЕЗА -- PROSTATE (анатомия и гистология, метаболизм, патология)
ЖИВОТНЫЕ -- ANIMALS
Аннотация: Hypercaloric intake can lead to obesity, which is a major risk factor associated with chronic subclinical inflammation and many types of cancer. It can increase the serum levels of leptin, prolactin, nuclear factor kappa B (NF-кB) and interleukin (IL)-6, implicated in cell proliferation, differentiation and survival. Aim: To explore the effects of obesity induced by chronic hypercaloric diet in rats on the long-term expression of leptin receptor (OB-R), prolactin receptor, NF-кB, and IL-6, and the changes of histology in rat prostate. Materials and Methods: From postnatal day 21, experimental males were fed with normal chow or chow plus enriched hypercaloric liquid diet. On the postnatal day 90 (13 week old), the animals were euthanized for prostate histology (hematoxylin and eosin staining) and hormone receptors analysis by Western blot. Results: Hypercaloric diet resulted in obesity (32% higher body weight). The prostates of the obese males showed epithelium anisocytosis and compressed interstice. There was also greater volume of lipidic content, anisokaryosis, alterations of the nucleus-cytoplasm ratio, and apparent proplasia. Measures in the ventral prostate (VP) showed that alveoli area increased, but epithelium height and nucleus area were reduced. In the dorsolateral prostate, there was only reduction of nucleus area and presence of mononuclear cells in the lumen. Hypercaloric males also expressed a trend for more OB-R 130 kD in the VP, but no changes were observed with regard to prolactin receptor, NF-кB and IL-6. Conclusion: The obesity due to chronic consumption of hypercaloric diet affects both prostatic regions, but VP is possibly more sensitive via OB-R. We suggest that longer periods of obesity are needed to alter other receptors or the molecular markers of inflammation
Доп.точки доступа:
Herrera-Covarrubias, D.
Perez-Leon, C. A.
Fernandez-Pomares, C.
Coria-Avila, G. A.
Sanchez-Zavaleta, V.
Aranda-Abreu, G. E.
Suarez-Medellin, J.
Rojas-Duran, F.
Hernandez, M. E.

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Studennikov, A. E.
Detection of antibodies against benzo[A]pyrene in blood sera of lung cancer patients by ELISA using human recombinant idiotypic and anti-idiotypic antibodies [Text] / A. E. Studennikov, A. N. Glushkov, V. A. Ustinov // Experimental Oncology. - 2021. - Том 43, N 4. - P323-327

MeSH-главная:
ЛЕГКИХ НОВООБРАЗОВАНИЯ -- LUNG NEOPLASMS (диагностика, кровь)
ИММУНОФЕРМЕНТНЫЕ МЕТОДЫ -- IMMUNOENZYME TECHNIQUES (использование)
Аннотация: Aim of this study was to develop and apply an ELISA method for assessment of the levels of endogenous antibodies against benzo[a]pyrene (Bp) in blood sera of lung cancer (LC) patients. Materials and Methods: ELISA was developed and applied for the detection of endogenous idiotypic and anti-idiotypic antibodies against Bp in human blood sera using recombinant human idiotypic and anti-idiotypic antibodies against Bp. Results: Serum samples of LC patients (n = 22) and healthy donors (n = 24) were analyzed by the new method. Statistical analysis showed that in sera of LC patients the levels of endogenous idiotypic and anti-idiotypic antibodies against Bp were significantly higher than in healthy donors. A logistic regression model for the LC detection utilizing such predictors as the serum levels of idiotypic and anti-idiotypic antibodies against Bp, smoking status, and age, identified LC patients with 83% specificity and 82% sensitivity. Conclusion: The proposed method could be further developed as additional lung cancer screening tool
Доп.точки доступа:
Glushkov, A. N.
Ustinov, V. A.

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High grade breast ductal carcinomas have high density of tumor-associated macrophages [Text] / Abbasi Ata [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P328-330

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика, классификация)
Аннотация: The role of tumor-associated macrophages (TAMs) is double-natured and still controversial. Depending on different settings, macrophages may suppress or promote tumor growth. TAM density may be one of the predictive factors of treatment outcome in cancer patients. Aim: To evaluate the density of tumor-associated macrophages in breast cancer and its relationship with various histopathologic findings. Materials and Methods: 55 patients with invasive ductal carcinoma of breast who underwent mastectomy were enrolled. Sections of tumor samples were stained and the density of CD68+ cells was evaluated. Results: There was an association between estrogen receptor (ER) expression and CD68 density (p = 0.010) as the higher densities of CD68 were seen in ER negative tumors. Moreover, there was a significant relationship between histological grade and CD68 density (p = 0.006). Conclusion: The higher TAM density is associated with higher tumor grade and negative ER expression in breast cancer tissues. These findings revealed that inflammation could have an important role in malignancies
Доп.точки доступа:
Ata, Abbasi
Sepideh, Rahimi
Leila, Mahmoudzadeh
Hengameh

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Zakhartseva, L.
Tumor-infiltrating lymphocytes as easily accessible prognostic tool in adenocarcinoma of the colon [Text] / L. Zakhartseva, B. Shkurupii // Experimental Oncology. - 2021. - Том 43, N 4. - P331-335

MeSH-главная:
АДЕНОКАРЦИНОМА -- ADENOCARCINOMA (диагностика)
ТОЛСТАЯ КИШКА -- INTESTINE, LARGE (патология)
ПРОГНОСТИЧЕСКАЯ ЦЕННОСТЬ ТЕСТОВ -- PREDICTIVE VALUE OF TESTS
Аннотация: To determine the prognostic value of tumor-infiltrating lymphocytes (TILs) in colon adenocarcinomas. Materials and Methods: The study was performed on 180 paraffin blocks of operation material from patients diagnosed with adenocarcinoma of the colon, treated at the Kyiv City Oncology Center in 2013–2018. TILs were counted on histological slides stained with hematoxylin-eosin. By TILs count percentage in tumor slides, the samples were divided into three groups: 0–9% TILs (n = 65); 10–39% TILs (n = 79); and 40% TILs (n = 36). Results: Kaplan — Meyer estimate showed that the difference in overall survival between groups was significant (p = 0.001). Multivariate Cox’s proportional hazard regression model analysis evidenced on significantly better overall survival rates in groups with moderate TILs percentage (hazard ratio 0.54, 95% CI 0.30–0.97, p = 0.042) and high TILs percentage (hazard ratio 0.36, 95% CI 0.13–0.99, p = 0.049), respectively, as compared with low TILs percentage group. Conclusion: TILs content can be considered as an independent prognostic factor for colon adenocarcinoma and used as an additional tool in routine practice of pathologists
Доп.точки доступа:
Shkurupii, B.

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10.

CYP2C19*2 gene variant (G681A, RS4244285) as a prognostic marketr for the clinical course of multiple myeloma [Text] / N. I. Kostiukova [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P336-340

MeSH-главная:
МИЕЛОМА МНОЖЕСТВЕННАЯ -- MULTIPLE MYELOMA (генетика, диагностика, патофизиология)
Аннотация: Multiple myeloma (MM) is the most common type of paraproteinemic hemoblastosis, which is characterized by an aggressive course, high mortality and a large number of complications. The G681A variant (*2, rs4244285) of the CYP2C19 gene leads to the formation of an inactive enzyme and, as a consequence, may affect the development and course of MM. The aim of this research was to analyze the effect of the G681A variant of the CYP2C19 gene on the risk of the development of MM and its course. Materials and Methods: The study enrolled 158 patients with MM, who underwent standard clinical and laboratory studies: cytological, general clinical, biochemical, as well as molecular cytogenetic and molecular genetic. Cytogenetic analysis of chromosome abnormalities was performed using interphase fluorescence in situ hybridization. Genotyping by the G681A variant of the CYP2C19 gene was performed by polymerase chain reaction-restriction fragment length polymorphism. Results: No association was found between the G681A variant of the CYP2C19 gene and the risk of developing MM. The association between the presence of the G allele and GG genotypes with significant changes in clinical and biochemical parameters (plasma cell count, α2-globulin, calcium content) in MM patients has been established. In the presence of the G allele of the CYP2C19 gene, the development of chromosomal rearrangements del(13q14.2) or del(13q34) with significantly increased levels of albumin occurs more frequently. Conclusions: The G681A variant of the CYP2C19 gene does not affect the risk of developing MM, but it is associated with significant changes in the clinical and biochemical parameters that determine the severity of the disease and its prognosis. Further research is important to develop new target strategies and maintenance therapy for carriers of different variants of the CYP2C19 gene (G681A)
Доп.точки доступа:
Kostiukova, N. I.
Fishchuk, L. Ye.
Rossokha, Z. I.
Medvedieva, N. L.
Andreieva, S. V.
Bloshchinska, S. V.
Popova, O. F.
Vydyborets, S. V.
Gorovenko, N. G.

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11.

Positive association between SRA1 RS801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females / I. M. Lukavenko [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P341-345

MeSH-главная:
МАСТОПАТИЯ ФИБРОЗНО-КИСТОЗНАЯ -- FIBROCYSTIC BREAST DISEASE (генетика, диагностика, патофизиология, эпидемиология)
УКРАИНА -- UKRAINE (эпидемиология)
Аннотация: To investigate the association between SRA1 rs801460 and rs10463297 variants and proliferative type of benign breast disease with atypia development in Ukrainian females. Materials and Methods: 83 individuals diagnosed with proliferative type of benign breast disease with atypia and 115 without atypia were enrolled in the study. The rs801460 and rs10463297 variants genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. Hematoxylin and eosin, toluidine blue and van Gieson’s picrofuchsin methods were used for sections staining. Results: It was revealed that SRA1 rs801460-variant is associated with proliferative type of benign breast disease with atypia development both before and after adjustment for risk factors (age, body mass index, age of menarche, oral contraceptives intake and burdened history of breast cancer). The risk for mentioned disease in the individuals with rs801460 TT-genotype is 2.2 times higher (confidence interval 1.010–4.800; p = 0.047) than in individuals with the CC and CT genotypes. No link between SRA1 rs10463297 and proliferative type of benign breast disease with atypia occurrence in Ukrainian females was found. Conclusion: The present study specified that SRA1 rs801460, but not rs10463297, can be the strong genetic predictor for benign breast disease with atypia in Ukrainian females
Доп.точки доступа:
Lukavenko, I. M.
Kolnoguz, A. V.
Levchenko, Z. M.
Harbuzova, V. Yu.

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12.

Ukrainian prospective study in patients with T-cell non-hodgkin lymphomas [Text] / I. Kriachok [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P346-350

MeSH-главная:
ЛИМФОМА НЕ-ХОДЖКИНА -- LYMPHOMA, NON-HODGKIN (диагностика, патофизиология, эпидемиология)
ПРОСПЕКТИВНЫЕ ИССЛЕДОВАНИЯ -- PROSPECTIVE STUDIES
УКРАИНА -- UKRAINE (эпидемиология)
Аннотация: T-cell lymphoma (TCL) is a heterogeneous group of lymphoproliferative diseases that account for 10–15% of all non-Hodgkin lymphomas. The aim of the study was to analyze the incidence of TCL in Ukraine, distribution according to subtypes and to assess the results of treatment of patients with TCL depending on lymphoma subtype and clinical-and-laboratory risk factors. Patients and Methods: Data from 70 patients with TCL were analyzed from February 2018 to May 2021. T-cell lymphoid neoplasms were diagnosed according to the 2016 WHO classification. The patients were divided into 4 groups: 1st (A) — leukemic forms (n = 13) (received SMILE or HyperCVAD +/- auto/alloSCT); 2nd (B) — nodal T-cell lymphomas (n = 43) (CHOP-like regimens); 3rd (C) — cutaneous T-cell lymphomas (n = 9) (PUVA therapy, interferon, and methotrexate); 4th (D) — extranodal T-cell lymphomas (n = 5) (CHOP-like regimens). The response was determined according to the Lugano 2014 criteria. Results: According to the study results, 5–6% of all non-Hodgkin lymphoma registered in Ukraine in 2018–2020 were T-cell lymphomas. The most common subtype was peripheral TCL (61%). In the studied groups of TCL patients, the overall response rate was 50% (n = 35). 2-years event-free survival rate was 62.27%. 2-years overall survival rate was 65.76%. 18-month progression-free and overall survival in group B was higher versus groups A, C and D. The factors of unfavorable prognosis were bone marrow involvement and the expression of Ki67 65% (p = 0.03 and p = 0.006, respectively). Conclusions: Histologic subtype of T-cell non-Hodgkin lymphoma influence the treatment outcome. The best overall response rate, overall survival rate, progression-free survival were in group of patients with nodal T-cell non-Hodgkin lymphomas, the worst — in patients from leukemic group. Poor prognostic factors are bone marrow involvement, and Ki-67 expression 65%
Доп.точки доступа:
Kriachok, I.
Studrak, N.
Tytorenko, I.
Stepanishyna, Ya.
Martynchik, A.
Aleksik, O.
Novosad, O.
Kadnikova, T.
Pastushenko, Ya.
Kyschevoy, E.
Shokun, N.

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13.

Comparison of ultrasound and MRI informativeness for detection and treatment monitoring of cervical cancer metastases in the vagina [Text] / T. S. Golovko [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P351-358

MeSH-главная:
ШЕЙКИ МАТКИ НОВООБРАЗОВАНИЯ -- UTERINE CERVICAL NEOPLASMS (осложнения)
НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS (диагностика, патофизиология)
ВЛАГАЛИЩА НОВООБРАЗОВАНИЯ -- VAGINAL NEOPLASMS (диагностика, этиология)
Аннотация: To assess ultrasound (US) method informativeness in the recurrence detection and treatment monitoring of patients with cervical cancer metastases in the vagina via comparing the US and magnetic resonance imaging (MRI) data. Materials and Methods: 42 patients with recurrence of cervical cancer were examined by transvaginal US and MRI. Data on radiation diagnostics of cervical cancer metastasis in the vagina were compared with pathomorphological data. US and MRI data on the metastatic tumors size were compared. Results: The diagnostic efficiency of US and MRI for recurrence detection was determined. The sensitivity, specificity and accuracy of US were 92.8; 93.3 and 93.3%, respectively, and of MRI — 95.2; 96.6 and 95.8%, respectively. The informativeness of MRI was higher than US in cervical cancer recurrences detection, but the difference was not significant (p 0.05). US can provide data as informative as MRI for estimation of metastases sizes in the vagina. The mean difference between MRI measurements and US measurements of the metastases volume was 0.79 mm (95% CI 0.62–0.95 cm3). Conclusions: US as a cheaper and simpler method could be an alternative for metastases detecting and treatment monitoring, especially if there are contraindications to MRI
Доп.точки доступа:
Golovko, T. S.
Bakai, O. A.
Ashykhmin, A. V.
Baranovskaya, L. M.

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14.

Efficacy of dispersed fibrous carbon sorbent in treatment of malignant fungating wounds [Text] / L. A. Sakhno [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P359-364

MeSH-главная:
РАНЫ И ТРАВМЫ -- WOUNDS AND INJURIES (диагностика, лекарственная терапия, микробиология)
РАНЫ ЗАЖИВЛЕНИЕ -- WOUND HEALING
ПОВЯЗКИ -- BANDAGES (использование)
УГЛЕРОД -- CARBON (терапевтическое применение)
АДСОРБЦИЯ -- ADSORPTION
ЭКСПЕРИМЕНТЫ НА ЖИВОТНЫХ -- ANIMAL EXPERIMENTATION
Аннотация: To evaluate the influence of dispersed fibrous carbon sorbent (DFCS) on malignant fungating wounds (MFWs) in Guerin’s carcinoma-bearing rats with an assessment of wound bacterial microflora. Materials and Methods: The study was performed on female Wistar rats inoculated subcutaneously with Guerin T8 carcinoma into the upper interscapular region. On day 20, the tumors were infected by injecting the suspension of S. aureus 8325-4. After 24 h, gauze dressings were applied daily to the wounds in the control group and DFCS in the experimental one. The state of the wounds was assessed by visual control with photo monitoring, odor control on a verbal rating scale and microbiological analysis of qualitative and quantitative characteristics of wound microbiota. Results: On the 3rd day after the start of dressings, the number of S. aureus of 8325-4 strain was significantly higher in the wounds of rats in control group than experimental one (5.14 ± 0.27 vs 3.43 ± 0.33 lg CFU/ml). The total number of Staphylococci in the DFCS-treated wounds did not differ statistically from the number of S. aureus 8325-4 strain whereas in control ones were higher by an order of magnitude. On the 10th day the total number of Staphylococci and S. aureus 8325-4 in particular, remained consistently high in the wounds of the control rats, while was almost five orders of magnitude lower and represented mainly by S. aureus 8325-4 in the experimental ones. The total number of aerobic and optionally anaerobic microorganisms was significantly lower as well. A greater variety of microorganisms in the gauze-covered wounds, as well as an their increased number were accompanied by enhancement of the wound odor from “noticeable” to “strong”. There was an appearance of a “barely noticeable” odor in only one animal from the experimental group. Conclusion: The study has demonstrated the ability of DFCS to control substantially the bacterial microflora as well as malodor of MWFs in vivo. The results obtained can contribute to solving the problem of improving the quality of palliative care for patients with malignant and other chronic wounds
Доп.точки доступа:
Sakhno, L. A.
Babenko, L. P.
Lazarenko, L. M.
Korotych, V. G.
Sarnatskaya, V. V.
Snezhkova, E. A.
Spivak, M. Ya.
Nikolaev, V. G.

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15.

Features of recurrence of endometrioid type endometrial cancer of I stage [Text] / O. M. Movchan [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P365-369

MeSH-главная:
ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS (лекарственная терапия, осложнения, терапия, хирургия)
НЕОПЛАСТИЧЕСКИЕ ПРОЦЕССЫ -- NEOPLASTIC PROCESSES
Аннотация: The aim of this study was to determine the rates of recurrences of stage I endometrial cancer (EC) and features of their localization depending on the clinical and pathological characteristics of the tumor and methods of patients’ treatment. Patients and Methods: The study included 968 patients with stage I endometrioid EC, who underwent surgical treatment in the Department of Oncogynecology of the National Cancer Institute in 2015–2019. Surveillance of patients lasted from January 2015 to December 2020, with a minimum follow-up period of 1 year from the date of surgery. Adjuvant radiation or chemotherapy was performed depending on the clinical and pathological characteristics of the EC case. Results: During the follow-up period, recurrences were observed in 7.0% of cases and were most often found in stage IC of low differentiation grade. It was found that during surgical treatment without adjuvant therapy relapses occurred in 12–36 months after the start of treatment, with adjuvant radiation therapy — in 6–18 months, and with adjuvant chemotherapy — in 32–60 months. Recurrences most often occurred in patients with EC who underwent surgical treatment in combination with chemotherapy (p 0.05). The lowest number of recurrences was recorded among patients who underwent surgery as an only treatment. The best 5-year survival rate was observed in the group of patients with surgical treatment (93%), and the worst — in the patients treated with combination of surgery and chemotherapy (57%). In patients without recurrences, the survival rate after treatment was 97%, while in patients diagnosed with relapses, the survival rate was 65%. Conclusion: Despite the predominantly favorable course of EC stage I, some patients develop relapses. The rate and localization of recurrences depend on the histological structure of the tumor and treatment regimens of the EC patients
Доп.точки доступа:
Movchan, O. M.
Svintsitskiy, V. S.
Tsip, N. P.
Nespryadko, S. V.
Bubliieva, O. I.
Iurchenko, N. P.

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16.

Kernychnyi, V. V.
Distal sacrectomy for recurrent rectal cancer [Text] / V. V. Kernychnyi, B. E. Li // Experimental Oncology. - 2021. - Том 43, N 4. - P370-372

MeSH-главная:
ПРЯМОЙ КИШКИ НОВООБРАЗОВАНИЯ -- RECTAL NEOPLASMS (осложнения)
НОВООБРАЗОВАНИЙ МЕТАСТАЗЫ -- NEOPLASM METASTASIS (патофизиология)
КРЕСТЦОВО-КОПЧИКОВАЯ ОБЛАСТЬ -- SACROCOCCYGEAL REGION (патофизиология, хирургия)
Аннотация: Surgical treatment of recurrent rectal tumors is a challenge for cancer surgeons. Due to the high risk of intraoperative and postoperative complications, such tumors are often considered inoperable. We present a clinical case of 56-years-old male patient with local recurrence and pathological fracture of the sacrum at S5 level to whom en-bloc distal sacrectomy was performed. Such surgical technique for recurrence of rectal cancer provides significant improvement in local and general condition and creates a favorable prognosis for the patient’s survival, which is demonstrated by the described clinical case
Доп.точки доступа:
Li, B. E.

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17.

The giant phyllodes tumor of the breast - a case report [Text] / V. V. Zaichuk [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P373-375

MeSH-главная:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика, лекарственная терапия)
Аннотация: Phyllodes tumors are rare tumors of the breast, which are often misdiagnosed as fibroadenomas and difficult to treat with adjuvant therapy. Here, we present a case of a female patient with giant phyllodes tumor of the breast
Доп.точки доступа:
Zaichuk, V. V.
Samusieva, A. A.
Diatel, M. V.
Plidiienko, M. M.

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18.

An unusual presentation of primary cutaneous follicle center lymphoma [Text] / A. Janowska [et al.] // Experimental Oncology. - 2021. - Том 43, N 4. - P376-378

MeSH-главная:
ЛИМФОМА ФОЛЛИКУЛЯРНАЯ -- LYMPHOMA, FOLLICULAR (диагностика, патофизиология)
КОЖИ НОВООБРАЗОВАНИЯ -- SKIN NEOPLASMS (диагностика, патофизиология)
Аннотация: Primary cutaneous follicle center lymphoma (PCFCL) is a rare low-grade cutaneous B-cell lymphoma. Clinically, PCFCL is usually an erythematous subcutaneous nodule or an infiltrated plaque. The dermoscopy is non-specific and it is characterized by polymorphous vascular pattern, arborizing vessels over a salmon-colored background and white areas. We reported a case of a 36-year-old woman presented with a rapidly growing, flashed-color, exophytic, soft consistency nodule on her scalp. Dermoscopy showed a diffuse structureless, skin-color area associated with a rare arborizing vascular pattern and brown circles. We reported a peculiar clinical and dermoscopic variant. This clinical presentation of PCFCL is unusual and represents a pitfall in the early clinical diagnosis. Histopathology is mandatory for a correct diagnosis
Доп.точки доступа:
Janowska, A.
Fidonzi, C.
Granieri, G.
Iannone, M.
Bonadio, A. G.

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