Шифр: ЕУ12/2020/42/1    Журнал Экспериментальная онкология [Текст] 2020р. Т. 42 № 1 Зміст: Bubnovskaya, L. Tumor microenvironment and metabolic factors: contribution to gastric cancer / L. Bubnovskaya, D. Osinsky. - С.2-10 Gong, Y. Rapamycin-induced autophagy plays a pro-survival role by enhancing up-regulation of intracellular ferritin expression in acute lymphoblastic leukemia / Y. Gong [et al.]. - С.11-15 Інші автори: Wu J., Yang R., Zhang L., Ma Z. Shcherbina, V. Sensitivity of chronic lymphocytic leukemia cells to chemotherapeutic drugs ex vivo depends on expression staus of cell surface receptors / V. Shcherbina [et al.]. - С.16-24 Інші автори: Gordiienko I., Shlapatska L., Ivanivska T., Sidorenko S. Siromolot, A. A. Antiproliferative and apoptotic effects of anti-human HB-EGF neutralizing polyclonal antibodies in vitro / A. A. Siromolot [et al.]. - С.25-30 Інші автори: Krynina O. I., Kolybo D. V., Komisarenko S. V. Shvachko, L. P. Aberrant expression of placental-like alkaline phosphatase in chronic myeloid leukemia cells in vitro and its modulation by vitamin E / L. P. Shvachko [et al.]. - С.31-34 Інші автори: Zavelevich M. P., Gluzman D. F., Telegeev G. D. Kolesnik, D. L. Metformin enhances cytotoxic action of dichloroacetate against lewis lung carcinoma cells in vitro / D. L. Kolesnik [et al.]. - С.35-39 Інші автори: Pyaskovskaya O. N., Gorbach O., Solyanik G. I. Sarnatskaya, V. V. Structural changes of serum albumin in response to oxidative stress caused by Walker-256 carcinosarcoma growth / V. V. Sarnatskaya [et al.]. - С.40-45 Інші автори: Yushko L. A., Prokopenko I. V., Hudenko N. V., Maslenny V. N., Paziuk L. M., Bubnovskaya L. N., Nikolaev V. G. Burlaka, A. A. Drag reducing polymers attenuate adverse effects of ischemia-reperfusion upon resection of liver metastases modeled by MC38 mouse colon adenocarcinoma / A. A. Burlaka [et al.]. - С.46-50 Інші автори: Burlaka A. P., Krotevych M. S., Rudiuk T. O., Orel V. E. Lifsics, A. Survival analysis of oropharyngeal squamous cell carcinoma patients linked to histopathology, disease stage, tumor stage, risk factors, and received therapy / A. Lifsics [et al.]. - С.51-59 Інші автори: Rate E., Ivanova A., Tars J., Murovska M., Groma V. Bilous, N. MYC copy number and mRNA expression in chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chornobyl NPP accident / N. Bilous [et al.]. - С.60-65 Інші автори: Abramenko I., Chumak A., Dyagil I., Martina Z. Fedorenko, Z. P. Incidence and long-term effects of treatment of malignant germ cell neoplasms in Ukraine / Z. P. Fedorenko [et al.]. - С.66-74 Інші автори: Mikchailovich Yu. I., Goulak L. O., Ryzhov A. Yu., Gorokh Ye. L., Soumkina O. V. Kozirovskis, V. High expression of GLI1 is associated with better survival in advanced SCLC / V. Kozirovskis [et al.]. - С.75-77 Інші автори: Zandberga E., Magone M., Purkalne G., Line A., Vikmanis U. Kearney, L. Frequency and spectrum of atypical BCR-ABL1 transcripts in chronic myeloid leukemia / L. Kearney, M. Grampe, S. E. Langabeer. - С.78-79 In commemoration of Dmitriy Vladimirovich Myasoyedov. - С.80 Є примірники у відділах: Прим. 1 (вільний)

Bubnovskaya, L.     Tumor microenvironment and metabolic factors: contribution to gastric cancer / L. Bubnovskaya, D. Osinsky // Experimental Oncology. - 2020. - Том 42, N 1. - P2-10 MeSH-головна: ЖЕЛУДКА НОВООБРАЗОВАНИЯ -- STOMACH NEOPLASMS (метаболизм, патофизиология, этиология) Анотація: Malignancy may be characterized as a state formed in the setting of specific tumor-host relationships at the molecular and cellular microenvironment levels. R.E. Kavetsky and his collaborators distinctly outlined the concept of tumor-host interaction. Tumor is a complicated biological system closely connected with the organism, where it arises and develops. Tumor cells are in the environment of different factors that form tumor microenvironment playing an active role in the disease progression. There are two types of tumor microenvironment: the metabolic microenvironment mediated by factors of tumor microphysiology (blood flow, vascular permeability, oxygenation, extracellular рН, interstitial fluid pressure, etc.) and the cellular-molecular microenvironment comprising interactions between tumor cells and non-tumor cells and the factors of the stromal compartment. Factors of tumor microphysio­logy can modify the interaction between tumor cells and surrounding non-tumor cells and molecular components and they form the tumor profile that influences the pressure of tumor on the host. The review presents the data concerning the role of metabolic microenvironment of tumor cells from the point of tumor-host interaction in order to employ these parameters to working out the methods of diagnosis and prognosis of disease outcome in patients with gastric cancer. Special attention has been paid to hypoxia as a key factor of metabolic microenvironment that positively affects tumor progression, stimulating its aggressiveness, metastasis and resistance to therapy and is regarded as a factor of unfavorable prognosis. It was shown that there is possible clinical relevance of tumor classification based on the level of tumor oxygenation that may be advantageous for selection of patients for individualized therapy that may give the hope for enhancement of treatment efficacy Дод.точки доступу: Osinsky, D. Вільних прим. немає

Structural changes of serum albumin in response to oxidative stress caused by Walker-256 carcinosarcoma growth / V. V. Sarnatskaya [et al.] // Experimental Oncology. - 2020. - Том 42, N 1. - P40-45 MeSH-головна: КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER (метаболизм, патофизиология) АЛЬБУМИН СЫВОРОТОЧНЫЙ -- SERUM ALBUMIN (метаболизм) ОКСИДАТИВНЫЙ СТРЕСС -- OXIDATIVE STRESS Анотація: To assess oxidative stress and structural changes of the serum albumin in rats with transplanted Walker-256 carcinosarcoma (W256) strains with varying sensitivity to doxorubicin (Dox). Materials and Methods: The study was performed on female Wistar rats with transplanted W256. On the 9th day after tumor cell transplantation an analysis of peripheral blood, oxidative stress para­meters, and structural changes of serum albumin of experimental animals was performed. Results: On the 9th day after W256 transplantation a significant increase in the leukocyte counts was observed in the groups of animals with the Dox-resistant and parental (Dox-sensitive) W256 tumors compared with the group of the intact animals: up to 14.24 ± 1.92 • 103/μl and 9.78 ± 1.03 • 103/μl, vs 8.92 ± 1.04 • 103/μl, respectively, due to the increase of granulocyte and monocyte counts. The number of lymphocytes was within the normal range. The level of hemoglobin and the erythrocyte counts were also within normal limits, but hematocrit in both groups of animals with tumors somewhat increased against the background of 1.2-fold elevation of the mean erythrocyte volume. In the group of rats with Dox-resistant W256, there was observed a decrease in the plateletcrit by almost 22% and thrombocyte counts — by 28%. Analysis of oxidative stress indices revealed a significant increase in the level of reactive oxygen species, 2-fold increase of malonic dialdehyde level and the degree of oxidative damage of blood plasma proteins, as well as a decrease in the activity of catalase in hemolysates (by 12–15%) in both groups of tumor-bearing rats. With the use of differential scanning calorimetry, UV and fluorescence spectroscopy we have revealed anomalous conformational changes of albumin caused by tumor development: structural rearrangements in the region of its first drug binding site located in the IIA domain, separation of globular parts of albumin molecule, and partial “opening” in a protein molecular three-domain structure resulting a loss of its thermal resistance. Conclusion: The development of transplanted Walker-256 carcinosarcoma, especially its Dox-resistant variant, results in severe metabolic intoxication reflected in alteration of hematological parameters, and indices of oxidative stress, as well as architectonic changes of serum albumin Дод.точки доступу: Sarnatskaya, V. V. Yushko, L. A. Prokopenko, I. V. Hudenko, N. V. Maslenny, V. N. Paziuk, L. M. Bubnovskaya, L. N. Nikolaev, V. G. Вільних прим. немає