Шифр: УУ60/2017/89/4 Журнал 2017р. Т. 89 № 4 Babenko, L. M. Lipoxygenase activity in ontogenesis of ferns Salvinia natans and Polystichum aculeatum / L. M. Babenko, T. D. Skaterna, I. V. Kosakivska. - P.5-12 Chekh, B. O. Characteristics of novel polymer based on pseudo-polyamino acids GluLa-DPG-PEG600: binding of albumin, biocompatibility, biodistribution and potential crossing the blood-brain barrier in rats / B. O. Chekh [et al.]. - P.13-21 Інші автори: Ferens M. V., Ostapiv D. D., Samaryk V. Y., Varvarenko S. M., Vlizlo V. V. Palagina, I. A. Pro-/antioxidant reactions and nitrogen oxide metabolism under sub-chronic effect of succinic acid derivatives / I. A. Palagina. - P.22-33 Kolupaev, Yu. E. Induction of plant cells heat resistance by hydrogen sulfide donor is mediated by H2O2 generation with participation of NADPH oxidase and superoxide dismutase / Yu. E. Kolupaev, E. N. Firsova, T. O. Yastreb. - P.34-42 Khomochkin, A. P. Reversible pH-dependent activation/inactivation of CF1-ATPase of spinach chloroplasts / A. P. Khomochkin [et al.]. - P.43-48 Інші автори: Onoiko O. B., Semenikhin A. V., Zolotareva O. K. Gozhenko, A. I. The experimental investigation of fibrinolytic system under the influence of flocalin in conditions of acute hypoxic kidney injury / A. I. Gozhenko [et al.]. - P.49-55 Інші автори: Gubsky Yu. I., Filipets N. D., Filipets O. O., Gozhenko O. A. Prysiazhniuk, A. I. Role of peripheral dopaminergic system in the pathogenesis of experimental colitis in rats / A. I. Prysiazhniuk [et al.]. - P.56-67 Інші автори: Rudyk M. P., Chervinska T. M., Dovbynchuk T. V., Opeida I. V., Skivka L. M., Tolstanova G. M. Horid’ko, T. M. Antistress effects of N-stearoylethanolamine in rats with chronic social stress / T. M. Horid’ko [et al.]. - P.68-76 Інші автори: Kosiakova H. V., Berdyshev A. G., Meged O. F., Gudz E. A., Onopchenko O. V., Asmolkova V. S., Lozova V. M., Tukalenko E. V., Bondarenko O. V., Tubalzeva I. I., Kovalenko O. A., Makarchuk M. Y., Hula N. M. Subekti, N. Determination of the major compounds in the extract of the subterranean termite Macrotermes gilvus Hagen digestive tract by GC-MS method / N. Subekti [et al.]. - P.77-82 Інші автори: Fibriana F., Widyaningrum P., Adfa M. Виноградова, Р. П. Науково-практичні розробки відділу молекулярної біології Інституту біохімії ім. О. В. Палладіна НАН України / Р. П. Виноградова, М. В. Григор’єва, В. М. Данилова. - P.83-90 Є примірники у відділах: Прим. 1 (вільний) |
Шифр: УУ60/2017/89/5 Журнал 2017р. Т. 89 № 5 Mikosha, A. S. Biochemical mechanism of the o,p’-DDD effect on the adrenal cortex / A. S. Mikosha, О. I. Kovzun. - P.5-14 Osadchuk, T. V. Influence of cations on furin activity / T. V. Osadchuk [et al.]. - P.15-20 Інші автори: Shybyryn O. V., Semyroz A. V., Bondarenko O. M., Kibirev V. K. Yatsenko, T. A. Ca2+-dependent regulation of fibrinolytic system activation on fibrin(ogen) D-domains / T. A. Yatsenko [et al.]. - P.21-31 Інші автори: Rybachuk V. М., Kharchenko S. M., Grinenko T. V. Protopopov, M. V. Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives / M. V. Protopopov [et al.]. - P.32-39 Інші автори: Ostrynska O. V., Ivanchenko D. H., Starosyla S. A., Bdzhola V. G., Romanenko M. I., Yarmoluk S. M. Minchenko, O. H. Expression of tumor growth related genes in IRE1 knockdown U87 glioma cells: effect of hypoxia / О. Н. Minchenko [et al.]. - P.40-51 Інші автори: Luzina O. Y., Hnatiuk O. S., Minchenko D. O., Garmash I. A., Ratushna O. O. Halkin, O. V. Expression of ubiquitin specific peptidase and ATG7 genes in U87 glioma cells upon glutamine deprivation / O. V. Halkin [et al.]. - P.52-61 Інші автори: Minchenko D. O., Riabovol O. O., Telychko V. V., Ratushna O. O., Minchenko O. H. Berdyshev, A. G. Modulation of LPS-induced ROS production and NF-кB nuclear translocation by N-stearoylethanolamine in macrophages / A. G. Berdyshev, H. V. Kosiakova, N. M. Hula. - P.62-69 Oriabinska, L. B. Ethylthiosulfanilate effect on Candida tropicalis / L. B. Oriabinska [et al.]. - P.70-76 Інші автори: Starovoitova S. O., Vasylyuk S. V., Novikov V. P., Lubenets V. I. Kobylinska, L. I. Indicators of oxidative and nitrosative stress and activity of enzymes of nitric oxide metabolism in rats treated with 4-thiazolidinone derivatives possessing antineoplastic activity / L. I. Kobylinska [et al.]. - P.77-83 Інші автори: Panchuk R. R., Lesyk R. B., Zimenkovsky B. S., Stoika R. S. Parkhomenko, Yu. M. Thiamine diphosphate synthesis and redox state indicator in the RAT brain during B1 hypovitaminosis / Yu. M. Parkhomenko [et al.]. - P.84-96 Інші автори: Pavlova A. S., Mejenskaya O. A., Stepanenko S. P., Chekhivska L. I. Manoilov, K. Yu. Enhancement of internalization of diphtheria toxin recombinant fragments in sensitive cells mediated by toxin’s T-domain / K. Yu. Manoilov [et al.]. - P.96-105 Інші автори: Labyntsev A. J., Korotkevych N. V., Kolybo D. V. Vovkun, T. V. The features of bile acids exchange in rats under the influence of corvitin / T. V. Vovkun [et al.]. - P.106-116 Інші автори: Yanchuk P. I., Shtanova L. Ya., Veselskiy S. P., Filimonova N. B., Shalamay A. S., Vedmid V. G. Виноградова, Р. П. Науково-практична діяльність лабораторії сигнальних механізмів клітини Інституту біохімії ім. О. В. Палладіна НАН України / Р. П. Виноградова, І. Ю. Черниш, В. М. Данилова. - P.117-123 The Nobel Prize in Physiology or Medicine 2017. - P.127 The Nobel Prize in Chemistry 2017. - P.128 Є примірники у відділах: Прим. 1 (вільний) |
Berdyshev, A. G. Modulation of LPS-induced ROS production and NF-кB nuclear translocation by N-stearoylethanolamine in macrophages / A. G. Berdyshev, H. V. Kosiakova, N. M. Hula // The Ukrainian Biochemical Journal. - 2017. - Том 89, N 5. - P62-69 MeSH-головна: МАКРОФАГИ -- MACROPHAGES (действие лекарственных препаратов) ЛИПОПОЛИСАХАРИДЫ -- LIPOPOLYSACCHARIDES (метаболизм) БРЮШНАЯ ПОЛОСТЬ -- ABDOMINAL CAVITY (патофизиология) ЭУКАРИОТЫ -- EUKARYOTA Анотація: N-Stearoylethanolamine (NSE) is a minor lipid that belongs to the N-acylethanolamines family that mediates a wide range of biological processes. The effect of the NSE on reactive oxygen species (ROS) production and NF-κB activation stimulated by lipopolysaccharide (LPS) in rat peritoneal macrophages (PM) was evaluated. PM were obtained from the rat peritoneal cavity. ROS were detected following DCFDA and DHE fluorescence. Nuclear translocation of p65 NF-κB was examined by immunofluorescent method using confocal microscopy. It was shown that NSE exposure to peritoneal macrophages (10[[p]]-7[[/p]] M) prior to 30 min LPS stimulation inhibited super oxide and hydrogen peroxide production and NF-κB translocation into nuclei. Thus, NSE exhibits therapeutic potential to treat inflammatory diseases associated with increased activation of macrophages Дод.точки доступу: Kosiakova, H. V. Hula, N. M. Вільних прим. немає |
Шифр: УУ60/2018/90/6 Журнал 2018р. Т. 90 № 6 Asmaa, Missoum. The role of gene GJB2 and connexin 26 in hearing impairment / Missoum Asmaa. - P.5-11 Kolupaev, Yu. E. Phenylalanine ammonia-lyase activity and content of flavonoid compounds in wheat seedlings at the action of hypothermia and hydrogen sulfide donor / Yu. E. Kolupaev [et al.]. - P.12-20 Інші автори: Horielova E. I., Yastreb T. O., Popov Yu. V., Ryabchun N. I. Chernyshenko, V. O. Haemostasis modulation by calix[4]arene methylenebisphosphonic acid C-145 and its sulfur-containing analogue / V. O. Chernyshenko [et al.]. - P.21-30 Інші автори: Savchuk O. V., Cherenok S. O., Silenko O. M., Negelia A. O., Kasatkina L. O., Pirogova L. V., Didkivskyi V. A., Yusova O. I., Kalchenko V. I., Garmanchuk L. V., Grinenko T. V., Lugovskoy E. V., Komisarenko S. V. Tykhomyrov, A. A. Plasminogen modulates formation of reactive oxygen species in human platelets / A. A. Tykhomyrov [et al.]. - P.31-40 Інші автори: Zhernosekov D. D., Guzyk M. M., Korsa V. V., Grinenko T. V. Siromolot, A. A. Specificity and sensitivity of the new test for serological evaluation of tuberculosis using MPT83-MPT63 fusion antigen / A. A. Siromolot [et al.]. - P.41-48 Інші автори: Chudina T. O., Danilova I. S., Rekalova O. M., Kolybo D. V., Komisarenko S. V. Lylyk, M. P. Effects of alpha-ketoglutarate on lifespan and functional aging. Of Drosophila melanogaster flies / M. P. Lylyk [et al.]. - P.49-61 Інші автори: Bayliak M. M., Shmihel H. V., Storey J. M., Storey K. B., Lushchak V. I. Purkan, P. Immunogenicity assay of KatG protein from Mycobacterium tuberculosis in mice: preliminary screening of TB vaccine / P. Purkan [et al.]. - P.62-69 Інші автори: Budiyanto R., Akbar R., Wahyuningsih S. P., Retnowati W. Zavodovskyi, D. O. Influence of C60 fullerene on the ischemia-reperfusion injury in the skeletal muscle of rat limb: mechanokinetic and biochemical analysis / D. O. Zavodovskyi [et al.]. - P.70-81 Інші автори: Zay S. Yu., Matvienko T. Yu., Prylutskyy Yu. I., Nurishchenko N. Y., Paradizova S. S., Bezuh L. L., Ritter U., Scharff P. Nakonechna, O. A. Disturbance of the transmembrane phosphatidylserine asymmetry in hepatocytes as an apoptosis marker under the action of xenobiotics on rats / O. A. Nakonechna, L. A. Babijchuk, A. I. Bezrodna. - P.82-88 Aminizadeh, S. The effects of PDK4 inhibition on AMPK protein levels and PGC-1α gene expression following endurance training in skeletal muscle of Wistar rats / S. Aminizadeh, Y. Masoumi-Ardakani, B. Shahouzehi. - P.89-96 Horid’ko, T. M. Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment / T. M. Horid’ko [et al.]. - P.97-109 Інші автори: Kosiakova H. V., Berdyshev A. G., Meged O. F., Onopchenko O. V., Klimashevsky V. M., Tkachenko O. S., Bazylianska V. R., Kholin V. O., Peschana K. O., Mykhalskiy S. A., Hula N. M. Hurmach, Y. The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma / Y. Hurmach [et al.]. - P.110-119 Інші автори: Rudyk M., Svyatetska V., Senchylo N., Skachkova O., Pjanova D., Vaivode K., Skivka L. Marounek, M. Long-term hypocholesterolemic effect of amidated alginate in rats / M. Marounek [et al.]. - P.120-125 Інші автори: Volek Z., Taubner T., Duskova D., Kalachniuk L. Данилова, В. М. Внесок Нобелівських лауреатів початку ХХ ст. в розвиток молекулярної імунології: Е. Берінг, І. І. Мечников, П. Ерліх, Ш. Ріше, Ж. Борде, К. Ландштейнер / В. М. Данилова, Р. П. Виноградова, С. В. Комісаренко. - P.126-142 Дмитро Олексійович Мельничук. До 75-річчя з дня народження. - P.143-144 Є примірники у відділах: Прим. 1 (вільний) |
Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment [Text] / T. M. Horid’ko [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 6. - P97-109 MeSH-головна: КОГНИТИВНЫЕ РАССТРОЙСТВА -- COGNITION DISORDERS (лекарственная терапия, метаболизм) СКОПОЛАМИНА ГИДРОБРОМИД -- SCOPOLAMINE HYDROBROMIDE ЭУКАРИОТЫ -- EUKARYOTA Анотація: The impairment of cognitive functions is the most studied medical and social problem nowadays. The aim of this study was to evaluate the protective effects of N-stearoylethanolamine (NSE) on memory state, blood and brain biochemical parameters in rats under scopolamine-induced cognitive impairment. The results of this study shown that NSE administration to rats per os (5 mg/kg, 5 days, during last 3 days NSE was administrated 20 min prior to scopolamine injection (1 mg/kg, once daily for 3 days, intraperitoneally)) prevented the development of memory impairment. In particular, NSE action was associated with the prevention of increase in acetylcholinesterase activity, changes in phospholipid, free and esterified cholesterol level in hippocampus and frontal cortex, and disruption in pro-/antioxidant balance in blood and studied brain sections. Considering the above mentioned biological effects, NSE is a promising drug candidate for integrative therapy of cognitive impairment of different profiles Дод.точки доступу: Horid’ko, T. M. Kosiakova, H. V. Berdyshev, A. G. Meged, O. F. Onopchenko, O. V. Klimashevsky, V. M. Tkachenko, O. S. Bazylianska, V. R. Kholin, V. O. Peschana, K. O. Mykhalskiy, S. A. Hula, N. M. Вільних прим. немає |
Шифр: УУ60/2020/92/2 Журнал 2020р. Т. 92 № 2 Vari, S. G. Homo scientist can lead HOMO SAPIENS to the next evolutionary stage, to HOMO ingenious / S. G. Vari. - P.5-6 Korolyuk, O. Ya. Hypertriclyceridemia is associated with long-term risk of cardiovascular events and specific comorbidity in very high-risk hypertensive patients / O. Ya. Korolyuk, O. M. Radchenko. - P.8-19 Bozhenko, M. Freezing influences, the exposure of IgG glycans in sera from multiple sclerosis patients / M. Bozhenko [et al.]. - P.21-31 Інші автори: Boichuk M., Bila G., Nehrych T., Bilyy R. Nasadyuk, C. M. Lectinocytochemical study of rat stomach mucosa under the conditions of cyclooxygenase-1/-2 blockage and pretreatment with H-GLU-ASP-GLY-OH / C. M. Nasadyuk [et al.]. - P.33-43 Інші автори: Sogomonyan E. A., Yashchenko A. M., Sklyarov A. Y. Onopchenko, O. V. The effect of N-stearoylethanolamine on the lipid composition of the rat testes and testosterone level during the early stages of streptozotocin-induced diabetes / O. V. Onopchenko [et al.]. - P.45-59 Інші автори: Horid’ko T. M., Kosiakova H. V., Berdyshev A. G., Klimashevsky V. M., Hula N. M. Tkachenko, O. S. Protective action of N-stearoylethanolamine on blood coagulation and arterial changes in spontaneously hypertensive rats fed cholesterol-rich diet / O. S. Tkachenko [et al.]. - P.60-71 Інші автори: Hydz Ie. A., Kosiakova H. V., Klymenko P. P., Stohnii Y. M., Didkivskyi V. A., Chernyshenko T. M., Chernyshenko V. O., Platonova T. M. Stohnii, Y. M. Aggregation of platelets, proliferation of endothelial cells and motility of cancer cells are mediated by the Bβ1(15)-42 residue of fibrin(ogen) / Y. M. Stohnii [et al.]. - P.72-85 Інші автори: Ryzhykova M. V., Rebriev A. V., Kuchma M. D., Marunych R. Y., Chernyshenko V. O., Shablii V. A., Lypova N. M., Slominskyi O. Yu., Garmanchhuk L. V., Platonova T. M., Komisarenko S. V. Revenko, O. Exogenous hydrogen sulfide for the treatment of mesenteric damage associated with fructose-induced malfunctions via inhibition of oxidative stress / O. Revenko [et al.]. - P.86-98 Інші автори: Zaichko N., Wallace J., Zayachkivska O. Bila, G. Novel approach for discrimination of eosinophilic granulocytes and evaluation of their surface receptors in a multicolor fluorescent histological assessment / G. Bila [et al.]. - P.99-107 Інші автори: Schneider M., Peshkova S., Krajnik B., Besh L., Lutsyk A., Matsyura O., Bilyy R. Kryshchyshyn, A. Synthesis and anti-leukemic activity of pyrrolidinedione-thiazolidinone hybrids / A. Kryshchyshyn [et al.]. - P.108-120 Інші автори: Kaminskyy D., Roman O., Kralovics R., Karpenko O., Lesyk R. Hreniukh, V. P. Effects of thiazole derivatives on intracellular structure and functions in murine lymphoma cells / V. P. Hreniukh [et al.]. - P.121-131 Інші автори: Finiuk N. S., Shalai Ya. R., Manko B. O., Manko B. V., Ostapiuk Yu. V., Kulachkovskyy O. R., Obushak M. D., Stoika R. S., Babsky A. M. Chaban, T. I. Development of effective anti-inflammatory drug candidates among novel thiazolopyridines / T. I. Chaban [et al.]. - P.132-139 Інші автори: Matiychuk V. S., Ogurtsov V. V., Chaban I. G., Nektegayev I. A. Є примірники у відділах: Прим. 1 (вільний) |
The effect of N-stearoylethanolamine on the lipid composition of the rat testes and testosterone level during the early stages of streptozotocin-induced diabetes / O. V. Onopchenko [et al.] // The Ukrainian biochemical journal. - 2020. - Vol. 92, № 2. - P45-59 MeSH-головна: ДИАБЕТ САХАРНЫЙ ЭКСПЕРИМЕНТАЛЬНЫЙ -- DIABETES MELLITUS, EXPERIMENTAL (патофизиология) ЯИЧНИКИ -- OVARY (действие лекарственных препаратов, патофизиология) ТЕСТОСТЕРОН -- TESTOSTERONE (анализ) ЭУКАРИОТЫ -- EUKARYOTA Анотація: Diabetes is a metabolic disorder with multiorgan complications, including reproductive system dysfunction where lipid imbalance of germ cells play an important role. N-stearoylethanolamine (NSE) shows a modulatory effect on the lipid composition under different pathologies. Therefore, the aim of our study was to investigate the NSE effect on the testes lipid composition and testosterone level in plasma of diabetic rats. Diabetes was induced in Sprague-Dawley rats by a single streptozotocin injection (50 mg/kg). Animals with glucose levels of 8-12 mmol/l were further selected. NSE was administrated to rats (50 mg/kg) for 10 days at 1.5 months after the streptozotocin injection. The rat testes were used for lipid analysis, namely, phospholipid level, fatty acid methyl esters and plasma testosterone estimation. NSE administration to diabetic rats triggered normalization of total and individual phospholipid content, as well as composition of free and phospholipids fatty acids in the rat testes. In addition, the testosterone content showed a slight increase under the action of NSE. Our results showed that the early stages of diabetes caused destructive changes in rat testes that may induce a decrease in future testicular function. NSE administration to diabetic rats normalized the lipid content of rat testes and was correlated with an increased testosterone level. NSE induced the restoration of testes structure and function during the early stages of streptozotocin-іnduced diabetes in rats Дод.точки доступу: Onopchenko, O. V. Horid’ko, T. M. Kosiakova, H. V. Berdyshev, A. G. Klimashevsky, V. M. Hula, N. M. Вільних прим. немає |