Cipher: ЕУ12/2017/39/1 Journal 2017year Т. 39 № 1 Circulating tumor cells in breast cancer : functional heterogeneity, pathogenetic and clinical aspects. - С.2-11 : il. Kashuba, E. Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtag. - С.12-16 : цв. ил. Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro. - С.17-24 : цв. ил. Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics. - С.25-29 : табл. Parthenolide reduces gene transcription of prosurvival mediators in U937 cells. - С.30-35 : il. Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells. - С.36-41 : il. Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma. - С.42-48 : табл. EPR spectroscopy studies of changes in erythrocyte membranes in patients with laryngeal cancer. - С.49-52 : табл. Auzina, D. Prognostic value of the bone turnover markers in multiple myeloma / D. Auzina, R. Erts, S. Lejniece. - С.53-56 : табл. Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population. - С.57-64 : табл. Chekhun, V. F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova. - С.65-68 : табл. Satinder, K. Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women / K. Satinder, R. C. Sobti, K. Pushpinder. - С.69-74 : табл. The impact of coloregional treatment on survival of patients with primary metastatic breast cancer. - С.75-77 : табл. Diagnostic challenges with intraoral myeloid sarcoma : Report of two cases & review of world literature. - С.78-85 : цв. ил. Trichilemmal cystis in metastatic melanoma : A case report. - С.86-87 : цв. ил. Materials of international vactrain/ 3-rd Swedish-Ukrainian conference on cancer diseases, January 16-17, 2017, Stockholm, Sweden. - С.88-93 Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells. - С.88-89 The adaptor protein Ruk/CIN85 paradoxically enhances EMT of triple negative mouse breast adenocarcinoma 4T1 cells. - С.89 Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines. - С.89-90 Alternative direction of inhibition of malignant properties in tumor cells in vitro and in vivo by gene therapy with INF-beta gene in recombinant baculovirus vector. - С.90 CD150/SLAMF1 as a new potential target for anti-tumor therapy. - С.90-91 CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia. - С.91-92 Borikun, T. Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer / T. Borikun, N. Lukianova, V. Chekhun. - С.92 The MRPS 18-2 protein as a putative marker of carcinogenesis. - С.92 High expression levels of MRPS 18-2 and presence of the RB protein are required for the maintenance of stem cell phenotype. - С.92-93 Mankovska, O. Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors / O. Mankovska, V. Kashuba. - С.93 Brieieva, O. Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients / O. Brieieva, I. Nesina, L. Buchynska. - С.93 Kyiv, May 11-12, 2017 Workshop with international participation. New trends in cancer research and innovative tumor vaccines. - С.94 International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine. - С.95 The copies are in the departments: Copies. 1 (free) |
Chekhun, V. F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova // Experimental Oncology. - 2017. - Том 39, N 1. - P65-68 : табл. - 16 ref. MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия) ХИМИОТЕРАПИЯ АДЪЮВАНТНАЯ -- CHEMOTHERAPY, ADJUVANT СИМПОРТЕРЫ -- SYMPORTERS Annotation: The aim of the research was to study the relation between expression of Na⁺/I⁻symporter (NIS) in breast cancer (BC) of different molecular subtypes and sensitivity of BC cells to neoadjuvant chemotherapy (NACT) and to assess whether NIS expression may be used as a predictive marker of treatment efficacy. Materials and Methods: The study included 148 women with BC of stage II–III who were treated at the Precarpathian Clinical Oncology Center during 2012–2017. All patients were treated with NACT that included 2–6 cycles of chemotherapy by FAC, AC scheme with 21 day intervals. NACT efficacy was evaluated every 2 cycles by mammography according to RECIST criteria. Morphological and immunohistochemical study of NIS expression was performed by the standard methods on paraffin sections of surgically resected tumors. Results: The heterogeneity of different molecular BC subtypes regarding response to the NACT has been found. Her2/neu-positive and basal BC subtypes were the least susceptible to the NACT (p 0.05). It was shown that NIS expression is related to the sensitivity of luminal B and basal BC subtypes to the NACT. The highest expression of NIS and impairment of its functional activity was registered in the group of patients with tumors resistant to NACT (stabilization of the disease or its progression) of luminal B (220 ± 8.6 points) and basal subtypes (290 ± 11.3 points) (p 0.05). It was revealed that the disease-free survival of patients with BC of luminal B and basal subtypes was higher in the absence of NIS expression in tumor cells (p 0.05). Conclusions: The results indicate that NIS can be used as an objective criterion for predicting the sensitivity of luminal B and basal BC subtypes to NACT, which will provide improved treatment outcomes in this group of patients Additional Access Points: Andriiv, A.V. Lukianova, N.Yu. There are no free copies |
Cipher: ЕУ12/2020/42/2 Journal 2020year Т. 42 № 2 Shvets, Yu. V. Human microbiota and effectiveness of cancer chemotherapy / Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun. - С.82-93 Zadvornyi, T. V. Nanog as prognostic factor of prostate cancer course / T. V. Zadvornyi [et al.]. - С.94-100 Other authors: Lukianova N. Yu., Borikun T. V., Vitruk Yu. V., Stakhovsky E. O., Chekhun V. F. Lamdan, H. Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin / H. Lamdan [et al.]. - С.101-108 Other authors: Garcia-Lazaro R. S., Lorenzo N., Galigiuri L. G., Alonso D. F., Farina H. G. Antonenko, S. V. Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells / S. V. Antonenko, G. D. Telegeev. - С.109-114 Onyshchenko, K. V. Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma / K. V. Onyshchenko [et al.]. - С.115-119 Other authors: Voitsitskyi T. V., Grygorenko V. M., Saidakova N. O., Pereta L. V., Onyschuk A. P., Skrypkina I. Ya. Stegantseva, M. V. Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model / M. V. Stegantseva [et al.]. - С.120-125 Other authors: Shinkevich V. A., Tumar E. M., Meleshko A. N. Andreieva, S. V. Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias / S. V. Andreieva [et al.]. - С.126-129 Other authors: Kyselova O. A., Serbin I. M., Alkhimova O. G. Bialik, P. HRM screening of the UBC9 gene encoding the SUMO-E2-conjugating enzyme - case-control study in breast cancer / P. Bialik [et al.]. - С.130-134 Other authors: Wysokinski D., Slomka M., Morawiec Z., Strapagiel D., Wozniak K. Pankaj, D. Clinicopathological correlation of the expression of excision repair cross complementation group 1 (ERCC1) in oral cavity squamous cell carcinomas: an immunohistochemical study / D. Pankaj, V. Guddattu, M. C. Solomon. - С.135-139 Lyalkin, S. A. Prognostic role of androgen receptor expression in patients with metastatic triple negative breast cancer / S. A. Lyalkin [et al.]. - С.140-143 Other authors: Verevkina N. O., Alekseyenko O. O., Syvak L. A. Perekhrestenko, T. Expression of Ki-67 and CD34 on blood and bone marrow cells of CML patients with different response to imatinib and nilotinib therapy / T. Perekhrestenko [et al.]. - С.144-147 Other authors: Melnyk U., Goryainova N., Diagil I. Glavatskyi, O. Ya. Temozolomide in glioblastoma treatment: 15-year clinical experience and analysis of its efficacy / O. Ya. Glavatskyi [et al.]. - С.148-156 Other authors: Zemskova O. V., Khmelnytskyi H. V., Kardash K. A., Shuba I. M., Stuley V. A. Kliusov, O. M. Specialized care provided to patients with rectal cancer in Kyiv city / O. M. Kliusov. - С.157-160 The copies are in the departments: Copies. 1 (free) |
Shvets, Yu. V. Human microbiota and effectiveness of cancer chemotherapy / Yu. V. Shvets, N. Yu. Lukianova, V. F. Chekhun // Experimental Oncology. - 2020. - Том 42, N 2. - P82-93 MeSH-main: НОВООБРАЗОВАНИЯ -- NEOPLASMS (лекарственная терапия, микробиология) Annotation: This review presents up-to-date information on the effects of microbiota on the individual chemotherapy sensitivity in cancer treatment. Recent studies have shown that a fine balance between the intestinal microbiota and the immune system is crucial for maintaining an efficacy of cancer chemotherapy. A number of antitumor drugs have complex mechanisms of action involving not only direct effects but also the activity of the intestinal microbiota and the immune system. A unique combination of these factors contributes to the individual chemotherapy sensitivity Additional Access Points: Lukianova, N. Yu. Chekhun, V. F. There are no free copies |
Cipher: ФУ6/2019/65/6 Journal 2019year Т. 65 № 6 Полякова, Л. І. Андрогенна функція сім’яників і стан сперматозоїдів молодих і старіючих щурів після тривалого інгібування ароматази стероїдів та його відміни / Л. І. Полякова [та ін.]. - С.3-11 Other authors: Сачинська О. В., Фалюш О. А., Резніков О. Г. Струтинська, Н. А. Аміногуанідин відновлює ендогенний синтез сірководню, конститутивний синтез оксиду азоту, ендотелійзалежну вазодилатацію та пригнічує відкривання мітохондріальної пори у серці старих щурів / Н. А. Струтинська [та ін.]. - С.12-21 Other authors: Лучкова А. Ю., Мись Л. А., Коркач Ю. В., Сагач В. Ф. Телька, М. В. Вплив норадреналіну на електричну активність культивованих нейронів ганглія трійчастого нерва / М. В. Телька [та ін.]. - С.22-29 Other authors: Маслов В. Ю., Федулова С. А., Веселовський М. С. Котлярова, А. Б. Функціонування катіонних каналів великої провідності ядерної мембрани під впливом модуляторів нікотинових холінорецепторів / А. Б. Котлярова [та ін.]. - С.30-37 Other authors: Котик О. А., Юришинець І. В., Харченко С. М. Драчук, К. О. Ендотеліальний моноцитактивуючий фактор II відновлює ендотелійзалежне розслаблення судин при старінні / К. О. Драчук [та ін.]. - С.38-42 Other authors: Коркач Ю. П., Дорофеєва Н. О., Корнелюк О. І., Сагач В. Ф. Грушка, Н. Г. Протективна дія цитрату германію на функціональний стан імунокомпетентних клітин та активність нейтрофілів при запаленні, індукованому ліпополісахаридом / Н. Г. Грушка [та ін.]. - С.43-50 Other authors: Павлович С. І., Кондрацька О. А., Пількевич Н. О., Янчій Р. І. Ісаєнко, О. Ю. Протидифтерійні властивості структурно-метаболітних комплексів пробіотичних штамів лактобактерій і сахароміцетів у тестах in vitro та in vivo / О. Ю. Ісаєнко. - С.51-60 Деген, А. С. Розподіл FOXP3+- та ROR?t+-лімфоцитів у кишковоасоційованій лімфоїдній тканині щурів при цукровому діабеті та введенні неселективних блокаторів фактора некрозу пухлин ? / А. С. Деген, О. М. Камишний. - С.61-69 Lozovska, Yu. V. Relationship aggressiveness of prostate cancer with tumor-associated serum markers / Yu. V. Lozovska [et al.]. - С.70-80 Other authors: Naleskina L. A., Zadvorniy T. V., Andrusishina I. M., Zhulkevych I. V., Stakhovskiy E. O., Kunska L. M., Lukianova N. Yu. Chernenko, O. Papillary thyroid cancer and thyroid stimulating hormone: does sex matter? / O. Chernenko, O. Sulaieva. - С.81-87 Бредун, О. Ю. Фактори природженого і антивірусного імунітету в ротоглотковому секреті, екстрактах тканин та лізатах клітин піднебінних мигдаликів дітей при їхній гіпертрофії та хронічному запаленні / О. Ю. Бредун [та ін.]. - С.88-93 Other authors: Мельников О. Ф., Тимченко М. Д., Фараон І. В. Натрус, Л. В. Роль NF-κβ у диференціюванні та активації нейтрофілів під час загоєння опікової рани шкіри щурів / Л. В. Натрус [та ін.]. - С.94-104 Other authors: Рижко І. М., Лісаковська О. О., Тихомиров А. О., Лабудзинський Д. О., Панова Т. І. Прудніков, І. М. Сучасні уявлення про міжклітинну везикулярну сигналізацію / І. М. Прудніков [та ін.]. - С.105-125 Other authors: Цивкін В. М., Смірнов А. М., Прісташ І. В., Черняк В. А., Селюк В. М., Музиченко П. Ф. Про XX з’їзд Українського фізіологічного товариства ім. П.Г. Костюка, з міжнародною участю, присвяченого 95-річчю від дня народження академіка П.Г. Костюка (Київ, 27-30 травня 2019 р.). - С.126-130 До ювілею Олександра Григоровича Резнікова. - С.131-132 The copies are in the departments: total 1 Free: 1 |
Relationship aggressiveness of prostate cancer with tumor-associated serum markers [Text] / Yu. V. Lozovska [et al.] // Фізіологічний журнал. - 2019. - Том 65, N 6. - P70-80 MeSH-main: ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (кровь) ЛАКТОФЕРРИН -- LACTOFERRIN (кровь) C-РЕАКТИВНЫЙ БЕЛОК -- C-REACTIVE PROTEIN (анализ) АЛЬБУМИН СЫВОРОТОЧНЫЙ -- SERUM ALBUMIN (анализ) Annotation: Досліджено вміст сироваткових пухлиноасоційованих маркерів: лактоферин (ЛФ), С-реактивний протеїн (СРП), альбумін, лактатдегідрогеназа (ЛДГ), співвідношення Ca/Mg та СРП/альбумін, у хворих на рак передміхурової залози залежно від клініко-патологічних характеристик захворювання. Крім того, визначено ступінь злоякісності новоутворень за Глісоном і наявність метастазів у регіонарні лімфатичні вузли. Показано, що у сироватці крові хворих на рак III стадії порівняно із II знижувався у 1,4 раза вміст ЛФ та зменшувалося співвідношення СРП/ альбумін на фоні достовірного збільшення вмісту СРП та співвідношення Ca/Mg (у 2,75 та 1,12 раза відповідно). Водночас у хворих із метастатичним ураженням регіонарних лімфатичних вузлів порівняно із пацієнтами без цих ознак виявлено зменшення у 1,3 раза вмісту ЛФ та альбуміну у 1,16 раза при одночасному зростанні вмісту СРП та співвідношення Ca/Mg (у 2,84 та 1,1 раза відповідно) та зниження СРП/альбумін. Показано, що у сироватці крові хворих із високим ступенем злоякісності новоутворень (8 та 9 балів за шкалою Глісона) та вмістом простатспецифічного антигена (ПСА) більш ніж 4 нг/мл, порівняно зі значеннями у пацієнтів з менш вираженими ознаками пухлинної прогресії, суттєво знижувався вміст сироваткового ЛФ та альбуміну на фоні підвищеного співвідношення Ca/Mg, СРП/альбумін і вмісту ЛДГ. Зазначені відмінності у різних ланках метаболічних шляхів в організмі хворих на рак передміхурової залози з більш агресивним проявом захворювання свідчать про несприятливий перебіг пухлинного процесу. Отримані результати дають підстави вважати, що сироватковий ЛФ може бути використаний як додатковий позапухлинний маркер для прогнозу цього захворювання. Additional Access Points: Lozovska, Yu. V. Naleskina, L. A. Zadvorniy, T. V. Andrusishina, I. M. Zhulkevych, I. V. Stakhovskiy, E. O. Kunska, L. M. Lukianova, N. Yu. There are no free copies |
Cipher: ЕУ12/2018/40/4 Journal 2018year Т. 40 № 4 Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F Chekhun. - С.258-260 Tari, K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia / K. Tari [et al.]. - С.261-267 Other authors: Shamsi Z., Ghafari H. R., Atashi A., Shahjahani M., Abroun S. Chekhun, V. F. Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.]. - С.268-274 Other authors: Todor I. N., Lukianova N. Yu., Horbyk D. M., Lozovskaya Yu. V., Burlaka A. P., Borikun T. V. Symchych, T. V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model / T. V. Symchych [et al.]. - С.275-281 Other authors: Fedosova N. I., Karaman O. M., Voyeykova I. M., Didenko G. V. Yakymenko, I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation / I. Yakymenko [et al.]. - С.282-287 Other authors: Burlaka A., Tsybulin O., Brieieva O., Buchynska L., Tsehmistrenko S., Chekhun V. Smal, M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer / M. P. Smal [et al.]. - С.288-298 Other authors: Kuzhir T. D., Savina N. V., Nikitchenko N. V., Rolevich A. I., Krasny S. A., Goncharova R. I. Abooshahab, R. Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer / R. Abooshahab [et al.]. - С.299-302 Other authors: Niyazi E., Yaghmaie P., Chadaksaz H. G., Hedayati M. Buchynska, L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.]. - С.303-308 Other authors: Iurchenko N. P., Kashuba E. V., Brieieva O. V., Glushchenko N. M., Mints M., Lukianova N. Yu., Chekhun V. F. Arabpour, F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients / F. Arabpour [et al.]. - С.309-314 Other authors: Shafizad A., Rahimzadeh M., Norouzian M., Naderi N. Gerashchenko, G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer / G. V. Gerashchenko [et al.]. - С.315-322 Other authors: Grygoruk O. V., Kononenko O. A., Gryzodub O. P., Stakhovsky E. O., Kashuba V. I. Tas, F. Clinical significance of serum caveolin-1 levels in gastric cancer patients / F. Tas [et al.]. - С.323-327 Other authors: Karabulut S., Erturk K., Duranyildiz D. Shvachko, L. P. Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells / L. P. Shvachko [et al.]. - С.328-331 Other authors: Zavelevich M. P., Gluzman D. F., Kravchuk I. V., Telegeev G. D. Kuzyk, P. V. Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis / P. V. Kuzyk, M. A. Savchyna, S. G. Gychka. - С.332-335 Zakhartseva, L. M. Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart / L. M. Zakhartseva [et al.]. - С.336-342 Other authors: Zakharova L. P., Shatrova K. M., Chitaeva G. E., Vitovsky R. M. Langabeer, S. E. The JAK2 V617F mutation in lung cancer: caveat emptor / S. E. Langabeer. - С.343-344 Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary). - С.345 The copies are in the departments: Copies. 1 (free) |
Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P268-274 MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (метаболизм, патофизиология) Annotation: To study the effect of Ferroplat (FrP) on the indexes of pro/antioxidant balance and energy metabolism in breast cancer cells of different malignancy degree and different sensitivity to drug therapy. Materials and Methods: The study was carried out on breast cancer cells of low (T47D, MCF-7) and high malignancy degree (MCF-7/DDP (cisplatin-resistant), MDA-MB-231, MDA-MB-468) using cell culture techniques, immunocytochemical, biochemical, biophysical methods, flow cytometry and polarography. Results: We established that the addition of FrP to the culture medium reduces the activity of glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD) and the level of non-protein thiols by 32–41% (p 0.05). At the same time, there was an increase of the total level of ROS and the rate of NO generation by inducible NO synthase by 1.7–2.5 times (p 0.05). This testifies that FrP disturbs the antioxidant balance in cells, resulting in their death. Also, the use of FrP led to a decrease in the rate of oxygen absorption in MCF-7 and T47D cells by 26% and 25%, respectively (p 0.05). In cells of high malignancy degree this index decreased by 38–40% under the influence of FrP. Incubation of MCF-7 and T47D cells with the indicated agent also reduced the content of phospholipid cardiolipin by 15–16% (p 0.05), and in MDA-MB-231, MCF-7/DDP, MDA-MB-468 cells — by 29%, 30% and 32%, respectively. In addition, the effect of FrP caused a decrease in the levels of Mg2+ and lactate in MCF-7 and T47D cells by 21–29% and 14–24%, respectively, whereas in MDA-MB-231, MDA-MB-468, MCF-7/DDP cells — by 34–38% and 32–35%, respectively. In this case, the agent raised the level of glucose in the cells of low malignancy degree by 20–23% (p 0.05), and in the cells of high malignancy degree and with the phenotype of drug resistance — by 31–36%. However, the nanocomposite did not affect the activity of lactate dehydrogenase in all studied breast cancer cells. Conclusion: The study has shown that FrP has an effect on the pro/antioxidant balance and energy metabolism of cancer cells. In addition, the denoted effect of FrP was more pronounced in the breast cancer cells with a high malignancy degree and the phenotype of drug resistance Additional Access Points: Chekhun, V. F. Todor, I. N. Lukianova, N. Yu. Horbyk, D. M. Lozovskaya, Yu. V. Burlaka, A. P. Borikun, T. V. There are no free copies |
Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P303-308 MeSH-main: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (диагностика, метаболизм, патофизиология) ВНУТРИКЛЕТОЧНЫЕ СИГНАЛЬНЫЕ ПЕПТИДЫ И БЕЛКИ -- INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS (метаболизм) Annotation: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients Additional Access Points: Buchynska, L. G. Iurchenko, N. P. Kashuba, E. V. Brieieva, O. V. Glushchenko, N. M. Mints, M. Lukianova, N. Yu. Chekhun, V. F. There are no free copies |
Cipher: ЕУ12/2018/40/3 Journal 2018year Т. 40 № 3 Akbarzadeh, A. Role of dendrimers in advanced drug delivery and biomedical applications: a review / A. Akbarzadeh [та ін.]. - С.178-183. - Bibliogr. at the end of the art. Other authors: Khalilov R., Mostafavi E., Annabi N., Abasi E., Kafshdooz T., Herizchi R., Kavetskyy T., Saghfi S., Nasibova A., Davaran S. Zadvornyi, T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro / T. V. Zadvornyi [та ін.]. - С.184-189. - Bibliogr. at the end of the art. Other authors: Lukianova N. Y., Borikun T. V., Chekhun V. F. Harper, P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies / P. Harper [та ін.]. - С.190-193. - Bibliogr. at the end of the art. Other authors: Hald O., Lwaleed B. A., Kyyaly A., Johnston D., Cooper A. J., Birch B. Apykhtina, О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles / О. L. Apykhtina [та ін.]. - С.194-199. - Bibliogr. at the end of the art. Other authors: Dybkova S. M., Sokurenko L. M., Chaikovsky Yu. B. Chekhun, V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats / V. F. Chekhun [та ін.]. - С.200-204. - Bibliogr. at the end of the art. Other authors: Storchai D. M., Todor I. N., Borikun T. V., Lukianova N. Yu. Prokhorova, I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6 / I. V. Prokhorova [та ін.]. - С.205-210. - Bibliogr. at the end of the art. Other authors: Pyaskovskaya O. N., Kolesnik D. L., Solyanik G. I. Abramenko, I. V. Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients / I. V. Abramenko [та ін.]. - С.211-217. - Bibliogr. at the end of the art. Other authors: Bilous N. I. , Chumak A. A., Dyagil I. S., Martina Z. V. Nesina, I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I. P. Nesina, N. P. Iurchenko, L. G. Buchynska. - С.218-222. - Bibliogr. at the end of the art. Vernygorodskyi, S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction / S. Vernygorodskyi, T. Rekun, P. Zhuchenko. - С.223-227. - Bibliogr. at the end of the art. Gerashchenko, T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles / T. S. Gerashchenko [та ін.]. - С.228-234. - Bibliogr. at the end of the art. Other authors: Denisov E. V., Novikov N. M., Tashireva L. A., Kaigorodova E. V., Savelieva O. E., Zavyalova M. V., Cherdyntseva N. V., Perelmuter V. M. Agishev, T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury / T. T. Agishev [та ін.]. - С.235-238. - Bibliogr. at the end of the art. Other authors: Topuzov E. E., Кrasnozhon D. A., Petrachkov A. O., Pavlov R. V., Doniyarov S. H. Dumansky, Yu. V. Paraneoplastic syndrome in lung cancer / Yu. V. Dumansky [та ін.]. - С.239-242. - Bibliogr. at the end of the art. Other authors: Syniachenko O. V., Stepko P. A., Yehudina Ye. D., Stoliarova O. Yu. Grybach, S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome / S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun. - С.243-248. - Bibliogr. at the end of the art. Chrysanthakopoulos, N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study / N. A. Chrysanthakopoulos, N. S. Dareioti. - С.249-250. - Bibliogr. at the end of the art. Tkachenko, R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy / R. Tkachenko, A. Golovko, O. Kuryk. - С.251-253 Svitlana Pavlivna Sidorenko (1953–2018). - С.254-255 Yurii Yosypovych Kudryavets (1946–2018). - С.256-257 The copies are in the departments: total 1 Free: 1 |
Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats [Text] / V. F. Chekhun [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 200-204. - Bibliogr. at the end of the art. Annotation: To investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF. Materials and Methods: The study was performed on Walker-256 tumor-bearing rats. Total lipids and phospholipids were determined by thin-layer chromatography. Comet assay was used to investigate the genotoxic effects of LF. Results: Daily i.p. administrations of exogenous LF at concentrations of 1 mg/kg and 10 mg/kg starting from the 4th day after tumor transplantation suppressed growth of Walker-256 carcinosarcoma by almost 44%. After treatment with recombinant LF in both doses, the phospholipid composition of Walker-256 carcinosarcoma cells was changed (3-fold increase of phosphatidylethanolamine, 3.4-fold increase of phosphatidylcholine, and 1.8-fold increase of sphingomyelin, while the cardiolipin content decreased by 67%. Exogenous LF was not genotoxic for bone marrow cells (as assessed by the ratio of PCE/NCE, number of micronuclei) and peripheral blood lymphocytes (percentage of DNA in the tail of a comet) in Walker-256 carcinosarcoma-bearing rats. Conclusion: Exogenous LF caused the inhibition of Walker-256 carcinosarcoma growth and a decrease in the microviscosity of plasma cell membranes, and exerted no genotoxicity toward bone marrow cells and peripheral blood of experimental animals. Key Words: lactoferrin, breast cancer, Walker-256 carcinosarcoma, phospholipid content, genotoxicity Additional Access Points: Chekhun, V. F. Storchai, D. M. Todor, I. N. Borikun, T. V. Lukianova, N. Yu. There are no free copies |
Cipher: ЕУ12/2019/41/1 Journal 2019year Т. 41 № 1 . - 45.41, р. Solyanik, G. I. Quinazoline compounds for antitumor treatment / G. I. Solyanik. - С.3-6. - Bibliogr. at the end of the art. Mahmoudian, J. Expression profiling of plac1 in murine cancer cell lines / J. Mahmoudian [та ін.]. - С.7-13. - Bibliogr. at the end of the art. Other authors: Ghods R., Nazari M., Jeddi-Tehrani M., Ghahremani M. H., Ostad S. N., Zarnani A. H. Kolesnik, D. L. Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma / D. L. Kolesnik [та ін.]. - С.14-19. - Bibliogr. at the end of the art. Other authors: Pyaskovskaya O. N., Yakshibaeva Yu. R., Solyanik G. I. Lozovska, Yu. V. The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma / Yu. V. Lozovska [та ін.]. - С.20-25. - Bibliogr. at the end of the art. Other authors: Andrusishina I. M., Lukianova N. Yu., Burlaka A. P., Naleskina L. A., Todor I. N., Chekhun V. F. Burlaka, A. A. DNA oxidation in patients with metastastic colorectal cancer: clinical significance of 8-hydroxy-deoxyguanosine as an independent prognostic factor / A. A. Burlaka [та ін.]. - С.26-31. - Bibliogr. at the end of the art. Other authors: Vovk A. V., Burlaka A. P., Kolesnik O. O. Stakheyeva, M. Integral characteristic of the immune system state predicts breast cancer outcome / M. Stakheyeva [та ін.]. - С.32-38. - Bibliogr. at the end of the art. Other authors: Eidenzon D., Slonimskaya E., Patysheva M., Bogdashin I., Kolegova E., Grigoriev E., Choinzonov E., Cherdyntseva N. Bilous, N. Analysis of LPL gene expression in patients with chronic lymphocytic leukemia / N. Bilous [та ін.]. - С.39-45. - Bibliogr. at the end of the art. Other authors: Abramenko I., Chumak A., Dyagil I., Martina Z. Alghamdi, S. Evaluation of dose calculation algorithms using different density materials for in-field and out-of-field conditions / S. Alghamdi, A. Tajaldeen. - С.46-52. - Bibliogr. at the end of the art. Poluben, L. Copy number alterations and copy-neutral loss of heterozygosity in Ukrainian patients with primary myelofibrosis / L. Poluben [та ін.]. - С.53-56. - Bibliogr. at the end of the art. Other authors: Bryke Ch. R., Hsu Y., Shumeiko O., Neumerzhitska L., Klimuk B., Rybchenko L., Klymenko S., Balk S. P., Fraenkel P. G. Bakai, O. A. Radiation research to determine local tumor invasion in patients with cervical cancer / O. A. Bakai [та ін.]. - С.57-60. - Bibliogr. at the end of the art. Other authors: Golovko T. S., Ganich A. V., Gavriluk O. N., Ashykhmin A. V. Zabolotnyi, D. I. Aggregated proteins in malignant and benign neoplasms / D. I. Zabolotnyi [та ін.]. - С.61-68. - Bibliogr. at the end of the art. Other authors: Belousova A. A., Zabolotna D. D., SavchenkoT. D., Voroshylova N. M., Timchenko M. D., Tsvirinko I. R., Verevka S. V. Shirin, V. Assessment of trace elements in serum of acute lymphoblastic and myeloid leukemia patients / V. Shirin [та ін.]. - С.69-71. - Bibliogr. at the end of the art. Other authors: Sayfidin J., Mina E. -R., Shohren K., Reza S. Tkachenko, R. Parathyroid carcinoma: a case report / R. Tkachenko [та ін.]. - С.72-75. - Bibliogr. at the end of the art. Other authors: Zakhartseva L., Golovko A., Golovko A., Kuryk O., Lazarenko G. Semko, S. A case of synchronous bilateral calyx urothelial carcinoma: combined treatment approach / S. Semko [та ін.]. - С.76-79. - Bibliogr. at the end of the art. Other authors: Pikul M., Voylenko O., Stakhovskyi O., Kononenko O., Vitruk Yu., Stakhovsky E. De, Giorgi V. Cutaneous leiomyosarcoma: a clinical, dermoscopic, pathologic case study / Giorgi V. De [та ін.]. - С.80-81. - Bibliogr. at the end of the art. Other authors: Scarfì F., Silvestri F., Maida P., Gori A., Trane L., Massi D. Langabeer, S. E. Suboptimal molecular response to tyrosine kinase inhibition associated with acquisition of a T240A ABL1 kinase domain mutation in a patient with chronic myeloid leukemia / S. E. Langabeer [та ін.]. - С.82-83. - Bibliogr. at the end of the art. Other authors: Haslam K., Crampe M., MacDonagh B., McHugh J. Brieieva, O. Scientific and Practical Conference of Young Scientists “Fundamental Medicine: Integrated Approaches to Cancer Therapy” / O. Brieieva. - С.84-86. - Bibliogr. at the end of the art. Tumor and Host: Novel Aspects of Old Problem. - С.87 Ludmyla Zakharivna Polishchuk (1937–2019). - С.88 The copies are in the departments: total 1 Free: 1 |
The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma [Text] / Yu. V. Lozovska [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 20-25. - Bibliogr. at the end of the art. Annotation: To investigate the content of essential elements (EE): copper, zinc, magnesium, iron and calcium and the evaluation of the activity of metal-containing enzymes — ceruloplasmin (CP), myeloperoxidase (MPO) and the content of transferrin (TF) in blood plasma (BP) and tumor tissue (TT) of animals with Walker-256 carcinosarcoma treated with lactoferrin (LF). Materials and Methods: The study of the EE content and the activity of the abovementioned enzymes was carried out on rats with Walker-256 carcinosarcoma treated with LF at the doses of 1 and 10 mg/kg of body weight. The quantitative content of EE in BP and TT of animals was determined using the inductively coupled plasma atomic emission spectroscopy (ICP-AES). Determination of CP activity, content of TF and hemochromes was performed using the method of electron paramagnetic resonance (EPR), and MPO — by unified biochemical method. Results: The introduction of LF at the doses of 1 and 10 mg/kg resulted in a decrease in the ratio of Cu/Zn in BP and even more expressed decrease of Ca/Mg ratio in TT. Administration of LF, especially at a dose of 10 mg/kg, affected the increase in CP and MPO activity in BP. It has been shown that administration of LF at a dose of 10 mg/kg led to an increase in oxidative products of destruction of the hemoglobin-hemochrom system in the TT, against the background of lowering the TF content. Conclusions: The administration of LF, especially at a dose of 10 mg/kg, led to metabolic alterations associated with inhibition of the tumor process. The detected modulating effect of LF on the content of the EE and the activity of the CP and MPO may be a basis for correction of the elemental balance in carcinogenesis Additional Access Points: Lozovska, Yu. V. Andrusishina, I. M. Lukianova, N. Yu. Burlaka, A. P. Naleskina, L. A. Todor, I. N. Chekhun, V. F. There are no free copies |
Cipher: ЕУ12/2019/41/3 Journal 2019year Т. 41 № 3 . - 45.41, р. R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine: 25 years with the OECI. - С.187 Chekhun, V. F. MicroRNAs are a key factor in the globalization of tumor-host relationships / V. F. Chekhun. - С.188-194. - Bibliogr. at the end of the art. Shlyakhovenko, V. O. The dual role of ribonucleases in tumor-host relationship / V. O. Shlyakhovenko, O. A. Samoylenko. - С.195-199. - Bibliogr. at the end of the art. Shuba, Ya. M. Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? / Ya. M. Shuba. - С.200-206. - Bibliogr. at the end of the art. Ivanivska, T. S. Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia / T. S. Ivanivska [та ін.]. - С.207-209. - Bibliogr. at the end of the art. Other authors: Sklyarenko L. M., Zavelevich M. P., Philchenkov A. A., Koval S. V., Polishchuk A. S., Gluzman D. F. Holotiuk, V. V. Role of nitric oxide in pathogenesis of tumor growth and its possible application in cancer treatment / V. V. Holotiuk [та ін.]. - С.210-215. - Bibliogr. at the end of the art. Other authors: Kryzhanivska A. Y., Churpiy I. K., Tataryn B. B., Ivasiutyn D. Ya. Oshyvalova, O. Modern view on epidermal dysplasia carcinogenesis / O. Oshyvalova, Z. Rossokha. - С.216-223. - Bibliogr. at the end of the art. Bazalytska, S. V. Моlecular mechanisms of initiation of carcinogenesis in the testis / S. V. Bazalytska, Y. Persidsky, A. M. Romanenko. - С.224-234. - Bibliogr. at the end of the art. Bogdanova, T. Histopathological characteristics and post-operative follow-up of patients with potentially radiogenic papillary thyroid carcinoma depending on oncocytic changes availability in the tumor cells / T. Bogdanova [та ін.]. - С.235-241. - Bibliogr. at the end of the art. Other authors: Zurnadzhy L., Masiuk S., Burko S., Degtyaryova T., Kovalenko A., Bolgov M., Chernyshov S., Gulevatyi S., Thomas G., Tronko M. Lukianova, N. Yu. Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer / N. Yu. Lukianova, T. V. Borikun, V. F. Chekhun. - С.242-247. - Bibliogr. at the end of the art. Patysheva, M. Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes / M. Patysheva [та ін.]. - С.248-253. - Bibliogr. at the end of the art. Other authors: Stakheyeva M., Larionova I., Fedorov A., Kzhyshkowska J., Cherdyntseva N. Sakhno, L. A. Adsorptive therapy as a modificator for tumor-host interaction / L. A. Sakhno [та ін.]. - С.254-257. - Bibliogr. at the end of the art. Other authors: Sarnatskaya V. V., Yushko L. A., Snezhkova E. A., Bardakhivskaya K. I., Shevchuk O. O., Sidorenko A. S., Nikolaev V. G. Materials of the II International Conference “Tumor and Host: Novel Aspects of Old Problem” (November 21–22, 2019, Kyiv, Ukraine). - С.258-280 The copies are in the departments: total 1 Free: 1 |
Lukianova, N. Yu. Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer [Text] / N. Yu. Lukianova, T. V. Borikun, V. F. Chekhun // Экспериментальная онкология. - 2019. - Т. 41, № 3. - С. 242-247. - Bibliogr. at the end of the art. Annotation: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) were analyzed in tissue of BC using immunohistochemical method. Relative expression levels of the miR-155, -320a, and -205 were examined in tissue and sera from BC patients using quantitative reverse transcription polymerase chain reaction. Results: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. Nevertheless, we established the relation of circulating and tissue miR-155, -320a, and -205 to lymph node metastases and basal breast cancer subtype. Conclusions: Changes of miR-155, -320a, and -205 expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC Additional Access Points: Borikun, T.V. Chekhun, V. F. There are no free copies |